Aggregate,
Journal Year:
2023,
Volume and Issue:
5(2)
Published: Nov. 20, 2023
Abstract
Messenger
RNA
(mRNA)
therapy
is
the
intracellular
delivery
of
mRNA
to
produce
desired
therapeutic
proteins.
Developing
strategies
for
local
still
required
where
direct
intra‐articular
injections
are
inappropriate
targeting
a
specific
tissue.
The
efficiency
depends
on
protecting
nucleic
acids
against
nuclease‐mediated
degradation
and
safe
site‐specific
delivery.
Herein,
novel
mRNA‐releasing
matrices
based
RGD‐moiety‐rich
gelatin
methacryloyl
(GelMA)
microporous
annealed
particle
(MAP)
scaffolds
reported.
GelMA
concentration
in
aerogel‐based
microgels
(µgels)
produced
through
microfluidic
process,
MAP
stiffnesses,
microporosity
crucial
parameters
cell
adhesion,
spreading,
proliferation.
After
being
loaded
with
complexes,
composed
10%
µgels
display
excellent
viability
increasing
infiltration,
proliferation,
gene
transfer.
achieved
by
sustained
release
complexes
from
adhesion
scaffolds.
These
findings
highlight
that
hybrid
systems
can
achieve
efficient
protein
expression
delivering
making
them
promising
biomaterials
tissue
engineering.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(19)
Published: Feb. 8, 2024
Cavernous
nerve
injury
(CNI),
resulting
in
erectile
dysfunction
(ED),
poses
a
significant
threat
to
the
quality
of
life
for
men.
Strategies
utilizing
conductive
hydrogels
have
demonstrated
promising
results
treatment
peripheral
nerves
with
large
diameter
(>2
mm).
However,
integrating
convenient
minimally
invasive
operation,
antiswelling
and
immunomodulatory
treating
small-diameter
injured
cavernous
remains
great
challenge.
Here,
sprayable
adhesive
hydrogel
(GACM)
composed
gelatin,
adenine,
carbon
nanotubes,
mesaconate
designed
repair
is
developed.
Multiple
hydrogen
bonds
provide
GACM
excellent
properties,
enabling
it
establish
conformal
electrical
bridge
damaged
aiding
regeneration
process.
Additionally,
mesaconate-loaded
suppresses
release
inflammatory
factors
by
macrophages
promotes
migration
proliferation
Schwann
cells.
In
vivo
tests
demonstrate
that
repairs
restores
function
fertility.
Furthermore,
feasibility
robotic
surgery
beagles
validated.
Given
benefits
therapeutic
effectiveness
clinical
convenience,
research
suggests
future
materials
as
advanced
solutions
repair.
Journal of Biomedical Science,
Journal Year:
2023,
Volume and Issue:
30(1)
Published: June 20, 2023
Abstract
Tissue
engineering
biomaterials
are
aimed
to
mimic
natural
tissue
and
promote
new
formation
for
the
treatment
of
impaired
or
diseased
tissues.
Highly
porous
biomaterial
scaffolds
often
used
carry
cells
drugs
regenerate
tissue-like
structures.
Meanwhile,
self-healing
hydrogel
as
a
category
smart
soft
with
ability
automatically
repair
its
own
structure
after
damage
has
been
developed
various
applications
through
designs
dynamic
crosslinking
networks.
Due
flexibility,
biocompatibility,
ease
functionalization,
great
potential
in
regenerative
medicine,
especially
restoring
function
neural
tissue.
Recent
researchers
have
drug/cell
carriers
support
matrices
targeted
injection
via
minimally
invasive
surgery,
which
become
promising
strategy
treating
brain
diseases.
In
this
review,
development
history
biomedical
design
strategies
according
different
(gel
formation)
mechanisms
summarized.
The
current
therapeutic
progress
hydrogels
diseases
is
described
well,
an
emphasis
on
validated
by
vivo
experiments.
most
recent
aspect
well
rationale
also
addressed.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(38)
Published: April 12, 2024
Abstract
Peripheral
nerve
injury
often
leads
to
the
loss
of
neurological
functions
due
slow
regeneration
rate
and
inefficient
functional
reconstruction.
