Post-COVID cognitive deficits at one year are global and associated with elevated brain injury markers and grey matter volume reduction: national prospective study

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 5, 2024

The spectrum, pathophysiology, and recovery trajectory of persistent post-COVID-19 cognitive deficits are unknown, limiting our ability to develop prevention treatment strategies. We report the one-year cognitive, serum biomarker, neuroimaging findings from a prospective, national longitudinal study cognition in 351 COVID-19 patients who had required hospitalisation, compared 2,927 normative matched controls. Cognitive were global associated with elevated brain injury markers reduced anterior cingulate cortex volume one year after admission. severity initial infective insult, post-acute psychiatric symptoms, history encephalopathy greatest deficits. There was strong concordance between subjective objective Treatment corticosteroids during acute phase appeared protective against Together, these support hypothesis that moderate severe is immune-mediated, should guide development therapeutic

Language: Английский

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Orchestration of antiviral responses within the infected central nervous system

Cellular and Molecular Immunology, Journal Year: 2024, Volume and Issue: 21(9), P. 943 - 958

Published: July 12, 2024

Abstract Many newly emerging and re-emerging viruses have neuroinvasive potential, underscoring viral encephalitis as a global research priority. Upon entry of the virus into CNS, severe neurological life-threatening conditions may manifest that are associated with high morbidity mortality. The currently available therapeutic arsenal against is rather limited, emphasizing need to better understand local antiviral immunity within infected CNS. In this review, we discuss new insights pathophysiology encephalitis, focus on myeloid cells CD8 + T cells, which critically contribute protection CNS infection. By illuminating prerequisites cell activation, discussing discoveries regarding their transcriptional signatures, dissecting mechanisms recruitment sites replication aim further delineate complexity responses Moreover, summarize current knowledge in field infection neurodegeneration potential links some neurotropic certain pathological hallmarks observed neurodegeneration.

Language: Английский

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Neurological complications caused by SARS-CoV-2

Clinical Microbiology Reviews, Journal Year: 2024, Volume and Issue: 37(4)

Published: Sept. 18, 2024

SUMMARYSARS-CoV-2 can not only cause respiratory symptoms but also lead to neurological complications. Research has shown that more than 30% of SARS-CoV-2 patients present neurologic during COVID-19 (A. Pezzini and A. Padovani, Nat Rev Neurol 16:636-644, 2020, https://doi.org/10.1038/s41582-020-0398-3). Increasing evidence suggests invade both the central nervous system (CNS) (M.S. Xydakis, M.W. Albers, E.H. Holbrook, et al. Lancet 20: 753-761, 2021 https://doi.org/10.1016/S1474-4422(21)00182-4 ) peripheral (PNS) (M.N. Soares, M. Eggelbusch, E. Naddaf, J Cachexia Sarcopenia Muscle 13:11-22, 2022, https://doi.org/10.1002/jcsm.12896), resulting in a variety disorders. This review summarized CNS complications caused by infection, including encephalopathy, neurodegenerative diseases, delirium. Additionally, some PNS disorders such as skeletal muscle damage inflammation, anosmia, smell or taste impairment, myasthenia gravis, Guillain-Barré syndrome, ICU-acquired weakness, post-acute sequelae were described. Furthermore, mechanisms underlying SARS-CoV-2-induced discussed, entering brain through retrograde neuronal hematogenous routes, disrupting normal function cytokine storms, inducing cerebral ischemia hypoxia, thus leading Moreover, an overview long-COVID-19 is provided, along with recommendations for care therapeutic approaches experiencing

Language: Английский

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Prevalence and co-occurrence of cognitive impairment in children and young people up to 12-months post infection with SARS-CoV-2 (Omicron variant)

Brain Behavior and Immunity, Journal Year: 2024, Volume and Issue: 119, P. 989 - 994

Published: May 10, 2024

Cognitive impairment is often reported after SARS-CoV-2 infection, yet evidence gaps remain. We aimed to (i) report the prevalence and characteristics of children young people (CYP) reporting "brain fog" (i.e., cognitive impairment) 12-months post PCR-proven infection determine whether differences by status exist (ii) explore CYP experiencing over a 12-month period post-infection investigate relationship between poor mental health well-being, fatigue sleep problems.

