Common genetic variants are associated with increased likelihood of some co-occurring mental health conditions among autistic individuals DOI Creative Commons
Adeniran Okewole, Vincent-Raphaël Bourque, Mahmoud Koko

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 11, 2024

ABSTRACT IMPORTANCE Autism frequently co-occurs with other mental health conditions. In the general population, these co-occurring conditions are highly heritable and genetically correlated; however, genetic architecture of among autistic individuals is unclear. OBJECTIVE To investigate relationship between common rare variation latent factors individuals. DESIGN Cross-sectional SETTING The study was conducted Simons Foundation Powering Research (SPARK) dataset, V9 release (12 December 2022). PARTICIPANTS Phenotypic data exploration factor analyses in 74,204 individuals, were a maximum 17,582 data. MAIN OUTCOMES AND MEASURES Genetic analysis limited to those probands included SPARK iWES1 dataset [n=17,582]. SNP heritability estimates correlations computed for three scores six diagnostic categories (attention deficit hyperactivity disorder or ADHD, bipolar disorder, depression, schizophrenia, anxiety disruptive behaviour disorders DBD) using bivariate GCTA-GREML LDSC. Polygenic generated summary statistics from most recent genome wide association studies (GWAS) five traits Associations categorical diagnoses tested separately polygenic (PGS), de novo variants (DNVs) copy number (CNVs). RESULTS 56% presented psychiatric condition. Confirmatory identified minimally correlated factors: behavioural factor, cothymic ‘Kraepelin’ thought heritabilities ranging 0.21 (s.e. 0.02) 0.09 0.03) factor. Among conditions, moderate significant heritabilites observed ADHD (0.18, s.e. = 0.04) DBD (0.52, 0.08). Moderate positive found DBD, corresponding external population cohorts. PGS educational attainment significantly associated all some tested. We no evidence an autism, CNVs, DNVs constrained genes increased likelihood phenotypes CONCLUSION RELEVANCE heritable, but have distinct autism itself. Key Points Question Do contribute individuals? Findings this cross-sectional without we single nucleotide polymorphism (SNP) Disruptive Behaviour Disorders (DBD), mental-health factors. Co-occurring anxiety, had case-control GWAS. linking linked Meaning correlates that suggesting additional development

Language: Английский

Advancing health-care equity for autistic people: mental health as a key priority DOI
David Wechsler, William Mandy, Meng‐Chuan Lai

et al.

The Lancet, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
Mental Health challenges among individuals with disabilities and their caregivers: A cross-sectional study in Vietnam DOI

Cong Minh Le,

Diem Ngoc Bui

Multidisciplinary Science Journal, Journal Year: 2025, Volume and Issue: 7(9), P. 2025496 - 2025496

Published: March 4, 2025

People with disabilities (PWD) and their caregivers encounter considerable mental health difficulties stemming from physical, psychological, social pressures. Depression anxiety are widespread in both demographics, intensified by societal stigma, restricted healthcare access, financial constraints. Although caregiving offers emotional satisfaction, it also entails psychological physical burdens, affecting the well-being of persons (PWD). This study aims to evaluate prevalence depression among disabilities, emphasizing burden experienced groups. It elucidate interrelated aspects experiences guide effective interventions policy suggestions. A cross-sectional was performed involving 1,847 people Dong Nai Tay Ninh provinces Vietnam. levels were assessed utilizing Vietnamese adaptations Generalized Anxiety Disorder-7 (GAD-7) Patient Health Questionnaire-9 (PHQ-9). Statistical studies, encompassing independent t-tests, employed compare outcomes between caretakers demonstrated markedly elevated (M = 0.48, SD 0.54) 0.43, 0.57) contrast caregivers, who exhibited reduced scores for 0.25, 0.38) 0.28, 0.46) (p < 0.001). These data suggest that although endure significant suffering, those disproportionately impacted issues. The research underscores immediate necessity specialized therapies individuals caretakers. Enhancing access specialist services, mitigating offering structured caregiver support programs essential improving these populations. Policies must prioritize integration care within comprehensive disability frameworks foster inclusive sustainable solutions.

