Conferring Ti‐Based MOFs with Defects for Enhanced Sonodynamic Cancer Therapy

Advanced Materials, Journal Year: 2021, Volume and Issue: 33(18)

Published: April 1, 2021

Abstract The development of highly efficient, multifunctional, and biocompatible sonosensitizer is still a priority for current sonodynamic therapy (SDT). Herein, defect‐rich Ti‐based metal–organic framework (MOF) (D‐MOF(Ti)) with greatly improved sonosensitizing effect simply constructed used enhanced SDT. Compared the commonly TiO 2 , D‐MOF(Ti) results in superior reactive oxygen species (ROS) yield under ultrasound (US) irradiation due to its narrow bandgap, which principally improves US‐triggered electron–hole separation. Meanwhile, existence Ti 3+ ions, also exhibits high level Fenton‐like activity enable chemodynamic therapy. Particularly, US as excitation source SDT can simultaneously enhance reaction achieve remarkably synergistic outcomes oncotherapy. More importantly, be degraded metabolized out body after completion therapeutic functions without off‐target toxicity. Overall, this work identifies novel Ti‐familial harboring great potential cancer

Language: Английский

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2D Piezoelectric Bi₂MoO₆ Nanoribbons for GSH‐Enhanced Sonodynamic Therapy

Advanced Materials, Journal Year: 2021, Volume and Issue: 33(51)

Published: Oct. 16, 2021

Abstract Reducing the scavenging capacity of reactive oxygen species (ROS) and elevating ROS production are two primary goals developing novel sonosensitizers for sonodynamic therapy (SDT). Hence, ultrathin 2D Bi 2 MoO 6 –poly(ethylene glycol) nanoribbons (BMO NRs) designed as piezoelectric glutathione (GSH)‐enhanced SDT. In cancer cells, BMO NRs can consume endogenous GSH to disrupt redox homeostasis, GSH‐activated (GBMO) exhibit an oxygen‐deficient structure, which promote separation electron–hole pairs, thereby enhancing efficiency in The GBMO piezoelectric, ultrasonic waves introduce mechanical strain nanoribbons, resulting polarization band tilting, thus accelerating toxic production. as‐synthesized enable excellent computed tomography imaging tumors significant tumor suppression vitro vivo. A sonosensitizer‐mediated two‐step enhancement SDT process, is activated by amplified exogenous ultrasound, proposed. This process not only provides new options improving but also broadens application materials

Language: Английский

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Guiding Transition Metal‐Doped Hollow Cerium Tandem Nanozymes with Elaborately Regulated Multi‐Enzymatic Activities for Intensive Chemodynamic Therapy

Advanced Materials, Journal Year: 2021, Volume and Issue: 34(7)

Published: Dec. 5, 2021

Clinical applications of nanozyme-initiated chemodynamic therapy (NCDT) have been severely limited by the poor catalytic efficiency nanozymes, insufficient endogenous hydrogen peroxide (H2 O2 ) content, and its off-target consumption. Herein, authors developed a hollow mesoporous Mn/Zr-co-doped CeO2 tandem nanozyme (PHMZCO-AT) with regulated multi-enzymatic activities, that is, enhancement superoxide dismutase (SOD)-like peroxidase (POD)-like activities inhibition catalase (CAT)-like activity. PHMZCO-AT as H2 homeostasis disruptor promotes evolution restrains elimination to achieve intensive NCDT. SOD-like activity catalyzes anion (O2•- into in tumor region. The suppression CAT depletion glutathione largely weaken decomposition O. Elevated is then catalyzed downstream POD-like generate toxic hydroxyl radicals, further inducing apoptosis death. T1 -weighted magnetic resonance imaging X-ray computed tomography are also achieved using due existence paramagnetic Mn2+ high attenuation ability elemental Zr, permitting vivo tracking therapeutic process. This work presents typical paradigm NCDT efficacy regulating nanozymes perturb homeostasis.

Language: Английский

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Metalated covalent organic frameworks: from synthetic strategies to diverse applications

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 51(15), P. 6307 - 6416

Published: Jan. 1, 2022

This review highlights the recent advances of metalated covalent organic frameworks, including synthetic strategies and applications, discusses current challenges future directions.

Language: Английский

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Piezocatalytic Medicine: An Emerging Frontier using Piezoelectric Materials for Biomedical Applications

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(25)

Published: Jan. 12, 2023

Abstract Emerging piezocatalysts have demonstrated their remarkable application potential in diverse medical fields. In addition to ultrahigh catalytic activities, inherent and unique charge‐carrier‐releasing properties can be used initiate various redox reactions, displaying bright prospects for future applications. Triggered by mechanical energy, piezocatalytic materials release electrons/holes, catalyze reactions of substrates, or intervene biological processes promote the production effector molecules purposes, such as decontamination, sterilization, therapy. Such a piezocatalysis is termed medicine (PCM) herein. To pioneer novel technologies, especially therapeutic modalities, this review provides an overview state‐of‐the‐art research progress medicine. First, principle preparation methodologies piezoelectric are introduced. Then, comprehensive summary applications tumor treatment, antisepsis, organic degradation, tissue repair regeneration, biosensing provided. Finally, main challenges perspectives discussed proposed, expecting fuel development emerging scientific discipline.

