Controlled Synthesis of the FeB Nanometallic Glasses with Stronger Electron Donating Capability to Activate Molecular Oxygen for the Enhanced Ferroptosis Therapy DOI

Guanjie Shi,

Yongxuan Zhang,

Wenting Wang

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 8, 2024

Abstract Considering the strong electron‐donating ability and superior biocompatibility, integration of zero‐valent iron nanostructure Fe 0 (electron‐reservoir) boron B offers great promise for fabricating novel ferroptosis nanoagents. Nevertheless, controlled facile synthesis alloyed nanostructure‐FeB nanometallic glasses (NMGs) has remained a long‐standing challenge. Herein, complexion‐reduction strategy is proposed FeB NMGs with greater electron donating capacity to activate molecular oxygen improved therapy. In‐depth mechanism reveales that effectively prevent long‐range diffusion , resulting in amorphous nanoparticles (FeB NPs). The NPs display stronger capability transfer rate 9.4 times higher than NPs, which produce ∙O 2 − H O ∙OH. vitro cellular experiments confirm FeB‐ss‐SiO₂ (encapsulation SiO outlayer containing ‐S‐S‐ bonds) demonstrates enhanced ferroptosis. tumor‐bearing mice models shows exhibited biocompatibility tumor inhibition effect (inhibition 73%), improve overall survival 30 days post‐treatment. This study will provide an innovative way design therapeutic nanoagents cancer treatments.

Language: Английский

Copper-Based Biomaterials for Anti-Tumor Therapy: Recent Advances and Perspectives DOI
Shufang Zhang, Shuping Peng

Acta Biomaterialia, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

5
Catalytic Nanoparticles in Biomedical Applications: Exploiting Advanced Nanozymes for Therapeutics and Diagnostics DOI
Divinah Manoharan,

Liu‐Chun Wang,

Ying‐Chi Chen

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(22)

Published: April 29, 2024

Catalytic nanoparticles (CNPs) as heterogeneous catalyst reveals superior activity due to their physio-chemical features, such high surface-to-volume ratio and unique optical, electric, magnetic properties. The CNPs, based on nature, can either increase the reactive oxygen species (ROS) level for tumor antibacterial therapy or eliminate ROS cytoprotection, anti-inflammation, anti-aging. In addition, catalytic of nanozymes specifically trigger a specific reaction accompanied by optical feature change, presenting feasibility biosensor bioimaging applications. Undoubtedly, CNPs play pivotal role in pushing evolution technologies medical clinical fields, advanced strategies nanomaterials rely input chemical experts develop. Herein, systematic comprehensive review challenges recent development biomedical applications is presented from viewpoint nanomaterial with additional functions. Furthermore, biosafety issue applying biodegradable non-biodegradable future perspectives are critically discussed guide promising direction developing span-new more intelligent overcoming current limitations.

Language: Английский

Citations

15
Sono-blasting Triggered Cascading-Amplification of Oxidative Stress for Enhanced Interventional Therapy of Hepatocellular Carcinoma DOI
Dong Li, Kexin Zhang, Kaiyang Wang

et al.

Nano Letters, Journal Year: 2024, Volume and Issue: 24(29), P. 8996 - 9003

Published: July 12, 2024

Interventional therapy is widely regarded as a highly promising treatment approach for nonsurgical liver cancer. However, the development of drug resistance and tolerance to hypoxic environments after embolization can lead increased angiogenesis, enhanced tumor cell stemness, greater invasiveness, resulting in metastasis recurrence. To address these challenges, novel involving use lecithin DSPE-PEG comodified Ca

Language: Английский

Citations

7
Pitaya‐Inspired Metal‐Organic Framework Nanozyme for Multimodal Imaging‐Guided Synergistic Cuproptosis, Nanocatalytic Therapy, and Photothermal Therapy DOI Open Access

Quer Yue,

Qingbin Zeng, Qianni Guo

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 23, 2024

Abstract Nature often provides invaluable insights into technological innovation and the construction of nanomaterials. Inspired by pitaya fruit's strategy wrapping seeds within its pulp to enhance seed survival, a unique nanocomposite based on metal‐organic framework (MOF)‐encapsulated CuS nanoparticles (NPs) is developed. This design effectively addresses challenge short retention time afforded NPs for therapeutic imaging purposes. The MOF acts as “pitaya pulp” protecting internal (“pitaya seeds”), thereby increasing their in vivo. system exhibits triple‐enzyme‐mimicking activities proposed application photoacoustic magnetic resonance imaging‐guided therapies, including chemodynamic therapy, photothermal cuproptosis‐related therapy. exceptional enzyme‐mimicking superoxide dismutase, catalase, peroxidase not only produce oxygen alleviate hypoxia but also generate reactive species (ROS) storm effective tumor destruction. By combining these multienzymatic properties, superior performance, Cu‐induced cuproptosis, nanozyme‐treated mice exhibited an 84% inhibition growth—approximately double effect observed treated with alone. study presents smart integrating modalities, achieving outcomes precise

