Near-Infrared Light-Triggered Nitric-Oxide-Enhanced Photodynamic Therapy and Low-Temperature Photothermal Therapy for Biofilm Elimination

ACS Nano, Journal Year: 2020, Volume and Issue: 14(3), P. 3546 - 3562

Published: Feb. 18, 2020

Photothermal treatment (PTT) involving a combination of therapeutic modalities recently emerged as an efficient alternative for combating biofilm. However, PTT-related local high temperature may destroy the surrounding healthy tissues. Herein, we present all-in-one phototherapeutic nanoplatform consisting l-arginine (l-Arg), indocyanine green (ICG), and mesoporous polydopamine (MPDA), namely, AI-MPDA, to eliminate already-formed The fabrication process included surface modification MPDA with l-Arg further adsorption ICG via π–π stacking. Under near-infrared (NIR) exposure, AI-MPDA not only generated heat but also produced reactive oxygen species, causing cascade catalysis release nitric oxide (NO). NIR irradiation, biofilm elimination was attributed NO-enhanced photodynamic therapy low-temperature PTT (≤45 °C). Notably, NIR-triggered strategy resulted in severe destruction bacterial membranes. displayed good cytocompatibility. NIR-irradiated nanoparticles prevented colonization realized rapid recovery infected wounds. More importantly, platform effective efficiency around 100% abscess formation model. Overall, this provides reliable tool biofilms clinical applications.

Language: Английский

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Emerging photothermal-derived multimodal synergistic therapy in combating bacterial infections

Chemical Society Reviews, Journal Year: 2021, Volume and Issue: 50(15), P. 8762 - 8789

Published: Jan. 1, 2021

Photothermal therapy (PTT)-derived multimodal synergistic treatments exhibit a super-additive effect in fighting bacterial infections.

Language: Английский

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Prussian Blue Analogues for Sodium‐Ion Batteries: Past, Present, and Future

Advanced Materials, Journal Year: 2021, Volume and Issue: 34(15)

Published: Dec. 17, 2021

Abstract Prussian blue analogues (PBAs) have attracted wide attention for their application in the energy storage and conversion field due to low cost, facile synthesis, appreciable electrochemical performance. At present stage, most research on PBAs is focused material‐level optimization, whereas properties practical battery systems are seldom considered. This review aims first provide an overview of history parameters PBA materials analyze fundamental principles toward rational design PBAs, then evaluate prospects challenges sodium‐ion batteries, hoping bridge gap between laboratory commercial reality.

Language: Английский

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Nanomaterials-based photothermal therapy and its potentials in antibacterial treatment

Journal of Controlled Release, Journal Year: 2020, Volume and Issue: 328, P. 251 - 262

Published: Sept. 1, 2020

Language: Английский

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Immunoregulation in Diabetic Wound Repair with a Photoenhanced Glycyrrhizic Acid Hydrogel Scaffold

Advanced Materials, Journal Year: 2022, Volume and Issue: 34(29)

Published: May 16, 2022

M1 macrophage accumulation and excessive inflammation are commonly encountered issues in diabetic wounds can fail the healing process. Hence, hydrogel dressings with immunoregulatory capacity have great promise clinical practice of wound healing. However, current hydrogels always needed for complex interventions high-cost treatments, such as cytokines cell therapies. In this study, a novel glycyrrhizic acid (GA)-based hybrid dressing intrinsic properties is developed to promote rapid This consists interpenetrating polymer networks composed inorganic Zn2+ -induced self-assembled GA photo-crosslinked methyl acrylated silk fibroin (SF), realizing both excellent injectability mechanical strength. Notably, SF/GA/Zn regulate responses inflammatory microenvironment, circumventing use any additives. The immunomodulatory be harnessed safe efficient therapeutics that accelerate three phases repair serve promising management wounds.

Language: Английский

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Interfacial engineering of Bi2S3/Ti3C2Tx MXene based on work function for rapid photo-excited bacteria-killing

Nature Communications, Journal Year: 2021, Volume and Issue: 12(1)

Published: Feb. 22, 2021

Abstract In view of increasing drug resistance, ecofriendly photoelectrical materials are promising alternatives to antibiotics. Here we design an interfacial Schottky junction Bi 2 S 3 /Ti C T x resulting from the contact potential difference between Ti and . The different work functions induce formation a local electrophilic/nucleophilic region. self-driven charge transfer across interface increases electron density on formed barrier inhibits backflow electrons boosts separation. photocatalytic activity intensively improved amount reactive oxygen species under 808 nm near-infrared radiation. They kill 99.86% Staphylococcus aureus 99.92% Escherichia coli with assistance hyperthermia within 10 min. We propose theory engineering based function accordingly photoresponsive using two kinds components effectively eradicate bacterial infection.

