Towards the sustainable discovery and development of new antibiotics

Nature Reviews Chemistry, Journal Year: 2021, Volume and Issue: 5(10), P. 726 - 749

Published: Aug. 19, 2021

An ever-increasing demand for novel antimicrobials to treat life-threatening infections caused by the global spread of multidrug-resistant bacterial pathogens stands in stark contrast current level investment their development, particularly fields natural-product-derived and synthetic small molecules. New agents displaying innovative chemistry modes action are desperately needed worldwide tackle public health menace posed antimicrobial resistance. Here, our consortium presents a strategic blueprint substantially improve ability discover develop new antibiotics. We propose both short-term long-term solutions overcome most urgent limitations various sectors research funding, aiming bridge gap between academic, industrial political stakeholders, unite interdisciplinary expertise order efficiently fuel translational pipeline benefit future generations.

Language: Английский

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Antimicrobial resistance and COVID-19: Intersections and implications

eLife, Journal Year: 2021, Volume and Issue: 10

Published: Feb. 16, 2021

Before the coronavirus 2019 (COVID-19) pandemic began, antimicrobial resistance (AMR) was among top priorities for global public health. Already a complex challenge, AMR now needs to be addressed in changing healthcare landscape. Here, we analyse how changes due COVID-19 terms of usage, infection prevention, and health systems affect emergence, transmission, burden AMR. Increased hand hygiene, decreased international travel, elective hospital procedures may reduce pathogen selection spread short term. However, opposite effects seen if antibiotics are more widely used as standard pathways break down. Over 6 months into pandemic, dynamics remain uncertain. We call community keep perspective while designing finely tuned surveillance research continue improve our preparedness response these intersecting challenges.

Language: Английский

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Defect‐Rich Adhesive Molybdenum Disulfide/rGO Vertical Heterostructures with Enhanced Nanozyme Activity for Smart Bacterial Killing Application

Advanced Materials, Journal Year: 2020, Volume and Issue: 32(48)

Published: Oct. 28, 2020

Abstract Nanomaterials with intrinsic enzyme‐like activities, namely “nanozymes,” are showing increasing potential as a new type of broad‐spectrum antibiotics. However, their feasibility is still far from satisfactory, due to low catalytic activity, poor bacterial capturing capacity, and complicated material design. Herein, facile synthesis defect‐rich adhesive molybdenum disulfide (MoS 2 )/rGO vertical heterostructure (VHS) through one‐step microwave‐assisted hydrothermal method reported. This simple, convenient but effective for rapid enables extremely uniform well‐dispersed MoS /rGO VHS abundant S Mo vacancies rough surface, performance approaching the requirements practical application. It demonstrated experimentally theoretically that as‐prepared possesses defect irradiation dual‐enhanced triple activities (oxidase, peroxidase, catalase) promoting free‐radical generation, owing much more active edge sites exposure. Meanwhile, VHS‐achieved surface exhibits excellent capacity capture, elevated reactive oxygen species (ROS) destruction local topological interactions. As result, optimized efficacy against drug‐resistant Gram‐negative Gram‐positive bacteria can be explored by such nanozymes, demonstrating simple powerful way engineered nanozymes alternative

Language: Английский

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Pharmaceutical Pollution in Aquatic Environments: A Concise Review of Environmental Impacts and Bioremediation Systems

Frontiers in Microbiology, Journal Year: 2022, Volume and Issue: 13

Published: April 26, 2022

The presence of emerging contaminants in the environment, such as pharmaceuticals, is a growing global concern. excessive use medication globally, together with recalcitrance pharmaceuticals traditional wastewater treatment systems, has caused these compounds to present severe environmental problem. In recent years, increase their availability, access and drugs concentrations water bodies rise substantially. Considered contaminants, represent challenge field remediation; therefore, alternative add-on systems for plants are continuously being developed mitigate impact reduce effects on environment human health. this review, we describe current status pharmaceutical focusing bodies, analyzing development bioremediation especially mycoremediation, removal special focus fungal technologies.

