Environment International,
Journal Year:
2022,
Volume and Issue:
169, P. 107488 - 107488
Published: Sept. 2, 2022
Antimicrobial
resistance
(AMR)
is
a
threat
to
human
and
animal
health,
with
the
environment
increasingly
recognised
as
playing
an
important
role
in
AMR
evolution,
dissemination,
transmission.
Antibiotics
can
select
for
at
very
low
concentrations,
similar
those
environment,
yet
their
release
into
e.g.,
from
wastewater
treatment
plants,
not
currently
regulated.
Understanding
selection
risk
antibiotics
pose
receiving
waters
key
understanding
if
environmental
regulation
of
required.
We
investigated
occurring
UK
by
determining
where
measured
concentration
data
(n
=
8187)
four
(ciprofloxacin,
azithromycin,
clarithromycin,
erythromycin)
collected
England
Wales
2015-2018
(sites
n
67)
exceeded
selective
thresholds
derived
complex
microbial
community
evolution
experiments
undertaken
previously.
show
that
ciprofloxacin
likely
have
occurred
routinely
during
period,
some
seasonal
regional
trends.
Wastewater
reduces
posed
significantly,
but
completely,
predicted
surface
remains
high
several
cases.
Conversely,
potential
risks
macrolides
(azithromycin,
were
lower
than
ciprofloxacin.
Our
demonstrate
further
action
needed
prevent
wastewater,
quality
standards
required
future,
solely
concern
low/middle
income
countries.
Nature Reviews Chemistry,
Journal Year:
2021,
Volume and Issue:
5(10), P. 726 - 749
Published: Aug. 19, 2021
An
ever-increasing
demand
for
novel
antimicrobials
to
treat
life-threatening
infections
caused
by
the
global
spread
of
multidrug-resistant
bacterial
pathogens
stands
in
stark
contrast
current
level
investment
their
development,
particularly
fields
natural-product-derived
and
synthetic
small
molecules.
New
agents
displaying
innovative
chemistry
modes
action
are
desperately
needed
worldwide
tackle
public
health
menace
posed
antimicrobial
resistance.
Here,
our
consortium
presents
a
strategic
blueprint
substantially
improve
ability
discover
develop
new
antibiotics.
We
propose
both
short-term
long-term
solutions
overcome
most
urgent
limitations
various
sectors
research
funding,
aiming
bridge
gap
between
academic,
industrial
political
stakeholders,
unite
interdisciplinary
expertise
order
efficiently
fuel
translational
pipeline
benefit
future
generations.
Before
the
coronavirus
2019
(COVID-19)
pandemic
began,
antimicrobial
resistance
(AMR)
was
among
top
priorities
for
global
public
health.
Already
a
complex
challenge,
AMR
now
needs
to
be
addressed
in
changing
healthcare
landscape.
Here,
we
analyse
how
changes
due
COVID-19
terms
of
usage,
infection
prevention,
and
health
systems
affect
emergence,
transmission,
burden
AMR.
Increased
hand
hygiene,
decreased
international
travel,
elective
hospital
procedures
may
reduce
pathogen
selection
spread
short
term.
However,
opposite
effects
seen
if
antibiotics
are
more
widely
used
as
standard
pathways
break
down.
Over
6
months
into
pandemic,
dynamics
remain
uncertain.
We
call
community
keep
perspective
while
designing
finely
tuned
surveillance
research
continue
improve
our
preparedness
response
these
intersecting
challenges.
Advanced Materials,
Journal Year:
2020,
Volume and Issue:
32(48)
Published: Oct. 28, 2020
Abstract
Nanomaterials
with
intrinsic
enzyme‐like
activities,
namely
“nanozymes,”
are
showing
increasing
potential
as
a
new
type
of
broad‐spectrum
antibiotics.
However,
their
feasibility
is
still
far
from
satisfactory,
due
to
low
catalytic
activity,
poor
bacterial
capturing
capacity,
and
complicated
material
design.
Herein,
facile
synthesis
defect‐rich
adhesive
molybdenum
disulfide
(MoS
2
)/rGO
vertical
heterostructure
(VHS)
through
one‐step
microwave‐assisted
hydrothermal
method
reported.
This
simple,
convenient
but
effective
for
rapid
enables
extremely
uniform
well‐dispersed
MoS
/rGO
VHS
abundant
S
Mo
vacancies
rough
surface,
performance
approaching
the
requirements
practical
application.
It
demonstrated
experimentally
theoretically
that
as‐prepared
possesses
defect
irradiation
dual‐enhanced
triple
activities
(oxidase,
peroxidase,
catalase)
promoting
free‐radical
generation,
owing
much
more
active
edge
sites
exposure.
Meanwhile,
VHS‐achieved
surface
exhibits
excellent
capacity
capture,
elevated
reactive
oxygen
species
(ROS)
destruction
local
topological
interactions.
As
result,
optimized
efficacy
against
drug‐resistant
Gram‐negative
Gram‐positive
bacteria
can
be
explored
by
such
nanozymes,
demonstrating
simple
powerful
way
engineered
nanozymes
alternative
Frontiers in Microbiology,
Journal Year:
2022,
Volume and Issue:
13
Published: April 26, 2022
The
presence
of
emerging
contaminants
in
the
environment,
such
as
pharmaceuticals,
is
a
growing
global
concern.
excessive
use
medication
globally,
together
with
recalcitrance
pharmaceuticals
traditional
wastewater
treatment
systems,
has
caused
these
compounds
to
present
severe
environmental
problem.
