The fast-growing field of photo-driven theranostics based on aggregation-induced emission

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 51(6), P. 1983 - 2030

Published: Jan. 1, 2022

This review summarized the progression of AIEgen-based photo-driven theranostics emphasizing on design strategies for efficient photosensitization, photothermal conversion and multimodal functionalities by adjusting excited energy dissipation.

Language: Английский

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Engineering Macrophage Exosome Disguised Biodegradable Nanoplatform for Enhanced Sonodynamic Therapy of Glioblastoma

Advanced Materials, Journal Year: 2022, Volume and Issue: 34(15)

Published: Feb. 8, 2022

Sonodynamic therapy (SDT) exhibits high tissue penetration and negligible radiation damage to normal tissues, thus emerges as a promising cancer therapeutic modality for glioblastoma (GBM). However, the blood-brain barrier (BBB) hypoxic microenvironment greatly limit SDT efficiency. In this work, biodegradable nanoplatform (termed CSI) is fabricated by encapsulating catalase (CAT) into silica nanoparticles (CAT@SiO2 ) tumor hypoxia relief, then loaded with sonosensitizer indocyanine green (ICG). Inspired ability of macrophages cross BBB, CSI further coated AS1411 aptamer-modified macrophage exosomes form CSI@Ex-A, which possesses efficient BBB good cancer-cell-targeting capability. After cell endocytosis, highly expressed glutathione (GSH) triggeres biodegradation released CAT catalyzes hydrogen peroxide (H2 O2 produce relieve hypoxia. The GSH depletion self-supplying effectively enhances efficiency both in vitro vivo. addition, resulting CSI@Ex-A biocompatibility long circulation time. These findings demonstrate that may serve competent GBM therapy, potential clinical translation.

Language: Английский

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Hydrogel‐Based Growth Factor Delivery Platforms: Strategies and Recent Advances

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(5)

Published: April 3, 2023

Growth factors play a crucial role in regulating broad variety of biological processes and are regarded as powerful therapeutic agents tissue engineering regenerative medicine the past decades. However, their application is limited by short half-lives potential side effects physiological environments. Hydrogels identified having promising to prolong growth mitigate adverse restricting them within matrix reduce rapid proteolysis, burst release, unwanted diffusion. This review discusses recent progress development factor-containing hydrogels for various biomedical applications, including wound healing, brain repair, cartilage bone regeneration, spinal cord injury repair. In addition, introduces strategies optimizing factor release affinity-based delivery, carrier-assisted stimuli-responsive spatial structure-based cellular system-based delivery. Finally, presents current limitations future research directions factor-delivering hydrogels.

Language: Английский

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Emerging Sonodynamic Therapy‐Based Nanomedicines for Cancer Immunotherapy

Advanced Science, Journal Year: 2022, Volume and Issue: 10(2)

Published: Nov. 27, 2022

Cancer immunotherapy effect can be greatly enhanced by other methods to induce immunogenic cell death (ICD), which has profoundly affected as a highly efficient paradigm. However, these treatments have significant limitations, either causing damage of the immune system or limited superficial tumors. Sonodynamic therapy (SDT) ICD promote without affecting because its excellent spatiotemporal selectivity and low side effects. Nevertheless, SDT is still reactive oxygen species yield complex tumor microenvironment. Recently, some emerging SDT-based nanomedicines made numerous attractive encouraging achievements in field cancer due high immunotherapeutic efficiency. this cross-cutting research far from being widely explored huge professional barriers. Herein, characteristics microenvironment mechanisms are firstly systematically summarized. Subsequently, therapeutic mechanism fully summarized, advantages limitations discussed. The representative advances for further highlighted. Finally, application prospects challenges future clinical translation

Language: Английский

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Theranostic Fluorescent Probes

Chemical Reviews, Journal Year: 2024, Volume and Issue: 124(5), P. 2699 - 2804

Published: Feb. 29, 2024

The ability to gain spatiotemporal information, and in some cases achieve control, the context of drug delivery makes theranostic fluorescent probes an attractive intensely investigated research topic. This interest is reflected steep rise publications on topic that have appeared over past decade. Theranostic probes, their various incarnations, generally comprise a fluorophore linked masked drug, which released as result certain stimuli, with both intrinsic extrinsic stimuli being reported. release then signaled by emergence signal. Importantly, use appropriate fluorophores has enabled not only this emerging fluorescence marker for but also provided modalities useful photodynamic, photothermal, sonodynamic therapeutic applications. In review we highlight recent work particular focus are activated tumor microenvironments. We summarize efforts develop other applications, such neurodegenerative diseases antibacterials. celebrates diversity designs reported date, from discrete small-molecule systems nanomaterials. Our aim provide insights into potential clinical impact still-emerging direction.

