Advances in Gerontology, Journal Year: 2024, Volume and Issue: 14(4), P. 151 - 160
Published: Dec. 1, 2024
Language: Английский
Cancer Letters, Journal Year: 2025, Volume and Issue: unknown, P. 217544 - 217544
Published: Feb. 1, 2025
Language: Английский
Citations
1
Ageing Research Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 102694 - 102694
Published: Feb. 1, 2025
Language: Английский
Citations
1
Nature reviews. Immunology, Journal Year: 2024, Volume and Issue: 24(12), P. 912 - 928
Published: Nov. 7, 2024
Language: Английский
Citations
4
The Journal of Biochemistry, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 6, 2025
Abstract As the global population continues to age, understanding complex role of cellular senescence and its implications in healthy lifespans has gained increasing prominence. Cellular is defined as irreversible cessation cell proliferation, accompanied by secretion a range pro-inflammatory factors, collectively termed senescence-associated secretory phenotype (SASP), response various stresses. While accumulation senescent cells been strongly implicated aging process pathogenesis age-related diseases owing their properties, recent research also highlighted essential roles processes such tumour suppression, tissue development, repair. This review provides comprehensive examination dual nature cells, evaluating deleterious contributions chronic inflammation, dysfunction, disease, well beneficial maintaining physiological homeostasis. Additionally, we explored therapeutic potential senolytic agents designed selectively eliminate detrimental while considering delicate balance between transient persistence pathological senescence. A deeper these dynamics critical develop novel interventions aimed at mitigating dysfunctions enhancing life expectancies.
Language: Английский
Citations
0
Nature Aging, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 15, 2025
Language: Английский
Citations
0
Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)
Published: Feb. 18, 2025
The persistent accumulation of senescence cells is one the characteristics radiation-induced skin injury (RISI), leading to fibrosis and impaired healing. However, reasons why these are resistant clearance remain unclear. mouse RISI model was established using an X-ray generator, a shield used cover all areas except right leg or back for protecting surrounding tissue. ScRNA sequencing, immunohistochemistry, immunofluorescence, qPCR, western blot, primary cell co-culture system fluorescence microsphere phagocytosis assay were performed functional mechanistic investigations. dynamic changes levels multiple immune during evaluated, we found that macrophages could remove from dermis, ability gradually strengthens over time. sequencing revealed with high capacity exhibited increased NOD-like receptor family pyrin domain-containing 3 (NLRP3) expression compared those low capacity. Inhibition conditional knockout Nlrp3 in led dysfunction Further studies interleukin-33 secreted by inhibited NLRP3 their phagocytize cells, especially early stages after radiation. In addition, Nocardia rubra wall skeleton (Nr-CWS), approved immunomodulator, activate macrophage expression, reduce burden, accelerate healing RISI. This study underscored as critical intervention target immunosurveillance emphasized Nr-CWS potential therapeutic agent accelerating
Language: Английский
Citations
0
Nature Aging, Journal Year: 2025, Volume and Issue: unknown
Published: March 4, 2025
Language: Английский
Citations
0
Cell Reports Methods, Journal Year: 2025, Volume and Issue: 5(3), P. 101006 - 101006
Published: March 1, 2025
Language: Английский
Citations
0
Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)
Published: April 2, 2025
Cellular senescence, a stable state of cell cycle arrest induced by various stressors or genomic damage, is recognized as hallmark cancer. It exerts context-dependent dual role in cancer initiation and progression, functioning tumor suppressor promoter. The complexity senescence arises from its mechanistic diversity, potential reversibility, heterogeneity. A key mediator these effects the senescence-associated secretory phenotype (SASP), repertoire bioactive molecules that influence microenvironment (TME) remodeling, modulate behavior, contribute to therapeutic resistance. Given intricate biology, presents both challenges opportunities for intervention. Strategies targeting pathways, including senescence-inducing therapies senolytic approaches, offer promising avenues treatment. This review provides comprehensive analysis regulatory mechanisms governing cellular tumors. We also discuss emerging strategies highlighting novel opportunities. deeper understanding processes essential developing precision improving clinical outcomes.
Language: Английский
Citations
0
Toxicology Research, Journal Year: 2025, Volume and Issue: 14(2)
Published: March 1, 2025
Abstract Fine particulate matter (PM2.5) exposure is significantly linked to lung epithelial cell senescence, and autophagy dysfunction being a key contributor the aging process. Although anti-aging properties of ellagic acid (EA) are well-documented, its specific protective effect on PM2.5-induced senescence still needs be studied in depth. To investigate impacts PM2.5 cells, 16HBE A549 cells were exposed suspension. Additionally, explore potential intervention EA, pretreated with EA before Cell morphology, proliferation, senescence-related markers, senescence-associated secretory phenotype (SASP), autophagy-related markers then assessed. Our results showed that proliferation inhibited induced under exposure. However, pretreatment can improve obstruction flux caused by PM2.5, thereby effectively alleviating senescence. This study reveals mechanism which induces confirms role this
Language: Английский
Citations
0