Host control of the microbiome: Mechanisms, evolution, and disease

Science, Journal Year: 2024, Volume and Issue: 385(6706)

Published: July 18, 2024

Many species, including humans, host communities of symbiotic microbes. There is a vast literature on the ways these microbiomes affect hosts, but here we argue for an increased focus how hosts their microbiomes. Hosts exert control over symbionts through diverse mechanisms, immunity, barrier function, physiological homeostasis, and transit. These mechanisms enable to shape ecology evolution generate natural selection microbial traits that benefit host. Our result from perpetual tension between symbiont evolution, can leverage host's evolved abilities regulate microbiota prevent treat disease. The study will be central our ability both understand manipulate microbiotas better health.

Language: Английский

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Modern microbiology: Embracing complexity through integration across scales

Cell, Journal Year: 2024, Volume and Issue: 187(19), P. 5151 - 5170

Published: Sept. 1, 2024

Language: Английский

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Host–microbe metabolic dialogue

Nature Microbiology, Journal Year: 2024, Volume and Issue: 9(2), P. 318 - 319

Published: Feb. 5, 2024

Language: Английский

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A review on recent taxonomic updates of gut bacteria associated with social bees, with a curated genomic reference database

Insect Science, Journal Year: 2024, Volume and Issue: unknown

Published: April 9, 2024

Honeybees and bumblebees play a crucial role as essential pollinators. The special gut microbiome of social bees is key factor in determining the overall fitness health host. Although harbor relatively simple microbial communities at genus level, recent studies have unveiled significant genetic divergence variations gene content within each bacterial genus. However, comprehensive refined genomics-based taxonomic database specific to bee microbiomes remains lacking. Here, we first provided an overview current knowledge on distribution function bacteria, well factors that influence population dynamics. We then consolidated all available genomes bacteria species-level taxonomy, by constructing maximum-likelihood core genome phylogeny calculating genome-wide pairwise average nucleotide identity. On basis species constructed curated genomic reference database, named microbe sequence (BGM-GDb). To evaluate species-profiling performance BGM-GDb, retrieved series metagenomic data inferred composition using intra-species diversity analysis system (MIDAS), compared results with those obtained from prebuilt MIDAS database. found default BGM-GDb excelled aligned read counts richness. Overall, this high-resolution precise will facilitate research understanding community structure bees.

Language: Английский

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Temporospatial dynamics and host specificity of honeybee gut bacteria

Cell Reports, Journal Year: 2024, Volume and Issue: 43(7), P. 114408 - 114408

Published: June 26, 2024

Honeybees are important pollinators worldwide, with their gut microbiota playing a crucial role in maintaining health. The bacteria of honeybees consist primarily five core lineages that spread through social interactions. Previous studies have provided basic understanding the composition and function honeybee microbiota, recent advancements focusing on analyzing diversity at strain level changes bacterial functional genes. Research across different regions globally has insights into microbial ecology. Additionally, findings shed light mechanisms host specificity bacteria. This review explores temporospatial dynamics discussing reasons behind these fluctuations. synopsis provides host-microbe interactions is invaluable for

Language: Английский

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Type VI secretion systems promote intraspecific competition and host interactions in a bee gut symbiont

Proceedings of the National Academy of Sciences, Journal Year: 2024, Volume and Issue: 121(44)

Published: Oct. 23, 2024

The Type VI Secretion System (T6SS) is a sophisticated mechanism utilized by gram-negative bacteria to deliver toxic effector proteins into target cells, influencing microbial community dynamics and host interactions. In this study, we investigated the role of T6SSs in Snodgrassella alvi wkB2, core bacterial symbiont honey bee gut microbiota. We generated single- double-knockout mutants targeting essential genes ( tssD tssE ) both T6SS-1 T6SS-2 assessed their colonization competition capabilities vivo. Our results indicate that are nonessential for gut, although mutant strains exhibited significantly lower levels compared wild-type (WT) strain. Further, defined experiment showed S. wkB2 do not impact interspecific among bacteria. However, cocolonization experiments with closely related demonstrated plays mediating intraspecific competition. Transcriptomic analysis guts monocolonized WT or T6SS revealed differential expression immunity-related relative microbiota-deprived bees, such as upregulation antimicrobial peptide apidaecin presence defensin , suggesting contribute shaping immune responses. These findings provide insight ecological roles microbiota, emphasizing importance maintaining competitive host–bacterial

Language: Английский

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A multimodal imaging pipeline to decipher cell-specific metabolic functions and tissue microenvironment dynamics

Nature Protocols, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 29, 2025

Language: Английский

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Bumble bee gut microbial community structure differs between species and commercial suppliers, but metabolic potential remains largely consistent

Applied and Environmental Microbiology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 6, 2025

ABSTRACT Bumble bees are key pollinators for natural and agricultural plant communities. Their health performance supported by a core gut microbiota composed of few bacterial taxa. However, the taxonomic composition community structure bumble bee microbiotas can vary with species, environment, origin (i.e., whether colonies come from wild or commercial rearing facility), it is unclear metabolic capabilities therefore as well. Here we used metagenomic sequencing to examine composition, structure, potential across two different Bombus impatiens suppliers, B. , three other species sampled sites within native range all four species. We found that varied between populations origins suppliers. Notably, Apibacter consistently present in some species—suggesting may be previously unrecognized phylotype bees—and lack phylotypes populations. despite variation high-level was largely consistent hosts, including related host performance, though activity remains investigated. IMPORTANCE Our study first compare genome-level whole suppliers In addition, profiled full time. Overall, our results provide new insight into function will help researchers evaluate how well studies conducted one population translate Research on increasing relevance continue discover ways social influence health, decline abundance.

Language: Английский

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Host specificity of gut microbiota associated with social bees: patterns and processes

Microbiology and Molecular Biology Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: March 20, 2025

SUMMARYGut microbes provide benefits to some animals, but their distribution and effects across diverse hosts are still poorly described. There is accumulating evidence for host specificity (i.e., a pattern where different tend associate with distinct lineages), the causes consequences of this unclear. Combining experimental tests in laboratory broad surveys wild promising approach gaining comprehensive mechanistic understanding prevalence, origin, importance. Social bees represent an ideal testbed endeavor because they phylogenetically functionally diverse, host-specific, stable, tractable gut microbiota. Furthermore, western honeybee (Apis mellifera) emerging model system studying microbiota-host interactions. In review, we summarize data on prevalence strength social bee microbiota (bumblebees, stingless bees, honeybees), as well potential proven ecological molecular mechanisms that maintain specificity. Overall, found relatively strong likely results from several processes, including filtering mediated by immune priority effects. However, more research needed multiple species confirm these findings. To help future research, hypotheses field propose comparative tests. Finally, conclude review highlighting need understand how can influence health.

Language: Английский

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Standard methods and good practices in Apis honey bee omics research

Journal of Apicultural Research, Journal Year: 2025, Volume and Issue: 64(2), P. 307 - 402

Published: March 15, 2025

Language: Английский

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