Research trends on cancer neuroscience: a bibliometric and visualized analysis DOI Creative Commons

Xinru Ma,

Kun Deng, Yingnan Sun

et al.

Frontiers in Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: Aug. 29, 2024

Background Recently, cancer neuroscience has become the focus for scientists. Interactions between nervous system and (both systemic local) can regulate tumorigenesis, progression, treatment resistance, compromise of anti-cancer immunity, provocation tumor-promoting inflammation. We assessed related research on through bibliometric analysis explored status hotspots from 2020 to 2024. Methods Publications retrieved Web Science Core Collection. CiteSpace, VOSviewer, Scimago Graphica were used analyze visualize result. Results A total 744 publications retrieved, with an upward trend in overall number articles published over last 5 years. As it highest ( n = 242) citations (average 13.63 per article), United States holds absolute voice field neuroscience. The most productive organizations journals Shanghai Jiaotong University 24) Cancers 45), respectively. Monje M (H-index 53), Hondermarck H 42), Amit 39) three researchers who have contributed field. From a global perspective, comprise nerve/neuron-tumor cell interactions, crosstalk other components tumor microenvironment (such as immune cells), well impact tumors therapies function. Conclusion European countries are dominating neuroscience, while developing such China growing rapidly but limited impact. next focal point this is likely be neurotrophic factors. Cancer still its infancy, which means that many interactions mechanisms not yet fully understood. Further investigation necessary probe subpopulations microenvironment.

Language: Английский

NMDAR antagonists suppress tumor progression by regulating tumor-associated macrophages DOI Creative Commons

Dongchen Yuan,

Jing Hu, Xiaoman Ju

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2023, Volume and Issue: 120(47)

Published: Nov. 15, 2023

Neurotransmitter receptors are increasingly recognized to play important roles in anti-tumor immunity. The expression of the ion channel N-methyl-D-aspartate receptor (NMDAR) on macrophages was reported, but role NMDAR tumor microenvironment (TME) remains unknown. Here, we show that activation triggered calcium influx and reactive oxygen species production, which fueled immunosuppressive activities tumor-associated (TAMs) hepatocellular sarcoma fibrosarcoma settings. antagonists, MK-801, memantine, magnesium, effectively suppressed these processes TAMs. Single-cell RNA sequencing analysis revealed blocking functionally metabolically altered TAM phenotypes, such they could better promote T cell- Natural killer (NK) cell-mediated Treatment with antagonists combination anti-PD-1 antibody led elimination majority established preclinical liver tumors. Thus, our study uncovered an unknown for regulating TME provided a rationale targeting immunotherapy.

Language: Английский

Citations

13
Novel therapeutic strategies in glioma targeting glutamatergic neurotransmission DOI
Ashwin Kumaria,

Keyoumars Ashkan

Brain Research, Journal Year: 2023, Volume and Issue: 1818, P. 148515 - 148515

Published: Aug. 3, 2023

Language: Английский

Citations

12
Advancing Glioblastoma Therapy: Learning From the Past and Innovations for the Future DOI

Mandeep Rana,

Ke-Chi Liou,

Amandeep Thakur

et al.

Cancer Letters, Journal Year: 2025, Volume and Issue: unknown, P. 217601 - 217601

Published: March 1, 2025

Language: Английский

Citations

0
A urine DNA methylation assay for early detection of renal cancer DOI

Tongshuai Shi,

Hanzhong Chen, Zhifeng Wang

et al.

Oncogene, Journal Year: 2025, Volume and Issue: unknown

Published: March 17, 2025

Language: Английский

Citations

0
Cancer neuroscience in head and neck: interactions, modulation, and therapeutic strategies DOI Creative Commons
Hanrui Wang, Xiaoyu Song, Hui Shen

et al.

Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)

Published: March 31, 2025

Head and neck cancer (HNC) is an aggressive malignancy with significant effects on the innervation. Not only it at top of spectrum a dismal prognosis, but also imposes considerable stress patients society owing to frequent neurological symptoms. With progress in neuroscience, interactions between HNC nervous system, as well underlying mechanisms, have become increasingly clear. Compelling evidence suggests communication information nerve cells devastation system tumor growth. However, thorough grasp neuroscience has been severely constrained by intricacy fragmented research. This review comprehensively organizes summarizes latest research crosstalk system. It aims clarify various aspects HNC, including physiology, progression, treatment cancer. Furthermore, opportunities challenges are discussed, which offers fresh perspectives diagnosis management.

Language: Английский

Citations

0
Rosmarinus officinalis L. as Fascinating Source of Potential Anticancer Agents Targeting Aromatase and COX-2: An Overview DOI Creative Commons
Adriana Gargano,

Ilario Greco,

Carmine Lupia

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(8), P. 1733 - 1733

Published: April 12, 2025

Cancer is the second leading cause of death in world, with scientific evidence indicating that enzymes aromatase and cyclooxygenase 2 are upregulated several types cancer. Over past 30 years, natural compounds have played a crucial role cancer chemotherapy, to date, many phytocompounds been reported interact these enzymes, inhibiting their activity. Notably, found Rosmarinus officinalis L., medicinal plant native Mediterranean region cultivated around shown ability enzymes. This review examines main contained L. as potential anticancer agents acting on cyclooxygenase-2.

