Statins inhibit paclitaxel-induced PD-L1 expression and increase CD8+ T cytotoxicity for better prognosis in breast cancer DOI Creative Commons
Lei Li,

Hongbin Wang,

Shiyuan Zhang

et al.

International Journal of Surgery, Journal Year: 2024, Volume and Issue: unknown

Published: May 13, 2024

Background: In recent years, the widespread use of lipid-lowering drugs, especially statins, has attracted people’s attention. Statin may be potentially associated with a reduced risk breast cancer. Objective: To explore relationship between statin and cancer risk. And further potential role statins in adjuvant treatment Methods: Data for Mendelian randomization portion study were obtained from genome-wide association studies common cancers UK Biobank FinnGen Global Lipid Genetics Consortium’s low density lipoprotein (LDL). addition, impacts chemotherapy drugs on examined using both vitro vivo models, particular attention to expression levels immune checkpoint protein PD-L1 its suppress tumor growth. Results: about 3.8 million patients approximately 1.3 LDL-measuring individuals analyzed. Genetically proxied HMGCR inhibition (statins) was reduction ( P = 0.0005). experiments showed that lovastatin significantly inhibited paclitaxel-induced assisted paclitaxel suppressing cell Furthermore, combination therapy involving amplified CD8 + T-cell infiltration, bolstering their tumor-killing capacity enhancing efficacy. Conclusion: The utilization is correlated improved prognoses play facilitating transition cold hot tumors. Combination enhances activity leads better prognostic characteristics.

Language: Английский

Microbiota-derived I3A protects the intestine against radiation injury by activating AhR/IL-10/Wnt signaling and enhancing the abundance of probiotics DOI Creative Commons
Liwei Xie, Shang Cai, Haiyan Lu

et al.

Gut Microbes, Journal Year: 2024, Volume and Issue: 16(1)

Published: May 5, 2024

The intestine is prone to radiation damage in patients undergoing radiotherapy for pelvic tumors. However, there are currently no effective drugs available the prevention or treatment of radiation-induced enteropathy (RIE). In this study, we aimed at investigating impact indole-3-carboxaldehyde (I3A) derived from intestinal microbiota on RIE. Intestinal organoids were isolated and cultivated screening radioprotective tryptophan metabolites. A RIE model was established using 13 Gy whole-abdominal irradiation male C57BL/6J mice. After oral administration I3A, its ability assessed through observation survival rates, clinical scores, pathological analysis. stem cell changes barrier observed immunofluorescence immunohistochemistry. Subsequently, mechanisms I3A investigated 16S rRNA transcriptome sequencing, respectively. Finally, human colon cancer cells cultured assess influence tumor radiotherapy. exhibited most potent effect organoids. Oral significantly increased rate irradiated mice, improved histological mitigated mucosal damage, enhanced proliferation differentiation Lgr5+ cells, maintained integrity. Furthermore, abundance probiotics, activated AhR/IL-10/Wnt signaling pathway promote epithelial proliferation. As a crucial metabolite, promotes upregulates probiotics treat Microbiota-derived demonstrates potential application value

Language: Английский

Citations

14
Postbiotics in colorectal cancer: intervention mechanisms and perspectives DOI Creative Commons
Wei Xie,

Yu-Sen Zhong,

Xuejian Li

et al.

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: Feb. 21, 2024

Colorectal cancer (CRC) is a common malignancy affecting the gastrointestinal tract worldwide. The etiology and progression of CRC are related to factors such as environmental influences, dietary structure, genetic susceptibility. Intestinal microbiota can influence integrity intestinal mucosal barrier modulate immunity by secreting various metabolites. Dysbiosis affect metabolites microbial, leading accumulation toxic metabolites, which trigger chronic inflammation or DNA damage ultimately lead cellular carcinogenesis development CRC. Postbiotics preparations inanimate microorganisms their components that beneficial health host, with main including bacterial (e.g., exopolysaccharides, teichoic acids, surface layer protein) short-chain fatty tryptophan metabolite, bile vitamins enzymes). Compared traditional probiotics, it has more stable chemical structure higher safety. In recent years, been demonstrated postbiotics involved in regulating microecology improving CRC, provides new ideas for prevention diagnosis this article, we review changes different states gut mechanisms anti-tumor activity postbiotic-related components, discuss potential significance treatment This reviews pathogenesis summarizes relevant resisting well advantages limitations process

Language: Английский

Citations

11
Interactions between diet and gut microbiota in cancer DOI
Geicho Nakatsu,

Natalia Andreeva,

M. Macdonald

et al.

Nature Microbiology, Journal Year: 2024, Volume and Issue: 9(7), P. 1644 - 1654

Published: June 21, 2024

Language: Английский

Citations

11
Gut microbiota regulates host melatonin production through epithelial cell MyD88 DOI Creative Commons
Bingnan Liu, Lijuan Fan,

Youxia Wang

et al.

Gut Microbes, Journal Year: 2024, Volume and Issue: 16(1)

Published: Feb. 14, 2024

Melatonin has various physiological effects, such as the maintenance of circadian rhythms, anti-inflammatory functions, and regulation intestinal barriers. The regulatory functions melatonin in gut microbiota remodeling have also been well clarified; however, role regulating host production remains poorly understood. To address this, we studied contribution to using microbiota-perturbed models. We demonstrated that antibiotic-treated germ-free mice possessed diminished levels serum elevated colon. influence on was further confirmed by fecal transplantation. Notably, Lactobacillus reuteri (L. R) Escherichia coli (E. coli) recapitulated effects production. Mechanistically, L. R E. activated TLR2/4/MyD88/NF-κB signaling pathway promote expression arylalkylamine N-acetyltransferase (AANAT, a rate-limiting enzyme for production), MyD88 deficiency colonic epithelial cells abolished Collectively, revealed specific underlying mechanism modulate production, which might provide novel therapeutic ideas melatonin-related diseases.

