Nutrients,
Journal Year:
2025,
Volume and Issue:
17(7), P. 1272 - 1272
Published: April 5, 2025
Research
on
postbiotics
derived
from
probiotic
fermented
milk
bases
require
further
expansion,
and
the
mechanisms
through
which
they
exert
their
effects
have
yet
to
be
fully
elucidated.
This
study
utilized
in
vitro
cell
co-culture,
digestion,
fermentation
experiments,
combined
with
targeted
T500
technology,
elucidate
mechanism
by
postbiotic
Pa
JY062
safeguards
intestinal
health.
Compared
LPS
group,
boosted
phagocytic
ability
RAW264.7
macrophages,
decreased
NO
levels,
alleviated
LPS-induced
excessive
inflammation.
suppressed
pro-inflammatory
cytokines
(IL-6,
IL-17α,
TNF-α)
while
elevating
anti-inflammatory
IL-10.
It
prevented
TEER
reduction
Caco-2
monolayers,
FITC-dextran
permeability,
restored
microvilli
integrity,
upregulated
tight
junction
genes
(ZO-1,
occludin,
claudin-1,
E-cadherin).
The
hydrolysis
rate
of
progressively
rose
gastrointestinal
fluids
0-120
min.
At
5
mg/mL,
it
enriched
gut
microbiota
diversity
elevated
proportions
Limosilactobacillus,
Lactobacillus,
Pediococcus,
Lacticaseibacillus
augmenting
microbial
production
acetic
acid
(120.2
±
8.08
μg/mL),
propionic
(9.9
0.35
butyric
(10.55
0.13
μg/mL).
incorporated
αs-casein/β-lactoglobulin
hydrolysate
(L-glutamic
acid,
alanine,
lysine,
tyrosine,
phenylalanine,
histidine,
arginine)
mitigate
protein
allergenic
potential
harboring
bioactive
components,
including
tryptophan
metabolites,
vitamin
B6
(VB6),
γ-aminobutyric
(GABA).
represented
a
novel
demonstrated
health-promoting
properties.
These
findings
advance
current
knowledge
postbiotic-mediated
homeostasis
regulation
expedite
translational
development
dairy-derived
formulations.
Journal of Controlled Release,
Journal Year:
2022,
Volume and Issue:
353, P. 1107 - 1126
Published: Dec. 25, 2022
Colonic
drug
delivery
can
facilitate
access
to
unique
therapeutic
targets
and
has
the
potential
enhance
bioavailability
whilst
reducing
off-target
effects.
Delivering
drugs
colon
requires
considered
formulation
development,
as
both
oral
rectal
dosage
forms
encounter
challenges
if
colon's
distinct
physiological
environment
is
not
appreciated.
As
opportunities
surrounding
colonic
multiply,
success
of
novel
pharmaceuticals
lies
in
their
design.
This
review
provides
a
modern
insight
into
key
parameters
determining
effective
design
development
colon-targeted
medicines.
Influential
features
governing
release,
dissolution,
stability,
absorption
are
first
discussed,
followed
by
an
overview
most
reliable
strategies.
Finally,
appropriate
vitro,
vivo,
silico
preclinical
investigations
presented,
with
goal
inspiring
strategic
new
therapeutics.
npj Science of Food,
Journal Year:
2024,
Volume and Issue:
8(1)
Published: April 2, 2024
Abstract
Gamma-aminobutyric
acid
(GABA)
plays
a
crucial
role
in
the
central
nervous
system
as
an
inhibitory
neurotransmitter.
Imbalances
of
this
neurotransmitter
are
associated
with
neurological
diseases,
such
Alzheimer’s
and
Parkinson’s
disease,
psychological
disorders,
including
anxiety,
depression,
stress.
Since
GABA
has
long
been
believed
to
not
cross
blood–brain
barrier,
effects
circulating
on
brain
neglected.
However,
emerging
evidence
demonstrated
that
changes
both
levels
gut
microbiota
composition
play
modulating
mental
health.
This
recent
research
raised
possibility
may
be
potent
mediator
gut–brain
axis.
review
article
will
cover
up-to-date
information
about
GABA-producing
microorganisms
isolated
from
human
food
sources,
explanation
why
those
produce
GABA,
factors
inducing
gut–GABA
production,
suggesting
linking
between
health,
stress,
epilepsy,
autism
spectrum
disorder,
attention
deficit
hyperactivity
novel
regarding
homocarnosine-a
predominant
peptide
is
putative
downstream
regulating
functions.
help
us
understand
how
GABA-homocarnosine
metabolism
significant
Nonetheless,
it
could
support
further
use
production-inducing
agents
treat
disorders.
Gut Microbes,
Journal Year:
2023,
Volume and Issue:
15(2)
Published: Nov. 7, 2023
The
advent
of
highthroughput
‘omics’
technologies
has
improved
our
knowledge
gut
microbiome
in
human
health
and
disease,
including
Alzheimer’s
disease
(AD),
a
neurodegenerative
disorder.
Frequent
bidirectional
communications
mutual
regulation
exist
between
the
gastrointestinal
tract
central
nervous
system
through
gut-brain
axis.
A
large
body
research
reported
close
association
microbiota
AD
development,
restoring
healthy
may
curb
or
even
improve
symptoms
progression.
