Meta-Analysis Reveals Compositional and Functional Microbial Changes Associated with Osteoporosis DOI Creative Commons
Oluwamayowa S. Akinsuyi, Luiz Fernando Würdig Roesch

Microbiology Spectrum, Journal Year: 2023, Volume and Issue: 11(3)

Published: April 12, 2023

Over the past decade, role of gut microbiota in many disease states has gained a great deal attention. Mounting evidence from case-control and observational studies linked changes to pathophysiology osteoporosis (OP). Nonetheless, results these contain discrepancies, leaving literature without consensus on osteoporosis-associated microbial signatures. Here, we conducted comprehensive meta-analysis combining reexamining five publicly available 16S rRNA partial sequence data sets identify bacteria consistently associated with across different cohorts. After adjusting for batch effect technical variation heterogeneity studies, observed significant shift composition group. An increase relative abundance opportunistic pathogens Clostridium sensu stricto, Bacteroides, Intestinibacter was OP Moreover, short-chain-fatty-acid (SCFA) producers, including members genera Collinsella, Megasphaera, Agathobaculum, Mediterraneibacter, XIV, Dorea, were depleted group healthy control (HC) Lactic acid-producing bacteria, Limosilactobacillus, significantly increased The random forest algorithm further confirmed that differentiate two groups. Furthermore, functional prediction revealed depletion SCFA biosynthesis pathway (glycolysis, tricarboxylic acid [TCA] cycle, Wood-Ljungdahl pathway) amino (methionine, histidine, arginine) HC This study uncovered OP-associated compositional alterations, providing robust insight into pathogenesis aiding possible development therapeutic intervention manage disease. IMPORTANCE Osteoporosis is most common metabolic bone aging. osteoporosis. However, which microbes are dysbiosis their impact density inflammation remain largely unknown due inconsistent literature. present standard workflow, statistical approaches, machine learning algorithms notable influencing

Language: Английский

The preventive effect of Glycyrrhiza polysaccharide on lipopolysaccharide-induced acute colitis in mice by modulating gut microbial communities DOI

Xinxin Wei,

Na Li, Xiaoying Wu

et al.

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 239, P. 124199 - 124199

Published: March 25, 2023

Language: Английский

Citations

34
Infant gut microbiome composition correlated with type 1 diabetes acquisition in the general population: the ABIS study DOI

Malin Bélteky,

Patricia L. Milletich, Angelica P. Ahrens

et al.

Diabetologia, Journal Year: 2023, Volume and Issue: 66(6), P. 1116 - 1128

Published: March 25, 2023

Language: Английский

Citations

27
Multigenerational adversity impacts on human gut microbiome composition and socioemotional functioning in early childhood DOI Creative Commons
Francesca R. Querdasi, Craig K. Enders, Neerja Karnani

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2023, Volume and Issue: 120(30)

Published: July 18, 2023

Adversity exposures in the prenatal and postnatal period are associated with an increased risk for psychopathology, which can be perpetuated across generations. Nonhuman animal research highlights gut microbiome as a putative biological mechanism underlying such generational risks. In sample of 450 mother–child dyads living Singapore, we examined associations between three distinct adversity experienced two generations—maternal childhood maltreatment, maternal anxiety, second-generation children’s exposure to stressful life events—and composition children at 2 y age. We found differences profiles linked each exposure, well some nonaffected features (e.g., beta diversity). Remarkably, microbial taxa concurrent prospective child socioemotional functioning shared overlapping functions those affected by adversity, suggesting that intergenerational transmission may have lasting impact on mental health via alterations functions. Our findings open up new avenue into mechanisms risks potential target intervention.

Language: Английский

Citations

25
Developmental Programming of the Fetal Immune System by Maternal Western-Style Diet: Mechanisms and Implications for Disease Pathways in the Offspring DOI Open Access

Benjamin N. Nelson,

Jacob E. Friedman

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(11), P. 5951 - 5951

Published: May 29, 2024

Maternal obesity and over/undernutrition can have a long-lasting impact on offspring health during critical periods in the first 1000 days of life. Children born to mothers with reduced immune responses stimuli which increase susceptibility infections. Recently, maternal western-style diets (WSDs), high fat simple sugars, been associated skewing neonatal cell development, recent evidence suggests that dysregulation innate immunity early life has long-term consequences metabolic diseases behavioral disorders later Several factors contribute abnormal tolerance or trained immunity, including changes gut microbiota, metabolites, epigenetic modifications. Critical knowledge gaps remain regarding mechanisms whereby these fetal postnatal especially precursor stem cells bone marrow liver. Components microbiota are transferred from consuming WSD their understudied identifying cause effect adaptive development needs be refined. Tools single-cell RNA-sequencing, analysis, spatial location specific liver for understanding system programming. Considering vital role function plays health, it will important understand how control developmental programming immunity.

Language: Английский

Citations

9
The relationship between the gut microbiota and thyroid disorders DOI
Marian Ludgate, Giulia Masetti, Paula Soares

et al.

Nature Reviews Endocrinology, Journal Year: 2024, Volume and Issue: 20(9), P. 511 - 525

Published: June 21, 2024

Language: Английский

Citations

9
From Microbes to Metabolites: Advances in Gut Microbiome Research in Type 1 Diabetes DOI Creative Commons

Lente Blok,

Nordin M.J. Hanssen,

Max Nieuwdorp

et al.

