Materials Today Bio,
Journal Year:
2024,
Volume and Issue:
26, P. 101111 - 101111
Published: June 1, 2024
Human
induced
pluripotent
stem
cell
(hiPSC)-derived
mesenchymal
cells
(iMSCs)
are
ideal
candidates
for
the
production
of
standardised
and
scalable
bioengineered
bone
grafts.
However,
stable
induction
osteogenic
differentiation
iMSCs
pose
challenges
in
industry.
We
developed
a
precise
method
to
produce
homogeneous
fully
differentiated
iMSCs.
In
this
study,
we
established
system
prepare
with
increased
potential
improved
bioactivity
by
introducing
CHIR99021
(C91)-treated
microenvironment
(COOME).
COOME
enhances
mineralisation
via
canonical
Wnt
signalling.
Global
transcriptome
analysis
co-culturing
experiments
indicated
that
pro-angiogenesis/neurogenesis
activity
The
superior
abilities
COOME-treated
were
also
confirmed
Bio3D
module
generated
using
polycaprolactone
(PCL)
cell-integrated
3D
printing
(PCI3D)
system,
which
is
closest
model
vivo
research.
This
offers
new
perspective
generating
highly
osteogenic,
bioactive,
anatomically
matched
grafts
clinical
applications.
Although
human
cell-derived
MSCs
seed
synthetic
implants,
hinder
their
application.
study
preparation
combining
our
iMSC
osteocyte
(COOME)
through
activation
Moreover,
upregulated
pro-angiogenic
pro-neurogenic
capacities
iMSCs,
crucial
integration
implanted
ability
was
modules
PCL
systems,
highlighting
functional
vivo.
contributes
tissue
engineering
providing
insights
into
regeneration.
Signal Transduction and Targeted Therapy,
Journal Year:
2023,
Volume and Issue:
8(1)
Published: Aug. 7, 2023
Cancer
remains
a
highly
lethal
disease
in
the
world.
Currently,
either
conventional
cancer
therapies
or
modern
immunotherapies
are
non-tumor-targeted
therapeutic
approaches
that
cannot
accurately
distinguish
malignant
cells
from
healthy
ones,
giving
rise
to
multiple
undesired
side
effects.
Recent
advances
nanotechnology,
accompanied
by
our
growing
understanding
of
biology
and
nano-bio
interactions,
have
led
development
series
nanocarriers,
which
aim
improve
efficacy
while
reducing
off-target
toxicity
encapsulated
anticancer
agents
through
tumor
tissue-,
cell-,
organelle-specific
targeting.
However,
vast
majority
nanocarriers
do
not
possess
hierarchical
targeting
capability,
their
indices
often
compromised
poor
accumulation,
inefficient
cellular
internalization,
inaccurate
subcellular
localization.
This
Review
outlines
current
prospective
strategies
design
organelle-targeted
nanomedicines,
highlights
latest
progress
technologies
can
dynamically
integrate
these
three
different
stages
static
maximize
outcomes.
Finally,
we
briefly
discuss
challenges
future
opportunities
for
clinical
translation
nanomedicines.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(24)
Published: April 3, 2024
Abstract
Glioblastoma
(GBM)
is
the
most
aggressive
and
prevalent
primary
malignant
tumor
of
central
nervous
system.
Traditional
chemotherapy
has
poor
therapeutic
effects
significant
side
due
to
drug
resistance,
natural
blood‐brain
barrier
(BBB),
nonspecific
distribution,
leading
a
lack
clinically
effective
drugs.
Here,
1430
small
molecule
compounds
are
screened
based
on
high‐throughput
screening
platform
novel
anti‐GBM
drug,
lomitapide
(LMP)
obtained.
Furthermore,
bionic
nanodrug
delivery
system
(RFA
NPs)
actively
targeting
GBM
constructed,
which
mainly
consists
tetrahedral
DNA
nanocages
(tFNA
loaded
with
LMP
as
core
folate‐modified
erythrocyte–cancer
cell–macrophage
hybrid
membrane
(FRUR)
shell.
FRUR
camouflage
conferred
unique
features
tFNA
NPs,
including
excellent
biocompatibility,
improved
pharmacokinetic
profile,
efficient
BBB
permeability,
ability.
The
results
show
that
RFA
NPs
exhibited
superior
specific
activities,
reduced
off‐target
delivery,
prolonged
lifespan,
negligible
in
tumor‐bearing
mice.
This
study
combines
biomimetic
technology
provide
theoretical
practical
basis
for
development
optimization
clinical
treatment
strategies
treatment.
Science Advances,
Journal Year:
2023,
Volume and Issue:
9(13)
Published: March 31, 2023
Three-dimensional
bioprinting
has
emerged
as
a
promising
tool
for
spatially
patterning
cells
to
fabricate
models
of
human
tissue.
