Infant Formula With a Specific Blend of Five Human Milk Oligosaccharides Drives the Gut Microbiota Development and Improves Gut Maturation Markers: A Randomized Controlled Trial DOI Creative Commons

Miroslava Bosheva,

István Tokodi,

Aleksander Krasnow

et al.

Frontiers in Nutrition, Journal Year: 2022, Volume and Issue: 9

Published: July 6, 2022

Human milk oligosaccharides (HMOs) have important biological functions for a healthy development in early life.This study aimed to investigate gut maturation effects of an infant formula containing five HMOs (2'-fucosyllactose, 2',3-di-fucosyllactose, lacto-N-tetraose, 3'-sialyllactose, and 6'-sialyllactose).In multicenter study, infants (7-21 days old) were randomly assigned standard cow's milk-based (control group, CG); the same with 1.5 g/L (test group 1, TG1); or 2.5 2, TG2). A human milk-fed (HMG) was enrolled as reference. Fecal samples collected at baseline (n∼150/formula group; HMG n = 60), age 3 (n∼140/formula 65) 6 (n∼115/formula 60) months analyzed microbiome (shotgun metagenomics), metabolism, biomarkers.At both post-baseline visits, weighted UniFrac analysis indicated different microbiota compositions two test groups (TGs) compared CG (P < 0.01) coordinates closer that HMG. The relative abundance Bifidobacterium longum subsp. infantis (B. infantis) higher TGs vs. 0.05; except months: TG2 P 0.083). by ∼45% 6-month approaching At toxigenic Clostridioides difficile 75-85% lower 0.05) comparable pH significantly CG, overall organic acid profile months, (vs. CG) had secretory immunoglobulin (sIgA) alpha-1-antitrypsin 0.05). sIgA remained 0.05), calprotectin TG1 CG.Infant specific blend supports intestinal immune system barrier function shifts breastfed bifidobacteria, particularly B. infantis, difficile.[https://clinicaltrials.gov/ct2/show/], identifier [NCT03722550].

Language: Английский

Early-life interactions between the microbiota and immune system: impact on immune system development and atopic disease DOI
Katherine Donald, B. Brett Finlay

Nature reviews. Immunology, Journal Year: 2023, Volume and Issue: 23(11), P. 735 - 748

Published: May 3, 2023

Language: Английский

Citations

139
Multi-omics analyses of airway host–microbe interactions in chronic obstructive pulmonary disease identify potential therapeutic interventions DOI
Zhengzheng Yan,

Boxuan Chen,

Yuqiong Yang

et al.

Nature Microbiology, Journal Year: 2022, Volume and Issue: 7(9), P. 1361 - 1375

Published: Aug. 22, 2022

Language: Английский

Citations

110
Immune-microbe interactions early in life: A determinant of health and disease long term DOI Open Access
Petter Brodin

Science, Journal Year: 2022, Volume and Issue: 376(6596), P. 945 - 950

Published: May 26, 2022

Research on newborn immunity has revealed the importance of cell ontogeny, feto-maternal tolerance, and transfer maternal antibodies. Less is known about postnatal adaptation to environmental exposures. The microbiome its for health have been extensively studied, but it remains unclear how mutually beneficial relationships between commensal microbes human cells first arise are maintained throughout life. Such immune-microbe mutualism, perturbations thereof, most likely a root cause increasing incidences immune-mediated disorders such as allergies autoimmunity across many industrialized nations during past century. In this Review, I discuss our current understanding immune development propose that mismatches among ancestral, early-life, adult environments can explain interactions, dysregulation, increased risks diseases.

Language: Английский

Citations

109
Postbiotics as the new frontier in food and pharmaceutical research DOI
Sahar Sabahi, Aziz Homayouni Rad, Leili Aghebati‐Maleki

et al.

Critical Reviews in Food Science and Nutrition, Journal Year: 2022, Volume and Issue: 63(26), P. 8375 - 8402

Published: March 29, 2022

Food is the essential need of human life and has nutrients that support growth health. Gastrointestinal tract microbiota involves valuable microorganisms develop therapeutic effects are characterized as probiotics. The investigations on appropriate probiotic strains have led to characterization specific metabolic byproducts probiotics named postbiotics. must maintain their survival against inappropriate lethal conditions processing, storage, distribution, preparation, digestion system so they can exhibit most health effects. Conversely, metabolites (postbiotics) successfully overcome these unfavorable may be an alternative Due chemical structure, safe profile, long shelf-life, fact contain various signaling molecules, postbiotics anti-inflammatory, immunomodulatory, antihypertensive properties, inhibiting abnormal cell proliferation antioxidative activities. Consequently, present scientific literature approves mimic fundamental clinical role probiotics, due unique characteristics, applied in oral delivery (pharmaceutical/functional foods), a preharvest food safety hurdle, promote shelf-life products novel functional foods or/and for developing benefits, aims. This review addresses latest postbiotic applications with regard pharmaceutical formulations commercial food-based products. Potential promotion host status, prevention disease, complementary treatment also reviewed.

Language: Английский

Citations

107
Microbiome-based interventions to modulate gut ecology and the immune system DOI Creative Commons
Thomas C. A. Hitch, Lindsay J. Hall, Sarah Kate Walsh

et al.

