Long-Term Exposure to Air Pollution and COVID-19 Vaccine Antibody Response in a General Population Cohort (COVICAT Study, Catalonia) DOI Creative Commons
Manolis Kogevinas, Marianna Karachaliou, Ana Espinosa

et al.

Environmental Health Perspectives, Journal Year: 2023, Volume and Issue: 131(4)

Published: April 1, 2023

BACKGROUND: Ambient air pollution has been associated with COVID-19 disease severity and antibody response induced by infection.OBJECTIVES: We examined the association between long-term exposure to vaccine-induced response.METHODS: This study was nested in an ongoing population-based cohort, COVICAT, GCAT-Genomes for Life Catalonia, Spain, multiple follow-ups.We drew blood samples 2021 from 1,090 participants of 2,404 who provided 2020, we included 927 this analysis.We measured immunoglobulin M (IgM), IgG, IgA antibodies against five viral-target antigens, including receptor-binding domain (RBD), spike-protein (S), segment (S2) triggered vaccines available Spain.We estimated prepandemic (2018-2019) fine particulate matter [PM ≤2:5 lm aerodynamic diameter (PM 2:5 )], nitrogen dioxide (NO 2 ), black carbon (BC), ozone (O 3 ) using Effects Low-Level Air Pollution: A Study Europe (ELAPSE) models.We adjusted estimates individual-and area-level covariates, time since vaccination, vaccine doses type stratified infection status.We used generalized additive models explore relationship according days vaccination.RESULTS: Among vaccinated persons not infected SARS-CoV-2 (n = 632), higher levels were a lower IgM (1 month post vaccination) IgG.Percentage change geometric mean IgG per interquartile range PM (1:7 lg=m -8:1 (95% CI: -15:9, 0.4) RBD, -9:9 (-16:2, -3:1) S, -8:4 (-13:5, -3:0) S2.We observed similar pattern NO BC inverse O .Differences persisted vaccination.We did observe among prior 295).DISCUSSION: Exposure response.The implications on risk breakthrough infections require further investigation.

Language: Английский

Gut microbiota in COVID-19: key microbial changes, potential mechanisms and clinical applications DOI Open Access
Fen Zhang, Raphaela Iris Lau, Qin Liu

et al.

Nature Reviews Gastroenterology & Hepatology, Journal Year: 2022, Volume and Issue: 20(5), P. 323 - 337

Published: Oct. 21, 2022

Language: Английский

Citations

188
Antibody tests for identification of current and past infection with SARS-CoV-2 DOI
Tilly Fox, Julia Geppert, Jacqueline Dinnes

et al.

Cochrane library, Journal Year: 2022, Volume and Issue: 2022(11)

Published: Nov. 17, 2022

Language: Английский

Citations

178
SARS-CoV-2-specific immune responses and clinical outcomes after COVID-19 vaccination in patients with immune-suppressive disease DOI Creative Commons
Eleanor Barnes, Carl S. Goodyear, Michelle Willicombe

et al.

Nature Medicine, Journal Year: 2023, Volume and Issue: 29(7), P. 1760 - 1774

Published: July 1, 2023

Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immune responses and infection outcomes were evaluated in 2,686 patients with varying immune-suppressive disease states after administration of two Coronavirus Disease 2019 (COVID-19) vaccines. Overall, 255 2,204 (12%) failed to develop anti-spike antibodies, an additional 600 (27%) generating low levels (<380 AU ml −1 ). Vaccine failure rates highest ANCA-associated vasculitis on rituximab (21/29, 72%), hemodialysis immunosuppressive therapy (6/30, 20%) solid organ transplant recipients (20/81, 25% 141/458, 31%). SARS-CoV-2-specific T cell detected 513 580 (88%) patients, lower magnitude or proportion hemodialysis, allogeneic hematopoietic stem transplantation liver (versus healthy controls). Humoral against Omicron (BA.1) reduced, although cross-reactive sustained all participants for whom these data available. BNT162b2 was associated higher antibody but cellular compared ChAdOx1 nCoV-19 vaccination. We report 474 SARS-CoV-2 episodes, including 48 individuals hospitalization death from COVID-19. Decreased both the serological response severe we identified clinical phenotypes that may benefit targeted COVID-19 therapeutic strategies.

Language: Английский

Citations

84
Accelerated waning of the humoral response to COVID-19 vaccines in obesity DOI Creative Commons
Agatha A. van der Klaauw, Emily C. Horner,

Pehuén Pereyra-Gerber

et al.

Nature Medicine, Journal Year: 2023, Volume and Issue: 29(5), P. 1146 - 1154

Published: May 1, 2023

Obesity is associated with an increased risk of severe Coronavirus Disease 2019 (COVID-19) infection and mortality. COVID-19 vaccines reduce the serious outcomes; however, their effectiveness in people obesity incompletely understood. We studied relationship among body mass index (BMI), hospitalization mortality due to 3.6 million Scotland using Early Pandemic Evaluation Enhanced Surveillance (EAVE II) surveillance platform. found that vaccinated individuals (BMI > 40 kg/m

Language: Английский

Citations

59
SARS-CoV-2 infection, vaccination, and antibody response trajectories in adults: a cohort study in Catalonia DOI Creative Commons
Marianna Karachaliou, Gemma Moncunill, Ana Espinosa

et al.

