An Immunomodulatory Hydrogel by Hyperthermia‐Assisted Self‐Cascade Glucose Depletion and ROS Scavenging for Diabetic Foot Ulcer Wound Therapeutics

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(48)

Published: Oct. 7, 2023

Abstract Current therapeutic protocols for diabetic foot ulcers (DFUs), a severe and rapidly growing chronic complication in patients, remain nonspecific. Hyperglycemia‐caused inflammation excessive reactive oxygen species (ROS) are common obstacles encountered DFU wound healing, often leading to impaired recovery. These two effects reinforce each other, forming an endless loop. However, adequate inclusive methods still lacking target these aspects break the vicious cycle. This study proposes novel approach treating wounds, utilizing immunomodulatory hydrogel achieve self‐cascade glucose depletion ROS scavenging regulate microenvironment. Specifically, AuPt@melanin‐incorporated (GHM3) dressing is developed facilitate efficient hyperthermia‐enhanced local scavenging. Mechanistically, vitro/vivo experiments RNA sequencing analysis demonstrate that GHM3 disrupts ROS‐inflammation cascade cycle downregulates ratio of M1/M2 macrophages, consequently improving outcomes dorsal skin wounds rats. In conclusion, this proposed offers facile, safe, highly treatment modality DFUs.

Language: Английский

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Cellulose‐Based pH‐Responsive Janus Dressing with Unidirectional Moisture Drainage for Exudate Management and Diabetic Wounds Healing

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 34(3)

Published: Oct. 6, 2023

Abstract Diabetic wounds with hyperglycemic tissue exudates and bacterial infections have become a great challenge that seriously delays the healing of diabetic wounds. Therefore, multifunctional dressings for exudate management wound are urgently needed. Herein, smart dressing rapid moisture‐drained non‐adhesive, pH‐responsive, antibacterial capabilities is proposed monitoring. The Janus assembled an antioxidant, pH‐sensitive, hydrophilic cellulose cover hydrophobic polycaprolactone bottom layer directly contacts wounds, which can unidirectionally irreversibly drain weaken wet adhesion to wound. In response humoral pH variations (5‐9) during process ofdiabetic be in situ monitored according distinct pH‐responsive colors at different stages. vivo assays histopathological studies suggest has superior pro‐healing rate, collagen deposition, angiogenesis than commercial gauze. Notably, such mulitfunctional provides real‐time monitoring simply through smartphone integrated Python‐RGB programs, significantly alleviate exudate‐flooded environment as alternative strategy treatment.

Language: Английский

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A Hybrid Hydrogel with Intrinsic Immunomodulatory Functionality for Treating Multidrug-Resistant Pseudomonas aeruginosa Infected Diabetic Foot Ulcers

ACS Materials Letters, Journal Year: 2024, Volume and Issue: 6(7), P. 2533 - 2547

Published: May 24, 2024

Contemporary options for multidrug-resistant bacteria infected diabetic foot ulcers (IDFUs) are predominantly nonspecific. These IDFU injuries often display prolonged inflammation and delayed tissue repair, mainly attributed to an overabundance of M1 macrophages in the hostile microenvironment. Although immunomodulatory hydrogels show promise IDFU-focused care, a targeted, safe transition from M2 using simplified techniques remains significant obstacle. Here, we introduce hybrid hydrogel (GGG) with inherent capabilities IDFUs. GGG is composed interpenetrating polymer networks featuring gallium-induced self-assembling glycyrrhizic acid photo-cross-linked gelatin methacryloyl matrix. Importantly, effectively decreases ratio conditions drug-resistant by disrupting iron metabolism scavenging reactive oxygen species, which contributes enhanced treatment results wounds. To sum up, strategy present provides straightforward, safe, highly effective therapeutic avenue managing

Language: Английский

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Oxygen-independent organic photosensitizer with ultralow-power NIR photoexcitation for tumor-specific photodynamic therapy

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: March 21, 2024

Abstract Photodynamic therapy (PDT) is a promising cancer treatment but has limitations due to its dependence on oxygen and high-power-density photoexcitation. Here, we report polymer-based organic photosensitizers (PSs) through rational PS skeleton design precise side-chain engineering generate •O 2 − •OH under oxygen-free conditions using ultralow-power 808 nm photoexcitation for tumor-specific photodynamic ablation. The designed skeletons can electron-hole pairs sensitize H O into with photoexcitation, achieving NIR-photoexcited oxygen-independent production. Further, compared commonly used alkyl side chains, glycol oligomer as the chain mitigates recombination offers more molecules around generated from hydrophobic skeletons, which yield 4-fold stronger production, thus allowing an high PDT effect. Finally, feasibility of developing activatable PSs in female mice further demonstrated irradiation 15 mW cm −2 . study not only provides insights mechanism also general guideline develop NIR PDT.

