Communications Chemistry,
Journal Year:
2024,
Volume and Issue:
7(1)
Published: Nov. 1, 2024
The
reproducibility
of
chemical
reactions,
when
obtaining
protocols
from
literature
or
databases,
is
highly
challenging
for
academicians,
industry
professionals
and
even
now
the
machine
learning
process.
To
synthesize
organic
molecule
under
photochemical
condition,
several
years
reaction
optimization,
skilled
manpower,
long
time
etc.
are
needed,
resulting
in
non-affordability
slow
down
research
development.
Herein,
we
have
introduced
DigiChemTree
backed
with
artificial
intelligence
to
auto-optimize
parameter
synthesizing
on
demand
library
molecules
fast
manner.
Newly,
auto-generated
digital
code
was
further
tested
late
stage
functionalization
various
active
pharmaceutical
ingredient.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(12), P. 2511 - 2516
Published: March 20, 2024
This
work
demonstrates
the
synthesis
of
a
variety
perfluoroalkyl
heterocycles
via
visible-light-driven
radical-polar
crossover
cyclization
strategy.
In
this
process,
single-electron
reduction/SNV-type/cyclization
sequences
follow
radical
addition
reaction
diazoester,
which
differs
from
current
role
diazoesters
as
precursors/acceptors.
transformation
excellent
functional
group
compatibility
and
allows
for
modification
many
bioactive
molecules
with
diazoesters.
Such
could
represent
novel
approach
to
photochemical
diazo
compounds.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(29), P. 6197 - 6202
Published: July 15, 2024
A
silver-promoted
three-component
heterocyclization
of
alkynes,
perfluoroalkyl
halides,
and
1,3-dinucleophiles
was
developed
for
the
efficient
synthesis
privileged
(E)-perfluoroalkenyl
pyrroles.
The
reaction
proceeded
through
a
rationally
designed
sequence
radical
perfluoroalkylation
intramolecular
defluorinative
[3
+
2]-heterocyclization.
utility
halide
as
perfluoroalkenyl
reagent,
by
selective
controllable
functionalization
two
inert
C(sp3)–F
bonds
at
vicinal
carbon
centers
on
chain,
provides
new
mode
value-added
organofluorides
starting
from
easily
available
low-cost
fluorinated
feedstock.
Molecules,
Journal Year:
2024,
Volume and Issue:
29(9), P. 1920 - 1920
Published: April 23, 2024
Skeleton
editing
has
rapidly
advanced
as
a
synthetic
methodology
in
recent
years,
significantly
streamlining
the
synthesis
process
and
gaining
widespread
acceptance
drug
development.
This
field
encompasses
diverse
ring
reactions,
many
of
which
exhibit
immense
potential
skeleton
editing,
facilitating
generation
novel
skeletons.
Notably,
reactions
that
involve
cleavage
two
distinct
rings
followed
by
reformation
new
through
insertion
play
pivotal
role
construction
article
aims
to
compile
systematize
this
category
emphasizing
primary
reaction
types
offering
thorough
exploration
their
associated
complexities
challenges.
Our
endeavor
is
furnish
readers
with
comprehensive
strategies,
igniting
research
interest
injecting
fresh
impetus
into
advancement
domain.
Organic Letters,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 12, 2025
We
have
explored
the
reactivity
of
diazo
compounds
under
electrochemical
conditions
to
establish
a
cascade
sequence
thiolation/cyclization/reduction
reactions.
Electrolyzing
styryl
imides
and
aryl
thiols
enables
direct
access
single
diastereoisomer
2,5-pyrrolidine-dione-fused
thiochromans
in
good
yield
mild
metal-free
conditions.
Notably,
tunable
has
been
achieved
via
S–H
insertion
at
center
modified
reaction
Based
on
experimental
evidences,
including
detection
key
intermediates
computational
studies,
mechanism
for
also
established.
Organic Letters,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 20, 2025
Herein,
we
developed
the
new,
powerful,
and
easy-to-handle
chemical
reagent,
dimethoxyacetaldehyde-N-triftosylhydrazone
(DMHz-Tfs),
as
a
convenient
in
situ
source
of
dimethoxydiazoethane
under
mild
conditions.
We
demonstrate
carbene
reactivity
DMHz-Tfs
iron-catalyzed
cyclopropanation
Doyle-Kirmse
reactions,
providing
access
to
diverse
acetal
functionalized
cyclopropanes
homoallylic-
allenyl-sulfides
at
gram-scale
with
high
stereoselectivity.
DFT
calculations
elucidated
involvement
most
stable
doublet
spin
state
iron-carbene
intermediate
over
other
possible
states.
Nature Communications,
Journal Year:
2025,
Volume and Issue:
16(1)
Published: March 8, 2025
Interfacial
photoelectrochemistry
at
photoanodes
has
been
extensively
researched
for
solar
energy
conversion,
but
its
application
the
production
of
high-value-added
chemical
compounds
in
organic
chemistry
still
presents
challenges.
Herein,
we
report
photoelectrocatalytic
Cl-mediated
C(sp3)–H
aminomethylation
alkanes
with
self-developed
and
reusable
BiVO4
photoanodes.
The
swift
condensation
aniline
aldehydes,
along
decrease
electricity
input
by
photogenerated
holes
photoanodes,
work
together
to
prevent
excessive
oxidation
aniline,
leading
high
yields
desired
product.
Mechanistic
experiments
demonstrate
that
Cl-
ions,
as
key
mediators,
could
be
attracted
oxidized
form
Cl2.
This
is
followed
light-promoted
homolytic
cleavage
Cl2,
generating
Cl
radicals
efficiently
abstract
hydrogen
atoms
from
hydrocarbons.
opens
an
avenue
interfacial
photoelectrochemical
synthesis
demonstrates
a
potential
method
optimizing
conversion
into
fuels.
A
stable
recyclable
photoelectrode
material
was
developed
efficient
hydrocarbons
cell,
which
provides
promising
fuel
conversion.
The Journal of Organic Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 17, 2025
A
photocatalytic
diazo
triplet
carbene-promoted
C(sp3)–H
oxidative
coupling
of
isochromans
and
triazoles
was
developed
in
up
to
83%
yield
at
room
temperature
air.
The
radical-like
carbenes
were
used
as
efficient
HAT
acceptors,
the
possible
synergistic
enabled
unprecedented
process
with
a
high
regioselectivity.
