Cell Systems, Journal Year: 2024, Volume and Issue: 15(3), P. 264 - 274.e9
Published: March 1, 2024
Language: Английский
Chemical Reviews, Journal Year: 2022, Volume and Issue: 123(5), P. 2349 - 2419
Published: Dec. 13, 2022
Recent advances in synthetic biology and materials science have given rise to a new form of materials, namely engineered living (ELMs), which are composed matter or cell communities embedded self-regenerating matrices their own artificial scaffolds. Like natural such as bone, wood, skin, ELMs, possess the functional capabilities organisms, can grow, self-organize, self-repair when needed. They also spontaneously perform programmed biological functions upon sensing external cues. Currently, ELMs show promise for green energy production, bioremediation, disease treatment, fabricating advanced smart materials. This review first introduces dynamic features systems potential developing novel We then summarize recent research progress on emerging design strategies from both perspectives. Finally, we discuss positive impacts promoting sustainability key future directions.
Language: Английский
Citations
127
Current Opinion in Microbiology, Journal Year: 2023, Volume and Issue: 73, P. 102286 - 102286
Published: March 4, 2023
A promising, sustainable way to enhance plant health and productivity is by leveraging beneficial microbes. Beneficial microbes are natural soil residents with proven benefits for performance health. When applied in agriculture improve crop yield performance, these commonly referred as bioinoculants. Yet, despite their promising properties, bioinoculant efficacy can vary dramatically the field, hampering applicability. Invasion of rhizosphere microbiome a critical determinant success. complex phenomenon that shaped interactions local, resident host plant. Here, we explore all dimensions cross-cutting ecological theory molecular biology microbial invasion rhizosphere. We refer famous Chinese philosopher strategist Sun Tzu, who believed solutions problems require deep understanding themselves, review major biotic factors determining effectiveness.
Language: Английский
Citations
63
Water Research, Journal Year: 2023, Volume and Issue: 249, P. 120891 - 120891
Published: Nov. 18, 2023
Language: Английский
Citations
45
Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)
Published: Sept. 23, 2024
Language: Английский
Citations
28
Cell Reports Medicine, Journal Year: 2024, Volume and Issue: 5(5), P. 101512 - 101512
Published: April 18, 2024
Our previous work developed acoustic response bacteria, which enable the precise tuning of transgene expression through ultrasound. However, it is still difficult to visualize these bacteria in order guide sound wave precisely irradiate them. Here, we develop ultrasound-visible engineered and chemically modify them with doxorubicin (DOX) on their surfaces. These (Ec@DIG-GVs) can produce gas vesicles (GVs), providing a real-time imaging for remote hyperthermia high-intensity focused ultrasound (hHIFU) induce interferon (IFN)-γ gene. The production IFN-γ kill tumor cells, macrophage polarization from M2 M1 phenotype, promote maturation dendritic cells. DOX be released acidic microenvironment, resulting immunogenic cell death concurrent effects activate tumor-specific T response, producing synergistic anti-tumor efficacy. study provides promising strategy bacteria-mediated chemo-immunotherapy.
Language: Английский
Citations
22
Water Research, Journal Year: 2024, Volume and Issue: 251, P. 121162 - 121162
Published: Jan. 18, 2024
Language: Английский
Citations
20
Microbiological Research, Journal Year: 2025, Volume and Issue: unknown, P. 128078 - 128078
Published: Jan. 1, 2025
Language: Английский
Citations
3
Cell Reports, Journal Year: 2022, Volume and Issue: 40(13), P. 111410 - 111410
Published: Sept. 1, 2022
Microbial communities execute metabolic pathways to drive global nutrient cycles. Within a community, functionally specialized strains can perform different yet complementary steps within linear pathway, phenomenon termed division of labor (MDOL). However, little is known about how such behaviors shape microbial communities. Here, we derive theoretical framework define the assembly community that degrades an organic compound through MDOL. The indicates ensure stability, performing initial should hold growth advantage (m) over "private benefit" (n) strain last step. steady-state frequency then determined by quotient n and m. Our experiments show accurately predicts our synthetic consortia degrade naphthalene results provide insights for designing managing stable systems pathway optimization.
Language: Английский
Citations
42
Nature Chemical Biology, Journal Year: 2023, Volume and Issue: 19(8), P. 951 - 961
Published: May 29, 2023
Abstract Nutritional codependence (syntrophy) has underexplored potential to improve biotechnological processes by using cooperating cell types. So far, design of yeast syntrophic communities required extensive genetic manipulation, as the co-inoculation most eukaryotic microbial auxotrophs does not result in cooperative growth. Here we employ high-throughput phenotypic screening systematically test pairwise combinations auxotrophic Saccharomyces cerevisiae deletion mutants. Although coculture pairs do enter growth, identify 49 that spontaneously form syntrophic, synergistic communities. We characterized stability and growth dynamics nine cocultures demonstrated a pair tryptophan grow exchanging pathway intermediate rather than end products. then introduced malonic semialdehyde biosynthesis split between different auxotrophs, which resulted increased production. Our results report spontaneous formation stable syntrophy S. illustrate dividing labor intraspecies community.
Language: Английский
Citations
33
Current Opinion in Biotechnology, Journal Year: 2023, Volume and Issue: 79, P. 102880 - 102880
Published: Jan. 6, 2023
Language: Английский
Citations
32