Language: Английский

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An Antioxidative and Active Shrinkage Hydrogel Integratedly Promotes Re‐Epithelization and Skin Constriction for Enhancing Wound Closure

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(21)

Published: Feb. 9, 2024

Abstract Delayed re‐epithelization and weakened skin contractions are the two primary factors that hinder wound closure in large‐scale acute or chronic wounds. However, effective strategies for targeting these aspects concurrently still lacking. Herein, an antioxidative active‐shrinkage hydrogel (AHF@AS Gel) is constructed can integratedly promote constriction to accelerate diabetic closure. The AHF@AS Gel encapsulated by amino‐ hydroxyl‐modified C 70 fullerene (AHF) a thermosensitive active shrinkage (AS Gel). Specifically, AHF relieves overactivated inflammation, prevents cellular apoptosis, promotes fibroblast migration vitro reducing excessive reactive oxygen species (ROS). Notably, achieved ≈2.7‐fold ≈1.7‐fold better wounds wounds, respectively, significantly contributing promotion of Using proteomic profiling mechanistic studies, it identified efficiently promoted transition inflammatory proliferative phases remodeling phase. demonstrated AS alone activates mechanosensitive epidermal growth factor receptor/Akt (EGFR/Akt) pathway cell proliferation. offers comprehensive strategy via biochemistry regulation integrating with mechanical forces stimulation.

Language: Английский

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Nanocatalysts for modulating antitumor immunity: fabrication, mechanisms and applications

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(5), P. 2643 - 2692

Published: Jan. 1, 2024

This review discusses the structures and engineering strategies of nanocatalysts, highlighting their underlying mechanisms applications in cancer immunotherapy.

Language: Английский

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Self‐Growing Hydrogel Bioadhesives for Chronic Wound Management

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(41)

Published: Aug. 16, 2024

Hydrogel bioadhesives have emerged as a promising alternative to wound dressings for chronic management. However, many existing do not meet the functional requirements efficient management through dynamically mechanical modulation, due reduced contractibility, frequent recurrence, incapability actively adapt external microenvironment variation, especially those gradually-expanded wounds. Here, self-growing hydrogel bioadhesive (sGHB) patch that exhibits instant adhesion biological tissues but also gradual increase in strength and interfacial adhesive within 120-h application is presented. The gradually increased mechanics of sGHB could effectively mitigate stress concentration at edge, resist expansion various stages, thus mechanically contracting wounds programmable manner. demonstrated enhanced healing efficacy mouse diabetic model, by regulating inflammatory response, promoting faster re-epithelialization angiogenesis modulation. Such kind potential clinical utility variety where dynamic modulation indispensable.

Language: Английский

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Stimuli-responsive hydrogel dressing for wound healing

APL Materials, Journal Year: 2025, Volume and Issue: 13(1)

Published: Jan. 1, 2025

Wound healing is a complex, variable, and time-dynamic repair process. Wounds can be classified as acute wounds or chronic wounds, effective wound management still major challenge in clinical nursing settings. The microenvironment collectively regulated by internal biomolecules, external drugs, sanitation. Traditional dressings (powders, bandages, sponges, etc.) often have poor therapeutic effects during processes because they cannot respond to the dynamic changes over long-term. Stimulus-responsive biomaterials, which are activated various factors intrinsic influences, hold great promise for precise drug delivery controlled release. Various stimulus-responsive hydrogels been developed recent years, exhibiting range of “smart” properties, such interacting with wound, sensing conditions environmental changes, responding accordingly, thereby effectively promoting healing. This review discusses latest advancements used We introduce design scheme stimulus-response detail based on local biological/biochemical peculiarities (pH, reactive oxygen species glucose, enzymes, physical microenvironments (temperature, light, ultrasound, electric fields, etc.). Furthermore, we explore several promising tissue-engineered constructs (nanofibers, scaffolds, microneedles, microspheres). Finally, summarize basis active research challenges, current progress, development trends field.

Language: Английский

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A one-two punch of inflammation and oxidative stress promotes revascularization for diabetic foot ulcers

Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101548 - 101548

Published: Feb. 4, 2025

Patients with diabetic foot ulcers (DFU) suffering from severe lower limb ischemia face the risk of amputation. Concomitant oxidative stress and hyperinflammation commonly manifest within tissue affected by DFU, exacerbating deterioration DFU wounds. One-two punch strategy anti-oxidative damage plus anti-inflammatory is anticipated to tackle challenge non-healing Here, we introduced a dual-approach treatment involving probiotic Weissella cibaria (WC) modified desferrioxamine (DFO). This engineered probiotic, known as WC@DPA, aims ameliorate ischemic microenvironment stimulate formation proliferation endothelial tubular structures. When applied chronic wounds hindlimb injuries in mice, WC@DPA gel demonstrated an effective performance modulating damage, reducing local vascular inflammation, facilitating muscle repair reconstruction. We believe that our represents promising therapeutic avenue for managing associated DFU.

Language: Английский

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In situ formed scaffold with royal jelly-derived extracellular vesicles for wound healing

Theranostics, Journal Year: 2023, Volume and Issue: 13(9), P. 2811 - 2824

Published: Jan. 1, 2023

Safe and effective wound healing can be a major clinical challenge. Inflammation vascular impairment are two main causes of inadequate healing.

Language: Английский

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