Targeting Metabolism to Improve the Tumor Microenvironment for Cancer Immunotherapy

Molecular Cell, Journal Year: 2020, Volume and Issue: 78(6), P. 1019 - 1033

Published: June 1, 2020

Language: Английский

---

Therapeutic targeting of the hypoxic tumour microenvironment

Nature Reviews Clinical Oncology, Journal Year: 2021, Volume and Issue: 18(12), P. 751 - 772

Published: July 29, 2021

Language: Английский

---

Spatial architecture of the immune microenvironment orchestrates tumor immunity and therapeutic response

Journal of Hematology & Oncology, Journal Year: 2021, Volume and Issue: 14(1)

Published: June 25, 2021

Tumors are not only aggregates of malignant cells but also well-organized complex ecosystems. The immunological components within tumors, termed the tumor immune microenvironment (TIME), have long been shown to be strongly related development, recurrence and metastasis. However, conventional studies that underestimate potential value spatial architecture TIME unable completely elucidate its complexity. As innovative high-flux high-dimensional technologies emerge, researchers can more feasibly accurately detect depict TIME. These findings improved our understanding complexity role in biology. In this review, we first epitomized some representative emerging study categorized description methods used characterize these structures. Then, determined functions biology effects gradient extracellular nonspecific chemicals (ENSCs) on We discussed clinical architectures TIME, as well current limitations future prospects novel field. This review will bring an dimension ecosystem research, attention promote application research practice.

Language: Английский

---

Three-Dimensional Spheroids as In Vitro Preclinical Models for Cancer Research

Pharmaceutics, Journal Year: 2020, Volume and Issue: 12(12), P. 1186 - 1186

Published: Dec. 6, 2020

Most cancer biologists still rely on conventional two-dimensional (2D) monolayer culture techniques to test in vitro anti-tumor drugs prior vivo testing. However, the vast majority of promising preclinical have no or weak efficacy real patients with tumors, thereby delaying discovery successful therapeutics. This is because 2D lacks cell–cell contacts and natural tumor microenvironment, important signaling drug response, resulting a reduced malignant phenotype compared tumor. In this sense, three-dimensional (3D) cultures cells that better recapitulate cell environments emerged as scientifically accurate low cost models for screening testing new candidates before moving expensive time-consuming animal models. Here, we provide comprehensive overview 3D systems highlight strategies spheroid construction evaluation tools targeted therapies, focusing their applicability research. Examples therapeutic nanomedicines are discussed.

Language: Английский

---

Role of tumor microenvironment in cancer progression and therapeutic strategy

Cancer Medicine, Journal Year: 2023, Volume and Issue: 12(10), P. 11149 - 11165

Published: Feb. 21, 2023

Abstract Cancer is now considered a tumor microenvironment (TME) disease, although it was originally thought to be cell and gene expression disorder. Over the past 20 years, significant advances have been made in understanding complexity of TME its impact on responses various anticancer therapies, including immunotherapies. immunotherapy can recognize kill cancer cells by regulating body's immune system. It has achieved good therapeutic effects solid tumors hematological malignancies. Recently, blocking programmed death‐1 (PD‐1), ligand‐1 (PD‐L1), death Ligand‐2 (PD‐L2), construction antigen chimeric T (CAR‐T) vaccines become popular immunotherapies Tumorigenesis, progression, metastasis are closely related TME. Therefore, we review characteristics molecules TME, interaction between PD‐1 promising therapeutics.

Language: Английский

---

Tumor-Associated Macrophages in Pancreatic Ductal Adenocarcinoma: Origin, Polarization, Function, and Reprogramming

Frontiers in Cell and Developmental Biology, Journal Year: 2021, Volume and Issue: 8

Published: Jan. 11, 2021

Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy. PDAC only cured by surgical resection in its early stage, but there remains relatively high possibility of recurrence. The development closely associated with the tumor microenvironment. Tumor-associated macrophages (TAMs) are one most abundant immune cell populations pancreatic stroma. TAMs inclined to M2 deviation microenvironment, which promotes and supports behaviors, including tumorigenesis, escape, metastasis, chemotherapeutic resistance. Herein, we comprehensively reviewed latest researches on origin, polarization, functions, reprogramming PDAC.

