Electrical Stimulation in Hippocampus and Entorhinal Cortex Impairs Spatial and Temporal Memory DOI Creative Commons
Abhinav Goyal,

Jonathan Miller,

Andrew J. Watrous

et al.

Journal of Neuroscience, Journal Year: 2018, Volume and Issue: 38(19), P. 4471 - 4481

Published: April 10, 2018

The medial temporal lobe (MTL) is widely implicated in supporting episodic memory and navigation, but its precise functional role organizing across time space remains elusive. Here we examine the specific cognitive processes implemented by MTL structures (hippocampus entorhinal cortex) to organize using electrical brain stimulation, leveraging ability establish causal links between regions features of behavior. We studied neurosurgical patients both sexes who performed spatial-navigation verbal-episodic tasks while stimulation was applied various during learning. During verbal task, disrupted organization encoded memories such that items learned with tended be recalled a more randomized order. spatial impaired subjects' abilities remember located far away from boundaries. These effects were MTL. Our findings thus provide first demonstration humans are encode when where events occurred. SIGNIFICANCE STATEMENT Numerous studies have encoding memories, they not been able causally demonstrate nature which this occurs real-time. Electrical region given function high precision. By examining behavior task as subjects received evidence demonstrating aspects memory.

Language: Английский

Inferring single-trial neural population dynamics using sequential auto-encoders DOI
Chethan Pandarinath, Daniel J. O’Shea,

Jasmine Collins

et al.

Nature Methods, Journal Year: 2018, Volume and Issue: 15(10), P. 805 - 815

Published: Sept. 14, 2018

Language: Английский

Citations

584
Theta Oscillations in Human Memory DOI Creative Commons
Nora A. Herweg, Ethan A. Solomon, Michael J. Kahana

et al.

Trends in Cognitive Sciences, Journal Year: 2020, Volume and Issue: 24(3), P. 208 - 227

Published: Feb. 3, 2020

Language: Английский

Citations

417
Modulating Human Memory via Entrainment of Brain Oscillations DOI
Simon Hanslmayr, Nikolai Axmacher, Cory S. Inman

et al.

Trends in Neurosciences, Journal Year: 2019, Volume and Issue: 42(7), P. 485 - 499

Published: June 6, 2019

Language: Английский

Citations

219
Representation, Pattern Information, and Brain Signatures: From Neurons to Neuroimaging DOI Creative Commons
Philip A. Kragel, Leonie Koban, Lisa Feldman Barrett

et al.

Neuron, Journal Year: 2018, Volume and Issue: 99(2), P. 257 - 273

Published: July 1, 2018

Language: Английский

Citations

205
Transcranial electrical stimulation (tES) mechanisms and its effects on cortical excitability and connectivity DOI Creative Commons
Thomas Reed, Roi Cohen Kadosh

Journal of Inherited Metabolic Disease, Journal Year: 2018, Volume and Issue: 41(6), P. 1123 - 1130

Published: July 13, 2018

Abstract In this review, we describe transcranial electrical stimulation (tES) techniques currently being used in neuroscientific research, including direct current (tDCS), alternating (tACS) and random noise (tRNS) techniques. We explain how these are summarise the proposed mechanisms of action for each technique. continue by describing method has been to alter endogenous neuronal oscillations connectivity between brain regions, conclude highlighting varying effects discussing future direction research.

Language: Английский

Citations

197
Time cells in the human hippocampus and entorhinal cortex support episodic memory DOI Creative Commons
Gray Umbach,

Pranish A. Kantak,

Joshua Jacobs

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2020, Volume and Issue: 117(45), P. 28463 - 28474

Published: Oct. 27, 2020

Significance Time cells are neurons in the hippocampus and entorhinal cortex that fire at specific moments within a cognitive task or experience. While many prominent theories of memory encoding offer time as source temporal component to memory, they have never been observed human recordings. We identify cell populations medial lobe humans during retrieval. Further, we demonstrate stability signal provided by influences ability temporally order memories

Language: Английский

Citations

163
Physical principles of brain–computer interfaces and their applications for rehabilitation, robotics and control of human brain states DOI
Alexander E. Hramov, Vladimir Maksimenko, Alexander N. Pisarchik

et al.

Physics Reports, Journal Year: 2021, Volume and Issue: 918, P. 1 - 133

Published: March 24, 2021

Language: Английский

Citations

155
Advances in human intracranial electroencephalography research, guidelines and good practices DOI Creative Commons
Manuel Mercier, Anne‐Sophie Dubarry, François Tadel

et al.

NeuroImage, Journal Year: 2022, Volume and Issue: 260, P. 119438 - 119438

Published: July 2, 2022

Since the second half of twentieth century, intracranial electroencephalography (iEEG), including both electrocorticography (ECoG) and stereo-electroencephalography (sEEG), has provided an intimate view into human brain. At interface between fundamental research clinic, iEEG provides high temporal resolution spatial specificity but comes with constraints, such as individual's tailored sparsity electrode sampling. Over years, researchers in neuroscience developed their practices to make most approach. Here we offer a critical review didactic framework for newcomers, well addressing issues encountered by proficient researchers. The scope is threefold: (i) common research, (ii) suggest potential guidelines working data answer frequently asked questions based on widespread practices, (iii) current neurophysiological knowledge methodologies, pave way good practice standards research. organization this paper follows steps processing. first section contextualizes collection. focuses localization electrodes. third highlights main pre-processing steps. fourth presents signal analysis methods. fifth discusses statistical approaches. sixth draws some unique perspectives Finally, ensure consistent nomenclature throughout manuscript align other guidelines, e.g., Brain Imaging Data Structure (BIDS) OHBM Committee Best Practices Analysis Sharing (COBIDAS), provide glossary disambiguate terms related

Language: Английский

Citations

131
Modelling and prediction of the dynamic responses of large-scale brain networks during direct electrical stimulation DOI
Yuxiao Yang, Shaoyu Qiao, Omid G. Sani

et al.

Nature Biomedical Engineering, Journal Year: 2021, Volume and Issue: 5(4), P. 324 - 345

Published: Feb. 1, 2021

Language: Английский

Citations

116
Augmenting hippocampal–prefrontal neuronal synchrony during sleep enhances memory consolidation in humans DOI Creative Commons
Maya Geva‐Sagiv, Emily A. Mankin,

Dawn Eliashiv

et al.

Nature Neuroscience, Journal Year: 2023, Volume and Issue: 26(6), P. 1100 - 1110

Published: June 1, 2023

Memory consolidation during sleep is thought to depend on the coordinated interplay between cortical slow waves, thalamocortical spindles and hippocampal ripples, but direct evidence lacking. Here, we implemented real-time closed-loop deep brain stimulation in human prefrontal cortex tested its effects electrophysiology overnight of declarative memory. Synchronizing active phases endogenous waves medial temporal lobe (MTL) enhanced spindles, boosted locking brain-wide neural spiking activity MTL improved coupling ripples oscillations. Furthermore, synchronized accuracy recognition By contrast, identical without this precise time-locking was not associated with, sometimes even degraded, these electrophysiological behavioral effects. Notably, individual changes memory were highly correlated with Our results indicate that hippocampo-thalamocortical synchronization causally supports consolidation.

Language: Английский

Citations

77