Language: Английский

Citations

4
Dual-Stimuli Regulation of DNAzyme Cleavage Reaction by Coordination-Driven Nanoprobes for Cancer Cell Imaging DOI

Yinbo Ban,

Fu Zhou,

Hao Wang

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(24), P. 30766 - 30775

Published: June 4, 2024

Endowing current artificial chemical reactions (ACRs) with high specificity and intricate activation capabilities is crucial for expanding their applications in accurate bioimaging within living cells. However, most of the reported ACR-based evaluations relied on either single biomarker stimuli or dual activators without obvious biological relevance, still limiting accuracy fidelity. Herein, taking metal-ion-dependent DNAzyme cleavage reaction as a model ACR, two regulators, glutathione (GSH) telomerase (TE) activated reactions, were exploited precise discrimination cancerous cells from normal DNA probe was self-assembled into ZIF-90 nanoparticle framework to construct coordination-driven nanoprobes. This approach enhances stability tumor imaging by utilizing biomarkers associated rapid proliferation those commonly overexpressed tumors. In conclusion, research not only paves way new perspectives cell biology pathology studies but also lays solid foundation advancement biomedical disease diagnostic technologies.

Language: Английский

Citations

3
Peptide-Guided Assembly of Silver Nanoparticles for the Diagnosis of HER2-Positive Breast Cancer DOI
Qianxi Zhou,

Yuying Pan,

Qizhi Liang

et al.

Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(49), P. 19304 - 19311

Published: Nov. 22, 2024

Peptide-engineered nanoparticles have great potential for biomedical research and application. In this work, we designed fabricated an electrochemical biosensor based on peptide-guided assembly of silver (AgNPs), in which a peptide is endowed with dual functions to recognize target guide AgNPs. As proof concept, the performance validated by quantifying human epidermal growth factor receptor 2 (HER2) protein. detail, end HER2-specific binding grafted positively charged peptide, can orderly AgNPs, while signals be obtained through phosphine-silver coordination. Using biosensor, HER2 protein quantified high sensitivity specificity, limit detection as low 0.05 pg/mL. Moreover, antifouling electrode surface prepared modification layer zwitterionic allows used serum from breast cancer patients, provides clear evidence distinction HER2+ patients HER2- patients.

Language: Английский

Citations

3
Exploring New Bioorthogonal Catalysts: Scaffold Diversity in Catalysis for Chemical Biology DOI Creative Commons
Yan Zhang, Qizhen Huang, Lei Fang

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 7, 2025

Bioorthogonal catalysis has revolutionized the field of chemical biology by enabling selective and controlled transformations within living systems. Research converged on development innovative catalyst scaffolds, seeking to broaden scope bioorthogonal reactions, boost their efficiency, surpass limitations conventional catalysts. This review provides a comprehensive overview latest advancements in research based different scaffold materials. Through an in-depth analysis fabrication strategies applications catalysts, this discusses design principles, mechanisms action, these novel catalysts biology. Current challenges future directions exploring diversity are also highlighted. The integration diverse scaffolds offers exciting prospects for precise manipulation biomolecules therapeutic In addition, fills gaps previous reviews, such as fully summarizing presented materials applied emphasizing potential impact advancing chemistry, offering field.

Language: Английский

Citations

0
Photothermal-Magnetic Driven Post-Targeting Retention and Cascade Therapy of “Biomimetic Glue”-Based Nanoreactor for Cancer Theranostics by Bystander-Like Killing DOI
Zihan Liu, Ting Yang,

Jiale Miao

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
A self-powered electromodulative system based on an abiotic-biotic hybrid for cancer catalytic therapy DOI Creative Commons

Shuncheng Yao,

Shaobo Wang, Zhuo Wang

et al.

Published: Feb. 1, 2025

Language: Английский

Citations

0
Aptamer-Induced Spatially Confined Electron Donors Enable Bi2S3/ZnIn2S4 Heterostructures for Attomolar Photoelectrochemical Detection of Antibiotic Resistance Genes DOI

Ruonan Qiao,

Fu Zhou,

Yinbo Ban

et al.

Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 27, 2025

Despite the fact that exploration of novel materials with excellent photoelectrochemical (PEC) performance is sought-after objective for its detection low abundance targets, introduction electron donors in a rational and efficient manner to further boost PEC signals still desirable. In this work, highly Bi2S3/ZnIn2S4 (BZ) heterojunctions were synthesized, strategy aptamer-induced spatially confined (ASED) was, first time, proposed enhanced stable photocurrent generation. With dopamine (DA) or ascorbic acid (AA) as donor model, ∼ 22-fold signal enhancement could be obtained system using ASED strategy. Furthermore, we established newly updated biosensor antibiotic resistance genes based on BZ by ingeniously incorporating catalytic hairpin assembly (CHA) DNAzyme cleavage reaction. It was demonstrated our exhibited an outstanding linear response concentration variations from 0.1 fM 1.0 nM achieved limit 3.24 aM, without need additional donors. This significantly enhances analytical situ aptamer-promoted toward simple, efficient, biosensors, which may shed light biorecognition smart biosensing broad applications.

Language: Английский

Citations

0