Targeting the gut and tumor microbiota in cancer

Nature Medicine, Journal Year: 2022, Volume and Issue: 28(4), P. 690 - 703

Published: April 1, 2022

Language: Английский

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Organic and Inorganic Carbon Sinks Reduce Long‐Term Deep Carbon Emissions in the Continental Collision Margin of the Southern Tibetan Plateau: Implications for Cenozoic Climate Cooling

Journal of Geophysical Research Solid Earth, Journal Year: 2024, Volume and Issue: 129(4)

Published: April 1, 2024

Abstract This paper aims to update our understanding of the carbon cycle in Himalayas, most intense collisional orogeny globally, by providing new insight into its impact on Cenozoic climate cooling through use isotopic variations both organic and inorganic an mass balance model. Our results from 20 selected hot springs show that relative contributions dissolved mantle, metamorphic decarbonization, aqueous dissolution, soil matter are approximately 2%, 82%, 6%, 10%, respectively. Approximately 87% ± 5% CO 2 generated deep crust precipitates as calcite, while 5.5% 1% this is converted biomass microbial chemosynthesis at depths less than km. random forests approach yielded a flux entire Himalayan orogenic belt 2.7 ∼ 4.5 × 10 12 mol/yr. The minor released atmosphere (2.5 4.2 11 mol/yr) comparable consumption driven weathering. provides insights cycling, notably 93% deeply sourced trapped shallow crust, rendering processes neutral possibly acting one major triggers long‐term Cenozoic.

Language: Английский

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Methane-hydrogen-rich fluid migration may trigger seismic failure in subduction zones at forearc depths

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Jan. 11, 2024

Abstract Metamorphic fluids, faults, and shear zones are carriers of carbon from the deep Earth to shallower reservoirs. Some these fluids reduced transport energy sources, like H 2 light hydrocarbons. Mechanisms pathways capable transporting sources towards reservoirs remain unidentified. Here we present geological evidence failure mechanically strong rocks due accumulation CH 4 -H -rich at forearc depths, which ultimately reached supralithostatic pore fluid pressure. These originated adjacent reduction carbonates by during serpentinization eclogite-to-blueschist-facies conditions. Thermodynamic modeling predicts that production aqueous can produce overpressure more easily than carbon-poor CO fluids. This study provides for migration along tectonic discontinuities, suggests causal relationships with brittle hard rock types may trigger seismic activity depths.

Language: Английский

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Chemolithoautotroph distributions across the subsurface of a convergent margin

The ISME Journal, Journal Year: 2022, Volume and Issue: 17(1), P. 140 - 150

Published: Oct. 18, 2022

Language: Английский

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Coupled surface to deep Earth processes: Perspectives from TOPO-EUROPE with an emphasis on climate- and energy-related societal challenges

Global and Planetary Change, Journal Year: 2023, Volume and Issue: 226, P. 104140 - 104140

Published: May 12, 2023

Understanding the interactions between surface and deep Earth processes is important for research in many diverse scientific areas including climate, environment, energy, georesources biosphere. The TOPO-EUROPE initiative of International Lithosphere Program serves as a pan-European platform integrated sciences, synergizing observational studies structure fluxes on all spatial temporal scales with modelling processes. This review provides survey developments our quantitative understanding coupled surface-deep achieved through TOPO-EUROPE. most notable innovations include (1) process-based connection upper mantle dynamics absolute plate motion frames; (2) models sediment source-to-sink dynamics, demonstrating importance mass transfer from mountains to basins basin basin; (3) demonstration key role polyphase evolution sedimentary basins, impact pre-rift pre-orogenic structures, subsequent lithosphere landscape dynamics; (4) improved conceptual back-arc extension tectonic inversion onset subduction; (5) explain strength Europe's lithosphere; (6) concepts governing interplay thermal stress-induced intraplate deformation; (7) constraints record vertical motions high-resolution data sets obtained geo-thermochronology topographic evolution; (8) recognition quantifications forcing by erosional and/or glacial-interglacial regional magmatism, major implications carbon cycle geological timescales emerging field biogeodynamics; (9) insights coupling domain geothermal energy exploration. Concerning future agenda TOPO-EUROPE, we also discuss rich potential further advances, multidisciplinary community building across frontiers, biosphere, climate energy. These will focus obtaining better insight into initiation subduction systems, plumes continental rifting (super)continent break-up, deformation reactivation cratons; interaction geodynamic, processes, such glaciation, sea level change processes; sensitivity, tipping points, spatio-temporal tectonics well rock melting outgassing affecting interactions; biogeodynamics, that – life Earth; tightening societal challenges regarding renewable georesources, change, natural geohazards, novel process-understanding system.

Language: Английский

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The Helium and Carbon Isotope Characteristics of the Andean Convergent Margin