Language: Английский

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A bottom-up view of antimicrobial resistance transmission in developing countries

Nature Microbiology, Journal Year: 2022, Volume and Issue: 7(6), P. 757 - 765

Published: May 30, 2022

Language: Английский

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Ampicillin-controlled glucose metabolism manipulates the transition from tolerance to resistance in bacteria

Science Advances, Journal Year: 2023, Volume and Issue: 9(10)

Published: March 8, 2023

The mechanism(s) of how bacteria acquire tolerance and then resistance to antibiotics remains poorly understood. Here, we show that glucose abundance decreases progressively as ampicillin-sensitive strains ampicillin. mechanism involves ampicillin initiates this event via targeting pts promoter pyruvate dehydrogenase (PDH) promote transport inhibit glycolysis, respectively. Thus, fluxes into pentose phosphate pathway generate reactive oxygen species (ROS) causing genetic mutations. Meanwhile, PDH activity is gradually restored due the competitive binding accumulated ampicillin, which lowers level, activates cyclic adenosine monophosphate (cAMP)/cAMP receptor protein (CRP) complex. cAMP/CRP negatively regulates ROS but enhances DNA repair, leading resistance. Glucose Mn2+ delay acquisition, providing an effective approach control same effect also determined in intracellular pathogen Edwardsiella tarda. metabolism represents a promising target stop/delay transition

Language: Английский

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Association between particulate matter (PM)2·5 air pollution and clinical antibiotic resistance: a global analysis

The Lancet Planetary Health, Journal Year: 2023, Volume and Issue: 7(8), P. e649 - e659

Published: Aug. 1, 2023

Antibiotic resistance is an increasing global issue, causing millions of deaths worldwide every year. Particulate matter (PM)2·5 has diverse elements antibiotic that increase its spread after inhalation. However, understanding the contribution PM2·5 to poor. Through univariate and multivariable analysis, we aimed present first estimates burden premature attributable resulting from pollution.For this data on multiple potential predictors (ie, air pollution, use, sanitation services, economics, health expenditure, population, education, climate, year, region) were collected in 116 countries 2000 2018 estimate effect via analysis. Data obtained ResistanceMap, European Centre for Disease Prevention Control Surveillance Atlas (antimicrobial-resistance sources), PLISA Health Information Platform Americas. Future aggregate mortality trends derived different scenarios (eg, 50% reduced use or controlled 5 μg/m3) projected until 2050.The final dataset included more than 11·5 million tested isolates. Raw antibiotic-resistance nine pathogens 43 types agents. Significant correlations between consistent globally most antibiotic-resistant bacteria (R2=0·42-0·76, p<0·0001), have strengthened over time. caused estimated 0·48 (95% CI 0·34-0·60) 18·2 (13·4-23·0) years life lost worldwide, corresponding annual welfare loss US$395 (290-500) billion due deaths. The μg/m3 target concentration quality guidelines set by WHO, if reached 2050, was reduce 16·8% 15·3-18·3) avoid 23·4% (21·2-25·6) resistance, equivalent a saving $640 (580-671) billion.This analysis describe association clinical globally. Results provide new pathways control environmental perspective.National Natural Science Foundation China, Fundamental Research Funds Central Universities, Zhejiang University Global Partnership Fund, China Postdoctoral Foundation.

Language: Английский

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Walking-induced electrostatic charges enable in situ electroporated disinfection in portable water bottles

Nature Water, Journal Year: 2024, Volume and Issue: 2(4), P. 360 - 369

Published: April 12, 2024

Language: Английский

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Antimicrobial multidrug resistance in the era of COVID-19: a forgotten plight?

Antimicrobial Resistance and Infection Control, Journal Year: 2021, Volume and Issue: 10(1)

Published: Jan. 29, 2021

Abstract Background Antimicrobial resistance (AMR) is a growing global problem to which the ongoing COVID-19 pandemic may further contribute. With resources deployed away from antimicrobial stewardship, evidence of substantial pre-emptive antibiotic use in patients and indirectly, with deteriorating economic conditions fuelling poverty potentially impacting on levels resistance, AMR threat remains significant. Main body In this paper, main countermeasures are revisited priorities tackle issue re-iterated. The need for collaboration stressed, acknowledging relationship between human health, animal health environment (“One Health” approach). Among stated priorities, initiative by European Medicines Regulatory Network strengthen measures combatting highlighted. Likewise, it asserted that other emerging threats require One Health approach offering valuable blueprint action. Conclusion authors stress importance an integrated preparedness strategy public peril.

Language: Английский

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Risk assessment of antibiotic resistance genes in the drinking water system

The Science of The Total Environment, Journal Year: 2021, Volume and Issue: 800, P. 149650 - 149650

Published: Aug. 14, 2021

Language: Английский

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