Linking drug and food addiction: an overview of the shared neural circuits and behavioral phenotype DOI Creative Commons

Alice Passeri,

Diana Municchi,

Giulia Cavalieri

et al.

Frontiers in Behavioral Neuroscience, Journal Year: 2023, Volume and Issue: 17

Published: Sept. 12, 2023

Despite a lack of agreement on its definition and inclusion as specific diagnosable disturbance, the food addiction construct is supported by several neurobiological behavioral clinical preclinical findings. Recognizing critical to understanding how why it manifests. In this overview, we focused those follows: 1. hyperpalatable effects in development; 2. brain regions involved both drug addiction; 3. animal models highlighting commonalities between substance use disorders addiction. Although results collected through studies emerged from protocols differing ways, they clearly highlight manifestations alterations characteristics. To develop improved models, heterogeneity should be acknowledged embraced so that research can systematically investigate role variables development different features addiction-like behavior models.

Language: Английский

‘Liking’ and ‘wanting’ in eating and food reward: Brain mechanisms and clinical implications DOI
Ileana Morales, Kent Berridge

Physiology & Behavior, Journal Year: 2020, Volume and Issue: 227, P. 113152 - 113152

Published: Aug. 23, 2020

Language: Английский

Citations

234
Positive affect: nature and brain bases of liking and wanting DOI
David P. Nguyen, Erin E. Naffziger, Kent Berridge

et al.

Current Opinion in Behavioral Sciences, Journal Year: 2021, Volume and Issue: 39, P. 72 - 78

Published: March 9, 2021

Language: Английский

Citations

80
Activating Corticotropin-Releasing Factor Systems in the Nucleus Accumbens, Amygdala, and Bed Nucleus of Stria Terminalis: Incentive Motivation or Aversive Motivation? DOI
Hannah Baumgartner, Jay Schulkin, Kent Berridge

et al.

Biological Psychiatry, Journal Year: 2021, Volume and Issue: 89(12), P. 1162 - 1175

Published: Jan. 22, 2021

Language: Английский

Citations

59
Valence and salience encoding in the central amygdala DOI Creative Commons
Mi-Seon Kong,

Ethan Ancell,

Daniela Witten

et al.

eLife, Journal Year: 2025, Volume and Issue: 13

Published: Jan. 10, 2025

The central amygdala (CeA) has emerged as an important brain region for regulating both negative (fear and anxiety) positive (reward) affective behaviors. CeA been proposed to encode information in the form of valence (whether stimulus is good or bad) salience (how significant stimulus), but extent which these two types representation occur not known. Here, we used single cell calcium imaging mice during appetitive aversive conditioning found that majority neurons (~65%) unconditioned (US) with a smaller subset cells (~15%) encoding US. Valence conditioned (CS) was also observed, albeit lesser extent. These findings show site convergence oppositely valenced US information.

Language: Английский

Citations

1
The central amygdala recruits mesocorticolimbic circuitry for pursuit of reward or pain DOI Creative Commons
Shelley M. Warlow, Erin E. Naffziger, Kent Berridge

et al.

Nature Communications, Journal Year: 2020, Volume and Issue: 11(1)

Published: June 1, 2020

Abstract How do brain mechanisms create maladaptive attractions? Here intense attractions are created in laboratory rats by pairing optogenetic channelrhodopsin (ChR2) stimulation of central nucleus amygdala (CeA) with encountering either sucrose, cocaine, or a painful shock-delivering object. We find that pairings make the respective pursue sucrose exclusively, cocaine repeatedly self-inflict shocks. CeA-induced attractions, even to shock-rod, recruit mesocorticolimbic incentive-related circuitry. Shock-associated cues also gain positive incentive value and pursued. Yet motivational effects paired CeA can be reversed negative valence Pavlovian fear learning situation, where ChR2 increases defensive reactions. Finally, switched neutral innocuous stimuli. These results reveal plasticity multiple modes for motivation via circuitry under control activation.

Language: Английский

Citations

66
Incentive motivation: ‘wanting’ roles of central amygdala circuitry DOI
Shelley M. Warlow, Kent Berridge

Behavioural Brain Research, Journal Year: 2021, Volume and Issue: 411, P. 113376 - 113376

Published: May 20, 2021

Language: Английский

Citations

52
Central amygdala circuits in valence and salience processing DOI Creative Commons
Mi-Seon Kong, Larry S. Zweifel

Behavioural Brain Research, Journal Year: 2021, Volume and Issue: 410, P. 113355 - 113355

Published: May 11, 2021

Language: Английский

Citations

45
Different hierarchical reconfigurations in the brain by psilocybin and escitalopram for depression DOI Creative Commons
Gustavo Deco, Yonatan Sanz Perl, Samuel Johnson

et al.

Nature Mental Health, Journal Year: 2024, Volume and Issue: 2(9), P. 1096 - 1110

Published: Aug. 5, 2024

Abstract Effective interventions for neuropsychiatric disorders may work by rebalancing the brain’s functional hierarchical organization. Here we directly investigated effects of two different serotonergic pharmacological on brain hierarchy in major depressive disorder a two-arm double-blind phase II randomized controlled trial comparing psilocybin therapy (22 patients) with escitalopram (20 patients). Patients received either 2 × 25 mg oral psilocybin, three weeks apart, plus six daily placebo (‘psilocybin arm’) or 1 (10–20 mg; ‘escitalopram arm’). Resting-state magnetic resonance imaging scans were acquired at baseline and after second dose ( NCT03429075 ). The mechanisms captured generative effective connectivity, estimated from whole-brain modeling resting state each session patient. Hierarchy was determined these sessions using measures directedness trophic levels which captures cycle structure, stability percolation. results showed that created significantly reconfigurations dynamics differential, opposite statistical effect responses. Furthermore, use machine learning revealed significant differential reorganization before treatments. Machine also able to predict treatment response an accuracy 0.85 ± 0.04. Overall, demonstrate ways depression. This suggests hypothesis could be closely linked breakdown regions orchestrating top hierarchy.

Language: Английский

Citations

8
Valence encoding in the amygdala influences motivated behavior DOI Creative Commons
Dana M. Smith, Mary M. Torregrossa

Behavioural Brain Research, Journal Year: 2021, Volume and Issue: 411, P. 113370 - 113370

Published: May 27, 2021

Language: Английский

Citations

41
Cellular, circuit and transcriptional framework for modulation of itch in the central amygdala DOI Creative Commons
Vijay K. Samineni, Jose G. Grajales‐Reyes,

Gary E. Grajales‐Reyes

et al.

eLife, Journal Year: 2021, Volume and Issue: 10

Published: May 25, 2021

Itch is an unpleasant sensation that elicits robust scratching and aversive experience. However, the identity of cells neural circuits organize this information remains elusive. Here, we show necessity sufficiency chloroquine-activated neurons in central amygdala (CeA) for both itch associated aversion. Further, CeA play important roles itch-related comorbidities, including anxiety-like behaviors, but not some appetitive behaviors previously ascribed to neurons. RNA-sequencing identified several differentially expressed genes as well potential key signaling pathways regulating pruritis. Finally, viral tracing experiments demonstrate these send projections ventral periaqueductal gray are critical modulation itch. These findings reveal a cellular circuit signature orchestrating behavioral affective responses pruritus mice.

Language: Английский

Citations

37