International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(19), P. 14709 - 14709
Published: Sept. 28, 2023
The
development
of
brain
in
vitro
models
requires
the
application
novel
biocompatible
materials
and
biopolymers
as
scaffolds
for
controllable
effective
cell
growth
functioning.
"ideal"
model
should
demonstrate
principal
features
plasticity
like
synaptic
transmission
remodeling,
neurogenesis
angiogenesis,
changes
metabolism
associated
with
establishment
new
intercellular
connections.
Therefore,
extracellular
that
are
helpful
maintenance
local
microenvironments
supporting
mechanisms
critical
importance.
In
this
review,
we
will
focus
on
some
carbohydrate
metabolites-lactate,
pyruvate,
oxaloacetate,
malate-that
greatly
contribute
to
regulation
cell-to-cell
communications
metabolic
cells
resorbable
may
reproduce
microenvironment
enriched
particular
metabolites.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(7), P. 3849 - 3849
Published: March 29, 2024
This
state-of-the-art
review
explores
the
emerging
field
of
regenerative
hydrogels
and
their
profound
impact
on
treatment
skin
wounds.
Regenerative
hydrogels,
composed
mainly
water-absorbing
polymers,
have
garnered
attention
in
wound
healing,
particularly
for
Their
unique
properties
make
them
well
suited
tissue
regeneration.
Notable
benefits
include
excellent
water
retention,
creating
a
crucially
moist
environment
optimal
facilitating
cell
migration,
proliferation.
Biocompatibility
is
key
feature,
minimizing
adverse
reactions
promoting
natural
healing
process.
Acting
as
supportive
scaffold
growth,
mimic
extracellular
matrix,
aiding
attachment
proliferation
cells
like
fibroblasts
keratinocytes.
Engineered
controlled
drug
release,
enhance
by
angiogenesis,
reducing
inflammation,
preventing
infection.
The
demonstrated
acceleration
process,
beneficial
chronic
or
impaired
wounds,
adds
to
appeal.
Easy
application
conformity
various
shapes
practical,
including
irregular
challenging
areas.
Scar
minimization
through
regeneration
crucial,
especially
cosmetic
functional
regions.
Hydrogels
contribute
pain
management
protective
barrier,
friction,
fostering
soothing
environment.
Some
with
inherent
antimicrobial
properties,
aid
infection
prevention,
which
crucial
aspect
successful
healing.
flexibility
ability
conform
contours
ensure
contact,
enhancing
overall
effectiveness.
In
summary,
present
promising
approach
improving
outcomes
across
diverse
clinical
scenarios.
provides
comprehensive
analysis
benefits,
mechanisms,
challenges
associated
use
this
review,
authors
likely
delve
into
rational
design
principles
efficacy
performance
Through
an
exploration
methodologies
approaches,
paper
poised
highlight
how
these
been
instrumental
refining
potentially
revolutionizing
therapeutic
potential
addressing
By
synthesizing
current
knowledge
highlighting
avenues
future
research,
aims
advancement
medicine
ultimately
improve
patients
Gels,
Journal Year:
2024,
Volume and Issue:
10(3), P. 190 - 190
Published: March 9, 2024
The
repair
of
nervous
tissue
is
a
critical
research
field
in
engineering
because
the
degenerative
process
injured
system.
In
this
review,
we
summarize
progress
injectable
hydrogels
using
vitro
and
vivo
studies
for
regeneration
tissue.
Traditional
treatments
have
not
been
favorable
patients,
as
they
are
invasive
inefficient;
therefore,
promising
treatment
damaged
This
review
will
contribute
to
better
understanding
potential
scaffolds
drug
delivery
system
neural
applications.
Applied Physics Reviews,
Journal Year:
2025,
Volume and Issue:
12(1)
Published: March 1, 2025
Smart
biomaterials
have
significantly
impacted
human
healthcare
by
advancing
the
development
of
medical
devices
designed
to
function
within
tissue,
mimicking
behavior
natural
tissues.
While
intelligence
has
evolved
from
inert
active
over
past
few
decades,
smart
take
this
a
step
further
making
their
surfaces
or
bulk
respond
based
on
interactions
with
surrounding
tissues,
imparting
outcomes
similar
tissue
functions.
