International Journal of Biological Macromolecules,
Journal Year:
2024,
Volume and Issue:
271, P. 132619 - 132619
Published: May 23, 2024
The
amelioration
of
refractory
diabetic
ulcers
presents
a
formidable
conundrum
on
global
scale,
attributable
to
the
elevated
peril
contagion
and
protracted
convalescence
durations.
Within
purlieus
this
reparative
epoch,
deployment
efficacious
wound
coverings
endowed
with
both
angiogenesis
antibacterial
attributes
is
paramount
significance.
Hydrogel
dressings
are
distinguished
by
their
biocompatibility,
adhesive
tenacity,
innate
regenerative
capacity.
Eugenol,
substance
distilled
from
blossoms
lilac,
serves
as
precursor
metformin
known
impede
genesis
reactive
oxygen
species.
Although
its
effects
have
been
extensively
chronicled,
angiogenic
ramifications
eugenol
within
context
remediation
remain
under-investigated.
This
research
aimed
evaluate
effectiveness
eugenol-infused
hydrogel
dressing
material.
In
context,
polyurethane
gelatin
(PG)
was
combined
at
concentrations
0.5%
1%,
creating
PG-eugenol
mixtures
specific
mass
ratios
for
in
vivo
vitro
assessments.
studies
indicated
that
hydrogels
infused
expedited
healing
fostering
angiogenesis.
Enhanced
noted,
attributed
improved
properties,
increased
cell
proliferation,
tissue
regeneration,
re-epithelialization.
analyses
revealed
eugenol-enriched
stimulated
growth
fibroblasts
(HFF-1)
human
umbilical
vein
endothelial
cells
(HUVECs)
exhibited
characteristics.
investigation
confirms
potential
eugenol-laden
effectively
treating
defects.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(38)
Published: April 21, 2024
Abstract
Persistent
oxidative
stress
and
bacterial
infection
are
significant
challenges
that
impede
diabetic
wound
healing.
By
combining
diagnosis
treatment,
pH
variation
on
the
tissue
can
be
monitored
in
real
time,
precise
treatment
carried
out
promptly
to
promote
In
this
study,
a
lipoic
acid‐modified
chitosa
(LAMC)
hydrogel
is
constructed
via
an
amidation
reaction,
ceria
oxide‐molybdenum
disulfide
nanoparticles
with
polydopamine
layer
(C@M@P),
along
carbon
quantum
dots
(CDs)
synthesized
by
hydrothermal
method,
loaded
into
hydrogel,
thus
developing
diagnostic
therapeutic
(LAMC/CD‐C@M@P).
incorporating
CDs,
exhibits
high
sensitivity
reversibility
under
ultraviolet
light.
Furthermore,
images
of
hydrogels
collected
using
smartphones
converted
signals,
providing
means
for
early
detection
infection.
Notably,
LAMC/CD‐C@M@P
excellent
photothermal
antibacterial
capability
against
Staphylococcus
aureus
Escherichia
coli
remarkable
antioxidant
anti‐inflammatory
abilities
alleviate
reactive
oxygen
species
relieve
inflammation
response.
summary,
multifunctional
offers
great
potential
as
innovative
dressing
platform,
representing
advancement
chronic
management.
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Feb. 10, 2024
Abstract
Extracellular
vesicles
have
shown
promising
tissue
recovery-promoting
effects,
making
them
increasingly
sought-after
for
their
therapeutic
potential
in
wound
treatment.
However,
traditional
extracellular
vesicle
applications
suffer
from
limitations
such
as
rapid
degradation
and
short
maintenance
during
administration.
To
address
these
challenges,
a
growing
body
of
research
highlights
the
role
hydrogels
effective
carriers
sustained
release,
thereby
facilitating
healing.
The
combination
with
development
3D
bioprinting
create
composite
hydrogel
systems
boasting
excellent
mechanical
properties
biological
activity,
presenting
novel
approach
to
healing
skin
dressing.
This
comprehensive
review
explores
remarkable
hydrogels,
specifically
suited
loading
vesicles.
We
delve
into
diverse
sources
analyzing
integration
within
formulations
Different
methods
well
bioprinting,
adapted
varying
conditions
construction
strategies,
are
examined
roles
promoting
results
highlight
vesicle-laden
advanced
tools
field
treatment,
offering
both
support
bioactive
functions.
By
providing
an
in-depth
examination
various
that
can
play
healing,
this
sheds
light
on
directions
further
development.
Finally,
we
challenges
associated
application
along
emerging
trends
domain.
discussion
covers
issues
scalability,
regulatory
considerations,
translation
technology
practical
clinical
settings.
In
conclusion,
underlines
significant
contributions
hydrogel-mediated
therapy
regeneration.
It
serves
valuable
resource
researchers
practitioners
alike,
fostering
deeper
understanding
benefits,
applications,
involved
utilizing
Graphical
abstract
Gels,
Journal Year:
2024,
Volume and Issue:
10(2), P. 147 - 147
Published: Feb. 14, 2024
Wound
healing
is
a
physiological
process
occurring
after
the
onset
of
skin
lesion
aiming
to
reconstruct
dermal
barrier
between
external
environment
and
body.
