Intestine‐Targeted Explosive Hydrogel Microsphere Promotes Uric Acid Excretion for Gout Therapy DOI
Yunkai Tang, Yawei Du, Junna Ye

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(3)

Published: Nov. 24, 2023

Uric acid metabolism disorder triggers metabolic diseases, especially gout. However, increasing uric excretion remains a challenge. Here, an accelerative pathway via oral intestine-explosive hydrogel microsphere merely containing uricase and dopamine is reported. After administration, exposed immobilized on intestinal mucosa along with in situ polymerization cascade reaction triggered by the specific environment. By this means, trace amount of required to up-regulate transporter proteins epithelial cells, causing accelerated excretion. From vitro data, fecal samples from gout patients could be significantly reduced up 37% mimic mucosa-immobilized isolated porcine tissues. Both hyperuricemia acute gouty arthritis vivo mouse models confirm efficacy microspheres. Fecal increased around 30% blood more than 70%. In addition, 16S ribosomal RNA sequencing showed that microspheres optimized flora composition as well. conclusion, unique intestine regulation realize efficient for therapy developed.

Language: Английский

Gut bacterial metabolism contributes to host global purine homeostasis DOI Creative Commons
Kazuyuki Kasahara, Robert L. Kerby, Qijun Zhang

et al.

Cell Host & Microbe, Journal Year: 2023, Volume and Issue: 31(6), P. 1038 - 1053.e10

Published: June 1, 2023

The microbes and microbial pathways that influence host inflammatory disease progression remain largely undefined. Here, we show variation in atherosclerosis burden is partially driven by gut microbiota associated with circulating levels of uric acid (UA) mice humans. We identify bacterial taxa spanning multiple phyla, including Bacillota, Fusobacteriota, Pseudomonadota, use purines, UA as carbon energy sources anaerobically. a gene cluster encodes key steps anaerobic purine degradation widely distributed among gut-dwelling bacteria. Furthermore, colonization gnotobiotic purine-degrading bacteria modulates other purines the systemically. Thus, are important drivers global homeostasis serum levels, catabolism may represent mechanism which health.

Language: Английский

Citations

95
The Role of the Intestine in the Development of Hyperuricemia DOI Creative Commons
Hui Yin, Na Liu, Jie Chen

et al.

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: Feb. 24, 2022

Gout is a common inflammatory arthritis caused by the deposition of sodium urate crystals in joints. Hyperuricemia fundamental factor gout. The onset hyperuricemia related to purine metabolism disorders or uric acid excretion disorders. Current studies have shown that intestine an important potential organ for outside kidneys. gut mainly achieved through action transporters and catabolism intestinal flora, which plays role body’s balance. Here we reviewed effects flora on excretion, provide new ideas treatment

Language: Английский

Citations

93
Gut microbiota remodeling: A promising therapeutic strategy to confront hyperuricemia and gout DOI Creative Commons
Zhilei Wang, Yuchen Li, Wenhao Liao

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2022, Volume and Issue: 12

Published: Aug. 10, 2022

The incidence of hyperuricemia (HUA) and gout continuously increases has become a major public health problem. gut microbiota, which colonizes the human intestine, mutually beneficial symbiotic relationship with host plays vital role in host’s metabolism immune regulation. Structural changes or imbalance microbiota could cause metabolic disorders participate synthesis purine-metabolizing enzymes release inflammatory cytokines, is closely related to occurrence development disease HUA gout. as an entry point explore pathogenesis new research hotspot. This review summarizes characteristics patients Meanwhile, influence different dietary structures on effect purine uric acid metabolism, internal between endotoxemia/inflammatory factors are explored. Moreover, intervention effects probiotics, prebiotics, fecal microbial transplantation also systematically reviewed provide flora solution for prevention treatment diseases.

Language: Английский

Citations

90
Gout and Diet: A Comprehensive Review of Mechanisms and Management DOI Open Access

Yingling Zhang,

Simin Chen,

Man Yuan

et al.

Nutrients, Journal Year: 2022, Volume and Issue: 14(17), P. 3525 - 3525

Published: Aug. 26, 2022

Gout is well known as an inflammatory rheumatic disease presenting with arthritis and abnormal metabolism of uric acid. The recognition diet-induced systemic metabolic pathways have provided new mechanistic insights potential interventions on gout progression. However, the dietary recommendations for gouty patients generally focus food categories, few simultaneous considerations nutritional factors metabolism. It worthwhile to comprehensively review findings diet-related nutrients against development gout, including purine metabolism, urate deposition, inflammation. Although piecemeal modifications various often provide incomplete recommendations, understanding role in can help choose their healthy diet based personal preference course. combination management medication may potentially achieve enhanced treatment effects, especially severe patients. Therefore, systematically reviewed propose modification strategies by: (1) reducing risk syndrome; (2) supplementing beneficial affect acid inflammation; (3) considering combined supplementation decrease frequency flares.

