Published: Feb. 1, 2025
Language: Английский
Advanced Materials, Journal Year: 2024, Volume and Issue: unknown
Published: Aug. 3, 2024
Compared with conventional therapies, photoimmunotherapy offers precise targeted cancer treatment minimal damage to healthy tissues and reduced side effects, but its efficacy may be limited by shallow light penetration the potential for tumor resistance. Here, an acceptor-donor-acceptor (A-D-A)-structured nanoaggregate is developed dual phototherapy, including photodynamic therapy (PDT) photothermal (PTT), triggered single near-infrared (NIR) light. Benefiting from strong intramolecular charge transfer (ICT), A-D-A-structured nanoaggregates exhibit broad absorption extending NIR region effectively suppressed fluorescence, which enables deep efficient conversion (η = 67.94%). A suitable HOMO-LUMO distribution facilitates sufficient intersystem crossing (ISC) convert ground-state oxygen (
Language: Английский
Citations
11
Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)
Published: March 10, 2025
Thermoelectric therapy has been emerging as a promising and versatile strategy for targeting malignant tumors treatment. However, the lack of effective time-space controlled triggering thermoelectric effect in vivo limits application therapy. Here magnetically triggered heterojunction (CuFe2O4/SrTiO3, CFO/STO) synergistic thermoelectric/chemodynamic/immuno-therapy is developed. The efficient magnetothermal nanoagent (CFO) synthesized using hydrothermal method, nanomaterials (STO) are grown on its surface to create heterojunction. To enhance oral delivery efficiency, fusion membrane (M) Staphylococcus aureus macrophage cell membranes coated CFO/STO heterojunction, enabling orthotopic colorectal cancer. Once CFO/STO@M reaches tumor region, vitro alternating magnetic field (AMF) stimulation activates catalytic treatment through magnetic-thermo-electric energy cascade conversion effect. Additionally, immunogenic death cells, down-regulating vascular endothelial growth factor heat shock protein HSP70, increasing expression adhesion molecule (ICAM-1/VCAM-1), M1 polarization macrophages contribute immunotherapy. Overall, based shows remarkable antitumor capability female mice, offering approach broaden both scope effectiveness cancer treatment, but limited by spatiotemporal control vivo. Here, authors report spatiotemporally controllable nanodevice that allows precise mediate thermoelectric/chemodynamic/immunotherapy
Language: Английский
Citations
1
Nano Today, Journal Year: 2024, Volume and Issue: 56, P. 102286 - 102286
Published: May 6, 2024
Language: Английский
Citations
7
Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)
Published: June 8, 2024
Abstract Mitochondria occupy a central role in the biology of most eukaryotic cells, functioning as hub oxidative metabolism where sugars, fats, and amino acids are ultimately oxidized to release energy. This crucial function fuels variety cellular activities. Disruption mitochondrial is common feature many diseases, including cancer, neurodegenerative conditions cardiovascular diseases. Targeting tumor cell with multifunctional nanosystems emerges promising strategy for enhancing therapeutic efficacy against cancer. review comprehensively outlines pathways metabolism, emphasizing their critical roles energy production metabolic regulation. The associations between aberrant initiation progression cancer highlighted, illustrating how these disruptions contribute oncogenesis sustainability. More importantly, innovative strategies employing nanomedicines precisely target therapy fully explored. Furthermore, key challenges future directions this field identified discussed. Collectively, provides comprehensive understanding current state potential nanomedicine targeting offering insights developing more effective therapies.
