Chinese Journal of Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 26, 2024
Comprehensive
Summary
The
invention
of
novel
linkers
is
a
long‐lasting
task
in
the
area
sulfur(VI)
fluoride
exchange
reaction
(SuFEx).
Compared
with
most
frequently
investigated
sulfonyl
fluorides,
synthetic
accessibility
toward
its
mono‐aza
isostere,
i.e.
,
sulfonimidoyl
fluorides
still
limited.
Herein,
we
report
an
electrochemical
carbonfluorination
readily
available
N
‐sulfinylamines
to
access
various
aryl
and
alkyl
fluorides.
transformation
characterized
by
ready
availability
starting
materials,
mild
conditions,
obviating
metal
catalysts
chemical
oxidants.
Green Chemistry,
Journal Year:
2024,
Volume and Issue:
26(6), P. 3435 - 3440
Published: Jan. 1, 2024
A
practical
electrosynthesis
of
aryl
sulfonyl
fluorides
from
nitroarenes
is
described.
Cheap
N
-methylimidazolium
p
-toluenesulfonate
has
been
found
to
be
an
effective
additive,
promoting
the
desired
fluorosulfonylation
under
very
mild
conditions.
ACS Catalysis,
Journal Year:
2024,
Volume and Issue:
14(5), P. 3115 - 3127
Published: Feb. 13, 2024
Although
the
transition
metal-catalyzed
radical
fluorine
atom
transfer
(FAT)
strategy
has
emerged
as
a
powerful
tool
for
construction
of
C–F
bonds,
to
our
knowledge,
this
approach
rarely
been
applied
formation
S–F
bonds.
Here,
we
report
that
4-methoxypyridine
1-oxide
can
serve
an
inexpensive
and
simple
yet
effective
ligand
thus
promote
transformation
copper-mediated
challengeable
FAT
sulfonyl
radicals,
paving
way
assembly
FSO2
group.
Based
on
concept,
three
Cu(I)-catalyzed
protocols
involving
site-selective
intra-
intermolecular
fluorosulfonylation
inert
C(sp3)–H
bonds
1,2-aminofluorosulfonylation
inactivated
alkenes
have
developed,
enabling
preparation
C(sp3)-rich
aliphatic
fluorides
cannot
be
easily
synthesized
by
known
methods.
These
practical
operationally
methods
result
in
high
functional
group
tolerance
under
mild
conditions
modification
bioactive
derivatives
highly
valued
molecules.
Detailed
mechanistic
studies
indicate
unique
role
facilitating
such
rare
FATs
via
outer-sphere
pathway.
European Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
27(23)
Published: May 25, 2024
Abstract
Sulfonyl
fluorides
have
widespread
applications
in
many
fields,
including
organic
synthesis,
chemical
biology,
drug
discovery
and
materials
science.
In
particular,
the
past
decade,
a
number
of
aliphatic
sulfonyl
been
identified
showing
various
biological
activities.
These
appealing
features
brought
about
significant
advancement
developing
synthetic
methods
to
access
fluorides.
this
review,
we
will
discuss
recent
developments
radical
approaches
for
synthesis
Organic Chemistry Frontiers,
Journal Year:
2024,
Volume and Issue:
11(15), P. 4318 - 4342
Published: Jan. 1, 2024
This
review
primarily
focuses
on
the
generation
of
aryl
radicals
via
an
electroreduction
strategy,
and
systematically
elaborates
synthetic
applications,
scope,
limitations
substrates.
Chemical Science,
Journal Year:
2024,
Volume and Issue:
15(29), P. 11418 - 11427
Published: Jan. 1, 2024
An
environmentally
friendly
electroreduction
approach
is
disclosed
for
site-specific
introduction
of
deuterium
via
anti-Markovnikov
selective
deuteroarylation
alkenes
and
aryl
iodides
with
bipyridine
as
a
mediator
D
2
O
‘D’
source.
Chemical Society Reviews,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
This
review
highlights
organo-mediators
that
enable
electrochemical
reactions
via
outer-sphere
electron
transfer
(ET),
offering
advantages
such
as
availability,
tunability,
and
simplified
post-processing
compared
to
direct
electrolysis.
Chemistry - A European Journal,
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 16, 2024
The
advancement
in
electrochemical
techniques
has
unlocked
a
new
path
for
achieving
unprecedented
oxidations
and
reductions
of
aryl
radical
precursors
controlled
selective
manner.
This
approach
facilitates
the
construction
aromatic
carbon-carbon
carbon-heteroatom
bonds.
In
light
green
merits
growing
importance
this
technique
chemistry,
review
aims
to
provide
an
overview
recent
advance
generation
radicals
organized
by
precursor
type,
with
focus
on
substrate
scope,
limitation,
underlying
mechanism,
thereby
inspiring
future
work
generation.
Organic Chemistry Frontiers,
Journal Year:
2024,
Volume and Issue:
11(18), P. 5232 - 5277
Published: Jan. 1, 2024
This
review
describes
recent
advances
in
the
generation
of
aryl
radicals
using
light
and
electricity.
Such
modern
techniques
allow
for
efficient
energy
resource
utilization,
thus
providing
more
sustainable
radical
arylation
methods.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(26), P. 5577 - 5581
Published: June 24, 2024
A
visible-light-mediated
catalyst-
and
additive-free
method
for
radical
ring-opening
fluorosulfonylation
of
methylenecyclobutanols
is
reported.
Sulfuryl
chlorofluoride
acts
as
a
FSO
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 5, 2024
Abstract
Sulfur‐centered
electrophilic
‘warheads’
have
emerged
as
key
components
for
chemical
proteomic
probes
through
sulfur‐exchange
chemistry
(SuFEx)
with
protein
nucleophiles.
Among
these
functional
groups,
sulfonimidoyl
fluorides
(SIFs)
stand
out
their
modifiable
sites,
tunable
electrophilicities,
and
chiral
sulfur‐center,
presenting
exciting
possibilities
new
covalent
probes.
However,
the
synthetic
access
to
SIFs
has
been
a
challenge,
limiting
exploration
applications.
In
this
study,
we
describe
convenient
route
obtain
from
readily
available
sulfenamides
via
series
of
one‐pot
tandem
reactions
high
enantiomeric
excess
(ees).
The
resulting
were
further
converted
into
diverse
array
S(VI)
derivatives
under
mild
conditions
or
in
buffer
solutions.
Most
significantly,
specificity
ligation
experiments
underscored
critical
role
sulfur‐center
chirality
design
screening
more‐selective
therapeutics.
