Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 336, P. 118704 - 118704
Published: Aug. 24, 2024
Language: Английский
Redox Biology, Journal Year: 2024, Volume and Issue: 70, P. 103077 - 103077
Published: Feb. 11, 2024
Inflammatory diseases present a serious health challenge due to their widespread prevalence and the severe impact on patients' lives. In quest alleviate burden of these diseases, nuclear factor erythroid 2-related 2 (Nrf2) has emerged as pivotal player. As transcription intimately involved in cellular defense against metabolic oxidative stress, Nrf2's role modulating inflammatory responses immune cells garnered significant attention. Recent findings suggest that ability alter redox status underlies its regulatory effects responses. Our review delves into preclinical clinical evidence underscores complex influence Nrf2 activators cell phenotypes, particularly milieu. By offering detailed analysis different populations, we cast light potential shaping response towards more regulated state, mitigating adverse inflammation through modeling cells. Furthermore, explore innovative use nanoencapsulation techniques enhance delivery efficacy activators, potentially advancing treatment strategies for ailments. We hope this will stimulate development expansion Nrf2-targeted treatments could substantially improve outcomes patients suffering from broad range diseases.
Language: Английский
Citations
27
Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(22), P. 12340 - 12355
Published: May 22, 2024
Lipid peroxidation (LP) leads to changes in the fluidity and permeability of cell membranes, affecting normal cellular function potentially triggering apoptosis or necrosis. This process is closely correlated with onset many diseases. Evidence suggests that phenolic hydroxyl groups food-borne plant polyphenols (FPPs) make them effective antioxidants capable preventing diseases triggered by membrane LP. Proper dietary intake FPPs can attenuate oxidative stress, especially damage phospholipids, activating Nrf2/GPx4 pathway. Nuclear factor E2-related 2 (Nrf2) an stress antagonist. The signaling pathway regulated Nrf2 a defense transduction organism against external stimuli such as reactive oxygen species exogenous chemicals. Glutathione peroxidase 4 (GPx4), under regulation Nrf2, only enzyme reduces lipid peroxides specificity, thus playing pivotal role regulating ferroptosis counteracting stress. study explored mechanism, antioxidant activity FPPs, mechanism It also highlighted bioprotective properties LP its associated mechanisms, including (i) activation pathway, GPx4 serving central target protein, (ii) activities, leading reduction production ROS other peroxides, (iii) effects on downstream phospholipid structure. In conclusion, play crucial natural However, further in-depth analysis coregulation multiple pathways required, combined these mechanisms need evaluation experimental models. Human trials could provide valuable insights into new directions for research application.
Language: Английский
Citations
14
Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)
Published: June 18, 2024
Abstract Acute lung injury ( ALI ) is a common complication in patients with severe burns and has complex pathogenesis high morbidity mortality rates. A variety of drugs have been identified the clinic for treatment ALI, but they toxic side effects caused by easy degradation body distribution throughout body. In recent years, as understanding mechanism underlying improved, scholars developed new nanomaterials that can be safely effectively targeted ALI. Most these methods involve such lipids, organic polymers, peptides, extracellular vesicles or cell membranes, inorganic nanoparticles other nanomaterials, which are to reach tissues perform their functions through active targeting passive targeting, process involves cells organelles. this review, first, mechanisms pathophysiological features occurrence after burn reviewed, potential therapeutic targets summarized, existing classified, possible problems challenges discussed provide reference development
Language: Английский
Citations
11
Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 331, P. 118333 - 118333
Published: May 14, 2024
Language: Английский
Citations
9
Phytotherapy Research, Journal Year: 2024, Volume and Issue: 38(4), P. 2041 - 2076
Published: Feb. 23, 2024
Abstract In recent years, heightened interest surrounds the exploration of natural phenols as potential agents for cancer therapy, specifically by inducing ferroptosis, a unique form regulated cell death characterized iron‐dependent lipid peroxidation. This review delves into roles key phenols, flavonoids, phenolic acids, curcumin, and stilbenes, in modulating ferroptosis their underlying mechanisms. Emphasizing significance amino acid, lipid, iron metabolism, study elucidates diverse pathways through which these regulate ferroptosis. Notably, well‐known polyphenol, exhibits multifaceted interactions with cellular components involved regulation, providing distinctive therapeutic avenue. Stilbenes, another class, demonstrate promising influencing metabolism processes, contributing to ferroptotic death. Understanding intricate interplay between not only illuminates complex regulatory networks but also unveils avenues novel therapies. Exploring compounds inducers presents strategy targeted treatment, capitalizing on delicate balance article synthesizes current knowledge, aiming stimulate further research context ferroptosis‐mediated therapy.