Language: Английский

Citations

10
The role of microbial indole metabolites in tumor DOI Creative Commons
Dingjiacheng Jia, Zheng Kuang, Liangjing Wang

et al.

Gut Microbes, Journal Year: 2024, Volume and Issue: 16(1)

Published: Oct. 1, 2024

The gut microbiota can produce a variety of microbial-derived metabolites to influence tumor development. Tryptophan, an essential amino acid in the human body, be converted by microorganisms via indole pathway such as Indole-3-Lactic Acid (ILA), Indole-3-Propionic (IPA), Indole Acetic (IAA) and Indole-3-Aldehyde (IAld). Recent studies have shown that play key roles progression, they used adjuvant regimens for immunotherapy or chemotherapy. Here, we summarize recent findings on common microbial provide review mechanisms different microenvironment. We further discuss limitations current metabolite research future possibilities. It is expected will new strategies clinical therapy.

Language: Английский

Citations

9
Macrophages and T cells in metabolic disorder-associated cancers DOI
Daniel Taranto, Daan J. Kloosterman, Leila Akkari

et al.

Nature reviews. Cancer, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 1, 2024

Language: Английский

Citations

9
A specific enterotype derived from gut microbiome of older individuals enables favorable responses to immune checkpoint blockade therapy DOI
Xiaoqiang Zhu, Xiaowen Huang,

Muni Hu

et al.

Cell Host & Microbe, Journal Year: 2024, Volume and Issue: 32(4), P. 489 - 505.e5

Published: March 20, 2024

Language: Английский

Citations

8
The tryptophan metabolic pathway of the microbiome and host cells in health and disease DOI Creative Commons
Kentaro Miyamoto, Tomohisa Sujino, Takanori Kanai∥

et al.

International Immunology, Journal Year: 2024, Volume and Issue: unknown

Published: June 13, 2024

Abstract The intricate and dynamic tryptophan (Trp) metabolic pathway in both the microbiome host cells highlights its profound implications for health disease. This involves complex interactions between cellular bacteria processes, producing bioactive compounds such as 5-hydroxytryptamine (5-HT) kynurenine derivatives. Immune responses to Trp metabolites through specific receptors have been explored, highlighting role of aryl hydrocarbon receptor inflammation modulation. Dysregulation this is implicated various diseases, Alzheimer’s Parkinson’s mood disorders, neuronal autoimmune diseases multiple sclerosis (MS), cancer. In article, we describe impact 5-HT, Trp, indole, on Furthermore, review microbiome-derived that affect immune contribute maintaining homeostasis, especially an experimental encephalitis model MS.

Language: Английский

Citations

8
Limosilactobacillus reuteri - a probiotic gut commensal with contextual impact on immunity DOI Creative Commons
Amanda Lee, David Álvarez Jiménez, Marlies Meisel

et al.

Gut Microbes, Journal Year: 2025, Volume and Issue: 17(1)

Published: Jan. 17, 2025

The gut microbiome plays a key role in human health, influencing various biological processes and disease outcomes. historical roots of probiotics are traced back to Nobel Laureate Élie Metchnikoff, who linked the longevity Bulgarian villagers their consumption sour milk fermented by Lactobacilli. His pioneering work led global recognition as beneficial supplements, now multibillion-dollar industry. Modern have been extensively studied for immunomodulatory effects. Limosilactobacillus reuteri (L. reuteri), widely used probiotic, has garnered significant attention its systemic immune-regulatory properties, particularly relation autoimmunity cancer. This review delves into L. modulating immune responses, with focus on impact diseases.

Language: Английский

Citations

1
Indole‐3‐Lactic Acid Inhibits Doxorubicin‐Induced Ferroptosis Through Activating Aryl Hydrocarbon Receptor/Nrf2 Signalling Pathway DOI Creative Commons
Jiangfang Lian, Hangyuan Guo,

Zuoquan Zhong

et al.

Journal of Cellular and Molecular Medicine, Journal Year: 2025, Volume and Issue: 29(2)

Published: Jan. 1, 2025

ABSTRACT The clinical application of doxorubicin (DOX) is limited due to its cardiotoxicity, which primarily attributed interaction with iron in mitochondria, leading lipid peroxidation and myocardial ferroptosis. This study aimed investigate the role gut microbiota‐derived metabolite, indole‐3‐lactic acid (ILA), mitigating DOX‐induced cardiotoxicity (DIC). Cardiac function, pathological changes, ferroptosis were assessed vivo. cardioprotective effects mechanisms ILA explored using multi‐omics approaches, including single‐nucleus RNA sequencing (snRNA‐seq) bulk RNA‐seq, further validated Nrf2 knockout mice. findings revealed that DOX treatment disrupted microbiota, significantly reducing levels tryptophan metabolite ILA. In DIC models, supplementation markedly improved cardiac reduced collagen deposition, mitigated atrophy. snRNA‐seq analyses indicated played a crucial Experimental data demonstrated decreased both mice DOX‐treated H9C2 cells, evidenced by restoration GPX4 SLC7A11 reduction ACSL4. Mechanistically, functions as ligand for aryl hydrocarbon receptor (AhR), upregulation expression. protective against abolished silencing AhR. Moreover, beneficial on eliminated Nrf2‐deficient conclusion, exerts therapeutic inhibiting through activation AhR/Nrf2 signalling pathway. Identifying microbial could offer viable strategies DIC.

Language: Английский

Citations

1