Language: Английский

Citations

0
Neurotransmitter power plays: the synaptic communication nexus shaping brain cancer DOI Creative Commons
Jayanta Mondal, Jason T. Huse

Acta Neuropathologica Communications, Journal Year: 2025, Volume and Issue: 13(1)

Published: April 30, 2025

Gliomas and brain metastases are notorious for their dismal prognosis low survival rates, a challenge exacerbated by our incomplete grasp of the complex dynamics that govern cancers. Recently, groundbreaking paradigm shift has emerged, highlighting crucial role synaptic communication between neurons tumor cells in reshaping neuronal signaling to favor growth. This review delves into pivotal interplay mechanisms, focusing on excitatory glutamatergic inhibitory GABAergic pathways. Glutamatergic synapses utilize glutamate propagate signals, while employ gamma-aminobutyric acid (GABA) inhibit firing. can be broadly classified ionotropic (NMDAR, AMPAR kainite receptors) metabotropic subtypes. The harmonious orchestration these types is essential normal function, dysregulation implicated neurodegenerative disorders such as Alzheimer's disease epilepsy. Emerging evidence reveals glioma metastatic exploit pathways neurotransmitters enhance proliferation survival. In this review, we will first explore intricate mechanisms underlying signaling. Next, summarize recent advancements understanding how cancer hijack advantage. Finally, propose novel therapeutic strategies aimed at disrupting aberrant neuron-tumor communication, offering potential treatment combating otherwise incurable

Language: Английский

Citations

0
Cancer-nervous system crosstalk: from biological mechanism to therapeutic opportunities DOI Creative Commons
Sirui Huang, Jing Zhu,

Liuting Yu

et al.

Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)

Published: May 5, 2025

A growing body of research suggests a bidirectional interaction between cancer and the nervous system. Neural cells exert their effects on tumors by secreting neurotransmitters cell adhesion molecules, which interact with specific receptors tumor to modulate behavior. Conversely, tumor-secreted factors, particularly including inflammatory can alter neural activity increase neuronal excitability, potentially contributing neurological manifestations such as epilepsy. The immune system also serves crucial intermediary in indirect communication These insights have opened promising avenues for novel therapeutic strategies targeting both associated complications. In this review, we synthesized key biological mechanisms underlying cancer-nervous interactions that emerged over past decade. We outline molecular cellular pathways mediating cross-talk explore clinical implications suppress growth metastasis, mitigate complications arising from progression, response through regulation context therapy.

Language: Английский

Citations

0
Photogenetic‐Like Liposomes Disrupt Neuroligin‐3 Dependency to Enhance Glioma Treatment DOI

Mengbin Ding,

Peng Liu, Yuan Xue

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: May 6, 2025

Abstract Neuronal activity is shown to potentiate glioma initiation, progression, and/or metastasis. A key mechanism in neural regulation of brain cancer involves the activity‐dependent cleavage and release synaptic adhesion molecule neuroligin‐3 (NLGN3). Here, this report describes preparation optogenetics‐like liposome Lip‐CuRA, which used regulate content NLGN3 neurons mediate phototherapy cells. Lip‐CuRA contains upconversion nanoparticles encapsulating CuS (CuS@PUCNPs), a visible light‐activated neurotransmitter prodrug RuBi‐GABA, disintegrin metalloproteinase (ADAM10) inhibitors GI254023X. Upon 980 nm laser irradiation, photothermal conversion not only induces tumor cell apoptosis, but also destroys structure, releasing Rubi‐GABA The UCNPs convert into 540 nm, activating RuBi‐GABA GABA. GABA selectively opens Cl⁻ channels nerve cells, reducing expression degree axonal connections. GI254023X inhibits ADAM10 enzyme on surface, NLGN3, thereby blocking transmission proliferation stemness signals. In GL261‐luc orthotopic model, C6‐luc patient‐derived xenograft (PDX) effectively recurrence, reduces stemness, extends survival through synergistic NLGN3‐regulating therapy.

Language: Английский

Citations

0
Bionic opto-responsive fiber for directing neurite growth DOI Creative Commons
Christoph Müller, Pengju Li, Yuzhuo Wang

et al.

Materials Today Nano, Journal Year: 2023, Volume and Issue: 22, P. 100311 - 100311

Published: Jan. 21, 2023

Mounting evidence indicates that the nervous system plays a central function in pathogenesis. To study association of diseases, tools allow delicate control neural behavior are crucial. Wireless electrical modulation cells via opto-stimulation is an emerging approach to trigger and behavior. Furthermore, imitate highly organized natural network, neurite outgrowth needs be guided achieve directionality. This work successfully combines bionic fibers with nano-groove topography evident opto-response guide outgrowth. With excellent biocompatibility, opto-responsive spatiotemporally controlled PC12 Transient photocurrent measurement revealed this effect was attributed anodic faradaic photocurrents. fiber has great potential act as tool system/disease interaction.

Language: Английский

Citations

9