Depending
on
nature
duration
process,
wounds
are
classified
as
acute
(e.g.,
trauma,
surgical
wounds)
chronic
diabetic
ulcers)
wounds.
The
latter
take
several
months
heal
or
do
not
(non-healing
wounds),
usually
prone
microbial
infection
represent
an
important
source
morbidity
since
they
affect
millions
people
worldwide.
Typical
wound
treatments
comprise
debridement,
grafts/flaps)
non-surgical
topical
formulations,
dressings)
methods.
Modern
experimental
approaches
include
among
others
three
dimensional
(3D)-(bio)printed
dressings.
present
paper
reviews
recently
developed
3D
(bio)printed
hydrogels
for
applications,
especially
focusing
results
their
in
vitro
vivo
assessment.
advanced
hydrogel
constructs
were
printed
using
different
types
bioinks
natural
and/or
synthetic
polymers
mixtures
with
biological
materials)
printing
methods
extrusion,
digital
light
processing,
coaxial
microfluidic
bioprinting,
etc.)
incorporated
various
bioactive
agents
growth
factors,
antibiotics,
antibacterial
agents,
nanoparticles,
cells
fibroblasts,
keratinocytes,
mesenchymal
stem
cells,
endothelial
etc.).
Theranostics,
Journal Year:
2024,
Volume and Issue:
14(11), P. 4198 - 4217
Published: Jan. 1, 2024
The
utilization
of
extracellular
vesicles
(EVs)
in
wound
healing
has
been
well-documented.However,
the
direct
administration
free
EVs
via
subcutaneous
injection
at
sites
may
result
rapid
dissipation
bioactive
components
and
diminished
therapeutic
efficacy.Functionalized
hydrogels
provide
effective
protection,
as
well
ensure
sustained
release
bioactivity
during
process,
making
them
an
ideal
candidate
material
for
delivering
EVs.In
this
review,
we
introduce
mechanisms
by
which
accelerate
healing,
then
elaborate
on
construction
strategies
engineered
EVs.Subsequently,
discuss
synthesis
application
delivery
systems
to
enhance
complicated
healing.Furthermore,
face
wounds,
functionalized
with
specific
microenvironment
regulation
capabilities,
such
antimicrobial,
anti-inflammatory,
immune
regulation,
used
loading
EVs,
potential
approaches
addressing
these
challenges.Ultimately,
deliberate
future
trajectories
outlooks,
offering
a
fresh
viewpoint
advancement
artificial
intelligence
(AI)-energized
materials
3D
bio-printed
multifunctional
hydrogel-based
dressings
biomedical
applications.
Biomaterials Research,
Journal Year:
2024,
Volume and Issue:
28
Published: Jan. 1, 2024
Reversal
of
endothelial
cell
(EC)
dysfunction
under
high-glucose
(HG)
conditions
to
achieve
angiogenesis
has
remained
a
big
challenge
in
diabetic
ulcers.
Herein,
exosomes
derived
from
medicinal
plant
ginseng
(GExos)
were
shown
as
excellent
nanotherapeutics
with
biomimetic
membrane-like
structures
be
able
efficiently
transfer
the
encapsulated
active
substances
ECs,
resulting
marked
reprogramming
glycolysis
by
up-regulating
anaerobic
and
down-regulating
oxidative
stress,
which
further
restore
proliferation,
migration,
tubule
formation
abilities
ECs
HG
conditions.
In
vivo,
GExos
enhance
nascent
vessel
network
reconstruction
full-thickness
complicated
skin
ulcer
wounds
mice
high
biosafety.
promising
stimulating
reprogramming-mediated
ulcers,
possessing
wide
application
potential
for
reversing
hyperglycemic
dysangiogenesis
vascular
regeneration.
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
13(27)
Published: July 7, 2024
Abstract
The
limited
and
unstable
absorption
of
excess
exudate
is
a
major
challenge
during
the
healing
infected
wounds.
In
this
study,
highly
stable,
multifunctional
Janus
dressing
with
unidirectional
transfer
capacity
fabricated
based
on
single
poly(lactide
caprolactone)
(PLCL).
success
method
relies
an
acid
hydrolysis
reaction
that
transforms
PLCL
fibers
from
hydrophobic
to
hydrophilic
in
situ.
resulting
interfacial
affinity
between
hydrophilic/phobic
endows
structure
excellent
liquid
high
structural
stability
against
repeated
stretching,
bending,
twisting.
Various
other
functions,
including
wound
status
detection,
antibacterial,
antioxidant,
anti‐inflammatory
properties,
are
also
integrated
into
by
incorporating
phenol
red
epigallocatechin
gallate.
An
vivo
methicillin‐resistant
Staphylococcus
aureus
‐infected
model
confirms
dressing,
capability
remove
site,
not
only
facilitates
epithelialization
collagen
deposition,
but
ensures
low
inflammation
angiogenesis,
thus
reaching
ideal
closure
rate
up
98.4%
day
14.
simple
structure,
multiple
easy
fabrication
may
offer
promising
strategy
for
treating
chronic
wounds,
rooted
challenges
bacterial
infection,
excessive
exudate,
persistent
inflammation.
