Journal of the Neurological Sciences, Journal Year: 2024, Volume and Issue: 457, P. 122889 - 122889
Published: Jan. 21, 2024
Language: Английский
Nutrients, Journal Year: 2024, Volume and Issue: 16(6), P. 789 - 789
Published: March 10, 2024
Recent research exploring the relationship between gut and brain suggests that condition of microbiota can influence cognitive health. A well-balanced may help reduce inflammation, which is linked to neurodegenerative conditions. Prebiotics, probiotics, symbiotics are nutritional supplements functional food components associated with gastrointestinal well-being. The bidirectional communication gut–brain axis essential for maintaining homeostasis, pre-, pro-, potentially affecting various functions such as attention, perception, memory. Numerous studies have consistently shown incorporating into a healthy diet lead improvements in mood. Maintaining support optimal function, crucial disease prevention our fast-paced, Westernized society. Our results indicate benefits older individuals probiotic supplementation but not who good adequate levels physical activity. Additionally, it appears there patients mild impairment Alzheimer’s disease, while mixed seem arise younger healthier individuals. However, important acknowledge individual responses vary, use these dietary should be tailored each individual’s unique health circumstances needs.
Language: Английский
Citations
21
Translational Neurodegeneration, Journal Year: 2024, Volume and Issue: 13(1)
Published: Feb. 27, 2024
The aetiologies and origins of neurodegenerative diseases, such as Alzheimer's disease (AD), Parkinson's (PD), amyotrophic lateral sclerosis (ALS) Huntington's (HD), are complex multifaceted. A growing body evidence suggests that the gut microbiome plays crucial roles in development progression diseases. Clinicians have come to realize therapeutics targeting potential halt This narrative review examines alterations AD, PD, ALS HD, highlighting close relationship between brain Processes mediate microbiome-brain communication including immunological, vagus nerve circulatory pathways, evaluated. Furthermore, we summarize for diseases modify its metabolites, diets, probiotics prebiotics, microbial antibacterials faecal transplantation. Finally, current challenges future directions discussed.
Language: Английский
Citations
19
Ageing Research Reviews, Journal Year: 2025, Volume and Issue: 104, P. 102659 - 102659
Published: Jan. 10, 2025
Language: Английский
Citations
2
Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 178, P. 117277 - 117277
Published: Aug. 9, 2024
Language: Английский
Citations
13
Nutrients, Journal Year: 2024, Volume and Issue: 16(5), P. 590 - 590
Published: Feb. 21, 2024
Amyotrophic Lateral Sclerosis (ALS) is a highly fatal neurodegenerative disorder characterized by the progressive wasting and paralysis of voluntary muscle. Despite extensive research, etiology ALS remains elusive, effective treatment options are limited. However, recent evidence implicates gut dysbiosis gut-brain axis (GBA) dysfunction in pathogenesis. Alterations to composition diversity microbial communities within flora have been consistently observed patients. These changes often correlated with disease progression patient outcome, suggesting that GBA modulation may therapeutic potential. Indeed, targeting microbiota has shown be neuroprotective several animal models, alleviating motor symptoms mitigating progression. translation these findings human patients challenging due complexity pathology varying microbiota. This review comprehensively summarizes current literature on ALS-related dysbiosis, focusing implications dysfunction. It delineates three main mechanisms which contributes pathology: compromised intestinal barrier integrity, metabolic dysfunction, immune dysregulation. also examines preclinical potential gut-microbiota-modulating agents (categorized as prebiotics, probiotics, postbiotics) ALS.
Language: Английский
Citations
7
Gut Microbes, Journal Year: 2024, Volume and Issue: 16(1)
Published: June 21, 2024
Gut bacteria regulate brain pathology of Alzheimer's disease (AD) patients and animal models; however, the underlying mechanism remains unclear. In this study, 3-month-old APP-transgenic female mice with without knock-out Il-17a gene were treated antibiotics-supplemented or normal drinking water for 2 months. The antibiotic treatment eradicated almost all intestinal bacteria, which led to a reduction in Il-17a-expressing CD4-positive T lymphocytes spleen gut, decrease bacterial DNA tissue. Depletion gut inhibited inflammatory activation both tissue microglia, lowered cerebral Aβ levels, promoted transcription Arc mice, effects abolished by deficiency Il-17a. As possible mechanisms regulating pathology, depletion β-secretase activity increased expression Abcb1 Lrp1 at blood-brain barrier, also reversed absence Interestingly, crossbreeding experiment between knockout further showed that had already barrier. Thus, attenuates amyloid via Il-17a-involved signaling pathways. Our study contributes better understanding gut-brain axis AD pathophysiology highlights therapeutic potential inhibition specific stimulate development cells.
