Author Response: Age-related differences in the functional topography of the locus coeruleus: implications for cognitive and affective functions DOI Open Access
Dániel Veréb, Mite Mijalkov, Anna Canal‐Garcia

et al.

Published: Aug. 17, 2023

The locus coeruleus (LC) is an important noradrenergic nucleus that has recently attracted a lot of attention because its emerging role in cognitive and psychiatric disorders. Although previous histological studies have shown the LC heterogeneous connections cellular features, no yet assessed functional topography vivo, how this heterogeneity changes over aging whether it associated with cognition mood. Here we employ gradient-based approach to characterize organization using 3T resting-state fMRI population-based cohort aged from 18 88 years old (Cambridge Centre for Ageing Neuroscience cohort, n=618). We show exhibits rostro-caudal gradient along longitudinal axis, which was replicated independent dataset (Human Connectome Project 7T dataset, n=184). main direction consistent across age groups, spatial features varied increasing age, emotional memory emotion regulation. More specifically, loss rostral-like connectivity, more clustered greater asymmetry between right left gradients higher worse behavioral performance. Furthermore, participants higher-than-normal Hospital Anxiety Depression Scale ratings exhibited alterations as well, manifested asymmetry. These results provide vivo account aging, imply are relevant markers LC-related measures psychopathology.

Language: Английский

Clinically probable RBD is an early predictor of malignant non-motor Parkinson’s disease phenotypes DOI Creative Commons
Alfonso Enrique Martinez-Nunez,

Hunter Hutchinson,

Patricia Coutinho

et al.

npj Parkinson s Disease, Journal Year: 2025, Volume and Issue: 11(1)

Published: Jan. 29, 2025

Non-motor symptoms (NMS) in Parkinson's disease (PD) significantly impact quality of life, especially later stages. REM sleep behavior disorder (RBD) affects approximately 42% all PD patients and frequently precedes motor symptoms. RBD is linked to increased rates depression cognitive decline. This study explores how early can predict the development NMS profiles patients, comparing those with without RBD. We identified a unique profile associated These had higher rate impairment (M2 = 326.84, p < 0.001), apathy 332.93, hallucinations 480.05, 0.0001), anxiety (corrected 0.01), impulse control disorders 77.577, autonomic dysfunction (F 251.8, 0001). A survival analysis revealed an association between faster progression impairment. may play critical role stratifying for targeted interventions.

Language: Английский

Citations

2
Age-related differences in the functional topography of the locus coeruleus and their implications for cognitive and affective functions DOI Creative Commons
Dániel Veréb, Mite Mijalkov, Anna Canal‐Garcia

et al.

eLife, Journal Year: 2023, Volume and Issue: 12

Published: May 9, 2023

The locus coeruleus (LC) is an important noradrenergic nucleus that has recently attracted a lot of attention because its emerging role in cognitive and psychiatric disorders. Although previous histological studies have shown the LC heterogeneous connections cellular features, no yet assessed functional topography vivo, how this heterogeneity changes over aging, whether it associated with cognition mood. Here, we employ gradient-based approach to characterize organization aging using 3T resting-state fMRI population-based cohort aged from 18 88 years age (Cambridge Centre for Ageing Neuroscience cohort, n=618). We show exhibits rostro-caudal gradient along longitudinal axis, which was replicated independent dataset (Human Connectome Project [HCP] 7T dataset, n=184). main direction consistent across groups, spatial features varied increasing age, emotional memory, emotion regulation. More specifically, loss rostral-like connectivity, more clustered topography, greater asymmetry between right left gradients higher worse behavioral performance. Furthermore, participants higher-than-normal Hospital Anxiety Depression Scale (HADS) ratings exhibited alterations as well, manifested asymmetry. These results provide vivo account imply are relevant markers LC-related measures psychopathology.

Language: Английский

Citations

13
Eye movements in Parkinson’s disease: from neurophysiological mechanisms to diagnostic tools DOI Open Access
Chrystalina A. Antoniades, Miriam Spering

Trends in Neurosciences, Journal Year: 2023, Volume and Issue: 47(1), P. 71 - 83

Published: Dec. 2, 2023

Language: Английский

Citations

13
Waking up to the role of sleep disturbances in freezing of gait among people with Parkinson’s disease DOI
Jennifer Zitser,

Talia Herman,

Nir Giladi

et al.

