Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
Key intracellular in situ synthesis processes, including the of near-infrared fluorescent dyes, oxidative cross-linking, polymerization, and bioorthogonal reactions, as well their biomedical applications were summarized.
Language: Английский
Advanced Science, Journal Year: 2024, Volume and Issue: 11(42)
Published: Sept. 16, 2024
Abstract The rapid advancement in attractive platforms such as biomedicine and human‐machine interaction has generated urgent demands for intelligent materials with high strength, flexibility, self‐healing capabilities. However, existing ability are challenged by a trade‐off between low elastic modulus, healing due to the inherent strength of noncovalent bonding. Here, drawing inspiration from human fibroblasts, monomer trapping synthesis strategy is presented based on dissociation reconfiguration amphiphilic ionic restrictors (7000‐times volume trapping) develop eutectogel. Benefiting nanoconfinement dynamic interfacial interactions, molecular chain backbone formed confined domains mechanically reinforced while preserving soft movement resulting eutectogels demonstrate superior mechanical properties (1799% 2753% higher tensile toughness than pure polymerized deep eutectic solvent), excellent efficiency (>90%), tangential modulus (0.367 MPa during working stage), sensitively monitor activities. This poised offer new perspective developing wearable electronics tailored body motion.
Language: Английский
Citations
16
Nature Protocols, Journal Year: 2024, Volume and Issue: 19(7), P. 1984 - 2025
Published: March 21, 2024
Language: Английский
Citations
10
Advanced NanoBiomed Research, Journal Year: 2024, Volume and Issue: 4(4)
Published: Feb. 6, 2024
Intracellular assemblies play vital roles in maintaining cellular functions through structural recognition‐mediated interactions. The introduction of artificial structures has garnered substantial interest modulating via activation/inhibition interactions with biomacromolecules. However, the uptake these high‐molecular‐weight may limit their performance. Recently, intracellular chemical‐reaction‐induced self‐assembly emerged as a promising strategy for generating situ nanostructures biofunctionalities interacting This approach addresses challenge synthetic reactions occurring complex environments by utilizing diverse chemical that respond to endogenous and exogenous stimuli. review provides an overview latest advancements techniques. It focuses on responsiveness specific conditions, such redox overexpressed enzymes. Additionally, initiation stimuli, including reagents irradiation is explored. Polymerization‐induced hydrophobicity highlighted, leading into micro‐/nanostructures. These processes contribute construction materials morphologies, offering versatile functionalities biological applications.
Language: Английский
Citations
9
Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 664, P. 63 - 73
Published: March 6, 2024
Language: Английский
Citations
7
ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: 7(7), P. 7345 - 7354
Published: April 4, 2024
Starvation therapy mediated by glucose oxidase is a widely used therapeutic approach for tumor treatment, but it limited the simultaneous drawbacks of weak efficacy, nonspecificity, and systemic toxicity. Thus, combination was to complement strategy anticancer therapy. On basis starvation therapy, we designed catalytic model nanosheets with biological cascade enzymes synergizing drugs. In short, two (glucose horseradish peroxidase) are covalently immobilized on Ti3C2 MXene nanosheet enzyme nanoreactor formed electrostatically adsorbing positive charged DOX. Finally, outer layer coated hyaluronic acid. By combining oxidase-mediated photothermal chemotherapy, have achieved effect "killing three birds one stone" dual stimulation response endogenous exogenous sources site. This method not only achieves targeting cancer cells also improves toxicity reduced efficacy realizes synergistic enhanced reactions. It opens up new path research nanomedicine.
Language: Английский
Citations
6
Advanced Materials, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 3, 2024
Abstract Sonodynamic therapy can trigger immunogenic cell death to augment immunotherapy, benefiting from its superior spatiotemporal selectivity and non‐invasiveness. However, the practical applications of sonosensitizers are hindered by their low efficacy in killing cancer cells activating immune responses. Here, two US Food Drug Administration‐approved drug ligands (ferricyanide nitroprusside) types metals (copper/iron) selected construct a bimetal‐biligand framework (Cu[PBA‐NO]). Through elaborate regulation multiple metal/ligand coordination, systemically administered Cu[PBA‐NO] nanoagent shows sono‐catalytic NO release ability under ultrasound irradiation, which be used for effective sono‐immunotherapy. Moreover, downregulate intracellular glutathione levels that would destroy redox homeostasis facilitate reactive oxygen species accumulation. The released tumor‐associated antigens subsequently dendritic maturation within tumor‐draining lymph node, effectively initiating T cell‐mediated response thereby bolstering capacity identify combat cells. This study paves new avenue efficient
Language: Английский
Citations
5
Advanced Materials, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 5, 2024
Abstract Chemical reactions underpin biological processes, and imbalances in critical biochemical pathways within organisms can lead to the onset of severe diseases. Within this context, emerging field “Nanocatalytic Medicine” leverages nanomaterials as catalysts modulate fundamental chemical specific microenvironments This approach is designed facilitate targeted synthesis localized accumulation therapeutic agents, thus enhancing treatment efficacy precision while simultaneously reducing systemic side effects. The effectiveness these nanocatalytic strategies critically hinges on a profound understanding kinetics intricate interplay particular pathological ensure effective catalytic actions. review methodically explores situ their associated biomaterials, emphasizing regulatory that control responses. Furthermore, discussion encapsulates crucial elements‐reactants, catalysts, reaction conditions/environments‐necessary for optimizing thermodynamics reactions, rigorously addressing both biophysical dimensions disease enhance outcomes. It seeks clarify mechanisms underpinning biomaterials evaluate potential revolutionize across various conditions.
Language: Английский
Citations
4
Exploration, Journal Year: 2025, Volume and Issue: unknown
Published: March 6, 2025
ABSTRACT Inorganic protein hybrid materials (IPHMs) due to editable structure present unrivalled potential at the intersection of synthetic biology and science. The synthesis IPHMs with a high degree biosafety from bioactive units represents shift in material design synthesis. This paper focuses on review structural basis principles proteins for specific physical chemical functions. It also provides valuable reference emerging through conformational relationship IPHMs, which extends applications IPHMs. In addition, construction strategy reaction system is analyzed perspective biology. possibility engineering batch discussed. Based physicochemical properties different applied‐oriented research biomedical optical imaging multimodal therapy, idea situ proposed. Ultimately, trends challenges are speculated detail.
Language: Английский
Citations
0
Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 161728 - 161728
Published: March 1, 2025
Language: Английский
Citations
0
Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown
Published: March 31, 2025
Enzymatic reactions can achieve efficient flow-polymerization with specificity and high stereoselectivity. However, current enzyme-mimic polymerization systems cannot stereoregularity in flow under mild conditions. This inefficient chain control may be due to the absence of a specific catalyst structure for target monomer. study reports model catalytic material In particular, photoinitiated benzyl acrylate was realized at 22 °C using zinc porphyrin metal–organic framework (Zn-PMOF) membranes one-dimensional nanochannels, achieving synthesis highly heterotactic polymers. Under visible light irradiation, core on membrane surface could initiate polymerization, while copper MOF similar structures not. The channel Zn-PMOF provided space stereochemical control. Control experiments, density functional theory simulations, spectroscopic characterizations show that combination size effect channel–monomer interactions higher monomer conversion polymer reaction. Furthermore, crystallinity, shear stress, ionic conductivity polymers were considerably better than those bulk products. Thus, this provides method stereoselectivity
Language: Английский
Citations
0