Here,
we
present
an
engineered
bioink
material
designed
have
viscoelastic
mechanical
behavior,
similar
that
living
This
is
cross-linked
through
dynamic
covalent
bonds,
reversible
bond
type
allows
cellular
remodeling
over
time.
Viscoelastic
materials
are
challenging
use
inks,
one
must
tune
the
kinetics
cross-links
allow
both
extrudability
and
long-term
stability.
We
overcome
this
challenge
small
molecule
catalysts
competitors
temporarily
modulate
cross-linking
degree
network
formation.
These
inks
were
then
used
print
model
breast
cancer
cell
invasion,
where
inclusion
was
found
be
required
formation
invasive
protrusions.
Together,
demonstrate
power
engineered,
bioinks
recapitulate
native
microenvironment
disease
modeling.
International Journal of Bioprinting,
Journal Year:
2023,
Volume and Issue:
9(5), P. 748 - 748
Published: May 9, 2023
Leveraging
three-dimensional
(3D)
bioprinting
in
the
fields
of
tissue
engineering
and
regenerative
medicine
has
rapidly
accelerated
progress
toward
development
living
constructs
biomedical
devices.
Ongoing
vigorous
research
pursued
3D
vitro
models
to
replicate
key
aspects
human
physiology
by
incorporating
relevant
cell
populations
adequate
environmental
cues.
Given
their
advantages
being
able
intimately
mimic
heterogeneity
complexity
native
counterparts,
hold
promise
as
alternatives
conventional
cultures
or
animal
for
translational
application
model
physiology/pathology
drug
screening.
Research
highlighted
importance
models,
a
sophisticated
biomanufacturing
strategy
is
vitally
required.
In
particular,
vascularization
critical
prolonged
survival
functional
maturation
engineered
tissues,
which
remained
one
major
challenges
establishment
physiologically
models.
To
this
end,
can
efficiently
generate
solid
reproducible
vascularized
with
high
architectural
compositional
similarity
leading
improve
structural
tissue-specific
functionality.
Multiple
strategies
have
been
developed
vascularize
tissues
spatially
controlled
patterning
vascular
precursors
generating
readily
perfusable
structures.
This
review
presents
an
overview
advanced
development.
We
present
elements
rebuilding
vasculature
3D-bioprinted
discuss
recent
achievements
using
bioprinting.
Finally,
we
delineate
current
future
outlooks
bioprinting-based
Biofabrication,
Journal Year:
2024,
Volume and Issue:
16(3), P. 032006 - 032006
Published: May 2, 2024
Abstract
Organoids
have
emerged
as
crucial
platforms
in
tissue
engineering
and
regenerative
medicine
but
confront
challenges
faithfully
mimicking
native
structures
functions.
Bioprinting
technologies
offer
a
significant
advancement,
especially
when
combined
with
organoid
bioinks-engineered
formulations
designed
to
encapsulate
both
the
architectural
functional
elements
of
specific
tissues.
This
review
provides
rigorous,
focused
examination
evolution
impact
bioprinting.
It
emphasizes
role
bioinks
that
integrate
key
cellular
components
microenvironmental
cues
more
accurately
replicate
complexity.
Furthermore,
this
anticipates
transformative
landscape
invigorated
by
integration
artificial
intelligence
bioprinting
techniques.
Such
fusion
promises
refine
bioink
optimize
parameters,
thus
catalyzing
unprecedented
advancements
medicine.
In
summary,
accentuates
pivotal
potential
advancing
therapies,
deepening
our
understanding
organ
development,
clarifying
disease
mechanisms.
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
13(21)
Published: Jan. 15, 2024
Microfluidic
chips
are
valuable
tools
for
studying
intricate
cellular
and
cell-microenvironment
interactions.
Traditional
in
vitro
cancer
models
lack
accuracy
mimicking
the
complexities
of
vivo
tumor
microenvironment.
However,
cancer-metastasis-on-a-chip
(CMoC)
combine
advantages
3D
cultures
microfluidic
technology,
serving
as
powerful
platforms
exploring
mechanisms
facilitating
drug
screening.
These
able
to
compartmentalize
metastatic
cascade,
deepening
understanding
its
underlying
mechanisms.
This
article
provides
an
overview
current
CMoC
models,
focusing
on
distinctive
that
simulate
invasion,
intravasation,
circulation,
extravasation,
colonization,
their
applications
Furthermore,
challenges
faced
by
technologies
discussed,
while
promising
future
directions
research.
The
ongoing
development
integration
these
into
studies
expected
drive
transformative
advancements
field.
