A large normative connectome for exploring the tractographic correlates of focal brain interventions

Scientific Data, Journal Year: 2024, Volume and Issue: 11(1)

Published: April 8, 2024

Abstract Diffusion-weighted MRI (dMRI) is a widely used neuroimaging modality that permits the in vivo exploration of white matter connections human brain. Normative structural connectomics – application large-scale, group-derived dMRI datasets to out-of-sample cohorts have increasingly been leveraged study network correlates focal brain interventions, insults, and other regions-of-interest (ROIs). Here, we provide normative, whole-brain connectome MNI space enables researchers interrogate fiber streamlines are likely perturbed by given ROIs, even absence subject-specific data. Assembled from multi-shell data 985 healthy Human Connectome Project subjects using generalized Q-sampling imaging multispectral normalization techniques, this comprises ~12 million unique streamlines, largest date. It has already utilized at least 18 peer-reviewed publications, most frequently context neuromodulatory interventions like deep stimulation focused ultrasound. Now publicly available, will constitute useful tool for understanding wider impact perturbations on architecture going forward.

Language: Английский

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Connectome reorganization associated with temporal lobe pathology and its surgical resection

Brain, Journal Year: 2024, Volume and Issue: 147(7), P. 2483 - 2495

Published: May 3, 2024

Network neuroscience offers a unique framework to understand the organizational principles of human brain. Despite recent progress, our understanding how brain is modulated by focal lesions remains incomplete. Resection temporal lobe most effective treatment control seizures in pharmaco-resistant epilepsy (TLE), making this syndrome powerful model study lesional effects on network organization young and middle-aged adults. Here, we assessed downstream consequences lesion its surgical resection brain's structural connectome, explored reorganization relates clinical variables at individual patient level. We included adults with TLE (n = 37) who underwent anterior lobectomy between two imaging time points, as well age- sex-matched healthy controls comparable 31). Core analysis was projection high-dimensional connectome data-derived from diffusion MRI tractography each subject-into lower-dimensional gradients. then compared gradients patients relative before surgery, tracked surgically-induced reconfiguration pre- postoperative examined associations patient-specific phenotypes. Before individuals presented marked changes bilateral temporo-parietal regions, reflecting an increased segregation ipsilateral rest Surgery-induced localized subnetwork, but primarily involved integration contralateral regions Using partial least-squares analysis, uncovered latent signature underlying reorganization, showing that displayed fronto-occipital cortices also had greater preoperative hippocampal atrophy, lower seizure frequency secondarily generalized seizures. Our results bridge their resections large-scale interindividual variability, thus offering new avenues examine fundamental malleability

Language: Английский

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Generative lesion pattern decomposition of cognitive impairment after stroke

Brain Communications, Journal Year: 2021, Volume and Issue: 3(2)

Published: April 1, 2021

Cognitive impairment is a frequent and disabling sequela of stroke. There however incomplete understanding how lesion topographies in the left right cerebral hemisphere brain interact to cause distinct cognitive deficits. We integrated machine learning Bayesian hierarchical modelling enable hemisphere-aware analysis 1080 acute ischaemic stroke patients with deep profiling ∼3 months after show relevance prediction language memory assessments visuospatial functioning. Global impairments were equally well predicted by from both sides. Damage hippocampal occipital regions on was particularly informative about lost naming functions, while damage these linked predominantly lesioned tissue supramarginal angular gyrus, post-central gyrus as lateral opercular cortices hemisphere. Hence, our strategy uncovered that patterns unique hemispheric distributions are characteristic capacity due damage.

Language: Английский

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A New Framework to Interpret Individual Inter-Hemispheric Compensatory Communication after Stroke

Journal of Personalized Medicine, Journal Year: 2022, Volume and Issue: 12(1), P. 59 - 59

Published: Jan. 6, 2022

Stroke constitutes the main cause of adult disability worldwide. Even after application standard rehabilitation protocols, majority patients still show relevant motor impairment. Outcomes protocols have led to mixed results, suggesting that factors for brain re-organization stroke not been considered in explanatory models. Therefore, finding a comprehensive model optimally define patient-dependent represents crucial topic clinical neuroscience. In this context, we first report on models conceived thus far attempt predicting outcomes. Then, propose new framework interpret results literature light latest evidence regarding: (1) role callosum inter-hemispheric communication, (2) prefrontal cortices exerting control function, and (3) diaschisis mechanisms. These pieces can help understand which compensatory mechanism may take place following stroke. Moreover, depending individual impairment, network will play different roles according need high-level control. We believe our model, includes overlooked factors, enable clinicians better individualized protocols.

Language: Английский

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The unique role of the frontal aslant tract in speech and language processing

NeuroImage Clinical, Journal Year: 2022, Volume and Issue: 34, P. 103020 - 103020

Published: Jan. 1, 2022

The frontal aslant tract (FAT) is a recently described intralobar that connects the superior and inferior gyri. FAT has been implicated in various speech language processes disorders, including motor impairments, stuttering opercular syndrome, verbal fluency, but specific function(s) of have yet to be elucidated. In current study, we aimed address this knowledge gap by investigating underlying role plays aspects abilities post-stroke aphasia. Our goals were three-fold: 1) To identify which or are impacted damage utilizing powerful imaging analysis method, High Angular Resolution Diffusion Imaging (HARDI) tractography; 2) determine whether associated with functional deficits on range tasks even when accounting for cortical adjacent regions; 3) explore subsections (lateral medial segments) play distinct roles performance. We hypothesized would most strongly performance comparison tasks. analyzed HARDI data from thirty-three people aphasia (PWA) history chronic left hemisphere stroke. metrics related scores several tests: Motor Speech Evaluation (MSE), Western Aphasia Battery (WAB) quotient subtests, Boston Naming Test (BNT). results indicated integrity was MSE as predicted, weakly negatively WAB subtest Naming, Comprehension, Repetition, likely reflecting fact these subtests posterior areas brain unlikely damaged lesion. also performed hierarchical stepwise regressions predict function based properties lesion load surrounding areas. After contributions gyrus, ventral precentral gyrus insula, still remained significant predictor apraxia scores. further showed lateral did not appear rather may indicate normal anatomical variations FAT. Overall, unique speech. These our understanding white matter tracts language.

Language: Английский

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