Epigenetic Regulations in Mammalian Cells: Roles and Profiling Techniques DOI Open Access
Uijin Kim, Dong-Sung Lee

Molecules and Cells, Journal Year: 2023, Volume and Issue: 46(2), P. 86 - 98

Published: Feb. 1, 2023

The genome is almost identical in all the cells of body.However, functions and morphologies each cell are different, factors that determine them genes proteins expressed cells.Over past decades, studies on epigenetic information, such as DNA methylation, histone modifications, chromatin accessibility, conformation have shown these properties play a fundamental role gene regulation.Furthermore, various diseases cancer been found to be associated with mechanisms.In this study, we summarized biological epigenetics single-cell epigenomic profiling techniques, discussed future challenges field epigenetics.

Language: Английский

Characterizing Cellular Differentiation Potency and Waddington Landscape via Energy Indicator DOI Creative Commons
Hanshuang Li, Chunshen Long, Hong Yan

et al.

Research, Journal Year: 2023, Volume and Issue: 6

Published: Jan. 1, 2023

The precise characterization of cellular differentiation potency remains an open question, which is fundamentally important for deciphering the dynamics mechanism related to cell fate transition. We quantitatively evaluated different stem cells based on Hopfield neural network (HNN). results emphasized that can be approximated by energy values. then profiled Waddington landscape embryogenesis and reprogramming processes. at single-cell resolution further confirmed decision progressively specified in a continuous process. Moreover, transition from one steady state another processes was dynamically simulated ladder. These two metaphorized as motion descending ascending ladders, respectively. deciphered gene regulatory (GRN) driving Our study proposes new indicator characterize without prior knowledge, facilitating exploration potential plasticity.

Language: Английский

Citations

17

Progress in single-cell multimodal sequencing and multi-omics data integration DOI
Xuefei Wang, Xinchao Wu, Ni Hong

et al.

Biophysical Reviews, Journal Year: 2023, Volume and Issue: 16(1), P. 13 - 28

Published: July 15, 2023

Language: Английский

Citations

17

Advances and applications in single-cell and spatial genomics DOI
Jingjing Wang, Fang Ye, Haoxi Chai

et al.

Science China Life Sciences, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 20, 2024

Language: Английский

Citations

7

Leukocyte telomere length in children born following blastocyst-stage embryo transfer DOI
Cheng Wang, Yayun Gu, Jun Zhou

et al.

Nature Medicine, Journal Year: 2022, Volume and Issue: 28(12), P. 2646 - 2653

Published: Dec. 1, 2022

Language: Английский

Citations

26

Epigenetic Regulations in Mammalian Cells: Roles and Profiling Techniques DOI Open Access
Uijin Kim, Dong-Sung Lee

Molecules and Cells, Journal Year: 2023, Volume and Issue: 46(2), P. 86 - 98

Published: Feb. 1, 2023

The genome is almost identical in all the cells of body.However, functions and morphologies each cell are different, factors that determine them genes proteins expressed cells.Over past decades, studies on epigenetic information, such as DNA methylation, histone modifications, chromatin accessibility, conformation have shown these properties play a fundamental role gene regulation.Furthermore, various diseases cancer been found to be associated with mechanisms.In this study, we summarized biological epigenetics single-cell epigenomic profiling techniques, discussed future challenges field epigenetics.

Language: Английский

Citations

16