Language: Английский

Citations

0
Examining an integrated path model of psychological and sociocultural predictors of camouflaging in autistic adults DOI Creative Commons
Sici Zhuang, Mackenzie Bougoure,

Dawn-joy Leong

et al.

Autism, Journal Year: 2024, Volume and Issue: unknown

Published: July 27, 2024

Camouflaging involves various strategies employed by autistic individuals to modulate the visibility of their characteristics in social situations and is thought be primarily motivated psychosocial factors. Most studies date have examined a limited number factors related camouflaging. This study tested an integrated model encompassing several hypothesised individual psychological (i.e. fear negative evaluation, self-esteem, identity) broader sociocultural predictors perceived stigma, vulnerability events, cultural tightness-looseness, independent interdependent self-construal). Participants were 225 adults (18–77 years; 60.9% female), who completed self-report measures online. Path analysis partially supported model, explaining about 25% variance Several – tightness self-construal indirectly associated with camouflaging through Notably, greater life events was only factor directly contributing more camouflaging, without mediation Fear evaluation emerged as strong predictor, mediating most relationships between Our findings highlight key crucial targets for change, advocating shift from stigmatisation acceptance inclusion alleviate pressure on people camouflage. Lay abstract Many use known ‘camouflaging’ change how noticeable traits are situations. Previous research suggests that largely However, so far looked at few In this study, we explored included (such being negatively judged, self-esteem emphasis conformity desire fit or stand out). We surveyed aged 18–77 years showed linked judged predictor Specifically, felt conform, had lesser out tended experience reported addition, those experienced likely engage identifies potential change. emphasise our societies need away stigmatising attitudes towards accepting including people, which could reduce camouflage

Language: Английский

Citations

3
Camouflaging, internalized stigma, and mental health in the general population DOI Creative Commons
Wei Ai, William A. Cunningham, Meng‐Chuan Lai

et al.

International Journal of Social Psychiatry, Journal Year: 2024, Volume and Issue: 70(7), P. 1239 - 1253

Published: Aug. 11, 2024

Camouflaging, the strategies that some autistic people use to hide their differences, has been hypothesized trigger mental health ramifications. Camouflaging might reflect ubiquitous impression management experiences are not unique and similarly impact of non-autistic people.

Language: Английский

Citations

3
“Consistent Support Is Good for My Mental Health”—Exploring the Lived Experience of Autistic Mental Health DOI
Katherine Browne, Wenn Lawson, Sarah McGarry

et al.

Autism in Adulthood, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 10, 2024

Language: Английский

Citations

2
What are social autistic traits and how do they affect quality of life? A causal inference approach DOI Open Access
Johan Pieslinger, Erik Igelström, Kajsa Igelström

et al.

Published: Feb. 28, 2024

BackgroundThe social interaction styles of autistic individuals are determined by neural differences across multiple brain systems, and these not necessarily pathological in nature or entirely specific for autism. Interventions that aim to modulate function simulate more neurotypical behavior can be detrimental self-acceptance quality life (QoL). Therefore, this cross-sectional study aimed test contributions six dimensions the neurotype then use causal inference identify which them have adverse effects on QoL. MethodsWe quantified individual socially relevant functions (social anhedonia, theory mind, affective empathy, anxiety, prosopagnosia alexithymia), as well confounding constructs, using validated questionnaires a sample 366 adults with wide range traits (ATs), including 78 diagnosed We first used Bayesian linear regression most likely predictive model ATs. Then, we constructed sufficient adjustment set estimate differential roles constructs lowering QoL.ResultsWe found 76% variance ATs was explained combination mind differences, alexithymia, face blindness, while empathy did contribute. However, only alexithymia anhedonia were adversely affect QoL.ConclusionWe suggest variation specific, neurally behaviorally, than broad AT construct. There autism/AT-related tested dimensions, but QoL disproportionately affected suggesting transdiagnostic markers poor outcomes.