Language: Английский

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Health outcomes one year after Omicron infection among 12,789 adults: a community-based cross-sectional study

The Lancet Regional Health - Western Pacific, Journal Year: 2025, Volume and Issue: unknown, P. 101507 - 101507

Published: March 1, 2025

Characterizing the paradigm and impact of long COVID is crucial for addressing this worldwide health challenge. This study aimed to investigate prevalence one year after primary Omicron infection characterize differences in long-term consequence between participants with persistent those who fully recovered. a community-based cross-sectional conducted from December 2023 March 2024 at China-Japan Friendship Hospital 16 administrative districts Beijing. 12,789 infected 2022 January were recruited through stratified multistage random sampling included final analysis. Of them, 376 229 without matched further physical examinations. The outcome was infection. Secondary outcomes muscle strength, exercise capacity, health-related quality life (HRQoL), mental health, work status, laboratory tests, Among (media [IQR] age, 48.4 [37.3 61.4] years; 7817 females [61.1%]), 995 them (7.8%) experienced within year, 651 (5.1%) having symptoms. Fatigue (598/995 [60.1%]) post-exertional malaise (367/995 [36.9%]) most common Brain fog had lowest resolution proportion as 4.2% year. odds increased reinfections (odds ratios reinfection 2.592 [95% CI: 2.188 3.061]; two or more: 6.171 [3.227 11.557]; all p < 0.001). Participants markedly lower strength (upper-limb: 26.9 ± 12.4 vs. 29.1 14.5 Kg; lower-limb: 40.0 [27.0 62.0] 43.0 [28.0 59.0] s), worse capacity poorer HRQoL, meaningful difference tests results compared COVID. They also exhibited significantly higher proportions abnormal lung function (FEV1 %pred<80%: 13.0% 2.0%; DLco 32.7% 19.9%) imaging abnormalities (23.5% 13.6%). considerable burden progression neurological symptoms following warrant close monitoring. Utilizing professional questionnaires developing reliable diagnostic tools are necessary improving diagnosis treatment supported by Beijing Research Center Respiratory Infectious Diseases (BJRID2024-012), Chinese Academy Medical Sciences Innovation Fund (2022-I2M-CoV19-005/CIFMS 2021-I2M-1-048), National Natural Science Foundation China (82241056/82200114/82200009), New Cornerstone Foundation.

Language: Английский

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The causal association of specific gut microbiota on the risk of membranous nephropathy: a Mendelian randomization study

International Urology and Nephrology, Journal Year: 2024, Volume and Issue: 56(6), P. 2021 - 2030

Published: Jan. 5, 2024

Language: Английский

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Long COVID as a Disease of Accelerated Biological Aging: An Opportunity to Translate Geroscience Interventions

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 99, P. 102400 - 102400

Published: June 28, 2024

Language: Английский

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The Role of Dental-derived Stem Cell-based Therapy and Their Derived Extracellular Vesicles in Post-COVID-19 Syndrome-induced Tissue Damage

Stem Cell Reviews and Reports, Journal Year: 2024, Volume and Issue: 20(8), P. 2062 - 2103

Published: Aug. 16, 2024

Language: Английский

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Serum Levels of Neurofilament Light Chain and Glial Fibrillary Acidic Protein Correlate with Disease Severity in Patients with West Nile Virus Infection

Emerging Microbes & Infections, Journal Year: 2025, Volume and Issue: 14(1)

Published: Feb. 13, 2025

West Nile virus (WNV) is a neurotropic mosquito-borne orthoflavivirus, representing relevant public health threat. Identification of biomarkers that would predict the course WNV infection interest for early identification patients at risk and supporting decisions on therapeutic interventions. In this study, serum levels glial fibrillary acidic protein (sGFAP) neurofilament light chain (sNfL), which are markers brain tissue damage inflammation, were analysed in 103 subjects with laboratory-confirmed infection, comprising 13 asymptomatic blood donors, 23 WN fever (WNF), 50 encephalitis/meningoencephalitis (E/ME) 17 acute flaccid paralysis (AFP). addition, 55 WNV-negative fever, encephalitis or healthy included as controls. Age-adjusted both sNfL sGFAP significantly higher neuroinvasive disease than those (both WNV-positive WNV-negative), suggesting broad association these systemic inflammation injury resulting from infection. patients, combined analysis after symptom onset allowed discrimination between 67.2% sensitivity 91.3% specificity, but not E/ME AFP. Furthermore, high associated prolonged hospital stay, intensive care unit admission occurrence death severe sequelae. Detection RNA CSF was increased sGFAP. conclusion, our study indicates potential utility severity adverse outcome.

Language: Английский

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Cognitive decline in post-COVID-19 syndrome does not correspond with persisting neuronal or astrocytic damage

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: March 4, 2024

Cognitive impairment is the most frequent symptom reported in post-COVID-19 syndrome (PCS). Aetiology of cognitive PCS still to be determined. Neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP) are increased acute COVID-19. Their role as biomarkers other neurological disorders under debate. We analysed serum levels NfL GFAP markers for neuronal astrocytic damage 53 patients presenting a Neurology outpatient clinic. Only individuals with self-reported complaints were included. In these individuals, further assessed by comprehensive neuropsychological assessment (NPA). Patients categorized into subgroups subjective decline, single domain impairment, or multi-domain impairment. Serum was normal range, however an increase detected 4% patients. correlated each other, even when adjusting patient age (r = 0.347, p 0.012). NPA showed deficits 70%; 40% showing several tested domains. No significant differences found between NfL- GFAP-levels comparing Persistent did not correlate PCS.

Language: Английский

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