In
recent
years,
increase
their
availability,
access
and
drugs
concentrations
water
bodies
rise
substantially.
Considered
contaminants,
represent
challenge
field
remediation;
therefore,
alternative
add-on
systems
for
plants
are
continuously
being
developed
mitigate
impact
reduce
effects
on
environment
human
health.
this
review,
we
describe
current
status
pharmaceutical
focusing
bodies,
analyzing
development
bioremediation
especially
mycoremediation,
removal
special
focus
fungal
technologies.
Science Advances,
Journal Year:
2023,
Volume and Issue:
9(10)
Published: March 8, 2023
The
mechanism(s)
of
how
bacteria
acquire
tolerance
and
then
resistance
to
antibiotics
remains
poorly
understood.
Here,
we
show
that
glucose
abundance
decreases
progressively
as
ampicillin-sensitive
strains
ampicillin.
mechanism
involves
ampicillin
initiates
this
event
via
targeting
pts
promoter
pyruvate
dehydrogenase
(PDH)
promote
transport
inhibit
glycolysis,
respectively.
Thus,
fluxes
into
pentose
phosphate
pathway
generate
reactive
oxygen
species
(ROS)
causing
genetic
mutations.
Meanwhile,
PDH
activity
is
gradually
restored
due
the
competitive
binding
accumulated
ampicillin,
which
lowers
level,
activates
cyclic
adenosine
monophosphate
(cAMP)/cAMP
receptor
protein
(CRP)
complex.
cAMP/CRP
negatively
regulates
ROS
but
enhances
DNA
repair,
leading
resistance.
Glucose
Mn2+
delay
acquisition,
providing
an
effective
approach
control
same
effect
also
determined
in
intracellular
pathogen
Edwardsiella
tarda.
metabolism
represents
a
promising
target
stop/delay
transition
The Lancet Planetary Health,
Journal Year:
2023,
Volume and Issue:
7(8), P. e649 - e659
Published: Aug. 1, 2023
Antibiotic
resistance
is
an
increasing
global
issue,
causing
millions
of
deaths
worldwide
every
year.
Particulate
matter
(PM)2·5
has
diverse
elements
antibiotic
that
increase
its
spread
after
inhalation.
However,
understanding
the
contribution
PM2·5
to
poor.
Through
univariate
and
multivariable
analysis,
we
aimed
present
first
estimates
burden
premature
attributable
resulting
from
pollution.For
this
data
on
multiple
potential
predictors
(ie,
air
pollution,
use,
sanitation
services,
economics,
health
expenditure,
population,
education,
climate,
year,
region)
were
collected
in
116
countries
2000
2018
estimate
effect
via
analysis.
Data
obtained
ResistanceMap,
European
Centre
for
Disease
Prevention
Control
Surveillance
Atlas
(antimicrobial-resistance
sources),
PLISA
Health
Information
Platform
Americas.
Future
aggregate
mortality
trends
derived
different
scenarios
(eg,
50%
reduced
use
or
controlled
5
μg/m3)
projected
until
2050.The
final
dataset
included
more
than
11·5
million
tested
isolates.
Raw
antibiotic-resistance
nine
pathogens
43
types
agents.
Significant
correlations
between
consistent
globally
most
antibiotic-resistant
bacteria
(R2=0·42-0·76,
p<0·0001),
have
strengthened
over
time.
caused
estimated
0·48
(95%
CI
0·34-0·60)
18·2
(13·4-23·0)
years
life
lost
worldwide,
corresponding
annual
welfare
loss
US$395
(290-500)
billion
due
deaths.
The
μg/m3
target
concentration
quality
guidelines
set
by
WHO,
if
reached
2050,
was
reduce
16·8%
15·3-18·3)
avoid
23·4%
(21·2-25·6)
resistance,
equivalent
a
saving
$640
(580-671)
billion.This
analysis
describe
association
clinical
globally.
Results
provide
new
pathways
control
environmental
perspective.National
Natural
Science
Foundation
China,
Fundamental
Research
Funds
Central
Universities,
Zhejiang
University
Global
Partnership
Fund,
China
Postdoctoral
Foundation.
Antimicrobial Resistance and Infection Control,
Journal Year:
2021,
Volume and Issue:
10(1)
Published: Jan. 29, 2021
Abstract
Background
Antimicrobial
resistance
(AMR)
is
a
growing
global
problem
to
which
the
ongoing
COVID-19
pandemic
may
further
contribute.
With
resources
deployed
away
from
antimicrobial
stewardship,
evidence
of
substantial
pre-emptive
antibiotic
use
in
patients
and
indirectly,
with
deteriorating
economic
conditions
fuelling
poverty
potentially
impacting
on
levels
resistance,
AMR
threat
remains
significant.
Main
body
In
this
paper,
main
countermeasures
are
revisited
priorities
tackle
issue
re-iterated.
The
need
for
collaboration
stressed,
acknowledging
relationship
between
human
health,
animal
health
environment
(“One
Health”
approach).
Among
stated
priorities,
initiative
by
European
Medicines
Regulatory
Network
strengthen
measures
combatting
highlighted.
Likewise,
it
asserted
that
other
emerging
threats
require
One
Health
approach
offering
valuable
blueprint
action.
Conclusion
authors
stress
importance
an
integrated
preparedness
strategy
public
peril.
