Advanced Materials,
Journal Year:
2023,
Volume and Issue:
36(3)
Published: Nov. 24, 2023
Uric
acid
metabolism
disorder
triggers
metabolic
diseases,
especially
gout.
However,
increasing
uric
excretion
remains
a
challenge.
Here,
an
accelerative
pathway
via
oral
intestine-explosive
hydrogel
microsphere
merely
containing
uricase
and
dopamine
is
reported.
After
administration,
exposed
immobilized
on
intestinal
mucosa
along
with
in
situ
polymerization
cascade
reaction
triggered
by
the
specific
environment.
By
this
means,
trace
amount
of
required
to
up-regulate
transporter
proteins
epithelial
cells,
causing
accelerated
excretion.
From
vitro
data,
fecal
samples
from
gout
patients
could
be
significantly
reduced
up
37%
mimic
mucosa-immobilized
isolated
porcine
tissues.
Both
hyperuricemia
acute
gouty
arthritis
vivo
mouse
models
confirm
efficacy
microspheres.
Fecal
increased
around
30%
blood
more
than
70%.
In
addition,
16S
ribosomal
RNA
sequencing
showed
that
microspheres
optimized
flora
composition
as
well.
conclusion,
unique
intestine
regulation
realize
efficient
for
therapy
developed.
Cell Host & Microbe,
Journal Year:
2023,
Volume and Issue:
31(6), P. 1038 - 1053.e10
Published: June 1, 2023
The
microbes
and
microbial
pathways
that
influence
host
inflammatory
disease
progression
remain
largely
undefined.
Here,
we
show
variation
in
atherosclerosis
burden
is
partially
driven
by
gut
microbiota
associated
with
circulating
levels
of
uric
acid
(UA)
mice
humans.
We
identify
bacterial
taxa
spanning
multiple
phyla,
including
Bacillota,
Fusobacteriota,
Pseudomonadota,
use
purines,
UA
as
carbon
energy
sources
anaerobically.
a
gene
cluster
encodes
key
steps
anaerobic
purine
degradation
widely
distributed
among
gut-dwelling
bacteria.
Furthermore,
colonization
gnotobiotic
purine-degrading
bacteria
modulates
other
purines
the
systemically.
Thus,
are
important
drivers
global
homeostasis
serum
levels,
catabolism
may
represent
mechanism
which
health.
Frontiers in Immunology,
Journal Year:
2022,
Volume and Issue:
13
Published: Feb. 24, 2022
Gout
is
a
common
inflammatory
arthritis
caused
by
the
deposition
of
sodium
urate
crystals
in
joints.
Hyperuricemia
fundamental
factor
gout.
The
onset
hyperuricemia
related
to
purine
metabolism
disorders
or
uric
acid
excretion
disorders.
Current
studies
have
shown
that
intestine
an
important
potential
organ
for
outside
kidneys.
gut
mainly
achieved
through
action
transporters
and
catabolism
intestinal
flora,
which
plays
role
body’s
balance.
Here
we
reviewed
effects
flora
on
excretion,
provide
new
ideas
treatment
Frontiers in Cellular and Infection Microbiology,
Journal Year:
2022,
Volume and Issue:
12
Published: Aug. 10, 2022
The
incidence
of
hyperuricemia
(HUA)
and
gout
continuously
increases
has
become
a
major
public
health
problem.
gut
microbiota,
which
colonizes
the
human
intestine,
mutually
beneficial
symbiotic
relationship
with
host
plays
vital
role
in
host’s
metabolism
immune
regulation.
Structural
changes
or
imbalance
microbiota
could
cause
metabolic
disorders
participate
synthesis
purine-metabolizing
enzymes
release
inflammatory
cytokines,
is
closely
related
to
occurrence
development
disease
HUA
gout.
as
an
entry
point
explore
pathogenesis
new
research
hotspot.
This
review
summarizes
characteristics
patients
Meanwhile,
influence
different
dietary
structures
on
effect
purine
uric
acid
metabolism,
internal
between
endotoxemia/inflammatory
factors
are
explored.
Moreover,
intervention
effects
probiotics,
prebiotics,
fecal
microbial
transplantation
also
systematically
reviewed
provide
flora
solution
for
prevention
treatment
diseases.
Nutrients,
Journal Year:
2022,
Volume and Issue:
14(17), P. 3525 - 3525
Published: Aug. 26, 2022
Gout
is
well
known
as
an
inflammatory
rheumatic
disease
presenting
with
arthritis
and
abnormal
metabolism
of
uric
acid.
The
recognition
diet-induced
systemic
metabolic
pathways
have
provided
new
mechanistic
insights
potential
interventions
on
gout
progression.
However,
the
dietary
recommendations
for
gouty
patients
generally
focus
food
categories,
few
simultaneous
considerations
nutritional
factors
metabolism.