Frontiers in Earth Science, Journal Year: 2022, Volume and Issue: 10

Published: June 13, 2022

Subduction zones represent the interface between Earth’s interior (crust and mantle) exterior (atmosphere oceans), where carbon other volatile elements are actively cycled Earth reservoirs by plate tectonics. Helium is a sensitive tracer of sources can be used to deconvolute mantle crustal in arcs; however it not thought recycled into subduction processes. In contrast, readily recycled, mostly form carbon-rich sediments, thus understand delivery via subduction. Further, chemically-reactive isotope fractionation determine main processes controlling movements within arc systems. Here, we report helium abundance data for 42 deeply-sourced fluid gas samples from Central Volcanic Zone (CVZ) Southern (SVZ) Andean Convergent Margin (ACM). Data assess influence parameters (e.g., thickness, inputs, convergence rate) on composition volatiles surface volcanic emissions. He isotopes CVZ backarc range 0.1 2.6 R A ( n = 23), with highest values Puna lowest Sub-Andean foreland fold-and-thrust belt. Atmosphere-corrected SVZ 0.7 5.0 19). Taken together, these reveal clear southeastward increase 3 He/ 4 He, (in SVZ) falling below nominal associated pure upper (8 ± 1 ), approaching mean value gases (5.4 1.9 ). Notably, found CVZ, suggesting more significant inputs (i.e., assimilation He) budget. The thickness (up 70 km) significantly larger than SVZ, just ∼40 km. We suggest that exerts primary control extent fluid-crust interaction, as rise through ACM. also 11) sites δ 13 C varies −15.3‰ −1.2‰ [vs. Vienna Pee Dee Belemnite (VPDB)] CO 2 / vary over two orders magnitude (6.9 × 10 8 –1.7 11 ratios reported 13) −17.2‰ −4.1‰. four (4.7 7 12 Low consistent removal calcite precipitation dissolution) shallow hydrothermal Carbon modeling suggests occurs at temperatures coincident temperature limit life (122°C), biology may play role C-He systematics arc-related

Language: Английский

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Terrigenous dissolved organic matter persists in the energy-limited deep groundwaters of the Fennoscandian Shield

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: Aug. 17, 2022

The deep terrestrial biosphere encompasses the life below photosynthesis-fueled surface that perseveres in typically nutrient and energy depleted anoxic groundwaters. composition cycling of this vast dissolved organic matter (DOM) reservoir relevant to global carbon cycle remains be deciphered. Here we show recent Baltic Sea-influenced ancient pre-Holocene saline Fennoscandian Shield bedrock fracture waters carried DOM with a strong terrigenous signature varying contributions from abiotic biotic processes. Removal easily degraded at surface-to-groundwater transition corresponding microbial community assembly processes likely resulted highly similar signatures across notably different water types selected for core microbiome. In combination aliphatic character, δ13C indicated production oldest, groundwater. Our study revealed persistence terrestrially-sourced severely limited continental groundwaters supporting life.

Language: Английский

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mebipred: identifying metal-binding potential in protein sequence

Bioinformatics, Journal Year: 2022, Volume and Issue: 38(14), P. 3532 - 3540

Published: May 27, 2022

metal-binding proteins have a central role in maintaining life processes. Nearly one-third of known protein structures contain metal ions that are used for variety needs, such as catalysis, DNA/RNA binding, structure stability, etc. Identifying is thus crucial understanding the mechanisms cellular activity. However, experimental annotation potential severely lacking, while computational techniques often imprecise and limited applicability.we developed novel machine learning-based method, mebipred, identifying from sequence-derived features. This method over 80% accurate recognizing bind ion-containing ligands; specific identity 11 ubiquitously present can also be annotated. mebipred reference-free, i.e. no sequence alignments involved, faster than alignment-based methods; it more other sequence-based prediction methods. Additionally, identify capabilities short stretches, e.g. translated sequencing reads, and, thus, may useful requirements metagenomic samples. We performed an analysis available microbiome data found ocean, hot spring sediments soil microbiomes use diverse set metals human host-related ones. For microbiomes, physiological conditions explain observed preferences. Similarly, subtle changes ocean sample ion concentration affect abundance relevant proteins. These results highlight mebipred's utility analyzing requirements.mebipred web server at services.bromberglab.org/mebipred standalone package https://pypi.org/project/mymetal/.Supplementary Bioinformatics online.

Language: Английский

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Sampling across large-scale geological gradients to study geosphere–biosphere interactions

Frontiers in Microbiology, Journal Year: 2022, Volume and Issue: 13

Published: Oct. 31, 2022

Despite being one of the largest microbial ecosystems on Earth, many basic open questions remain about how life exists and thrives in deep subsurface biosphere. Much this ambiguity is due to fact that it exceedingly difficult often prohibitively expensive directly sample subsurface, requiring elaborate drilling programs or access mines. We propose a sampling approach which involves collection large suite geological, geochemical, biological data from numerous deeply-sourced seeps—including lower temperature sites—over spatial scales. This enables research into interactions between geosphere biosphere, expanding classical local regional even planetary Understanding interplay geology, geochemistry biology such scales essential for building ecosystem models extrapolating ecological biogeochemical roles microbes beyond single site interpretations. has been used successfully across Central South American Convergent Margins, can be applied more broadly other types geological regions (i.e., rifting, intraplate volcanic, hydrothermal settings). Working inherently encompasses broad temporal (e.g., millions years volatile cycling convergent margin), providing framework interpreting evolution functions through time space. tectonic are fundamental maintaining habitability feedbacks stabilize ecosphere, biosphere studies understanding geo-bio these processes global scale.

Language: Английский

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Tectonic settings influence the geochemical and microbial diversity of Peru hot springs

Communications Earth & Environment, Journal Year: 2023, Volume and Issue: 4(1)

Published: April 11, 2023

Abstract Tectonic processes control hot spring temperature and geochemistry, yet how this in turn shapes microbial community composition is poorly understood. Here, we present geochemical 16 S rRNA gene sequencing data from 14 springs contrasting styles of subduction along a convergent margin the Peruvian Andes. We find that tectonic influence on geochemistry composition. Hot flat-slab back-arc regions system had similar pH but differed microbiology, with significant relationships between composition, geologic setting. Flat-slab were chemically heterogeneous, modest surface temperatures (up to 45 °C), dominated by members metabolically diverse phylum Proteobacteria. Whereas, geochemically more homogenous, exhibited high concentrations dissolved metals gases, higher 81 host thermophilic archaeal bacterial lineages.

Language: Английский

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