BMC Medicine, Journal Year: 2022, Volume and Issue: 20(1)

Published: Sept. 16, 2022

Abstract Background Heterogeneity of the population in relation to infection, COVID-19 vaccination, and host characteristics is likely reflected underlying SARS-CoV-2 antibody responses. Methods We measured IgM, IgA, IgG levels against spike nucleocapsid antigens 1076 adults a cohort study Catalonia between June November 2020 second time May July 2021. Questionnaire data electronic health records on vaccination testing were available both periods. Data several lifestyle, health-related, sociodemographic also available. Results Antibody seroreversion occurred 35.8% 64 participants non-vaccinated infected almost year ago was related asymptomatic age above 60 years, smoking. Moreover, analysis kinetics revealed that among all responses, RBD, IgA S2 decreased less within 1 after infection. Among vaccinated, 2.1% did not present antibodies at approximately 1% had breakthrough infections post-vaccination. In post-vaccination era, IgM responses those nucleoprotein much prevalent. previously individuals, boosted immune response there slight but statistically significant increase 2nd compared 1st dose. Infected vaccinated superior across naïve-vaccinated people. mRNA vaccines and, particularly Spikevax, induced higher doses Vaxzevria or Janssen vaccines. multivariable regression analyses, predicted by type vaccine, infection age, sex, smoking, mental cardiovascular diseases. Conclusions Our support people would benefit from vaccination. indicate hybrid immunity results infection-naïve need booster dose earlier than Mental diseases are associated with efficient

Language: Английский

Citations

39
Evolution of long-term vaccine-induced and hybrid immunity in healthcare workers after different COVID-19 vaccine regimens DOI Creative Commons
Shona C. Moore, Barbara Kronsteiner,

Stephanie Longet

et al.

Med, Journal Year: 2023, Volume and Issue: 4(3), P. 191 - 215.e9

Published: Feb. 16, 2023

Both infection and vaccination, alone or in combination, generate antibody T cell responses against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, the maintenance of such responses-and hence protection from disease-requires careful characterization. In a large prospective study UK healthcare workers (HCWs) (Protective Immunity Cells Healthcare Workers [PITCH], within larger SARS-CoV-2 Reinfection Evaluation [SIREN] study), we previously observed that prior strongly affected subsequent cellular humoral immunity induced after long short dosing intervals BNT162b2 (Pfizer/BioNTech) vaccination.

Language: Английский

Citations

36
Molecularly imprinted miniature electrochemical biosensor for SARS-CoV-2 spike protein based on Au nanoparticles and reduced graphene oxide modified acupuncture needle DOI Open Access

Xu Yang,

Zheng‐Zhi Yin,

Guojun Zheng

et al.

Bioelectrochemistry, Journal Year: 2023, Volume and Issue: 151, P. 108375 - 108375

Published: Jan. 27, 2023

Language: Английский

Citations

33
Previous immunity shapes immune responses to SARS-CoV-2 booster vaccination and Omicron breakthrough infection risk DOI Creative Commons
Laura Pérez‐Alós, Cecilie Bo Hansen, José Juan Almagro Armenteros

et al.

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Sept. 12, 2023

The heterogeneity of the SARS-CoV-2 immune responses has become considerably more complex over time and diverse imprinting is observed in vaccinated individuals. Despite vaccination, following emergence Omicron variant, some individuals appear susceptible to primary infections reinfections than others, underscoring need elucidate how are influenced by previous vaccination. IgG, IgA, neutralizing antibodies T-cell 1,325 (955 which were infection-naive) investigated before after three doses BNT162b2 vaccine, examining their relation breakthrough context Omicron. Our study shows that both humoral cellular vaccination generally higher infection compared infection-naive. Notably, viral exposure was crucial achieving a robust IgA response. Individuals with lower antibody postvaccination had significantly risk reinfection future infections. This not for responses. A subsequent dampened infection, consistent imprinting. These results underscore significant impact hybrid immunity general, particularly even revaccination, importance preventing

Language: Английский

Citations

32
Demographic and Clinical Factors Associated With SARS-CoV-2 Spike 1 Antibody Response Among Vaccinated US Adults: the C4R Study DOI Creative Commons
John S. Kim, Yifei Sun, Pallavi Balte

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Feb. 19, 2024

Abstract This study investigates correlates of anti-S1 antibody response following COVID-19 vaccination in a U.S. population-based meta-cohort adults participating longstanding NIH-funded cohort studies. Anti-S1 antibodies were measured from dried blood spots collected between February 2021-August 2022 using Luminex-based microsphere immunoassays. Of 6245 participants, mean age was 73 years (range, 21-100), 58% female, and 76% non-Hispanic White. Nearly 52% participants received the BNT162b2 vaccine 48% mRNA-1273 vaccine. Lower levels are associated with 65 or older, male sex, higher body mass index, smoking, diabetes, COPD receipt BNT16b2 (vs mRNA-1273). Participants prior infection, particularly those history hospitalized illness, have levels. These results suggest that certain socio-demographic clinical characteristics may less robust responses to could be prioritized for more frequent re-vaccination.

Language: Английский

Citations

8
Impact of SARS-CoV-2 spike antibody positivity on infection and hospitalisation rates in immunosuppressed populations during the omicron period: the MELODY study DOI Creative Commons

Lisa Mumford,

Rachel Hogg, Adam Taylor

et al.

The Lancet, Journal Year: 2025, Volume and Issue: 405(10475), P. 314 - 328

Published: Jan. 1, 2025

Language: Английский

Citations

1