Multifunctional sonosensitizers in sonodynamic cancer therapy

Chemical Society Reviews, Journal Year: 2020, Volume and Issue: 49(11), P. 3244 - 3261

Published: Jan. 1, 2020

Phototherapy, including photodynamic therapy and photothermal therapy, has the potential to treat several types of cancer.

Language: Английский

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Recent Advances in Nanomaterial‐Assisted Combinational Sonodynamic Cancer Therapy

Advanced Materials, Journal Year: 2020, Volume and Issue: 32(47)

Published: Oct. 16, 2020

Ultrasound (US)-triggered sonodynamic therapy (SDT), as a promising noninvasive therapeutic modality, has received ever-increasing attention in recent years. Its specialized chemical agents, named sonosensitizers, are activated by low-intensity US to produce lethal reactive oxygen species (ROS) for oncotherapy. Compared with phototherapeutic strategies, SDT provides many noteworthy opportunities and benefits, such deeper penetration depth, absence of phototoxicity, fewer side effects. Nevertheless, previous studies have also demonstrated its intrinsic limitations. Thanks the facile engineering nature nanotechnology, numerous novel nanoplatforms being applied this emerging field tackle these barriers achieve continuous innovations. In particular, combination other treatment strategies superior efficacy improving anticancer activity relative that monotherapies alone. Therefore, it is necessary summarize nanomaterial-assisted combinational cancer applications. Herein, design principles achieving synergistic effects based on nanomaterial methods highlighted. The ultimate goals stimulate better-quality combined schemes provide innovative ideas perspectives promoting future transformation clinical application.

Language: Английский

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Solutions to the Drawbacks of Photothermal and Photodynamic Cancer Therapy

Advanced Science, Journal Year: 2021, Volume and Issue: 8(3)

Published: Jan. 5, 2021

Phototherapy such as photothermal therapy and photodynamic in cancer treatment has been developed quickly over the past few years for its noninvasive nature high efficiency. However, there are still many drawbacks phototherapy that prevent it from clinical applications. Thus, scientists have designed different systems to overcome issues associated with phototherapy, including enhancing targeting ability of low-temperature therapy, replacing near-infrared light other excitation sources, so on. This article discusses problems shortcomings encountered development highlights possible solutions address them may become a useful approach practice. aims give brief summary about current research advancements provides quick guideline toward future developments field.

Language: Английский

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A Multifunctional Cascade Bioreactor Based on Hollow‐Structured Cu₂MoS₄ for Synergetic Cancer Chemo‐Dynamic Therapy/Starvation Therapy/Phototherapy/Immunotherapy with Remarkably Enhanced Efficacy

Advanced Materials, Journal Year: 2019, Volume and Issue: 31(51)

Published: Nov. 4, 2019

The unique tumor microenvironment (TME) facilitates cancer proliferation and metastasis, it is hard to cure completely via monotherapy. Herein, a multifunctional cascade bioreactor based on hollow mesoporous Cu2 MoS4 (CMS) loaded with glucose oxidase (GOx) constructed for synergetic therapy by chemo-dynamic (CDT)/starvation therapy/phototherapy/immunotherapy. CMS harboring multivalent elements (Cu1+/2+ , Mo4+/6+ ) exhibit Fenton-like, glutathione (GSH) peroxidase-like catalase-like activity. Once internalized into the tumor, could generate ·OH CDT Fenton-like reaction deplete overexpressed GSH in TME alleviate antioxidant capability of tumors. Moreover, under hypoxia TME, react endogenous H2 O2 activating catalyzed oxidation GOx starvation accompanied regeneration . regenerated can devote realizing GOx-catalysis-enhanced CDT. Meanwhile, 1064 nm laser irradiation shows remarkable tumor-killing ability phototherapy due its excellent photothermal conversion efficiency (η = 63.3%) cytotoxic superoxide anion (·O2- generation performance. More importantly, PEGylated CMS@GOx-based synergistic combined checkpoint blockade elicit robust immune responses both effectively ablating primary tumors inhibiting metastasis.

Language: Английский

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Ultrafine Titanium Monoxide (TiO_1+x) Nanorods for Enhanced Sonodynamic Therapy

Journal of the American Chemical Society, Journal Year: 2020, Volume and Issue: 142(14), P. 6527 - 6537

Published: March 19, 2020

Ultrasound (US)-triggered sonodynamic therapy (SDT) that enables noninvasive treatment of large internal tumors has attracted widespread interest. For improvement in the therapeutic responses to SDT, more effective and stable sonosensitizers are still required. Herein, ultrafine titanium monoxide nanorods (TiO1+x NRs) with greatly improved sono-sensitization Fenton-like catalytic activity were fabricated used for enhanced SDT. TiO1+x NRs an rodlike structure successfully prepared then modified polyethylene glycol (PEG). Compared conventional sonosensitizer, TiO2 nanoparticles, PEG–TiO1+x resulted much efficient US-induced generation reactive oxygen species (ROS) because oxygen-deficient NR, which predominantly serves as charge trap limit recombination US-triggered electron–hole pairs. Interestingly, also exhibit horseradish-peroxidase-like nanozyme can produce hydroxyl radicals (•OH) from endogenous H2O2 tumor enable chemodynamic (CDT). Because their passive retention post intravenous injection, be a sonosensitizer CDT agent highly ablation under US treatment. In addition, no significant long-term toxicity was found treated mice. This work highlights new type titanium-based nanostructure great performance

