Acta Biomaterialia, Journal Year: 2025, Volume and Issue: unknown
Published: April 1, 2025
Language: Английский
International Journal of Oral Science, Journal Year: 2024, Volume and Issue: 16(1)
Published: April 16, 2024
Abstract Bacterial resistance and excessive inflammation are common issues that hinder wound healing. Antimicrobial peptides (AMPs) offer a promising versatile antibacterial option compared to traditional antibiotics, with additional anti-inflammatory properties. However, the applications of AMPs limited by their antimicrobial effects stability against bacterial degradation. TFNAs regarded as drug delivery platform could enhance properties nanodrugs. Therefore, in this study, composite hydrogel (HAMA/t-GL13K) was prepared via photocross-linking method, which tFNAs carry GL13K. The injectable, biocompatible, be instantly photocured. It exhibited broad-spectrum inhibiting expression inflammatory factors scavenging ROS. Thereby, inhibited infection, shortened healing time skin defects infected full-thickness defect models reduced scarring. constructed HAMA/tFNA-AMPs hydrogels exhibit potential for clinical use treating microbial infections promoting
Language: Английский
Citations
38
Proceedings of the National Academy of Sciences, Journal Year: 2024, Volume and Issue: 121(30)
Published: July 18, 2024
Rechargeable zinc–air batteries (ZABs) are regarded as a remarkably promising alternative to current lithium-ion batteries, addressing the requirements for large-scale high-energy storage. Nevertheless, sluggish kinetics involving oxygen reduction reaction (ORR) and evolution (OER) hamper widespread application of ZABs, necessitating development high-efficiency durable bifunctional electrocatalysts. Here, we report atom–bridged Fe, Co dual-metal dimers (FeOCo-SAD), in which active site Fe–O–Co–N 6 moiety boosts exceptional reversible activity toward ORR OER alkaline electrolytes. Specifically, FeOCo-SAD achieves half-wave potential ( E 1/2 ) 0.87 V an overpotential 310 mV at density 10 mA cm –2 OER, with gap (Δ only 0.67 V. Meanwhile, manifests high performance peak power 241.24 mW −2 realistic rechargeable ZABs. Theoretical calculations demonstrate that introduction bridge dimer induced charge spatial redistribution around Fe atoms. This enhances activation optimizes adsorption/desorption dynamics intermediates. Consequently, energy barriers effectively reduced, leading strong promotion intrinsic OER. work suggests oxygen-bridging offer prospects significantly enhancing electrocatalysis creating innovative catalysts exhibit synergistic effects electronic states.
Language: Английский
Citations
22
International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 299, P. 140156 - 140156
Published: Jan. 21, 2025
Language: Английский
Citations
3
Advanced Materials, Journal Year: 2024, Volume and Issue: 36(32)
Published: June 5, 2024
Antibiotic-resistant pathogens have become a global public health crisis, especially biofilm-induced refractory infections. Efficient, safe, and biofilm microenvironment (BME)-adaptive therapeutic strategies are urgently demanded to combat antibiotic-resistant biofilms. Here, inspired by the fascinating biological structures functions of phages, de novo design spiky Ir@Co
Language: Английский
Citations
17
Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(13)
Published: Jan. 11, 2024
Various nanomaterials as biocatalysts could be custom-designed and modified to precisely match the specific microenvironment of diseases, showing a promise in achieving effective therapy outcomes. Compared conventional biocatalysts, single metal atom catalysts (SMACs) with maximized utilization through well-defined structures offer enhanced catalytic activity selectivity. Currently, there is still gap comprehensive overview connection between biocatalytic mechanisms SMACs. Therefore, it crucial deeply investigate role SMACs biocatalysis from atomic structure level elucidate their potential processes. In this minireview, we summarize catalysis regulation methods at level, focusing on optimization active sites, coordination environment, site-support interactions, briefly discuss for biomedical applications.
Language: Английский
Citations
16
Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)
Published: Oct. 17, 2024
As a transdermal drug delivery method, microneedles offer minimal invasiveness, painlessness, and precise in-situ treatment. However, current rely on passive diffusion, leading to uncontrollable penetration. To overcome this, we developed pneumatic microneedle patch that uses live Enterobacter aerogenes as microengines actively control delivery. These microbes generate gas, driving drugs into deeper tissues, with adjustable glucose concentration allowing over the process. Our results showed this microorganism-powered system increases depth by 200%, reaching up 1000 μm below skin. In psoriasis animal model, technology effectively delivered calcitriol subcutaneous offering rapid symptom relief. This innovation addresses limitations of conventional microneedles, enhancing efficiency, permeability, introducing creative paradigm for on-demand controlled
Language: Английский
Citations
15
Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)
Published: Sept. 10, 2024
Language: Английский
Citations
10
Phytomedicine, Journal Year: 2024, Volume and Issue: 128, P. 155412 - 155412
Published: Feb. 4, 2024
Language: Английский
Citations
9
Biomaterials, Journal Year: 2024, Volume and Issue: 311, P. 122665 - 122665
Published: June 12, 2024
Language: Английский
Citations
9
Biomaterials, Journal Year: 2025, Volume and Issue: unknown, P. 123120 - 123120
Published: Jan. 1, 2025
Language: Английский
Citations
1