Lactate modulation of immune responses in inflammatory versus tumour microenvironments

Nature reviews. Immunology, Journal Year: 2020, Volume and Issue: 21(3), P. 151 - 161

Published: Aug. 24, 2020

Language: Английский

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The Role of HIF in Immunity and Inflammation

Cell Metabolism, Journal Year: 2020, Volume and Issue: 32(4), P. 524 - 536

Published: Aug. 26, 2020

Language: Английский

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Targeting immunometabolism as an anti-inflammatory strategy

Cell Research, Journal Year: 2020, Volume and Issue: 30(4), P. 300 - 314

Published: March 4, 2020

Abstract The growing field of immunometabolism has taught us how metabolic cellular reactions and processes not only provide a means to generate ATP biosynthetic precursors, but are also way controlling immunity inflammation. Metabolic reprogramming immune cells is essential for both inflammatory as well anti-inflammatory responses. Four therapies, DMF, Metformin, Methotrexate Rapamycin all work by affecting metabolism and/or regulating or mimicking endogenous metabolites with effects. Evidence emerging the targeting specific events strategy limit inflammation in different contexts. Here we discuss these recent developments speculate on prospect effort develop novel therapeutics. As accumulating evidence roles an intricate elaborate network processes, including lipid, amino acid nucleotide provides key focal points developing new here turn our attention glycolysis TCA cycle examples intermediates enzymes can potential therapeutic targets.

Language: Английский

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Dendritic cell migration in inflammation and immunity

Cellular and Molecular Immunology, Journal Year: 2021, Volume and Issue: 18(11), P. 2461 - 2471

Published: July 23, 2021

Language: Английский

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CCR7 Chemokine Receptor-Inducible lnc-Dpf3 Restrains Dendritic Cell Migration by Inhibiting HIF-1α-Mediated Glycolysis

Immunity, Journal Year: 2019, Volume and Issue: 50(3), P. 600 - 615.e15

Published: Feb. 26, 2019

Language: Английский

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Immunity, Hypoxia, and Metabolism–the Ménage à Trois of Cancer: Implications for Immunotherapy

Physiological Reviews, Journal Year: 2019, Volume and Issue: 100(1), P. 1 - 102

Published: Aug. 15, 2019

It is generally accepted that metabolism able to shape the immune response. Only recently we are gaining awareness metabolic crosstalk between different tumor compartments strongly contributes harsh microenvironment (TME) and ultimately impairs cell fitness effector functions. The major aims of this review provide an overview on system in cancer; position oxygen shortage competition as ground a restrictive TME important players anti-tumor response; define how immunotherapies affect hypoxia/oxygen delivery landscape tumor; vice versa, metabolites within impinge success immunotherapies. By analyzing preclinical clinical endeavors, will discuss characterization can identify novel targets signatures could be exploited combination with standard help predict benefit new traditional immunotherapeutic drugs.

Language: Английский

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Metabolic Control of Dendritic Cell Functions: Digesting Information

Frontiers in Immunology, Journal Year: 2019, Volume and Issue: 10

Published: April 25, 2019

Dendritic cells (DCs) control innate and adaptive immunity by patrolling tissues to gather antigens danger signals derived from microbes tissue. Subsequently, DCs integrate those environmental cues, orchestrate or tolerance regulate tissue homeostasis. Recent advances in the field of immunometabolism highlight notion that immune markedly alter cellular metabolic pathways during differentiation upon activation, which has important implications on their functionality. Previous studies showed active oxidative phosphorylation mitochondria is associated with immature tolerogenic DCs, while increased glycolysis pathogen sensing can promote immunogenic DC functions. However, new results last years suggest regulation metabolism steady state, after activation different pathophysiological settings may be more complex. Moreover, ontogenically distinct subsets show functional specializations T cell responses. It thus relevant how influences plasticity, what potential differences exist among subsets. Better understanding emerging connection between adaptions specification will likely allow development therapeutic strategies manipulate

Language: Английский

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Metabolism in tumor microenvironment: Implications for cancer immunotherapy

MedComm, Journal Year: 2020, Volume and Issue: 1(1), P. 47 - 68

Published: June 1, 2020

Abstract Tumor microenvironment is a special environment for tumor survival, which characterized by hypoxia, acidity, nutrient deficiency, and immunosuppression. The consists of the vasculature, immune cells, extracellular matrix, proteins or metabolic molecules. A large number recent studies have shown that not only cells but also in undergone reprogramming, closely related to drug resistance malignant progression. immunotherapy based on T gives patients new hope, faces dilemma low response rate. New strategies sensitizing cancer are urgently needed. Metabolic reprogramming can directly affect biological activity regulate differentiation activation cells. authors aim review characteristics microenvironment, changes tumor‐associated regulatory role immunotherapy.

Language: Английский

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Targeting innate immune pathways for cancer immunotherapy

Immunity, Journal Year: 2023, Volume and Issue: 56(10), P. 2206 - 2217

Published: Sept. 12, 2023

Language: Английский

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Emerging roles of lactate in acute and chronic inflammation

Cell Communication and Signaling, Journal Year: 2024, Volume and Issue: 22(1)

Published: May 16, 2024

Abstract Traditionally, lactate has been considered a ‘waste product’ of cellular metabolism. Recent findings have shown that is substance plays an indispensable role in various physiological functions and contributes to energy metabolism signal transduction during immune inflammatory responses. The discovery lactylation further revealed the regulating processes. In this review, we comprehensively summarize paradoxical characteristics microenvironment highlight pivotal roles homeostasis, shuttle, (‘lactate clock’) acute chronic responses from molecular perspective. We especially focused on receptors with either proinflammatory or anti-inflammatory effects complex biological signalling pathways investigated dynamic changes cells lactate-related microenvironment. Moreover, reviewed progress use as therapeutic target for response, which may provide new perspective treating inflammation-related diseases.

Language: Английский

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