Language: Английский

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Ultrasound‐Activated Sensitizers and Applications

Angewandte Chemie International Edition, Journal Year: 2019, Volume and Issue: 59(34), P. 14212 - 14233

Published: July 3, 2019

Modalities for photo-triggered anticancer therapy are usually limited by their low penetrative depth. Sonotheranostics especially sonodynamic (SDT), which is different from photodynamic (PDT) the use of highly penetrating acoustic waves to activate a class sound-responsive materials called sonosensitizers, has gained significant interest in recent years. The effect SDT closely related structural and physicochemical properties led development new sound-activated as sonosensitizers various biomedical applications. This Review provides summary discussion types novel developed last few years outlines specific designs potential challenges. applications with functions such imaging drug delivery well combination other treatment modalities would provide strategies disease therapy.

Language: Английский

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Activatable polymer nanoagonist for second near-infrared photothermal immunotherapy of cancer

Nature Communications, Journal Year: 2021, Volume and Issue: 12(1)

Published: Feb. 2, 2021

Abstract Nanomedicine in combination with immunotherapy offers opportunities to treat cancer a safe and effective manner; however, remote control of immune response spatiotemporal precision remains challenging. We herein report photothermally activatable polymeric pro-nanoagonist (APNA) that is specifically regulated by deep-tissue-penetrating second near-infrared (NIR-II) light for combinational photothermal immunotherapy. APNA constructed from covalent conjugation an immunostimulant onto NIR-II semiconducting transducer through labile thermo-responsive linker. Upon photoirradiation, mediates effect, which not only triggers tumor ablation immunogenic cell death but also initiates the cleavage thermolabile linker liberate caged agonist in-situ activation deep solid (8 mm). Such controlled regulation potentiates systemic antitumor immunity, leading promoted cytotoxic T lymphocytes helper infiltration distal tumor, lung liver inhibit metastasis. Thereby, present work illustrates generic strategy prepare pro-immunostimulants nano-immunotherapy.

Language: Английский

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Platelet Membrane‐Camouflaged Magnetic Nanoparticles for Ferroptosis‐Enhanced Cancer Immunotherapy

Small, Journal Year: 2020, Volume and Issue: 16(22)

Published: April 27, 2020

Abstract Although cancer immunotherapy has emerged as a tremendously promising therapy method, it remains effective only for several cancers. Photoimmunotherapy (e.g., photodynamic/photothermal therapy) could synergistically enhance the immune response of immunotherapy. However, excessively generated immunogenicity will cause serious inflammatory syndrome. Herein, biomimetic magnetic nanoparticles, Fe 3 O 4 ‐SAS @ PLT, are reported novel approach to sensitize ferroptosis and generate mild immunogenicity, enhancing rate non‐inflamed tumors ‐SAS@PLT built from sulfasalazine (SAS)‐loaded mesoporous nanoparticles (Fe ) platelet (PLT) membrane camouflage triggered ferroptotic cell death via inhibiting glutamate‐cystine antiporter system X c − pathway. PLT‐mediated significantly improves efficacy programmed 1 checkpoint blockade achieves continuous tumor elimination in mouse model 4T1 metastatic tumors. Proteomics studies reveal that not induce tumor‐specific but also efficiently repolarize macrophages immunosuppressive M2 phenotype antitumor M1 phenotype. Therefore, concomitant with expected provide great potential clinical treatment metastasis.

Language: Английский

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Advanced biotechnology-assisted precise sonodynamic therapy

Chemical Society Reviews, Journal Year: 2021, Volume and Issue: 50(20), P. 11227 - 11248

Published: Jan. 1, 2021

Herein, we provide the enhancement of SDT effect through elaborate strategies including design and modification sonosensitizers, combination other therapy modalities, molecular imaging-guided for precise treatment.

Language: Английский

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Ultrasound-Augmented Mitochondrial Calcium Ion Overload by Calcium Nanomodulator to Induce Immunogenic Cell Death

Nano Letters, Journal Year: 2021, Volume and Issue: 21(5), P. 2088 - 2093

Published: Feb. 17, 2021

Immunogenic cell death (ICD), a manner of tumor that can trigger antitumor immune responses, has received extensive attention as potential synergistic modality for cancer immunotherapy. Although many calcium ion (Ca2+) nanomodulators have been developed therapy through mitochondrial Ca2+ overload, their ICD-inducing properties not explored. Herein, an acid-sensitive PEG-decorated carbonate (CaCO3) nanoparticle incorporating curcumin (CUR; enhancer) (PEGCaCUR) was prepared using simple one-pot strategy. PEGCaCUR served only nanomodulator inducing efficient overload but also ICD inducer during improved therapy. Combination with ultrasound (US), PEGCaCUR+US, led to enhanced effect attributable the along subsequent upregulation reactive oxygen species levels. facilitates photoacoustic/fluorescence dual-mode imaging, well effectively suppressing growth and metastasis, indicating promising theranostic properties.

Language: Английский

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