An Esophageal Stent Integrated with Wireless Battery-Free Movable Photodynamic-Therapy Unit for Targeted Tumor Treatment DOI Creative Commons
Qian Han, Pingjin Zou, Xianhao Wei

et al.

Materials Today Bio, Journal Year: 2024, Volume and Issue: 30, P. 101394 - 101394

Published: Dec. 9, 2024

Esophageal cancer is the eighth most common worldwide and sixth leading cause of cancer-related deaths. In this study, we propose a novel esophageal stent equipped with wireless, battery-free, movable photodynamic therapy (PDT) unit designed to treat tumors flexibility, precision, real-time control. This system integrates PDT an electrochemical pneumatic soft actuator into conventional stent. Each module incorporates piezoelectric transducer capable receiving external ultrasound power respective module. These transducers selectively respond different frequencies, enabling independent operation without mutual interference. The provides light source for PDT, inducing production cytotoxic reactive oxygen species (ROS) in tumor cells promoting apoptosis. based on principles plays critical role controlling position source, movement up 200 mm within 15 min. allows control maintain near tumor, ensuring precise targeted treatment. can wirelessly source's via ultrasound, offering approach treating patients according need tumor's progression.

Language: Английский

Flexible Pressure, Humidity, and Temperature Sensors for Human Health Monitoring DOI
Jiaqi Li, Z. Fang,

Dongsong Wei

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 17, 2024

Abstract The rapid advancements in artificial intelligence, micro‐nano manufacturing, and flexible electronics technology have unleashed unprecedented innovation opportunities for applying sensors healthcare, wearable devices, human–computer interaction. human body's tactile perception involves physical parameters such as pressure, temperature, humidity, all of which play an essential role maintaining health. Inspired by the sensory function skin, many bionic been developed to simulate skin's various stimuli are widely applied health monitoring. Given urgent requirements sensing performance integration field devices monitoring, here is a timely overview recent advances multi‐functional It covers fundamental components categorizes them based on different response mechanisms, including resistive, capacitive, voltage, other types. Specifically, application these area monitoring highlighted. Based this, extended dual/triple‐mode integrating temperature presented. Finally, challenges discussed.

Language: Английский

Citations

18
Emerging Wearable Acoustic Sensing Technologies DOI Creative Commons
Tao Liu,

Y. J. Mao,

Hanjie Dou

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 3, 2025

Sound signals not only serve as the primary communication medium but also find application in fields such medical diagnosis and fault detection. With public healthcare resources increasingly under pressure, challenges faced by disabled individuals on a daily basis, solutions that facilitate low-cost private hold considerable promise. Acoustic methods have been widely studied because of their lower technical complexity compared to other solutions, well high safety threshold human body acoustic energy. Furthermore, with recent development artificial intelligence technology applied speech recognition, recognition devices, systems capable assisting interacting scenes are constantly being updated. This review meticulously summarizes sensing mechanisms, materials, structural design, multidisciplinary applications wearable devices health human-computer interaction. Further, advantages disadvantages different approaches used flexible various examined. Finally, current roadmap for future research analyzed based existing progress achieve more comprehensive personalized healthcare.

Language: Английский

Citations

4
Soft Bioelectronics for Heart Monitoring DOI
Hadi Mirzajani, Michaël Kraft

ACS Sensors, Journal Year: 2024, Volume and Issue: 9(9), P. 4328 - 4363

Published: Sept. 6, 2024

Cardiovascular diseases (CVDs) are a predominant global health concern, accounting for over 17.9 million deaths in 2019, representing approximately 32% of all fatalities. In North America and Europe, adults undergo cardiac surgeries annually. Despite the benefits, such pose risks require precise postsurgery monitoring. However, during postdischarge period, where monitoring infrastructures limited, continuous vital signals is hindered. this area, introduction implantable electronics altering medical practices by enabling real-time out-of-hospital physiological biological information postsurgery. The multimodal bioelectronic platforms have capability heart sensing stimulation, both settings. Furthermore, with emergence machine learning algorithms into healthcare devices, next-generation implantables will benefit artificial intelligence (AI) connectivity skin-interfaced to provide more user-specific results. This Review outlines recent advancements bioelectronics their utilization cardiovascular monitoring, highlighting transformative deployment stimulation toward reaching truly personalized compatible Sustainable Development Goal 3.4 WHO 2030 observatory roadmap. also discusses challenges future prospects these devices.

Language: Английский

Citations

9
Artificial piezoelectric metamaterials DOI

Ziyan Gao,

Yu Lei,

Zhanmiao Li

et al.

Progress in Materials Science, Journal Year: 2025, Volume and Issue: unknown, P. 101434 - 101434

Published: Jan. 1, 2025

Citations

1
Advances in Polysaccharide-Based Microneedle Systems for the Treatment of Ocular Diseases DOI Creative Commons

Qingdong Bao,

Xiaoting Zhang,

Zhankun Hao

et al.