Language: Английский

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The recent progress on metal–organic frameworks for phototherapy

Chemical Society Reviews, Journal Year: 2021, Volume and Issue: 50(8), P. 5086 - 5125

Published: Jan. 1, 2021

Some infectious or malignant diseases such as cancers are seriously threatening the health of human beings all over world. The commonly used antibiotic therapy cannot effectively treat these within a short time, and also bring about adverse effects drug resistance immune system damage during long-term systemic treatment. Phototherapy is an emerging antibiotic-free strategy to diseases. Upon light irradiation, phototherapeutic agents can generate cytotoxic reactive oxygen species (ROS) induce temperature increase, which leads death targeted cells. These two kinds killing strategies referred photodynamic (PDT) photothermal (PTT), respectively. So far, many photo-responsive have been developed. Among them, metal-organic framework (MOF) becoming one most promising materials because its structure chemical compositions be easily modulated achieve specific functions. MOFs intrinsic ability under rational design MOF construction, serve carrier therapeutic agents, owing tunable porosity. provide feasibility for various combined therapies targeting methods, improves efficiency phototherapy. In this review, we firstly investigated principles phototherapy, comprehensively summarized recent advances in PDT, PTT synergistic therapy, from construction modification. We expect that our demonstration will shed on future development field, it step closer clinical trials.

Language: Английский

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Wound Dressing: From Nanomaterials to Diagnostic Dressings and Healing Evaluations

ACS Nano, Journal Year: 2022, Volume and Issue: 16(2), P. 1708 - 1733

Published: Jan. 20, 2022

Wound dressings based on nanomaterials play a crucial role in wound treatment and are widely used whole range of medical settings, from minor to life-threatening tissue injuries. This article presents an educational review the accumulating knowledge this multidisciplinary area lay out challenges opportunities that lie ahead ignite further faster development clinically valuable technologies. The analyzes functional advantages nanomaterial-based gauzes hydrogels as well hybrid structures thereof. On basis, state-of-the-art advances transfer (semi)blind approaches evaluation state smart enable real-time monitoring diagnostic functions could help during healing. explores translation related aspects into real-world use. ongoing future associated with clinical decisions presented reviewed.

Language: Английский

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Conductive Antibacterial Hemostatic Multifunctional Scaffolds Based on Ti₃C₂T_x MXene Nanosheets for Promoting Multidrug-Resistant Bacteria-Infected Wound Healing

ACS Nano, Journal Year: 2021, Volume and Issue: 15(2), P. 2468 - 2480

Published: Feb. 10, 2021

Chronic bacterial-infected wound healing/skin regeneration remains a challenge due to drug resistance and the poor quality of repair. The ideal strategy is combating bacterial infection, while facilitating satisfactory healing. However, reported hardly achieves these two goals simultaneously without help antibiotics or bioactive molecules. In this work, two-dimensional (2D) Ti3C2Tx MXene with excellent conductivity, biocompatibility, antibacterial ability was applied in developing multifunctional scaffolds (HPEM) for methicillin-resistant Staphylococcus aureus (MRSA)-infected HPEM were fabricated by reaction between poly(glycerol-ethylenimine), MXene@polydopamine (MXene@PDA) nanosheets, oxidized hyaluronic acid (HCHO). presented properties containing self-healing behavior, electrical tissue-adhesive feature, activity especially MRSA resistant many commonly used (antibacterial efficiency 99.03%), rapid hemostatic capability. enhanced proliferation normal skin cells negligible toxicity. Additionally, obviously accelerated MRSA-infected healing (wound closure ratio 96.31%) efficient anti-inflammation effects, promoting cell proliferation, angiogenic process, stimulating granulation tissue formation, collagen deposition, vascular endothelial differentiation, angiogenesis. This study indicates important role 2D MXene@PDA nanosheets infected provide potential regeneration.

Language: Английский

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Surface Design for Antibacterial Materials: From Fundamentals to Advanced Strategies

Advanced Science, Journal Year: 2021, Volume and Issue: 8(19)

Published: Aug. 5, 2021

Healthcare-acquired infections as well increasing antimicrobial resistance have become an urgent global challenge, thus smart alternative solutions are needed to tackle bacterial infections. Antibacterial materials in biomedical applications and hospital hygiene attracted great interest, particular, the emergence of surface design strategies offer effective antibiotics, thereby preventing possible development resistance. In this review, recent progress on advanced modifications prevent addressed comprehensively, starting with key factors against adhesion, followed by varying that can inhibit biofilm formation effectively. Furthermore, "super antibacterial systems" through pre-treatment defense targeted bactericidal system, proposed evidence clinical potential. Finally, advantages future challenges resist healthcare-associated discussed, promising prospects developing novel materials.

Language: Английский

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