Language: Английский

Citations

71
A genomic compendium of cultivated human gut fungi characterizes the gut mycobiome and its relevance to common diseases DOI

Qiulong Yan,

Shenghui Li, Qingsong Yan

et al.

Cell, Journal Year: 2024, Volume and Issue: 187(12), P. 2969 - 2989.e24

Published: May 21, 2024

Language: Английский

Citations

36
Intestinal toxicity alleviation and efficacy potentiation through therapeutic administration of Lactobacillus paracasei GY-1 in the treatment of gout flares with colchicine DOI

Jiaqi Zeng,

Yan Li,

Yizhi Zou

et al.

Food & Function, Journal Year: 2024, Volume and Issue: 15(3), P. 1671 - 1688

Published: Jan. 1, 2024

The therapeutic administration of Lactobacillus paracasei GY-1 attenuates the physical, behaviral, and intestinal toxicity colchicine, enhances effect for gout flares when combined with colchicine.

Language: Английский

Citations

29
Isolation of potentially novel species expands the genomic and functional diversity of Lachnospiraceae DOI Creative Commons
Xiaoqian Lin, Tongyuan Hu,

Zhinan Wu

et al.

iMeta, Journal Year: 2024, Volume and Issue: 3(2)

Published: Feb. 13, 2024

Abstract The Lachnospiraceae family holds promise as a source of next‐generation probiotics, yet comprehensive delineation its diversity is lacking, hampering the identification suitable strains for future applications. To address this knowledge gap, we conducted an in‐depth genomic and functional analysis 1868 high‐quality genomes, combining data from public databases with our new isolates. This set represented 387 colonization‐selective species‐level clusters, which eight genera multilineage clusters. Pan‐genome analysis, single‐nucleotide polymorphism (SNP) identification, probiotic predictions revealed that species taxonomy, habitats, geography together shape Lachnospiraceae. Moreover, analyses associations atherosclerotic cardiovascular disease (ACVD) inflammatory bowel (IBD) indicated several potentially novel possess capacity to reduce abundance opportunistic pathogens, thereby imparting potential health benefits. Our findings shed light on untapped enabling knowledge‐based selection development probiotics holding improving human management.

Language: Английский

Citations

24
Uric acid extrarenal excretion: the gut microbiome as an evident yet understated factor in gout development DOI
Eder Orlando Méndez-Salazar, Gabriela Angélica Martínez‐Nava

Rheumatology International, Journal Year: 2021, Volume and Issue: 42(3), P. 403 - 412

Published: Sept. 29, 2021

Language: Английский

Citations

63
Exploring the gut microbiota: lifestyle choices, disease associations, and personal genomics DOI Creative Commons
Sharlize Pedroza Matute, Sasitaran Iyavoo

Frontiers in Nutrition, Journal Year: 2023, Volume and Issue: 10

Published: Oct. 5, 2023

The gut microbiota is a rich and dynamic ecosystem that actively interacts with the human body, playing significant role in state of health disease host. Diet, exercise, mental health, other factors have exhibited ability to influence bacterial composition, leading changes can prevent improve, or favor worsen, both intestinal extra-intestinal conditions. Altered microbial states, ‘dysbiosis’, associated conditions diseases are often characterized by shifts abundance diversity, including an impaired Firmicutes Bacteroidetes ratio. By understanding effect lifestyle on microbiota, personalized advice be generated suit each individual profile foster adoption ameliorate dysbiosis. delivery effective reliable advice, however, depends not only available research current topic, but also methods used assess individuals discover associations, which introduce bias at multiple stages. aim this review summarize how variability defined what choices shown association composition. Furthermore, popular investigate outlined, focus possible caused lack use standardized methods. Finally, overview based testing presented, underlining its power limitations.

Language: Английский

Citations

43
Live and pasteurized Akkermansia muciniphila attenuate hyperuricemia in mice through modulating uric acid metabolism, inflammation, and gut microbiota DOI
Lihua Zhang, Jiaxiu Liu, Tong Jin

et al.

Food & Function, Journal Year: 2022, Volume and Issue: 13(23), P. 12412 - 12425

Published: Jan. 1, 2022

Akkermansia muciniphila (A. muciniphila) has been demonstrated to exhibit beneficial effects against various metabolic diseases, but whether A. an anti-hyperuricemia effect remains unexplored. In this study, live and pasteurized were examined for their efficacy in alleviating hyperuricemia mice. Live (approximately 2 × 108 CFU) given a hyperuricemic mice model via oral gavage three weeks. Both forms of decreased serum urate inhibited xanthine oxidase the liver. addition, fecal urinal was increased both treatment groups, which corresponds changes mRNA protein expression levels renal uric acid-related transporters (URAT1, GLUT9, ABCG2) intestinal ABCG2. bacteria reduced inflammatory factors liver, kidneys colon. enhanced tight junction proteins improved dysbiosis flora. These findings suggest that or could effectively attenuate by moderating acid metabolism inflammation, additional on gut microbiota. highlight be potentially developed as probiotic postbiotic combat hyperuricemia.

Language: Английский

Citations

42