Enhancing the Therapeutic Potential of Peptide Antibiotics Using Bacteriophage Mimicry Strategies DOI Creative Commons
Hongping Wan, Xinyi Zhong, Shinong Yang

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 25, 2024

Abstract The rise of antibiotic resistance, coupled with a dwindling pipeline, presents significant threat to public health. Consequently, there is an urgent need for novel therapeutics targeting antibiotic‐resistant pathogens. Nisin, promising peptide antibiotic, exhibits potent bactericidal activity through mechanism distinct from that clinically used antibiotics. However, its cationic nature leads hemolysis and cytotoxicity, which has limited clinical application. Here, nanodelivery systems have been developed by mimicking the mechanisms bacteriophages use deliver their genomes host bacteria. These utilize bacteriophage receptor‐binding proteins conjugated loading modules, enabling efficient bacterial Peptide antibiotics are loaded via dynamic covalent bonds, allowing infection microenvironment‐responsive payload release. demonstrate remarkable specificity against target pathogens effectively localize bacteria‐infected lungs in vivo. Notably, they significantly reduce acute toxicity nisin, rendering it suitable intravenous administration. Additionally, these bacteriophage‐mimicking nanomedicines exhibit excellent therapeutic efficacy mouse model MRSA‐induced pneumonia. facile synthesis, antimicrobial performance, favorable biocompatibility highlight potential as alternative combating This study underscores effectiveness mimicry strategy transforming into viable therapeutics.

Language: Английский

A Comprehensive Review on Phage Therapy and Phage-Based Drug Development DOI Creative Commons
Longzhu Cui, Shinya Watanabe, Kazuhiko Miyanaga

et al.

Antibiotics, Journal Year: 2024, Volume and Issue: 13(9), P. 870 - 870

Published: Sept. 11, 2024

Phage therapy, the use of bacteriophages (phages) to treat bacterial infections, is regaining momentum as a promising weapon against rising threat multidrug-resistant (MDR) bacteria. This comprehensive review explores historical context, modern resurgence phage and phage-facilitated advancements in medical technological fields. It details mechanisms action applications phages treating MDR particularly those associated with biofilms intracellular pathogens. The further highlights innovative uses vaccine development, cancer gene delivery vectors. Despite its targeted efficient approach, therapy faces challenges related stability, immune response, regulatory approval. By examining these areas detail, this underscores immense potential remaining hurdles integrating phage-based therapies into practices.

Language: Английский

Citations

17
Advances in Engineered Phages for Disease Treatment DOI Open Access
Xiaolin Hou,

Zhai Lin,

Laiying Fu

et al.

Small Methods, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 11, 2025

Abstract Phage therapy presents a promising solution for combating multidrug‐resistant (MDR) bacterial infections and other bacteria‐related diseases, attributed to their innate ability target lyse bacteria. Recent clinical successes, particularly in treating MDR‐related respiratory post‐surgical infections, validated the therapeutic potential of phage therapy. However, complex microenvironment within human body poses significant challenges activity efficacy vivo. To overcome these barriers, recent advances engineering have aimed enhance targeting accuracy, improve stability survivability, explore synergistic combinations with modalities. This review provides comprehensive overview therapy, emphasizing application engineered phages antibacterial tumor vaccine development. Furthermore, highlights current future trends advancing toward broader applications.

Language: Английский

Citations

1
Engineering Phages to Fight Multidrug-Resistant Bacteria DOI Creative Commons
Huan Peng, Irene A. Chen, Udi Qimron

et al.

Chemical Reviews, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 16, 2024

Facing the global "superbug" crisis due to emergence and selection for antibiotic resistance, phages are among most promising solutions. Fighting multidrug-resistant bacteria requires precise diagnosis of bacterial pathogens specific cell-killing. Phages have several potential advantages over conventional antibacterial agents such as host specificity, self-amplification, easy production, low toxicity well biofilm degradation. However, narrow range, uncharacterized properties, risks from exponential replication evolution natural phages, currently limit their applications. Engineering can not only enhance range improve phage efficacy, but also confer new functions. This review first summarizes major engineering techniques including both chemical modification genetic engineering. Subsequent sections discuss applications engineered pathogen detection ablation through interdisciplinary approaches synthetic biology nanotechnology. We future directions persistent challenges in ongoing exploration control.

Language: Английский

Citations

8
Recent Development of Nanozymes for Combating Bacterial Drug Resistance: A Review DOI

Lingping Xie,

Haoyue Wu, Yuanfeng Li

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 10, 2024

The World Health Organization has warned that without effective action, deaths from drug-resistant bacteria can exceed 10 million annually, making it the leading cause of death. Conventional antibiotics are becoming less due to rapid bacterial drug resistance and slowed new antibiotic development, necessitating strategies. Recently, materials with catalytic/enzymatic properties, known as nanozymes, have been developed, inspired by natural enzymes essential for eradication. Unlike recent literature reviews broadly cover nanozyme design biomedical applications, this review focuses on latest advancements in nanozymes combating resistance, emphasizing their design, structural characteristics, applications combination therapy, future prospects. This approach aims promote development especially towards clinical translation.

