Chemistry - A European Journal,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 1, 2024
Abstract
Visible‐light‐driven
organic
synthesis
is
a
green
and
sustainable
method
for
producing
fine
chemicals
highly
desirable
at
both
laboratory
industrial
scales.
In
this
study,
we
developed
broad‐range
(including
the
red
region)
visible‐light‐driven
carbonylation
of
CCl
4
,
CBr
3
F
with
nucleophiles,
such
as
amines
alcohols,
using
B
12
−Mg
2+
/TiO
2
hybrid
catalyst.
Carbonyl
molecules
ureas,
carbamates,
carbonate
esters,
carbamoyl
fluorides
were
synthesized
high
selectivity
efficiency
under
mild
conditions.
Diffuse
reflectance
UV‐vis
spectroscopy,
femtosecond
time‐resolved
diffuse
density
functional
theory
calculations
revealed
reaction
mechanism
combination
S
N
single‐electron
transfer.
This
rare
example
low‐energy,
red‐light‐driven
photocatalysis,
which
has
been
desired
in
recent
years.
We
believe
that
study
provides
general
platform
to
access
diverse
carbonyl
could
promote
photocatalytic
reactions
on
pilot
scale.
Nature Communications,
Journal Year:
2023,
Volume and Issue:
14(1)
Published: Dec. 7, 2023
Abstract
Prodrug
photolysis
enables
spatiotemporal
control
of
drug
release
at
the
desired
lesions.
For
photoactivated
therapy,
near-infrared
(NIR)
light
is
preferable
due
to
its
deep
tissue
penetration
and
low
phototoxicity.
However,
most
photocleavable
groups
cannot
be
directly
activated
by
NIR
light.
Here,
we
report
a
upconversion-like
process
via
only
one
step
energy
transfer
for
light-triggered
prodrug
photolysis.
We
utilize
photosensitizer
(PS)
that
can
singlet-triplet
(S-T)
absorption
achieve
boron-dipyrromethene
(BODIPY)-based
prodrugs
triplet-triplet
transfer.
Using
strategy,
green
light-responsive
with
single-photon
process.
A
wide
range
drugs
bioactive
molecules
are
designed
demonstrated
released
under
low-irradiance
(100
mW/cm
2
,
5
min)
high
yields
(up
87%).
Moreover,
micellar
nanosystem
encapsulating
both
PS
developed
demonstrate
practicality
our
strategy
in
normoxia
aqueous
environment
cancer
therapy.
This
study
may
advance
development
photoresponsive
delivery
systems
photo-activated
Chemistry - A European Journal,
Journal Year:
2024,
Volume and Issue:
30(31)
Published: March 28, 2024
Abstract
Photoinduced
aryl
radical
generation
is
a
powerful
strategy
in
organic
synthesis
that
facilitates
the
formation
of
diverse
carbon‐carbon
and
carbon‐heteroatom
bonds.
The
synthetic
applications
photoinduced
complex
compounds,
including
natural
products,
physiologically
significant
molecules,
functional
materials,
have
received
immense
attention.
An
overview
current
developments
production
methods
their
uses
given
this
article.
A
generalized
idea
how
to
choose
reagents
approach
for
radicals
described,
along
with
techniques
associated
mechanistic
insights.
Overall,
article
offers
critical
assessment
results
as
well
selection
reaction
parameters
specific
context
cascades,
cross‐coupling
reactions,
functionalization,
selective
C−H
functionalization
substrates.
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
63(47)
Published: July 31, 2024
Abstract
Near‐infrared
photosensitizers
are
valuable
tools
to
improve
treatment
depth
in
photodynamic
therapy
(PDT).
However,
their
low
singlet
oxygen
(
1
O
2
)
generation
ability,
indicated
by
quantum
yield,
presents
a
formidable
challenge
for
PDT.
To
overcome
this
challenge,
the
heptamethine
cyanine
was
decorated
with
biocompatible
S
Scy7
and
Se
Secy7
atom.
We
observe
that
exhibits
redshift
main
absorption
~840
nm
an
ultra‐efficient
capacity.
The
emergence
of
strong
intramolecular
charge
transfer
effect
between
atom
polymethine
chain
considerably
narrows
energy
gap
(0.51
eV),
heavy
strengthens
spin–orbit
coupling
(1.44
cm
−1
),
both
which
greatly
improved
high
triplet
state
yield
(61
%),
determines
.
Therefore,
demonstrated
excellent
capacity,
is
~24.5‐fold
indocyanine
green,
~8.2‐fold
IR780,
~1.3‐fold
methylene
blue
under
low‐power‐density
850
irradiation
(5
mW
−2
).
considerable
phototoxicity
toward
cancer
cells
buried
12
mm
tissue.
Nanoparticles
formed
encapsulating
within
amphiphilic
polymers
lecithin,
promising
antitumor
anti‐pulmonary
metastatic
effects,
exhibiting
remarkable
potential
advancing
PDT
deep
tissues.
Journal of the American Chemical Society,
Journal Year:
2023,
Volume and Issue:
145(20), P. 11402 - 11414
Published: May 15, 2023
Sensitized
triplet–triplet
annihilation
upconversion
is
a
promising
strategy
to
use
visible
light
for
chemical
reactions
requiring
the
energy
input
of
UV
photons.
This
avoids
unsafe
ultraviolet
sources
and
can
mitigate
photo-damage
provide
access
reactions,
which
filter
effects
hamper
direct
excitation.
Here,
we
report
new
approach
make
blue-to-UV
more
amenable
photochemical
applications.
The
tethering
naphthalene
unit
cyclometalated
iridium(III)
complex
yields
bichromophore
with
high
triplet
(2.68
eV)
naphthalene-based
reservoir
featuring
lifetime
72.1
μs,
roughly
factor
20
longer
than
photoactive
excited
state
parent
complex.
In
combination
three
different
annihilators,
consistently
lower
thresholds
crossover
from
quadratic
into
linear
excitation
power
dependence
regime
were
observed
compared
system
composed
2,5-diphenyloxazole
annihilator
sufficiently
robust
under
long-term
blue
irradiation
continuously
high-energy
singlet-excited
that
drive
normally
light.
Both
photoredox
transfer
catalyses
feasible
using
this
concept,
including
reductive
N–O
bond
cleavage
Weinreb
amides,
C–C
coupling
reaction
based
on
aryl
debromination,
two
Paternò–Büchi
[2
+
2]
cycloaddition
reactions.
Our
work
seems
relevant
in
context
developing
strategies
driving
energetically
demanding
photochemistry
low-energy
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(18), P. 3929 - 3934
Published: April 26, 2024
[5,15-Bis(pentafluorophenyl)-10,20-diphenylporphinato]zinc(II)
(1),
a
metalloporphyrin
derivative
that
was
recently
reported
as
an
efficient
photocatalyst
driven
by
blue
LEDs
our
group,
found
to
catalyze
red-light-promoted
(630
nm
LEDs)
radical
cascade
reaction
of
N-3-arylpropionyloxyphthalimides
with
radicophiles
including
electron-deficient
alkenes
and
alkynes,
providing
access
range
functionalized
tetralin
dialin
derivatives.
The
catalyzed
1
took
place
via
oxidative
quenching
cycle
in
DMSO,
where
no
sacrificial
electron
donor
required,
uncovering
unique
solvent
effect
capable
promoting
the
porphyrin
catalysis.