Current
clinical
treatments
using
guidance
conduits
(NGCs)
still
face
challenges
in
providing
a
biomimetic
microenvironment
promote
repair.
Herein,
decellularized
extracellular
matrix
(dECM)
is
obtained
from
porcine
Achilles
tendon
crosslinked
with
3‐amino‐4‐methoxybenzoic
acid
grafted
gelatin
(PAMB‐G)
obtain
conductive
hydrogels.
Then,
novel
conduit
developed
by
assembling
poly(vinyl
alcohol)
(PVA)
ECM@PAMB‐G
hydrogel.
This
bioengineered
ECM@PAMB‐G/PVA
demonstrated
excellent
cytocompatibility,
electrical
conductivity,
mechanical
properties,
biodegradability.
In
vitro
experiments
confirmed
that
hydrogel
significantly
promotes
proliferation
migration
PC12
cells
primary
Schwann
cells,
as
well
growth
dorsal
root
ganglion
(DRG)
axons.
Furthermore,
vivo
studies
rat
sciatic
model
exhibited
improvements
axonal
regeneration,
cell
migration,
myelin
sheath
formation,
recovery
mediated
conduit.
work
demonstrates
synergistic
effects
cues
enhancing
peripheral
regeneration.
The
shows
potential
an
alternative
autografts
for
supporting
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
35(42)
Published: July 27, 2023
Living
materials
represent
a
new
frontier
in
functional
material
design,
integrating
synthetic
biology
tools
to
endow
with
programmable,
dynamic,
and
life-like
characteristics.
However,
major
challenge
creating
living
is
balancing
the
tradeoff
between
structural
stability,
mechanical
performance,
programmability.
To
address
this
challenge,
sheath-core
hydrogel
fiber
platform
that
synergistically
integrates
bacteria
fibers
achieve
both
diversity
robustness
proposed.
In
microfluidic
spinning
used
produce
fiber,
which
offers
advantages
designability
due
their
hierarchical
porous
architectures
can
be
tailored
performance
enhanced
through
variety
of
post-processing
approaches.
By
introducing
bacteria,
endowed
programmable
functionality
capabilities.
This
work
reconstructs
genetic
circuits
express
chromoproteins
fluorescent
proteins
as
two
prototypes
enable
coloration
sensing
water
pollutants
by
monitoring
amount
protein
expressed.
Altogether,
study
establishes
structure-property-function
optimized
platform,
providing
tool
for
accelerating
practical
applications
emerging
systems.
Nano Convergence,
Journal Year:
2023,
Volume and Issue:
10(1)
Published: Sept. 7, 2023
Abstract
Recently,
the
3D
printing
of
conductive
hydrogels
has
undergone
remarkable
advances
in
fabrication
complex
and
functional
structures.
In
field
neural
engineering,
an
increasing
number
reports
have
been
published
on
tissue
engineering
bioelectronic
approaches
over
last
few
years.
The
convergence
methods
electrically
conducting
may
create
new
clinical
therapeutic
possibilities
for
precision
regenerative
medicine
implants.
this
review,
we
summarize
(i)
advancements
preparation
strategies
materials,
(ii)
various
techniques
enabling
electroconductive
hydrogels,
(iii)
required
physicochemical
properties
printed
constructs,
(iv)
their
applications
bioelectronics
regeneration
(v)
unconventional
outlooks
hydrogels.
This
review
provides
technical
insights
into
printable
encompasses
recent
developments,
specifically
years
research
field.
Science Advances,
Journal Year:
2024,
Volume and Issue:
10(44)
Published: Nov. 1, 2024
Osteoporotic
bone
defects
refer
to
the
disruption
of
structural
integrity
in
patients
with
osteoporosis
and
pose
a
substantial
challenge
orthopedic
surgeons.
In
this
study,
we
developed
biomimetic
hydrogel
improve
osteogenic
microenvironment
promote
stem
cell
homing.
This
served
as
container
for
S-nitrosoglutathione
Ca
