Exercise to Prevent Accelerated Vascular Aging in People Living With HIV DOI
Raymond C. F. Jones, Austin T. Robinson, Lauren B. Beach

et al.

Circulation Research, Journal Year: 2024, Volume and Issue: 134(11), P. 1607 - 1635

Published: May 23, 2024

Given advances in antiretroviral therapy, the mortality rate for HIV infection has dropped considerably over recent decades. However, people living with (PLWH) experience longer life spans coupled persistent immune activation despite viral suppression and potential toxicity from long-term therapy use. Consequently, PLWH face a cardiovascular disease (CVD) risk more than twice that of general population, making it leading cause death among this group. Here, we briefly review epidemiology CVD highlighting disparities at intersections sex gender, age, race/ethnicity, contributions social determinants health psychosocial stress to increased individuals marginalized identities. We then overview pathophysiology discuss primary factors implicated as contributors on therapy. Subsequently, highlight functional evidence premature vascular dysfunction an early pathophysiological determinant PLWH, several mechanisms underlying synthesize current research accelerated aging focusing activation, chronic inflammation, oxidative stress. consider understudied aspects such HIV-related changes gut microbiome stress, which may serve through exercise can abrogate aging. Emphasizing significance exercise, various modalities their impacts health, proposing holistic approach managing risks PLWH. The discussion extends critical future study areas related aging, CVD, efficacy interventions, call inclusive considers diversity population.

Language: Английский

Host variables confound gut microbiota studies of human disease DOI
Ivan Vujkovic-Cvijin, Jack Sklar, Lingjing Jiang

et al.

Nature, Journal Year: 2020, Volume and Issue: 587(7834), P. 448 - 454

Published: Nov. 4, 2020

Language: Английский

Citations

440
The role of T cells in age-related diseases DOI
Elisa Carrasco, Manuel M. Gómez de las Heras, Enrique Gabandé‐Rodríguez

et al.

Nature reviews. Immunology, Journal Year: 2021, Volume and Issue: 22(2), P. 97 - 111

Published: June 7, 2021

Language: Английский

Citations

139
Distinct intestinal microbial signatures linked to accelerated systemic and intestinal biological aging DOI Creative Commons
Shalini Singh, Leila B. Giron,

Maliha Shaikh

et al.

Microbiome, Journal Year: 2024, Volume and Issue: 12(1)

Published: Feb. 22, 2024

People living with HIV (PLWH), even when viral replication is controlled through antiretroviral therapy (ART), experience persistent inflammation. This inflammation partly attributed to intestinal microbial dysbiosis and translocation, which may lead non-AIDS-related aging-associated comorbidities. The extent - influenced by the infection itself, ART usage, sexual orientation, or other associated factors affects biological age of intestines unclear. Furthermore, role translocation in aging PLWH remains be elucidated. To investigate these uncertainties, we used a systems biology approach, analyzing colon ileal biopsies, blood samples, stool specimens from on people without (PLWoH) as controls. exhibit accelerated colon, ileum, blood, measured various epigenetic clocks, compared PLWoH. Investigating relationship between aging, had decreased levels tight junction proteins intestines, along increased translocation. permeability correlated faster When investigating higher abundance specific pro-inflammatory bacteria, such Catenibacterium Prevotella. These bacteria aging. Conversely, lower known for producing anti-inflammatory short-chain fatty acids, Subdoligranulum Erysipelotrichaceae, were slower Correlation networks revealed significant links genera ileum (but not feces), rise microbe-related metabolites (e.g., those tryptophan metabolism pathway), decrease like hippuric acid. We identified compositions microbiota-related metabolic pathways that are intertwined systemic signature likely reflecting including aspects HIV. A deeper understanding mechanisms underlying connections could offer potential strategies mitigate its health complications. Video Abstract.

Language: Английский

Citations

18
Modulation of inflammatory responses by gastrointestinal Prevotella spp. – From associations to functional studies DOI Creative Commons

Aida Iljazović,

Lena Amend, Eric J. C. Gálvez

et al.

International Journal of Medical Microbiology, Journal Year: 2021, Volume and Issue: 311(2), P. 151472 - 151472

Published: Jan. 12, 2021

Numerous studies have associated alterations in the gut microbiota composition with almost every known inflammatory disease. However, proving biological relevance of distinct microbial signatures and linking specific microorganisms to host phenotypes, remains a considerable challenge. Correspondingly, increased abundance members Prevotella genus within communities colonizing mucosal surfaces has been found individuals diagnosed rheumatoid arthritis, periodontitis, metabolic disorders, intestinal vaginal dysbiosis. Still, role spp. incidence these diseases continues be debated. For many years, poor understanding biology could large part attributed lack experimental tools. recent years significant advances made towards overcoming limitations, including number isolates improved genetic diversity. Besides discussing most relevant associations between present review we examine efforts expand "toolbox" highlight remaining challenges that should advance future research our Prevotella-host interplay.

Language: Английский

Citations

67
Unique Gut Microbiome in HIV Patients on Antiretroviral Therapy (ART) Suggests Association with Chronic Inflammation DOI
Aya Ishizaka, Michiko Koga, Taketoshi Mizutani

et al.

Microbiology Spectrum, Journal Year: 2021, Volume and Issue: 9(1)

Published: Aug. 11, 2021

Chronic inflammation is a hallmark of HIV infection and associated with the development progression age-related comorbidities. Although gastrointestinal tract major site replication CD4 + T-cell depletion, role HIV-associated imbalance gut microbiome in chronic unclear.