Language: Английский

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Harnessing Nanomaterials for Cancer Sonodynamic Immunotherapy

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(33)

Published: March 7, 2023

Abstract Immunotherapy has made remarkable strides in cancer therapy over the past decade. However, such emerging still suffers from low response rates and immune‐related adverse events. Various strategies have been developed to overcome these serious challenges. Therein, sonodynamic (SDT), as a non‐invasive treatment, received ever‐increasing attention especially treatment of deep‐seated tumors. Significantly, SDT can effectively induce immunogenic cell death trigger systemic anti‐tumor immune response, termed immunotherapy. The rapid development nanotechnology revolutionized effects with robust induction. As result, more innovative nanosonosensitizers synergistic modalities are established superior efficacy safe profile. In this review, recent advances immunotherapy summarized particular emphasis on how be explored harness for amplifying response. Moreover, current challenges field prospects its clinical translation also presented. It is anticipated that review provide rational guidance facilitate nanomaterials‐assisted immunotherapy, helping pave way next‐generation eventually achieve durable patients.

Language: Английский

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Smart drug delivery systems for precise cancer therapy

Acta Pharmaceutica Sinica B, Journal Year: 2022, Volume and Issue: 12(11), P. 4098 - 4121

Published: Aug. 22, 2022

Language: Английский

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Porphyrin-Based Two-Dimensional Layered Metal–Organic Framework with Sono-/Photocatalytic Activity for Water Decontamination

ACS Nano, Journal Year: 2021, Volume and Issue: 16(1), P. 1346 - 1357

Published: Dec. 27, 2021

Water treatment is crucial to improve the water quality and reduce diarrheal chronological diseases caused by excessive discharge of organic dyes other waste. The development expansion efficient catalysts for degradation sterilization has attracted widespread attention. Herein, we report an example a porphyrin-based two-dimensional layered metal-organic framework (MOF) (2DZnTcpp) its sono-/photocatalytic bactericidal activity. dislocated layers effectively avoid close π-π stacking provide porous space oxygen/water/dye contact. introduction Zn ions increases spin orbital coupling through heavy atom effect promotes intersystem crossing process singlet oxygen generation. effective ligand-to-metal charge transfer open catalytic sites also facilitate splitting hydroxyl radical These features together promote reactive species (ROS) generation 2DZnTcpp under light illumination or ultrasound sonication. It worth noting that with high specific surface area porosity shows dye Moreover, could largely inactivate Escherichia coli irradiation (the power 1 sun) sonication 30 min efficiencies over 99.99999%. This work provides approach design synthesis MOF-based sono-/photocatalysts used in purification textile wastewater committed establishment more efficient, fast, environmentally friendly system.

Language: Английский

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Activatable Cancer Sono‐Immunotherapy using Semiconducting Polymer Nanobodies

Advanced Materials, Journal Year: 2022, Volume and Issue: 34(28)

Published: May 7, 2022

Despite the great promises of sonodynamic therapy (SDT) in combination cancer therapy, its clinical applications are hindered by "always-on" pharmacological activities therapeutic agents and lack efficient sonosensitizers. Herein, development semiconducting polymers as sonosensitizers further sono-immunotherapeutic nanobodies (SPNAb ) for activatable sono-immunotherapy reported. Conjugation anti-CTLA-4 antibodies onto polymer nanoparticles through a 1 O2 -cleavable linker affords SPNAb with relatively low CTLA-4 binding affinity. Upon sono-irradiation, generates not only to elicit effect induce immunogenic cell death, but also release trigger situ checkpoint blockade. Such synergistic action mediated modulates tumoricidal function T-cell immunity promoting proliferation cytotoxic T lymphocytes depleting immunosuppressive regulatory cells, resulting effective tumor regression, metastasis inhibition, durable immunological memory, prevention relapse. Therefore, this study represents proof-of-concept strategy using precise spatiotemporal control over immunotherapy.

Language: Английский

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Drug-induced oxidative stress in cancer treatments: Angel or devil?

Redox Biology, Journal Year: 2023, Volume and Issue: 63, P. 102754 - 102754

Published: May 18, 2023

Oxidative stress (OS), defined as redox imbalance in favor of oxidant burden, is one the most significant biological events cancer progression. Cancer cells generally represent a higher level, which suggests dual therapeutic strategy by regulating status (i.e., pro-oxidant therapy and/or antioxidant therapy). Indeed, exhibits great anti-cancer capability, attributing to accumulation within cells, whereas restore homeostasis has been claimed fail several clinical practices. Targeting vulnerability pro-oxidants capable generating excessive reactive oxygen species (ROS) surfaced an important strategy. However, multiple adverse effects caused indiscriminate attacks uncontrolled drug-induced OS on normal tissues and drug-tolerant capacity some certain greatly limit their further applications. Herein, we review representative oxidative drugs summarize side organs, emphasizing that seeking balance between damage value exploiting next-generation OS-based chemotherapeutics.

Language: Английский

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