Language: Английский

Citations

1
Autism in ICU DOI Creative Commons
Rosaleen Baruah

Journal of the Intensive Care Society, Journal Year: 2024, Volume and Issue: 25(3), P. 319 - 325

Published: April 22, 2024

Autism is a lifelong neurodevelopmental condition. Autistic people face challenges as patients in the intensive care unit (ICU) and providers of healthcare ICU. This article describes experience autistic using neurodiversity-affirming approach. Using 'Autistic SPACE' framework, needs are described terms sensory needs, need for predictability, acceptance, communication differences how to approach them, benefits person-centred empathy-based people. The reasonable adjustments within framework positive risk taking. For supervisors managers professionals, autism-friendly training working practice, with rationales, suggested.

Language: Английский

Citations

1
The missing clinical guidance: a scoping review of care for autistic transgender and gender-diverse people DOI Creative Commons

Lorna Bo,

Anna I. R. van der Miesen, Sascha E. Klomp

et al.

EClinicalMedicine, Journal Year: 2024, Volume and Issue: 76, P. 102849 - 102849

Published: Sept. 27, 2024

Language: Английский

Citations

1
Unmet need for autism-aware care for gynaecological, menstrual and sexual wellbeing DOI Creative Commons
Richard de Visser, Rachel Moseley, Julie M. Turner‐Cobb

et al.

Autism, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 15, 2024

Autistic people often experience difficulties with healthcare, and are more likely than neurotypical to have unmet healthcare needs. They may also be find menstruation menopause difficult women. Healthcare professionals (HCPs) insufficient training support work autistic adults, they lack the skills or confidence discuss reproductive sexual health (RSH) patients. When these two issues combined, it would appear that particular when seeking RSH care. The aim of this study was explore people's experiences related in United Kingdom. Surveys were distributed assistance an autism charity, completed by 136 adults. survey consisted mainly tick-box responses, but there several opportunities for participants write comments about their experiences. Respondents felt HCPs almost never seem know how affects RSH. There broad agreement need aware impact on general, specific impacts data provide a clear picture needs autism-aware RSH, further research is required HCPs' knowledge Combined our findings, such could inform development resources improve people.

Language: Английский

Citations

1
How are autistic traits associated with mental health among Chinese university students: An examination of the mediating role of alexithymia and social camouflaging DOI Creative Commons

Qianyi Xie,

Xiangpeng Li, Li‐Zi Lin

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: May 30, 2024

Abstract Background Autistic traits are distributed along a continuum ranging from clinical presentations to the general population, being associated with high-risk of mental health problems. However, underlying mechanism remains unclear. Given that alexithymia, which contributes emotional difficulties related autistic traits, utilization social camouflaging as potential for coping, may exacerbate issues. This study aimed examine mediating effects alexithymia and in associations between symptoms anxiety/depression. Methods A total 1085 Chinese university students (age: 21.8 ± 2.7 years, 51.9% males) were recruited through an online survey measured problems (anxiety depression), camouflaging. The mediator on anxiety depression conducted, two serial mediation models verified by regression analysis. Results findings revealed significant positive association depression. manifestation was found be influenced mediated sequentially (β = 0.022, 95% confidence interval [CI]: 0.011–0.035). Differently, linked solely 0.499, 95%CI: 0.423–0.578). According subgroup analysis, results within female group consistent observations made overall sample. male group, statistical significance effect no longer evident. Limitations can only identify camouflaging, not causal relationships. Neuroimaging research is necessary unravel neural mechanisms underlie these associations. Conclusions Our play role relationship students, especially anxiety. issues vary males females. highlights pathway has improve well-being individuals exhibiting high traits.

Language: Английский

Citations

0