Language: Английский

Citations

4
New Advances in Periodontal Functional Materials Based on Antibacterial, Anti‐Inflammatory, and Tissue Regeneration Strategies DOI Open Access
Haoyue Wu, Yuanfeng Li, Linqi Shi

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 2, 2025

With the global population aging, awareness of oral health is rising. Periodontitis, a widespread bacterial infectious disease, gaining attention. Current novel biomaterials address key clinical issues like infection, gum inflammation, tooth loosening, and loss, focusing on antibacterial, anti-inflammatory, tissue regeneration properties. However, strategies that integrate advantages these to achieve synergistic therapeutic effects by clearing biofilms, inhibiting inflammation activation, restoring periodontal soft hard functions remain very limited. Recent studies highlight link between periodontitis systemic diseases, underscoring complexity disease. There an urgent need find comprehensive treatment plans requirements. Whether integrating new enhance existing treatments or developing approaches replace traditional therapies, efforts will drive advancements in treatment. Therefore, this review compares with treatments. It highlights design concepts mechanisms functional materials, their properties, discusses importance strategies. This aims provide guidance for emerging research promote development precise efficient

Language: Английский

Citations

0
Antibiotics in decompensated liver disease - who, when and for how long? DOI

Frederic Haedge,

Tony Bruns

Expert Review of Gastroenterology & Hepatology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 8, 2025

Bacterial infections are a leading cause of hospitalization and mortality in patients with decompensated cirrhosis. Antibiotic prophylaxis cirrhotic has demonstrated significant short-term reductions bacterial randomized controlled trials, but at the cost drug resistance uncertain survival benefits. This review examines antibiotic use cirrhosis, focusing on patient most likely to benefit from prophylaxis, management strategies for through risk-based selection timely treatment initiation, challenges posed by emergence multidrug-resistant organisms, principles antimicrobial stewardship. The efficacy decreased over time, current registry data have questioned its use, emphasizing need better individualized strategies. When occur, therapies depends heavily local epidemiological patterns individual risk factors, necessitating tailored based regional specific clinical scenarios. Nosocomial infections, colonization prior exposure systemic antibiotics key factors that should guide empirical therapy selection. Until evidence-based algorithms available, clinicians continue adopt approaches, guided available evidence, specificities, stewardship optimize outcomes.

Language: Английский

Citations

0
A peptide-nanoparticle conjugate to steer elimination of drug-resistance bacteria and LPS DOI
Yajie Wang,

Han Zhou,

Yaodong Liu

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 161993 - 161993

Published: March 1, 2025

Language: Английский

Citations

0
The current use of nanotechnology in the fight against antimicrobial resistance: promising approaches to global health challenge DOI
Gideon Sadikiel Mmbando,

Ombeni Ally,

Shedrack Reuben Kitimu

et al.

Journal of Nanoparticle Research, Journal Year: 2025, Volume and Issue: 27(4)

Published: April 1, 2025

Language: Английский

Citations

0
Photothermal‐Mediated In Situ Delivery of Polycations Into Bacteria via Alternating Polymer‐Modified Nanoparticles for Targeted Bacterial Killing and Enhanced Biofilm Penetration DOI Open Access

Shilong Cai,

Hao You,

Xiao Wang

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 18, 2024

Abstract To achieve targeted clearance of bacteria and their biofilms, a straightforward strategy to integrate antimicrobial alternating polymers with photothermal polydopamine nanoparticles (PDA NPs) is proposed. By manipulating the distribution electrostatic, hydrophobic, hydrogen bonding units in polymer backbone, thermal stability polymer‐particle interaction can be tuned, enabling photothermal‐mediated situ delivery cationic into bacteria. The coating significantly enhances penetration capability NPs Methicillin‐resistant Staphylococcus aureus ( MRSA ) Escherichia coli E. biofilm, achieving 99% bactericidal rate within biofilm at low concentration after 10 min near‐infrared irradiation, whereas pristine PDA shows negligible effects. in‐vitro co‐culture model demonstrates that alternating‐polymer‐loaded selectively eradicate 1 × 7 CFU mL −1 while preserving over 75% viability mammalian cells, including mice fibroblasts, human kidney cervical cancer macrophages. efficacy these biocompatible targeting further validated mouse ‐infected wound model. This approach represents significant advancement developing safe efficient therapies bacterial killing minimal off‐target effects based on polymers.

Language: Английский

Citations

2
Phage-guided nanocarriers: a precision strategy against bacterial pathogens DOI
Temoor Ahmed,

Xinyan Xu,

Muhammad Noman

et al.

Trends in biotechnology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 1, 2024

Language: Английский

Citations

1