Parkinsonism & Related Disorders, Journal Year: 2025, Volume and Issue: unknown, P. 107342 - 107342

Published: Feb. 1, 2025

Language: Английский

Citations

0
Differential brainstem connectivity according to sex and menopausal status in healthy male and female individuals DOI Creative Commons
Lisa A. Kilpatrick,

Amelia Church,

David Meriwether

et al.

Biology of Sex Differences, Journal Year: 2025, Volume and Issue: 16(1)

Published: April 18, 2025

Abstract Background Brainstem nuclei play a critical role in both ascending monoaminergic modulation of cortical function and arousal, descending bulbospinal pain modulation. Even though sex-related differences the systems have been reported animal models, complete understanding sex differences, as well menopausal effects, brainstem connectivity humans is lacking. This study evaluated resting-state dorsal raphe nucleus, right left locus coeruleus complex (LCC), periaqueductal gray (PAG) according to status healthy individuals. In addition, relationships between systemic estrogen levels brainstem-network were examined subset participants. Methods Resting-state fMRI was performed 47 male (age, 31.2 ± 8.0 years), 53 premenopausal female 24.7 7.3 years; 22 follicular phase, 31 luteal phase), 20 postmenopausal participants 54.6 7.2 years). Permutation Analysis Linear Models (5000 permutations) used evaluate status, controlling for age. 10 males 17 females (9 premenopausal; 8 postmenopausal), metabolite plasma stool determined by liquid chromatography-mass spectrometry/mass spectrometry. Relationships partial least squares analysis. Results Left LCC-executive control network showed an overall difference (p = 0.02), with higher than males; however, this mainly due 0.008). Additional dependent on status: PAG-default mode (DMN) 0.04), PAG-sensorimotor (SMN) 0.03) 0.007). Notably, free 2-hydroxyestrone reliably associated PAG-SMN PAG-DMN < 0.01). Conclusions Healthy show involved cognitive control, sensorimotor function, self-relevant processes males, their status. Further, 2-hydroxyestrone, implicated pain, may modulate PAG females. These findings relate differential vulnerabilities chronic stress-sensitive disorders at different life stages.

Language: Английский

Citations

0
Enhancing Neuroprotection in Mouse Model of Parkinson’s Disease through Protein Nanosystem Conjugation with ApoE Peptide for miR-124 Delivery DOI

Juan Zhang,

Bozhou Cui,

Ting He

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(7), P. 8199 - 8212

Published: Feb. 12, 2024

Parkinson's disease (PD) affects millions of people's lives worldwide. The main pathogenesis PD is dopaminergic neuron necrosis and neuroinflammation mediated by activated microglia cells. In recent years, the anti-inflammatory ability neuroprotective effects miR-124 in models were well proved, but vivo delivery remains challenging. Herein, we report a protein nanosystem modified with brain-targeting peptide ApoE that could efficiently deliver across blood-brain barrier (BBB). This showed good cell viability on brain endothelial cells cells, administration this significantly decreased loss, as recovered parts neurobehavioral deficits. peptide-based holds great promise for RNA therapeutics to realizing protection treatment.

Language: Английский

Citations

3
Understanding REM Sleep Behavior Disorder through Functional MRI: A Systematic Review DOI Creative Commons
L. Churchill, Yu‐Chi Chen, Simon J.G. Lewis

et al.

Movement Disorders, Journal Year: 2024, Volume and Issue: 39(10), P. 1679 - 1696

Published: June 27, 2024

Abstract Neuroimaging studies in rapid eye movement sleep behavior disorder (RBD) can inform fundamental questions about the pathogenesis of Parkinson's disease (PD). Across modalities, functional magnetic resonance imaging (fMRI) may be better suited to identify changes between neural networks earliest stages Lewy body diseases when structural subtle or absent. This review synthesizes findings from all fMRI RBD gain further insight into pathophysiology and progression diseases. A total 32 were identified using a systematic conducted according PRISMA guidelines January 2000 February 2024 for original patients with either isolated (iRBD) secondary PD. Common alterations detectable iRBD compared healthy controls across brainstem nuclei, basal ganglia, frontal occipital lobes, whole brain network measures. Patients established PD demonstrated decreased connectivity but increased cerebellum lobe those without RBD. Finally, longitudinal resting state found track progression. Currently, have early signatures neurodegeneration both motor non‐motor pathways. Although more work is needed, such potential our understanding disease, help distinguish prodromal dementia bodies, support development fMRI‐based outcome measures phenoconversion future modifying trials. © The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf International Parkinson Disorder Society.

