Molecules and Cells,
Journal Year:
2023,
Volume and Issue:
46(2), P. 86 - 98
Published: Feb. 1, 2023
The
genome
is
almost
identical
in
all
the
cells
of
body.However,
functions
and
morphologies
each
cell
are
different,
factors
that
determine
them
genes
proteins
expressed
cells.Over
past
decades,
studies
on
epigenetic
information,
such
as
DNA
methylation,
histone
modifications,
chromatin
accessibility,
conformation
have
shown
these
properties
play
a
fundamental
role
gene
regulation.Furthermore,
various
diseases
cancer
been
found
to
be
associated
with
mechanisms.In
this
study,
we
summarized
biological
epigenetics
single-cell
epigenomic
profiling
techniques,
discussed
future
challenges
field
epigenetics.
The
precise
characterization
of
cellular
differentiation
potency
remains
an
open
question,
which
is
fundamentally
important
for
deciphering
the
dynamics
mechanism
related
to
cell
fate
transition.
We
quantitatively
evaluated
different
stem
cells
based
on
Hopfield
neural
network
(HNN).
results
emphasized
that
can
be
approximated
by
energy
values.
then
profiled
Waddington
landscape
embryogenesis
and
reprogramming
processes.
at
single-cell
resolution
further
confirmed
decision
progressively
specified
in
a
continuous
process.
Moreover,
transition
from
one
steady
state
another
processes
was
dynamically
simulated
ladder.
These
two
metaphorized
as
motion
descending
ascending
ladders,
respectively.
deciphered
gene
regulatory
(GRN)
driving
Our
study
proposes
new
indicator
characterize
without
prior
knowledge,
facilitating
exploration
potential
plasticity.
Molecules and Cells,
Journal Year:
2023,
Volume and Issue:
46(2), P. 86 - 98
Published: Feb. 1, 2023
The
genome
is
almost
identical
in
all
the
cells
of
body.However,
functions
and
morphologies
each
cell
are
different,
factors
that
determine
them
genes
proteins
expressed
cells.Over
past
decades,
studies
on
epigenetic
information,
such
as
DNA
methylation,
histone
modifications,
chromatin
accessibility,
conformation
have
shown
these
properties
play
a
fundamental
role
gene
regulation.Furthermore,
various
diseases
cancer
been
found
to
be
associated
with
mechanisms.In
this
study,
we
summarized
biological
epigenetics
single-cell
epigenomic
profiling
techniques,
discussed
future
challenges
field
epigenetics.