Language: Английский
Citations
7
MedComm, Journal Year: 2024, Volume and Issue: 5(4)
Published: March 15, 2024
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) recently caused a global pandemic, resulting in more than 702 million people being infected and over 6.9 deaths. Patients with disease (COVID-19) may suffer from diarrhea, sleep disorders, depression, even cognitive impairment, which is associated long COVID during recovery. However, there remains no consensus on effective treatment methods. Studies have found that patients COVID-19 alterations microbiota their metabolites, particularly the gut, be involved regulation of immune responses. Consumption probiotics alleviate discomfort by inflammation oxidative stress. pathophysiological process underlying alleviation COVID-19-related symptoms complications targeting unclear. In current study, we summarize latest research evidence together SARS-CoV-2 vaccine use, focus relationship between use. This work provides probiotic-based interventions improve regulating gut systemic immunity. Probiotics also used as adjuvants to efficacy.
Language: Английский
Citations
6
Neurotherapeutics, Journal Year: 2024, Volume and Issue: 21(6), P. e00470 - e00470
Published: Oct. 1, 2024
Multiple studies over the last decade have established that Alzheimer's disease and related dementias (ADRD) are associated with changes in gut microbiome. These alterations organismal composition result abundances of functions encoded by microbial community, including metabolic capabilities, which likely impact host mechanisms. Gut microbes access dietary components other molecules made produce metabolites can enter circulation cross blood-brain barrier (BBB). In recent years, several been or shown to influence pathways relevant ADRD pathology. include short chain fatty acids, secondary bile tryptophan derivatives (such as kynurenine, serotonin, tryptamine, indoles), trimethylamine/trimethylamine N-oxide. Notably, some these BBB various effects on brain, modulating release neurotransmitters neuronal function, inducing oxidative stress inflammation, impacting synaptic function. Microbial also central nervous system through immune, enteroendocrine, enteric pathways, perturbations turn function peripheral immune responses, well integrity, homeostasis neurogenesis, glial cell maturation activation. This review examines evidence supporting notion is influenced microbiota its metabolites. The potential therapeutic advantages for preventing treating discussed, highlighting their role developing new treatments.
Language: Английский
Citations
6
Frontiers in Aging Neuroscience, Journal Year: 2024, Volume and Issue: 16
Published: Aug. 21, 2024
Introduction Alzheimer’s disease (AD), a major cause of dementia globally, imposes significant societal and personal costs. This review explores the efficacy physical exercise as non-pharmacological intervention to mitigate impacts AD. Methods draws on recent studies that investigate effects neuroinflammation neuronal enhancement in individuals with Results Consistent alters neuroinflammatory pathways, enhances cognitive functions, bolsters brain health among AD patients. It favorably influences activation states microglia astrocytes, fortifies integrity blood-brain barrier, attenuates gut inflammation associated These changes are substantial improvements performance indicators. Discussion The findings underscore potential integrating into comprehensive management strategies. Emphasizing necessity for further research, this advocates refinement regimens maximize their enduring benefits decelerating progression
Language: Английский
Citations
5
mBio, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 31, 2025
Sepsis-induced acute liver injury (SALI) is a prevalent and life-threatening complication associated with sepsis. The gut microbiota plays crucial role in the maintenance of health development diseases. impact physical exercise on modulation has been well-documented. However, potential microbiome training-induced protection against SALI remains uncertain. Here, we discovered training ameliorated systemic inflammation septic mice. Notably, pre-depletion abolished protective effects Fecal transplantation treatment revealed that training-associated contributed to beneficial effect SALI. Exercise modulated metabolism Ligilactobacillus enriched betulinic acid (BA) levels Functionally, BA conferred by inhibiting hepatic inflammatory response bound inactivated hnRNPA2B1, thus suppressing NLRP3 inflammasome activation macrophages. Collectively, this study reveals involved SALI, microbiota-derived inhibits via hnRNPA2B1-NLRP3 axis, providing therapeutic strategy for Sepsis characterized dysregulated immune an infection leads multiple organ dysfunction. occurrence frequently observed during initial stage sepsis directly linked mortality intensive care unit. preventive well recognized, yet underlying mechanism poorly elucidated. alters mice, increasing abundance promoting generation BA. Additionally, supplementation can suppress macrophages binding thereby mitigating These results highlight response, which represents stride toward implementing microbiome-based strategies clinical management
Language: Английский
Citations
0