Language: Английский

Citations

3
The activities of daily living partially mediate the relationship between rapid eye movement sleep behavior disorder and depressive symptoms in Parkinson's disease DOI Creative Commons

QiuShuang Wang,

ShuangShuang Zheng,

Jing Bian

et al.

Frontiers in Neurology, Journal Year: 2024, Volume and Issue: 15

Published: July 22, 2024

A longitudinal study was conducted to investigate whether rapid eye movement sleep behavior disorder affect depression in patients with Parkinson's disease through activities of daily living.

Language: Английский

Citations

2
Advances in functional and structural imaging of the brainstem: implications for disease DOI
Jiayue Cai, Yuheng Wang, Martin J. McKeown

et al.

Current Opinion in Neurology, Journal Year: 2024, Volume and Issue: 37(4), P. 361 - 368

Published: June 17, 2024

Purpose of review The brainstem's complex anatomy and relatively small size means that structural functional assessment this structure is done less frequently compared to other brain areas. However, recent years have seen substantial progress in brainstem imaging, enabling more detailed investigations into its function, as well role neuropathology. Recent findings Advancements ultrahigh field MRI technology allowed for unprecedented spatial resolution facilitating the new creation brainstem-specific atlases. Methodological improvements significantly enhanced accuracy physiological (cardiac respiratory) noise correction within imaging studies. These technological methodological advancements in-depth analyses anatomy, including quantitative assessments examinations connectivity both gray white matter. Furthermore, studies, activation patterns connectivity, revealed roles specialized functions broader neural integration. Notably, these identified alterations function associated with various neurological disorders. Summary aforementioned developments a greater appreciation importance wider context neuroscience clinical neurology.

Language: Английский

Citations

1
Differential brainstem connectivity according to sex and menopausal status in healthy men and women DOI Creative Commons
Lisa A. Kilpatrick,

Arpana Gupta,

David Meriwether

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 12, 2024

Abstract Background Brainstem nuclei play a critical role in both ascending monoaminergic modulation of cortical function and arousal, descending bulbospinal pain modulation. Even though sex-related differences the systems have been reported animal models, complete understanding sex differences, as well menopausal effects, brainstem connectivity humans is lacking. This study evaluated resting-state dorsal raphe nucleus (DRN), right left locus coeruleus complex (LCC), periaqueductal gray (PAG) according to status healthy individuals. In addition, relationships between systemic estrogen levels brainstem-network were examined subset participants. Methods Resting-state fMRI was performed 50 men (age, 31.2 ± 8.0 years), 53 premenopausal women 24.7 7.3 years; 22 follicular phase, 31 luteal phase), 20 postmenopausal 54.6 7.2 years). Permutation Analysis Linear Models (5000 permutations) used evaluate status, controlling for age. 10 17 (9 premenopausal; 8 postmenopausal), metabolite plasma stool determined by liquid chromatography-mass spectrometry/mass spectrometry. Relationships partial least squares analysis. Results Left LCC-executive control network (ECN) showed an overall difference (p = 0.02), with higher than men; however, this mainly due pre-menopausal 0.008). Additional dependent on status: PAG-default mode (DMN) 0.04), PAG-sensorimotor (SMN) 0.03) 0.007). Notably, free 2-hydroxyestrone associated PAG-SMN PAG-DMN < 0.01). Conclusions Healthy show involved cognitive control, sensorimotor function, self-relevant processes men, their status. Further, 2-hydroxyestrone, implicated pain, may modulate PAG women. These findings relate differential vulnerabilities chronic stress-sensitive disorders at different life stages.

Language: Английский

Citations

1