Metabolites, Journal Year: 2025, Volume and Issue: 15(2), P. 138 - 138

Published: Feb. 19, 2025

Background: Type 1 diabetes (T1D) is a severe chronic T-cell mediated autoimmune disease that attacks the insulin-producing beta cells of pancreas. The multifactorial nature T1D involves both genetic and environmental components, with recent research focusing on gut microbiome as crucial factor in pathogenesis. its metabolites play an important role modulating immunity autoimmunity. In years, studies have revealed significant alterations taxonomic functional composition associated development islet autoimmunity T1D. These changes include reduced production short-chain fatty acids, altered bile acid tryptophan metabolism, increased intestinal permeability consequent perturbations host (auto)immune responses. Methods/Results: this review, we summarize discuss observational, mechanistic etiological investigating elucidating intricate microbes Moreover, highlight advances intervention targeting microbiota for prevention or treatment human Conclusions: A deeper understanding evolution before after onset microbial signals conditioning may provide us essential insights exploiting prognostic therapeutic tool.

Language: Английский

Citations

1
Gastrointestinal Microbiota and Type 1 Diabetes Mellitus: The State of Art DOI Creative Commons
Marilena Durazzo, Arianna Ferro, Gabriella Gruden

et al.

Journal of Clinical Medicine, Journal Year: 2019, Volume and Issue: 8(11), P. 1843 - 1843

Published: Nov. 2, 2019

The incidence of autoimmune type 1 diabetes (T1DM) is increasing worldwide and disease onset tends to occur at a younger age. Unfortunately, clinical trials aiming detect predictive factors disease, in individuals with high risk T1DM, reported negative results. Hence, actually there are no tools or strategies prevent T1DM onset. importance the gut microbiome diseases increasingly recognized recent data suggest that intestinal dysbiosis has pathogenic role by affecting both immunostasis permeability barrier. An improved understanding mechanisms whereby favors development may help develop new intervention reduce burden T1DM. This review summarizes available on associations between microbiota experimental animals humans discusses future perspectives this novel exciting area research.

Language: Английский

Citations

62
Effect of combined chronic predictable and unpredictable stress on depression-like symptoms in mice DOI Open Access
Yajun Qiao,

Jiubo Zhao,

Cen Li

et al.

Annals of Translational Medicine, Journal Year: 2020, Volume and Issue: 8(15), P. 942 - 942

Published: Aug. 1, 2020

Mental stress mainly induces depression, and predictable stress, as well a constant bombardment of chronic unpredictable micro-stressors, always coexist in daily life. However, the combined effect on depression is still not fully understood.The restraint (CRS) to restrain mice for 6 h per day 3 weeks, mild (CUMS) stimulate with 7 different stressors weeks. We evaluated CRS CUMS depression-like symptoms using behavioral tests investigated action mechanism through analysis neurotransmitters, brain-derived factors, inflammatory antioxidants, intestinal microorganisms.Our data suggested caused significant weight loss, food intake reduction, behaviors-including anhedonia, learned helplessness, reduction spontaneous activity-and even atrophy severe structural damage hippocampus mice. Our pathogenesis study showed that stress-induced glucocorticoid receptor (GR) levels, loss oligodendrocytes (NG2 Olig2 cells), inhibition neuron proliferation CA1, CA3, DG regions hippocampus, decreased contents monoamine neurotransmitters (5-HT NE) BDNF cerebral cortex, hyperactivity HPA system, led immune dysfunction, aggravated oxidative weakened capacity antioxidants Compared single gave rise more diversity change gut microbiota.Combined behaviors, atrophy, via neurotransmitter, BDNF, axis, neurogenesis, neurodegenerative, immune, gut-brain axis pathways.

Language: Английский

Citations

55
Environmental Determinants of Type 1 Diabetes: From Association to Proving Causality DOI Creative Commons
Lauren M. Quinn, F. Susan Wong, Parth Narendran

et al.

Frontiers in Immunology, Journal Year: 2021, Volume and Issue: 12

Published: Oct. 1, 2021

The rising incidence of type 1 diabetes (T1D) cannot be ascribed to genetics alone, and causative environmental triggers drivers must also contributing. prospective TEDDY study has provided the greatest contributions in modern time, by addressing misconceptions refining search strategy for future. This review outlines evidence date support pathways from association causality, across all stages T1D (seroconversion beta cell failure). We focus on infections vaccinations; infant growth childhood obesity; gut microbiome lifestyle factors which cultivate it. Of these, determinants have most supporting are enterovirus infection, rapid weight gain early life, microbiome. provide an infographic illustrating key their likelihood effect. next steps investigate these triggers, ideally though gold-standard randomised controlled trials further studies, help explore public health prevention strategies.

Language: Английский

Citations

54
Mechanisms of skin autoimmunity: Cellular and soluble immune components of the skin DOI
Jóhann E. Guðjónsson, Kenji Kabashima, Kilian Eyerich

et al.

Journal of Allergy and Clinical Immunology, Journal Year: 2020, Volume and Issue: 146(1), P. 8 - 16

Published: July 1, 2020

Language: Английский

Citations

53