Language: Английский
Citations
7
Advanced Materials, Journal Year: 2024, Volume and Issue: 36(32)
Published: May 31, 2024
Photothermal immunotherapy has shown great promise in the treatment of tumor metastasis. However, thermal resistance cells substantially compromises effect photothermal immunotherapy. Herein, a high-performance organic pyroelectric nanoplatform,
Language: Английский
Citations
6
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown
Published: July 2, 2024
Abstract The treatment outcomes of nanomedicines against colorectal cancer are severely restricted by their insufficient accumulation in the tumor tissues, unsatisfactory antitumor effect, and weak immunometabolic modulation. To address these issues, flying‐saucer‐shaped nanoheterojunctions coating copper oxide (Cu x O) onto surface PEGylated zinc (ZnO) nanoparticles constructed. When exposed to ultrasound, resultant Cu O@ZnO exhibit increased locomotor activities, facilitating mucus infiltration, deep penetration, cell internalization. decoration O suppresses rapid recombination electrons holes promoting production singlet oxygen hydroxyl radical, which generated through a Fenton‐like chemodynamic reaction sonodynamic reaction. After rectal administration, sono‐chemodynamic plus PD‐L1 antibodies effectively inhibit growth orthotopic distant tumors. It elicits responses inducing immunogenic death, activating interferon genes signaling pathway stimulator, inhibiting glucose transport glycolytic pathways. This combined modality also increases proportion beneficial microbes ( e.g ., Bifidobacterium ) decreases abundance harmful microorganisms Romboutsia intestine. ultrasound antibodies) is promising strategy for synergistic cancer.
Language: Английский
Citations
6
Small, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 11, 2024
Abstract Thermoelectrics (TEs), enabling the direct conversion between heat and electrical energy, have demonstrated extensive application potential in biomedical fields. Herein, mechanism of TE effect, recent developments materials, biocompatibility assessment materials are provided. In addition to fundamentals TEs, a timely comprehensive review progress advanced their applications is presented, including wearable power generation, personal thermal management, biosensing. addition, new‐emerged medical wound healing, disease treatment, antimicrobial therapy, anti‐cancer therapy thoroughly reviewed. Finally, main challenges future possibilities outlined for TEs fields, as well material selection criteria specific scenarios. Together, these advancements can provide innovative insights into development broader
Language: Английский
Citations
6
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 9, 2024
Abstract The existence of the blood–brain barrier (BBB) and characteristics immunosuppressive microenvironment in glioblastoma (GBM) present significant challenges for targeted GBM therapy. To address this, a biomimetic hybrid cell membrane‐modified dual‐driven heterojunction nanomotor (HM@MnO 2 ‐AuNR‐SiO ) is proposed treatment. These nanomotors are designed to bypass BBB target glioma regions by mimicking surface macrophage membranes. More importantly, MnO structure enables propulsion through near‐infrared‐II (NIR‐II) light oxygen bubbles, allowing effective treatment at deep tumor sites. Meanwhile, plasmonic AuNR‐MnO heterostructure facilitates separation electron–hole pairs generates reactive species (ROS), inducing immunogenic death under NIR‐II laser irradiation. Furthermore, reacts release Mn 2+ ions, activating cGAS‐STING pathway enhancing antitumor immunity. In vitro vivo experiments demonstrate that these achieve active targeting infiltration, promoting M1 polarization, dendritic maturation, effector T‐cell activation, thereby catalysis immunotherapy ROS production STING activation.
Language: Английский
Citations
6
Advanced Science, Journal Year: 2024, Volume and Issue: 11(25)
Published: April 23, 2024
The generally undesirable bandgap and electron-hole complexation of inorganic sonosensitizers limit the efficiency reactive oxygen species (ROS) generation, affecting effectiveness sonodynamic therapy (SDT). Comparatively, novel polyvinylpyrrolidone-modified copper bismuthate (PCBO) are manufactured for a "three-step" SDT promotion. In brief, first, strong hybridization between Bi 6s O 2p orbitals in PCBO narrows (1.83 eV), facilitating rapid transfer charge carriers. Additionally, nonequivalent [CuO
Language: Английский
Citations
5
Small, Journal Year: 2024, Volume and Issue: 20(43)
Published: June 20, 2024
Catalytic therapy has shown great potential for clinical application. However, conventional catalytic therapies rely on reactive oxygen species (ROS) as "therapeutic drugs," which have limitations in effectively inhibiting tumor recurrence and metastasis. Here, a biomimetic heterojunction catalyst is developed that can actively target orthotopic rectal cancer after oral administration. The composed of quatrefoil star-shaped BiVO
Language: Английский
Citations
5