Language: Английский
Citations
6
Antioxidants, Journal Year: 2024, Volume and Issue: 13(3), P. 334 - 334
Published: March 10, 2024
Ferroptosis is a recently discovered type of programmed cell death that mechanistically different from other types such as apoptosis, necroptosis, and autophagy. It characterized by the accumulation intracellular iron, overproduction reactive oxygen species, depletion glutathione, extensive lipid peroxidation lipids in membrane. was ferroptosis interconnected with many diseases, neurodegenerative ischemia/reperfusion injury, cancer, chronic kidney disease. Polyphenols, plant secondary metabolites known for bioactivities, are being extensively researched context their influence on which resulted great number publications showing need systematic review. In this review, an literature search performed. Databases (Scopus, Web Science, PubMed, ScienceDirect, Springer) were searched time span 2017 to November 2023, using keyword “ferroptosis” alone combination “flavonoid”, “phenolic acid”, “stilbene”, “coumarin”, “anthraquinone”, “chalcone”; after selection studies, we had 311 papers 143 phenolic compounds. total, 53 compounds showed ability induce ferroptosis, 110 able inhibit out those compounds, 20 both abilities depending model system. The most shikonin, curcumin, quercetin, resveratrol, baicalin. common modes action modulation Nrf2/GPX4 Nrf2/HO-1 axis iron metabolism.
Language: Английский
Citations
6
Chemico-Biological Interactions, Journal Year: 2024, Volume and Issue: 391, P. 110892 - 110892
Published: Feb. 15, 2024
Language: Английский
Citations
5
Shock, Journal Year: 2024, Volume and Issue: 62(2), P. 245 - 254
Published: June 26, 2024
ABSTRACT Sepsis is a lethal clinical syndrome, and acute lung injury (ALI) the earliest most serious complication. We aimed to explore role of growth differentiation factor 11 (GDF11) in sepsis-induced dysfunction microvascular endothelial barrier vivo vitro elucidate its potential mechanism related sirtuin 1 (SIRT1)/NADPH oxidase 4 (NOX4) signaling. Cecal ligation puncture (CLP)-induced sepsis mice lipopolysaccharide (LPS)-induced pulmonary cells (PMECs) were used this study. Histopathological changes tissues tested by hematoxylin-eosin staining. Lung wet-to-dry weight ratio inflammatory factors contents bronchoalveolar lavage fluid assessed. Evens blue index, trans-epithelial electrical resistance, expression zona occludens (ZO-1), occludin-1, claudin-1 evaluate alveolar integrity. Reactive oxygen species, lipid peroxidation, ferroptosis markers analyzed. Iron deposition was assessed using Prussian Intracellular Fe 2+ level detected FerroOrange Additionally, GDF11, SIRT1, NOX4 estimated with western blot. Then, EX527, SIRT1 inhibitor, employed treat GDF11-overexpressed PMECs LPS stimulation clarify regulatory mechanism. Results showed that GDF11 overexpression attenuated pathological inflammation maintained Moreover, inhibited ferroptosis, upregulated downregulated expression. EX527 treatment relieved impacts on destruction integrity human exposed LPS. Taken together, could alleviate damage activating SIRT1/NOX4 signaling inhibit ferroptosis. Our findings potentially provide new molecular target for therapy ALI.
Language: Английский
Citations
5
Cell Death and Disease, Journal Year: 2024, Volume and Issue: 15(11)
Published: Nov. 18, 2024
Abstract Ferroptosis is a distinctive process of cellular demise that linked to amino acid metabolism, lipid oxidation, and iron oxidation. The ferroptosis cascade genes, which are closely associated with the onset lung diseases, among regulatory targets nuclear factor erythroid 2-related 2 (Nrf2). Although regulation mostly mediated by Nrf2, precise roles underlying mechanisms Nrf2 in illness remain unclear. This review provides new insights from recent discoveries involving modulation range diseases. It also systematically describes peroxidation, intracellular antioxidant levels, ubiquitination expression FSP1 GPX4. Finally, it summarises active ingredients drugs potential for treatment With overarching aim expediting improvements treatment, this reference novel therapeutic offers suggestions development medications variety disorders.
Language: Английский
Citations
5
Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 179, P. 117323 - 117323
Published: Aug. 28, 2024
Recently, increased attention has been focused on the regulatory mechanism and potential clinical application of ferroptosis in cancer cells, especially therapy-related ferroptosis. However, treatment-related prospects strategies for future treatment still require further clarification. This review highlights molecular relationships between different antitumour drugs, including commonly used chemotherapy radiation therapy vitamins, also proposes treatments that involve ferroptosis, with an aim to develop a new strategy transformative emerging field improve therapy.
Language: Английский
Citations
4