Language: Английский

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Low-Temperature Photothermal Therapy: Strategies and Applications

Research, Journal Year: 2021, Volume and Issue: 2021

Published: Jan. 1, 2021

Although photothermal therapy (PTT) with the assistance of nanotechnology has been considered as an indispensable strategy in biomedical field, it still encounters some severe problems that need to be solved. Excessive heat can induce treated cells develop thermal resistance, and thus, efficacy PTT may dramatically decreased. In meantime, uncontrollable diffusion pose a threat surrounding healthy tissues. Recently, low-temperature (also known mild or mild-temperature PTT) demonstrated its remarkable capacity conquering these obstacles shown excellent performance bacterial elimination, wound healing, cancer treatments. Herein, we summarize recently proposed strategies for achieving based on nanomaterials introduce synthesis, characteristics, applications nanoplatforms. Additionally, combination other therapeutic modalities defeating cancers synergistic effect combined treatments are discussed. Finally, current limitations future directions inspiring more researchers make contributions promoting toward successful preclinical clinical disease

Language: Английский

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Liquid exfoliation of TiN nanodots as novel sonosensitizers for photothermal-enhanced sonodynamic therapy against cancer

Nano Today, Journal Year: 2021, Volume and Issue: 39, P. 101170 - 101170

Published: May 7, 2021

Language: Английский

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Hydrogel‐Based Growth Factor Delivery Platforms: Strategies and Recent Advances

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(5)

Published: April 3, 2023

Growth factors play a crucial role in regulating broad variety of biological processes and are regarded as powerful therapeutic agents tissue engineering regenerative medicine the past decades. However, their application is limited by short half-lives potential side effects physiological environments. Hydrogels identified having promising to prolong growth mitigate adverse restricting them within matrix reduce rapid proteolysis, burst release, unwanted diffusion. This review discusses recent progress development factor-containing hydrogels for various biomedical applications, including wound healing, brain repair, cartilage bone regeneration, spinal cord injury repair. In addition, introduces strategies optimizing factor release affinity-based delivery, carrier-assisted stimuli-responsive spatial structure-based cellular system-based delivery. Finally, presents current limitations future research directions factor-delivering hydrogels.

Language: Английский

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Catalytically Active CoFe₂O₄ Nanoflowers for Augmented Sonodynamic and Chemodynamic Combination Therapy with Elicitation of Robust Immune Response

ACS Nano, Journal Year: 2021, Volume and Issue: 15(7), P. 11953 - 11969

Published: June 18, 2021

A hypoxic and acidic tumor microenvironment (TME) plays a significant role in cancer development through complex cellular signaling networks, it is thus challenging to completely eradicate tumors via monotherapy. Here, PEGylated CoFe2O4 nanoflowers (CFP) with multiple enzymatic activities, serving as bioreactors responsive TME cues, were synthesized typical solvothermal method for augmented sonodynamic therapy (SDT) chemodynamic (CDT) elicitation of robust immune response. The CFP occupying multivalent elements (Co2+/3+, Fe2+/3+) exhibited strong Fenton-like catalase-like activity. In another aspect, itself brand-new sonosensitizer high-performance SDT based on ultrasound-triggered electron (e–)/hole (h+) pair separation from the energy band promptness high efficiency. With efficient enrichment tumorous tissue revealed by magnetic resonance imaging, CPF could generate •OH CDT relying reactions. Moreover, catalase-mimicking react endogenous H2O2 molecular oxygen, O2 level may promote production 1O2 SDT. What's more, reactive oxygen species obtained combined SDT/CDT efficiently trigger immunogenic cell death synergistic antitumor immunity aid an checkpoint blockade sake suppressing primary distant well lung metastasis. Taken together, this paradigm delivers useful insights developing in-coming nanocomposites cobalt ferrite theranostics.

Language: Английский

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Stanene‐Based Nanosheets for β‐Elemene Delivery and Ultrasound‐Mediated Combination Cancer Therapy

Angewandte Chemie International Edition, Journal Year: 2021, Volume and Issue: 60(13), P. 7155 - 7164

Published: Jan. 15, 2021

Abstract Ultrasound (US)‐mediated sonodynamic therapy (SDT) has emerged as a superior modality for cancer treatment owing to the non‐invasiveness and high tissue‐penetrating depth. However, developing biocompatible nanomaterial‐based sonosensitizers with efficient SDT capability remains challenging. Here, we employed liquid‐phase exfoliation strategy obtain new type of two‐dimensional (2D) stanene‐based nanosheets (SnNSs) band gap 2.3 eV, which is narrower than those most extensively studied nano‐sonosensitizers, allowing more US‐triggered separation electron (e − )‐hole (h + ) pairs reactive oxygen species (ROS) generation. In addition, discovered that such SnNSs could also serve robust near‐infrared (NIR)‐mediated photothermal (PTT) agents their conversion, nanocarriers anticancer drug delivery inherent 2D layered structure. This study not only presents general nanoplatforms SDT‐enhanced combination therapy, but highlights utility field nanomedicine.

Language: Английский

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