It
worthwhile
to
comprehensively
review
findings
diet-related
nutrients
against
development
gout,
including
purine
metabolism,
urate
deposition,
inflammation.
Although
piecemeal
modifications
various
often
provide
incomplete
recommendations,
understanding
role
in
can
help
choose
their
healthy
diet
based
personal
preference
course.
combination
management
medication
may
potentially
achieve
enhanced
treatment
effects,
especially
severe
patients.
Therefore,
systematically
reviewed
propose
modification
strategies
by:
(1)
reducing
risk
syndrome;
(2)
supplementing
beneficial
affect
acid
inflammation;
(3)
considering
combined
supplementation
decrease
frequency
flares.
Food & Function,
Journal Year:
2024,
Volume and Issue:
15(3), P. 1671 - 1688
Published: Jan. 1, 2024
The
therapeutic
administration
of
Lactobacillus
paracasei
GY-1
attenuates
the
physical,
behaviral,
and
intestinal
toxicity
colchicine,
enhances
effect
for
gout
flares
when
combined
with
colchicine.
Abstract
The
Lachnospiraceae
family
holds
promise
as
a
source
of
next‐generation
probiotics,
yet
comprehensive
delineation
its
diversity
is
lacking,
hampering
the
identification
suitable
strains
for
future
applications.
To
address
this
knowledge
gap,
we
conducted
an
in‐depth
genomic
and
functional
analysis
1868
high‐quality
genomes,
combining
data
from
public
databases
with
our
new
isolates.
This
set
represented
387
colonization‐selective
species‐level
clusters,
which
eight
genera
multilineage
clusters.
Pan‐genome
analysis,
single‐nucleotide
polymorphism
(SNP)
identification,
probiotic
predictions
revealed
that
species
taxonomy,
habitats,
geography
together
shape
Lachnospiraceae.
Moreover,
analyses
associations
atherosclerotic
cardiovascular
disease
(ACVD)
inflammatory
bowel
(IBD)
indicated
several
potentially
novel
possess
capacity
to
reduce
abundance
opportunistic
pathogens,
thereby
imparting
potential
health
benefits.
Our
findings
shed
light
on
untapped
enabling
knowledge‐based
selection
development
probiotics
holding
improving
human
management.
Frontiers in Nutrition,
Journal Year:
2023,
Volume and Issue:
10
Published: Oct. 5, 2023
The
gut
microbiota
is
a
rich
and
dynamic
ecosystem
that
actively
interacts
with
the
human
body,
playing
significant
role
in
state
of
health
disease
host.
Diet,
exercise,
mental
health,
other
factors
have
exhibited
ability
to
influence
bacterial
composition,
leading
changes
can
prevent
improve,
or
favor
worsen,
both
intestinal
extra-intestinal
conditions.
Altered
microbial
states,
‘dysbiosis’,
associated
conditions
diseases
are
often
characterized
by
shifts
abundance
diversity,
including
an
impaired
Firmicutes
Bacteroidetes
ratio.
By
understanding
effect
lifestyle
on
microbiota,
personalized
advice
be
generated
suit
each
individual
profile
foster
adoption
ameliorate
dysbiosis.
delivery
effective
reliable
advice,
however,
depends
not
only
available
research
current
topic,
but
also
methods
used
assess
individuals
discover
associations,
which
introduce
bias
at
multiple
stages.
aim
this
review
summarize
how
variability
defined
what
choices
shown
association
composition.
Furthermore,
popular
investigate
outlined,
focus
possible
caused
lack
use
standardized
methods.
Finally,
overview
based
testing
presented,
underlining
its
power
limitations.
Food & Function,
Journal Year:
2022,
Volume and Issue:
13(23), P. 12412 - 12425
Published: Jan. 1, 2022
Akkermansia
muciniphila
(A.
muciniphila)
has
been
demonstrated
to
exhibit
beneficial
effects
against
various
metabolic
diseases,
but
whether
A.
an
anti-hyperuricemia
effect
remains
unexplored.
In
this
study,
live
and
pasteurized
were
examined
for
their
efficacy
in
alleviating
hyperuricemia
mice.
Live
(approximately
2
×
108
CFU)
given
a
hyperuricemic
mice
model
via
oral
gavage
three
weeks.
Both
forms
of
decreased
serum
urate
inhibited
xanthine
oxidase
the
liver.
addition,
fecal
urinal
was
increased
both
treatment
groups,
which
corresponds
changes
mRNA
protein
expression
levels
renal
uric
acid-related
transporters
(URAT1,
GLUT9,
ABCG2)
intestinal
ABCG2.
bacteria
reduced
inflammatory
factors
liver,
kidneys
colon.
enhanced
tight
junction
proteins
improved
dysbiosis
flora.
These
findings
suggest
that
or
could
effectively
attenuate
by
moderating
acid
metabolism
inflammation,
additional
on
gut
microbiota.
highlight
be
potentially
developed
as
probiotic
postbiotic
combat
hyperuricemia.