Mucosal Immunology, Journal Year: 2022, Volume and Issue: 15(6), P. 1095 - 1113

Published: Sept. 30, 2022

The gut microbiome lies at the intersection between environment and host, with ability to modify host responses disease-relevant exposures stimuli. This is evident in how enteric microbes interact immune system, e.g., supporting maturation early life, affecting drug efficacy via modulation of responses, or influencing development cell populations their mediators. Many factors modulate ecosystem dynamics during daily life we are just beginning realise therapeutic prophylactic potential microbiome-based interventions. These approaches vary application, goal, mechanisms action. Some entire community, such as nutritional faecal microbiota transplantation, while others, phage therapy, probiotics, prebiotics, target specific taxa strains. In this review, assessed experimental evidence for interventions, a particular focus on clinical relevance, ecological effects, system.

Language: Английский

Citations

107
Implications of the changing epidemiology of inflammatory bowel disease in a changing world DOI Creative Commons
Manasi Agrawal, Tine Jess

United European Gastroenterology Journal, Journal Year: 2022, Volume and Issue: 10(10), P. 1113 - 1120

Published: Oct. 17, 2022

Abstract The epidemiology of inflammatory bowel disease (IBD) has undergone considerable shifts since its emergence in the Western world over a century ago, especially last few decades, with increasing global burden disease. IBD incidence continues to rise developed countries all age groups which is contributing compounding prevalence. Further, rising sharply Asia and other recently developing countries. In this review, we discuss implications changing trends epidemiology. First, patterns provide insights into causes, as they occur concurrent environment, cultures, attitudes. Understanding impact environment on risk can help towards prediction prevention strategies. Second, must prepare healthcare systems for address it at various levels improving outcomes health, overall.

Language: Английский

Citations

99
The developing infant gut microbiome: A strain-level view DOI Creative Commons
Hagay Enav, Fredrik Bäckhed, Ruth E. Ley

et al.

Cell Host & Microbe, Journal Year: 2022, Volume and Issue: 30(5), P. 627 - 638

Published: May 1, 2022

Language: Английский

Citations

71
Bifidobacterium mechanisms of immune modulation and tolerance DOI Creative Commons
Samuel J. Gavzy, Allison Kensiski,

Zachariah L Lee

et al.

Gut Microbes, Journal Year: 2023, Volume and Issue: 15(2)

Published: Dec. 6, 2023

Bifidobacterium is a widely distributed commensal bacterial genus that displays beneficial pro-homeostatic and anti-inflammatory immunomodulatory properties. Depletion or absence of in humans model organisms associated with autoimmune responses impaired immune homeostasis. At the cellular level, upregulates suppressive regulatory T cells, maintains intestinal barrier function, modulates dendritic cell macrophage activity, dampens Th2 Th17 programs. While there has been large volume literature characterizing probiotic properties various Bifidobacterial species, likely multifactorial mechanisms underlying these effects remain elusive, particular, its tolerogenic effect. However, recent work shed light on surface structural polysaccharide protein elements, as well metabolic products, mediators This review aims to discuss several utilizes for modulation their indirect impact regulation gut microbiome structure from molecules produced metabolites. These are pertinent an increasingly networked understanding tolerance homeostasis health disease.

Language: Английский

Citations

70
Microbiota-derived indoles alleviate intestinal inflammation and modulate microbiome by microbial cross-feeding DOI Creative Commons
Gang Wang, Yuxin Fan, Guolong Zhang

et al.

Microbiome, Journal Year: 2024, Volume and Issue: 12(1)

Published: March 19, 2024

Abstract Background The host–microbiota interaction plays a crucial role in maintaining homeostasis and disease susceptibility, microbial tryptophan metabolites are potent modulators of host physiology. However, whether how these mediate interactions, particularly terms inter-microbial communication, remains unclear. Results Here, we have demonstrated that indole-3-lactic acid (ILA) is key molecule produced by Lactobacillus protecting against intestinal inflammation correcting dysbiosis. Specifically, metabolizes into ILA, thereby augmenting the expression bacterial enzymes implicated metabolism, leading to synthesis other indole derivatives including indole-3-propionic (IPA) indole-3-acetic (IAA). Notably, IPA, IAA possess ability mitigate modulate gut microbiota both DSS-induced IL-10 −/− spontaneous colitis models. ILA increases abundance tryptophan-metabolizing bacteria (e.g., Clostridium ), as well mRNA acyl-CoA dehydrogenase indolelactate vivo vitro, resulting an augmented production IPA IAA. Furthermore, mutant strain fails protect producing derivatives. ILA-mediated cross-feeding was microbiota-dependent specifically enhanced under conditions dysbiosis induced Citrobacter rodentium or DSS, but not disruption with antibiotics. Conclusion Taken together, highlight mechanisms which microbiome-host crosstalk cooperatively control homoeostasis through microbiota-derived indoles mediating communication. These findings may contribute development targeted “postbiotic” potential interventions for treatment prevention dysbiosis-driven diseases.

Language: Английский

Citations

64
Urea cycle activation triggered by host-microbiota maladaptation driving colorectal tumorigenesis DOI Creative Commons

Haoyan Chen,

Tianying Tong,

Shiyuan Lu

et al.

Cell Metabolism, Journal Year: 2023, Volume and Issue: 35(4), P. 651 - 666.e7

Published: March 23, 2023

Language: Английский

Citations

56