Nano-Micro Letters, Journal Year: 2024, Volume and Issue: 16(1)

Published: Aug. 13, 2024

Abstract The eye, a complex organ isolated from the systemic circulation, presents significant drug delivery challenges owing to its protective mechanisms, such as blood-retinal barrier and corneal impermeability. Conventional administration methods often fail sustain therapeutic levels may compromise patient safety compliance. Polysaccharide-based microneedles (PSMNs) have emerged transformative solution for ophthalmic delivery. However, comprehensive review of PSMNs in ophthalmology has not been published date. In this review, we critically examine synergy between polysaccharide chemistry microneedle technology enhancing ocular We provide thorough analysis PSMNs, summarizing design principles, fabrication processes, addressed during fabrication, including improving comfort also describe recent advances performance various both research clinical scenarios. Finally, current regulatory frameworks market barriers that are relevant commercial advancement final perspective on area.

Language: Английский

Citations

8
Enhancing Ultrasound Power Transfer: Efficiency, Acoustics, and Future Directions DOI Creative Commons
Yi Zheng, Zhuomin Zhang, Yanhu Zhang

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: July 23, 2024

Abstract Implantable medical devices (IMDs), like pacemakers regulating heart rhythm or deep brain stimulators treating neurological disorders, revolutionize healthcare. However, limited battery life necessitates frequent surgeries for replacements. Ultrasound power transfer (UPT) emerges as a promising solution sustainable IMD operation. Current research prioritizes implantable materials, with less emphasis on sound field analysis and maximizing energy during wireless delivery. This review addresses this gap. A comprehensive of UPT technology, examining cutting‐edge system designs, particularly in supply efficiency is provided. The critically examines existing models, summarizing the key parameters influencing transmission systems. For first time, an flow diagram general proposed to offer insights into overall functioning. Additionally, explores development stages showcasing representative designs applications. remaining challenges, future directions, exciting opportunities associated are discussed. By highlighting importance IMDs advanced functions biosensing closed‐loop drug delivery, well UPT's potential, aims inspire further advancements field.

Language: Английский

Citations

4
Implantable and wireless-controlled antibacterial patch for deep abscess eradication and therapeutic efficacy monitoring DOI
Yuan Chen,

Hongye Guan,

Xinlu Wang

et al.

Nano Energy, Journal Year: 2024, Volume and Issue: 131, P. 110193 - 110193

Published: Aug. 31, 2024

Language: Английский

Citations

4
Patient-Centric Care: Unveiling the Potential of Wearable Electronics in Clinical Practice DOI Creative Commons
Pengcheng Zhao,

Jie Xu,

Mengdi Han

et al.

Wearable electronics., Journal Year: 2024, Volume and Issue: 1, P. 119 - 136

Published: Aug. 10, 2024

Wearable electronics have the capability to monitor human activities and various physiological indicators in a real-time, continuous, non-invasive, wireless manner, making them valuable complement traditional clinical health monitoring technologies. Currently, adoption of specialized reliable wearable for disease diagnosis, monitoring, treatment is flourishing. This article delves into development from application perspective, examining modes, mechanisms, benefits (1) commercial electronics, (2) customized (3) flexible settings. The focus on analyzing diverse forms electronic systems utilizing mechanical, thermal, optical, electrophysiological, electrochemical technologies, alignment with requirements. Furthermore, outlines challenges encountered by environments discusses potential future directions applications.

Language: Английский

Citations

2
Electrical Microneedles for Wound Treatment DOI Creative Commons
Yu Wang, Lijun Cai, Fan Lü

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 8, 2024

Electrical stimulation has been hotpot research and provoked extensive interest in a broad application such as wound closure, tissue injury repair, nerve engineering. In particular, immense efforts have dedicated to developing electrical microneedles, which demonstrate unique features terms of controllable drug release, real-time monitoring, therapy, thus greatly accelerating the process healing. Here, review state-of-art concerning microneedles applied for treatment is presented. After comprehensive analysis mechanisms on healing, derived three types are clarified summarized. Further, their applications healing highlighted. Finally, current perspectives directions development future improving addressed.

Language: Английский

Citations

1
Retinal glia in myopia: current understanding and future directions DOI Creative Commons

Pengfan Chen,

Jing Ji, Xinyi Chen

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12

Published: Dec. 20, 2024

Myopia, a major public health problem, involves axial elongation and thinning of all layers the eye, including sclera, choroid retina, which defocuses incoming light thereby blurs vision. How various populations glia in retina are involved disorder is unclear. Astrocytes Müller cells provide structural support to retina. Astrogliosis myopia may influence blood oxygen supply, neuronal function, axon diameter, turn affect signal conduction. act as sensor mechanical stretching trigger downstream molecular responses. Microglia, for their part, exhibit reactive morphology elevated response inflammation myopia. This review assesses current knowledge about how involve retinal glia, it explores directions future research into that question.

Language: Английский

Citations

1