Language: Английский

Citations

61
HIV-associated gut microbial alterations are dependent on host and geographic context DOI Creative Commons

Muntsa Rocafort,

David B. Gootenberg,

Jesús M. Luévano

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Feb. 5, 2024

Abstract HIV-associated changes in intestinal microbiota are believed to be important drivers of disease progression. However, the majority studies have focused on populations high-income countries rather than developing regions where HIV burden is greatest. To better understand impact fecal globally, we compare microbial community individuals U.S., Uganda, and Botswana. We identify significant bacterial taxa alterations with both treated untreated infection a high degree uniqueness each cohort. also significantly different between that report men who sex (MSM) behavior non-MSM populations. Additionally, while find consistently associated higher soluble markers immune activation, most specific these region not shared none across all three geographic locations our study. Our findings demonstrate overall distinct among geographical sexual groups, although small number pairs warrant further investigation, highlighting importance considering host context fully assess gut microbiome human health disease.

Language: Английский

Citations

10
Association of gut microbiota with the pathogenesis of SARS-CoV-2 Infection in people living with HIV DOI Creative Commons
Aya Ishizaka, Michiko Koga, Taketoshi Mizutani

et al.

BMC Microbiology, Journal Year: 2024, Volume and Issue: 24(1)

Published: Jan. 3, 2024

Abstract Background People living with HIV (PLWH) chronic inflammation may have an increasing risk for coronavirus disease 2019 (COVID-19) severity; however, the impact of their gut microbiota on COVID-19 is not fully elucidated. Here, we analyzed temporal changes in composition hospitalized severe acute respiratory syndrome 2 (SARS-CoV-2)-infected PLWH (PLWH-CoV) and correlation severity. Result The 16S rRNA analysis results using stool samples (along timeline from onset) 12 PLWH-CoV, whose median CD4 + T cell count was 671 cells/µl, were compared to those 19 healthy people 25 PLWH. Bacterial diversity PLWH-CoV significantly different that SARS-CoV-2 non-infected PLWH, but a significant difference observed classification according Immediately after onset, remarkable changing decrease some short-chain fatty acid-producing bacteria increase colitis-related pathobiont. In second week relative amounts specific distinguished between One month dysbiosis persisted, number Enterobacteriaceae, mainly Escherichia-Shigella , which potentially pathogenic, increased enriched patients who developed post-acute sequelae (PASC). Conclusion associated infection this study indicated persistent SCFA-producing intestinal environment opportunistic pathogens enteritis. This report demonstrates tends show delayed improvement even recovery, highlights importance as potential factor severity PASC

Language: Английский

Citations

9
Prediction of new HIV infection in men who have sex with men based on machine learning: secondary analysis of a prospective cohort study from Western China DOI Creative Commons
Kangjie Li, Guiqian Shi, Cong Zhang

et al.

Annals of Medicine, Journal Year: 2025, Volume and Issue: 57(1)

Published: March 10, 2025

Objective This study aimed to construct a model based on machine learning predict new HIV infections in HIV-negative men who have sex with (MSM).

Language: Английский

Citations

1
Signature changes in gut microbiome are associated with increased susceptibility to HIV-1 infection in MSM DOI Creative Commons
Yue Chen, Huang Lin,

Mariah Cole

et al.

Microbiome, Journal Year: 2021, Volume and Issue: 9(1)

Published: Dec. 9, 2021

Abstract Background Men who have sex with men (MSM) been disproportionately affected by HIV-1 since the beginning of AIDS pandemic, particularly in USA and Europe. Compared to women (MSW), MSM a distinct fecal microbiome regardless infection. However, it is unclear whether MSM-associated gut affects susceptibility progression We studied profiles, short-chain fatty acids, blood plasma inflammatory cytokines 109 seroconverters (SC) from early, 1984–1985 phase pandemic Multicenter Cohort Study (MACS) before after infection compared 156 HIV-1-negative MACS (negative controls [NC]). Results found that family Succinivibrionaceae , S24-7, Mogibacteriaceae, Coriobacteriaceae Erysipelotrichaceae were significantly higher ( p <0.05), whereas Odoribacteraceae Verucomicrobiaceae Bacteroidaceae Barnesiellaceae Rikenellaceae lower SC NC. At species level, Prevotella stercorea Eubacterium biforme Collinsella aerofaciens dolichum, Desulfovibrio D168, Alistipes onderdonkii, Ruminococcus torques Bacteroides fragilis, caccae, putredinis Akkermansia muciniphila uniformis ovatus <0.05) After infection, Prevotellaceae Victivallaceae fragilis cylindroides developed within 5 years free for more than 10 without antiretroviral therapy (ART). In addition, Coprococcus eutactus Butyrivibrio crossotus Gemmiger formicilis Blautia obeum 5–10 AIDS-free ART. Furthermore, cytokine levels sCD14, sCD163, interleukin 6, lipopolysaccharide binding protein <0.05 Conclusions Our results suggest pathogenic changes present several months prior early USA. This was associated increased biomarkers risk development AIDS.

Language: Английский

Citations

54
Similarities and differences between HIV and SARS-CoV-2 DOI Creative Commons
Francisco Illanes-Álvarez, Denisse Márquez-Ruiz, Mercedes Márquez-Coello

et al.

International Journal of Medical Sciences, Journal Year: 2021, Volume and Issue: 18(3), P. 846 - 851

Published: Jan. 1, 2021

In the last 50 years we have experienced two big pandemics, HIV pandemic and caused by SARS-CoV-2.Both pandemics are RNA viruses reached us from animals.These different in transmission mode symptoms they generate.However, important similarities: fear population, increase proinflammatory cytokines that generate intestinal microbiota modifications or NETosis production polymorphonuclear neutrophils, among others.They been implicated clinical, prognostic therapeutic attitudes.

Language: Английский

Citations

47