Intracerebral fate of organic and inorganic nanoparticles is dependent on microglial extracellular vesicle function

Nature Nanotechnology, Journal Year: 2023, Volume and Issue: 19(3), P. 376 - 386

Published: Dec. 29, 2023

Language: Английский

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Aspergillus terreus-Mediated Selenium Nanoparticles and Their Antimicrobial and Photocatalytic Activities

Crystals, Journal Year: 2023, Volume and Issue: 13(3), P. 450 - 450

Published: March 4, 2023

Selenium (Se) is a nutritional component necessary for animal and plant development reproduction. nanoparticles (SeNPs) have high absorption rate during routine supplementation. In the current study, cell-free extract of Aspergillus terreus was used as reducing stabilizing agent in synthesis SeNPs using green eco-friendly method. The mycosynthesized were characterized by UV-visible spectrophotometry, Fourier transform infrared spectroscopy, X-ray diffraction dynamic light scattering, transmission electron microscopy, scanning microscopy. results characterization process showed that had spherical shapes sizes less than 100 nm. Results exhibited promising antibacterial activity against both Gram-positive Gram-negative bacteria where inhibition zones 14, 20, 16, 13 mm toward S. haemolyticus, aureus, E. coli, K. pneumoniae, respectively. However, it weak antifungal C. albicans, zone 12 mm. efficacy decolorization malachite dye investigated. illustrated rapid biodegradation dye, reaching up to 89% after 240 min. conclusion, successfully biosynthesized A. demonstrated antimicrobial photocatalytic activities.

Language: Английский

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Nanoparticles-mediated ion channels manipulation: From their membrane interactions to bioapplications

Advanced Drug Delivery Reviews, Journal Year: 2023, Volume and Issue: 195, P. 114763 - 114763

Published: Feb. 24, 2023

Language: Английский

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Bridging Smart Nanosystems with Clinically Relevant Models and Advanced Imaging for Precision Drug Delivery

Advanced Science, Journal Year: 2024, Volume and Issue: 11(14)

Published: Jan. 28, 2024

Abstract Intracellular delivery of nano‐drug‐carriers (NDC) to specific cells, diseased regions, or solid tumors has entered the era precision medicine that requires systematic knowledge nano‐biological interactions from multidisciplinary perspectives. To this end, review first provides an overview membrane‐disruption methods such as electroporation, sonoporation, photoporation, microfluidic delivery, and microinjection with merits high‐throughput enhanced efficiency for in vitro NDC delivery. The impact characteristics including particle size, shape, charge, hydrophobicity, elasticity on cellular uptake are elaborated several types systems aiming hierarchical targeting vivo reviewed. Emerging ex human/animal‐derived pathophysiological models further explored highly recommended use studies since they might mimic features fill translational gaps animals humans. exploration modern microscopy techniques precise nanoparticle (NP) tracking at cellular, organ, organismal levels informs tailored development NDCs application clinical translation. Overall, integrates latest insights into smart nanosystem engineering, physiological models, imaging‐based validation tools, all directed towards enhancing efficient intracellular NDCs.

Language: Английский

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Plant-derived exosomes as cell homogeneous nanoplatforms for brain biomacromolecules delivery ameliorate mitochondrial dysfunction against Parkinson’s disease

Nano Today, Journal Year: 2024, Volume and Issue: 58, P. 102438 - 102438

Published: Aug. 13, 2024

Language: Английский

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