This
interaction
helps
in
creating
stimuli-responsive
biomaterials,
which
can
be
useful
engineering,
regenerative
medicine,
autonomous
drug
delivery,
orthopedics,
and
much
more.
Traditionally,
material
engineering
focused
refining
static
properties
accommodate
them
body
without
evoking
an
immune
response,
was
major
obstacle
unrestricted
operation.
review
highlights
explains
various
approaches
currently
under
research
for
developing
that
tune
responses
bodily
factors
like
temperature,
pH,
ion
concentration
external
magnetism,
light,
conductivity.
Applications
soft
hard
4D
printing,
scaffold
design
are
also
discussed.
The
advanced
application
microfluidics,
organ-on-a-chip
models,
extensively
benefits
intrinsic
discussed
below.
elaborates
how
biomaterial
could
revolutionize
biosensor
applications,
thereby
improving
patient
care
quality.
We
delineate
limitations
key
challenges
associated
providing
insights
into
path
forward
outlining
future
directions
next-generation
will
facilitate
clinical
translation.
Biomaterials Advances,
Journal Year:
2024,
Volume and Issue:
161, P. 213869 - 213869
Published: April 22, 2024
Considering
the
global
burden
related
to
tissue
and
organ
injuries
or
failures,
self-healing
hydrogels
may
be
an
attractive
therapeutic
alternative
for
future.
Self-healing
are
highly
hydrated
3D
structures
with
ability
self-heal
after
breaking,
this
property
is
attributable
a
variety
of
dynamic
non-covalent
covalent
bonds
that
able
re-linking
within
matrix.
specially
benefits
minimal
invasive
medical
treatments
cell-delivery
support.
Moreover,
those
tissue-engineered
network
have
demonstrated
effectiveness
myriad
purposes;
instance,
they
could
act
as
delivery-platforms
different
cargos
(drugs,
growth
factors,
cells,
among
others)
in
tissues
such
bone,
cartilage,
nerve
skin.
Besides,
currently
found
their
way
into
new
novel
applications;
example,
development
adhesive
hydrogels,
by
merely
aiding
surgical
closing
processes
providing
biomaterial-tissue
adhesion.
Furthermore,
conductive
permit
stimuli
monitoring
natural
electrical
signals,
which
facilitated
better
fitting
native
diagnosis
various
health
diseases.
Lastly,
part
cyborganics
–
merge
between
biology
machinery
can
pave
finer
healthcare
devices
diagnostics
precision
therapies.
Biomacromolecules,
Journal Year:
2024,
Volume and Issue:
25(4), P. 2462 - 2475
Published: March 27, 2024
With
wide
clinical
demands,
therapies
for
traumatic
brain
injury
(TBI)
are
a
major
problem
in
surgical
procedures
and
after
trauma.
Due
to
the
difficulty
regeneration
of
neurons
or
axons
injury,
as
well
inhibition
blood
vessel
growth
by
formation
neural
scars,
existing
treatment
measures
have
limited
effectiveness
repairing
tissue.
Herein,
biomultifunctional
hydrogels
developed
TBI
based
on
Schiff
base
reaction
calcium
ion
(Ca2+)-cross-linked
oxidized
sodium
alginate
(OSA)
carboxymethyl
chitosan
(CMCS).
The
obtained
COCS
hydrogel
exhibits
excellent
adhesion
wet
tissues,
self-repair
capability,
antimicrobial
properties.
What's
particularly
interesting
is
that
addition
Ca2+
increases
hydrogel's
extensibility,
enhancing
its
hemostatic
capabilities.
Biological
assessments
indicate
demonstrates
biocompatibility,
properties,
ability
promote
arterial
repair.
Importantly,
promotes
cerebral
microvessels
upregulating
CD31,
accelerates
proliferation
astrocytes,
enhances
expression
GFAP,
stimulates
neuron-specific
markers
such
NEUN
β-tubulin.
All
these
findings
highlight
strongly
adhesive,
self-healing,
shows
great
potential
repair
other
tissue
therapy.