Language: Английский

---

A Hepatocellular Carcinoma Targeting Nanostrategy with Hypoxia-Ameliorating and Photothermal Abilities that, Combined with Immunotherapy, Inhibits Metastasis and Recurrence

ACS Nano, Journal Year: 2020, Volume and Issue: 14(10), P. 12679 - 12696

Published: Sept. 10, 2020

Hepatocellular carcinoma (HCC) is a common and highly malignant tumor that prone to recurrence metastasis has no effective treatment. Unsurprisingly, its prognosis quite poor; early detection methods low-toxicity treatments are urgently needed. To achieve these goals, we designed multifunctional, U.S. Food Drug Administration-approved Prussian blue (PB) nanoparticle (NP) with porous metal organic frame loaded sorafenib (SF), conjugated HCC-specific targeting peptide SP94 the near-infrared dye cyanine (Cy)5.5. These NPs amenable multimodal imaging for dynamic monitoring of their biodistribution tumor-targeting effects. The SP94-PB-SF-Cy5.5 achieved targeted delivery controlled SF release exhibited good photothermal In this strategy, therapy treatment complement each other, reducing side effects achieving therapeutic effect without local recurrence. addition, catalase-like ability alleviates hypoxia, induce immunogenic cell death, leading tumor-associated antigens. combine trigger an antitumor immune response; also displayed promising inhibitory on produced abscopal long-term immunological memory when combined antiprogrammed death-ligand 1 (PD-L1) immunotherapy. safe, multifunctional represent valuable option HCC. next-generation model may provide some ideas management HCC other cancers.

Language: Английский

---

Single‐Nucleus RNA Sequencing and Spatial Transcriptomics Reveal the Immunological Microenvironment of Cervical Squamous Cell Carcinoma

Advanced Science, Journal Year: 2022, Volume and Issue: 9(29)

Published: Aug. 19, 2022

The effective treatment of advanced cervical cancer remains challenging. Herein, single-nucleus RNA sequencing (snRNA-seq) and SpaTial enhanced resolution omics-sequencing (Stereo-seq) are used to investigate the immunological microenvironment squamous cell carcinoma (CSCC). expression levels most immune suppressive genes in tumor inflammation areas CSCC not significantly higher than those non-cancer samples, except for LGALS9 IDO1. Stronger signals CD56

Language: Английский

---

The role of lipid metabolic reprogramming in tumor microenvironment

Theranostics, Journal Year: 2023, Volume and Issue: 13(6), P. 1774 - 1808

Published: Jan. 1, 2023

Metabolic reprogramming is one of the most important hallmarks malignant tumors.Specifically, lipid metabolic has marked impacts on cancer progression and therapeutic response by remodeling tumor microenvironment (TME).In past few decades, immunotherapy revolutionized treatment landscape for advanced cancers.Lipid plays pivotal role in regulating immune to immunotherapy.Here, we systematically reviewed characteristics, mechanism, cells TME, appraised effects various cell death modes (specifically ferroptosis) metabolism, summarized antitumor therapies targeting metabolism.Overall, profound microenvironment; therefore, may lead development innovative clinical applications including sensitizing immunotherapy.

Language: Английский

---

Hypoxia signaling in cancer: Implications for therapeutic interventions

MedComm, Journal Year: 2023, Volume and Issue: 4(1)

Published: Jan. 23, 2023

Abstract Hypoxia is a persistent physiological feature of many different solid tumors and key driver malignancy, in recent years, it has been recognized as an important target for cancer therapy. occurs the majority due to poor vascular oxygen supply that not sufficient meet needs rapidly proliferating cells. A hypoxic tumor microenvironment (TME) can reduce effectiveness other therapies, such radiotherapy, chemotherapy, immunotherapy. In this review, we discuss critical role hypoxia development, including metabolism, immunity, angiogenesis. The treatment methods TME are summarized, hypoxia‐targeted therapy improving oxygenation by alleviating itself. Hyperoxia be used improve tissue partial pressure relieve hypoxia. We focus on underlying mechanisms hyperoxia their impact current therapies prospects treatment.

Language: Английский

---