Unique macrophage phenotypes activated by BMP signaling in breast cancer bone metastases DOI Creative Commons
Claire L. Ihle,

Desiree Straign,

Johana A Canari

et al.

JCI Insight, Journal Year: 2024, Volume and Issue: 9(1)

Published: Jan. 8, 2024

Metastatic breast cancer (mBC) tissue in bone was systematically profiled to define the composition of tumor microenvironment. Gene expression identified a high myeloid signature patients with improved survival outcomes. Bone metastases were by spatial proteomics examine populations within stroma that correlated macrophage functions. Single-cell analysis uncovered activation mBC lesions. Matched BC patient samples primary and metastasis tissues compared for gene bone, where morphogenetic protein 2 (BMP2) most significantly upregulated. Immune cell changes from demonstrated loss lymphoid cells but consistent population macrophages. BMP-activated macrophages increased uniquely bone. marrow-derived coupled BMP inhibition inflammatory responses. Using experimental mouse models trained immunity, we found restricts progression early state not after tumors established This study revealed unique states are distinctly integrated metastases.

Language: Английский

Inflammatory memory and tissue adaptation in sickness and in health DOI
Shruti Naik, Elaine Fuchs

Nature, Journal Year: 2022, Volume and Issue: 607(7918), P. 249 - 255

Published: July 13, 2022

Language: Английский

Citations

122
Inducing trained immunity in pro-metastatic macrophages to control tumor metastasis DOI
Chuanlin Ding, Rejeena Shrestha, Xiaojuan Zhu

et al.

Nature Immunology, Journal Year: 2023, Volume and Issue: 24(2), P. 239 - 254

Published: Jan. 5, 2023

Language: Английский

Citations

97
Influenza-trained mucosal-resident alveolar macrophages confer long-term antitumor immunity in the lungs DOI Open Access
Tao Wang,

Jinjing Zhang,

Yanling Wang

et al.

Nature Immunology, Journal Year: 2023, Volume and Issue: 24(3), P. 423 - 438

Published: Feb. 20, 2023

Language: Английский

Citations

86
A temporal perspective for tumor-associated macrophage identities and functions DOI
Camille Blériot, Garett Dunsmore, Direna Alonso‐Curbelo

et al.

Cancer Cell, Journal Year: 2024, Volume and Issue: 42(5), P. 747 - 758

Published: April 25, 2024

Language: Английский

Citations

24
Trained immunity in chronic inflammatory diseases and cancer DOI
George Hajishengallis, Mihai G. Netea, Triantafyllos Chavakis

et al.

Nature reviews. Immunology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 31, 2025

Language: Английский

Citations

4
β-Glucan reprograms neutrophils to promote disease tolerance against influenza A virus DOI Creative Commons
Nargis Khan, Kim A. Tran, Raphael Chevre

et al.

Nature Immunology, Journal Year: 2025, Volume and Issue: 26(2), P. 174 - 187

Published: Jan. 8, 2025

Disease tolerance is an evolutionarily conserved host defense strategy that preserves tissue integrity and physiology without affecting pathogen load. Unlike resistance, the mechanisms underlying disease remain poorly understood. In present study, we investigated whether adjuvant (β-glucan) can reprogram innate immunity to provide protection against influenza A virus (IAV) infection. β-Glucan treatment reduces morbidity mortality IAV infection, independent of resistance. The enhanced survival result increased recruitment neutrophils via RoRγt+ T cells in lung tissue. promotes granulopoiesis a type 1 interferon-dependent manner leads generation unique subset immature utilizing mitochondrial oxidative metabolism producing interleukin-10. Collectively, our data indicate β-glucan reprograms hematopoietic stem generate with new 'regulatory' function, which required for promoting maintaining viral

Language: Английский

Citations

2
Trained immunity: Target for prophylaxis and therapy DOI

Athanasios Ziogas,

Mariolina Bruno, Roy van der Meel

et al.

Cell Host & Microbe, Journal Year: 2023, Volume and Issue: 31(11), P. 1776 - 1791

Published: Nov. 1, 2023

Language: Английский

Citations

30
Recognition of yeast β-glucan particles triggers immunometabolic signaling required for trained immunity DOI Creative Commons
Cian J. H. Horneck Johnston, Anna E. Ledwith, Mimmi L. E. Lundahl

et al.

iScience, Journal Year: 2024, Volume and Issue: 27(3), P. 109030 - 109030

Published: Jan. 26, 2024

Fungal β-glucans are major drivers of trained immunity which increases long-term protection against secondary infections. Heterogeneity in β-glucan source, structure, and solubility alters interaction with the phagocytic receptor Dectin-1 could impact strategies to improve humans. Using a panel diverse β-glucans, we describe ability specific yeast-derived whole-glucan particle (WGP) reprogram metabolism thereby drive human monocyte-derived macrophages

Language: Английский

Citations

11
Trained immunity inducers in cancer immunotherapy DOI Creative Commons
Yongjun Sui, Jay A. Berzofsky

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: July 16, 2024

While most of the cancer immunotherapy strategies engage adaptive immunity, especially tumor-associated T cells, small fraction responding patients and types cancers amenable, possibility severe adverse effects limit its usage. More effective general interventions are urgently needed. Recently, a de facto innate immune memory, termed ‘trained immunity’, has become new research focal point, promises to be powerful tool for achieving long-term therapeutic benefits against cancers. Trained immunity-inducing agents such as BCG fungal glucan have been shown able avert suppressive tumor microenvironment (TME), enhance cell responses, eventually lead regression. Here, we review current understating trained immunity induction highlight critical roles emergency granulopoiesis, interferon γ tissue-specific induction. Preclinical clinical studies that exploited inducers summarized, repurposed from other fields proposed. We also outline challenges opportunities in future immunotherapies. envisage more vaccines will combine with therapies.

Language: Английский

Citations

10
Leishmania braziliensis enhances monocyte responses to promote anti-tumor activity DOI Creative Commons
Jéssica Cristina dos Santos, María Moreno, Lisa U. Teufel

et al.

Cell Reports, Journal Year: 2024, Volume and Issue: 43(3), P. 113932 - 113932

Published: March 1, 2024

Innate immune cells can undergo long-term functional reprogramming after certain infections, a process called trained immunity (TI). Here, we focus on antigens of Leishmania braziliensis, which induced anti-tumor effects via in human monocytes. We reveal that monocytes exposed to promastigote L. braziliensis develop an enhanced response subsequent exposure Toll-like receptor (TLR)2 or TLR4 ligands. Mechanistically, the induction TI by is mediated multiple pattern recognition receptors, changes metabolism, and increased deposition H3K4me3 at promoter regions genes. The administration exerts potent capabilities delaying tumor growth prolonging survival mice with non-Hodgkin lymphoma. Our work reveals mechanisms vitro identifies its potential for cancer immunotherapy.

Language: Английский

Citations

9