Thus,
modulation
become
novel
paradigm
for
clinical
management
AD,
emerging
effort
focused
on
developing
potential
strategies
preventing
and/or
treating
disease.
In
this
review,
we
provide
an
overview
connection
causal
relationship
dysbiosis
mechanisms
driving
progression,
successes
challenges
implementing
available
microbiome-targeted
therapies
(including
probiotics,
prebiotics,
synbiotics,
postbiotics,
fecal
transplantation)
preventive
therapeutic
preclinical
intervention
studies
AD.
Finally,
discuss
future
directions
field.
Biomedicine & Pharmacotherapy,
Journal Year:
2024,
Volume and Issue:
179, P. 117302 - 117302
Published: Aug. 19, 2024
Inflammatory
bowel
disease
(IBD),
including
Crohn's
and
ulcerative
colitis,
is
a
complex
disorder
with
an
unknown
cause.
However,
the
dysbiosis
of
gut
microbiome
has
been
found
to
play
role
in
IBD
etiology,
exacerbated
immune
responses
defective
intestinal
barrier
integrity.
The
can
also
be
potential
biomarker
for
several
diseases,
IBD.
Currently,
conventional
treatments
targeting
pro-inflammatory
cytokines
pathways
IBD-associated
do
not
yield
effective
results.
Other
therapies
that
directly
target
dysbiotic
outcomes
are
emerging.
We
review
health
its
as
diagnostic,
prognostic,
therapeutic
This
explores
emerging
advancements
microbiome-associated
alterations
IBD,
such
nanoparticle
or
encapsulation
delivery,
fecal
microbiota
transplantation,
nutritional
therapies,
microbiome/probiotic
engineering,
phage
therapy,
mesenchymal
stem
cells
(MSCs),
proteins,
herbal
formulas.
Trends in Microbiology,
Journal Year:
2023,
Volume and Issue:
32(3), P. 252 - 269
Published: Sept. 25, 2023
The
provision
of
probiotics
benefits
the
health
a
wide
range
organisms,
from
humans
to
animals
and
plants.
Probiotics
can
enhance
stress
resilience
endangered
many
which
are
critically
threatened
by
anthropogenic
impacts.
use
so-called
'probiotics
for
wildlife'
is
nascent
application,
field
needs
reflect
on
standards
its
development,
testing,
validation,
risk
assessment,
deployment.
Here,
we
identify
main
challenges
this
emerging
intervention
provide
roadmap
validate
effectiveness
wildlife
probiotics.
We
cover
essential
inert
negative
controls
in
trials
investigation
probiotic
mechanisms
action.
also
suggest
alternative
microbial
therapies
that
could
be
tested
parallel
with
application.
Our
recommendations
align
approaches
used
humans,
aquaculture,
plants
concept
wildlife.
Nutrients,
Journal Year:
2023,
Volume and Issue:
15(15), P. 3377 - 3377
Published: July 29, 2023
Inflammatory
bowel
disease
(IBD)
is
a
complex
disorder
characterized
by
chronic
inflammation
of
the
gastrointestinal
tract
(GIT).
IBD
mainly
includes
two
distinct
diseases,
namely
Crohn's
and
ulcerative
colitis.
To
date,
precise
etiology
these
conditions
not
fully
elucidated.
Recent
research
has
shed
light
on
significant
role
oral
gut
microbiome
in
development
progression
its
collective
influence
health.
This
review
aims
to
investigate
connection
between
context
IBD,
exploring
intricate
interplay
microbial
communities
their
impact
overall
advances
have
revealed
compelling
link
microbiome,
highlighting
pivotal
maintaining
The
cavity
GIT
are
interconnected
ecosystems
that
harbor
implicated
pathogenesis
several
ways.
Reduction
diversity
abundance
beneficial
bacterial
species
with
colonization
opportunistic
pathogens
can
induce
inflammation.
Some
arise
from
origin,
especially
patients
diseases
such
as
periodontitis.
It
essential
discern
mechanisms
transmission,
health
potential
dysbiosis
development.
By
elucidating
this
relationship,
we
enhance
our
understanding
identify
therapeutic
avenues
for
managing
disease.
Furthermore,
innovative
strategies
modulating
promote
prevent
occurrence
progression.
npj Science of Food,
Journal Year:
2023,
Volume and Issue:
7(1)
Published: May 24, 2023
Probiotic
functional
products
have
drawn
wide
attention
because
of
their
increasing
popularity.
However,
few
studies
analyzed
probiotic-specific
metabolism
in
the
fermentation
process.
This
study
applied
UPLC-QE-MS-based
metabolomics
to
track
changes
milk
metabolomes
course
by
two
probiotic
strains,
Lacticaseibacillus
paracasei
PC-01
and
Bifidobacterium
adolescentis
B8589.
We
observed
substantial
fermented
metabolome
between
0
36
h
fermentation,
differences
at
interim
period
(36
60
h)
ripening
stage
(60
72
were
less
obvious.
A
number
time
point-specific
differential
metabolites
identified,
mainly
belonging
organic
acids,
amino
fatty
acids.
Nine
identified
are
linked
tricarboxylic
acid
cycle,
glutamate
metabolism,
metabolism.
The
contents
pyruvic
acid,
γ-aminobutyric
capric
increased
end
which
can
contribute
nutritional
quality
properties
milk.
time-course
fermentative
milk,
providing
detailed
information
a
matrix
potential
beneficial
mechanism
