Bioorganic Chemistry, Journal Year: 2023, Volume and Issue: 133, P. 106429 - 106429
Published: Feb. 20, 2023
Language: Английский
EP Europace, Journal Year: 2024, Volume and Issue: 26(9)
Published: July 30, 2024
Abstract Aims The concept of “atrial cardiomyopathy” (AtCM) had been percolating through the literature since its first mention in 1972. Since then, publications using term were sporadic until decision was made to convene an expert working group with representation from four multinational arrhythmia organizations prepare a consensus document on atrial cardiomyopathy 2016 (EHRA/HRS/APHRS/SOLAECE cardiomyopathies: definition, characterization, and clinical implication). Subsequently, AtCM have increased progressively. Methods results present elaborates further implement simple staging system (AtCM stages 1–3) by integrating biomarkers, geometry, electrophysiological changes. However, proposed needs validation. Importantly, it is clearly stated that presence might serve as substrate for development fibrillation (AF) AF may accelerates substantially, but per se be viewed separate entity. Conclusion Thus, serves statement European Heart Rhythm Association (EHRA) ESC, Society (HRS), Asian Pacific (APHRS), Latin American (LAHRS) contribute evolution concept.
Language: Английский
Citations
41
Antioxidants, Journal Year: 2024, Volume and Issue: 13(1), P. 117 - 117
Published: Jan. 17, 2024
The adipose tissue has long been thought to represent a passive source of triglycerides and fatty acids. However, extensive data have demonstrated that the is also major endocrine organ directly or indirectly affects physiological functions almost all cell types. Obesity recognized as risk factor for multiple systemic conditions, including metabolic syndrome, type 2 diabetes mellitus, sleep apnea, cardiovascular disorders, many others. Obesity-related changes in induce functional structural cardiac myocytes, promoting wide range atrial fibrillation (AF). Due wealth epidemiologic linking AF obesity, mechanisms underlying occurrence obese patients are an area rich ongoing investigation. progress somewhat slowed by complex phenotypes both obesity AF. triad inflammation, oxidative stress, mitochondrial dysfunction critical pathogenesis setting via proarrhythmic at level atria. aim this paper provide comprehensive view close relationship between obesity-induced clinical implications these mechanistic insights discussed.
Language: Английский
Citations
23
The Lancet Regional Health - Europe, Journal Year: 2024, Volume and Issue: 37, P. 100785 - 100785
Published: Feb. 1, 2024
Atrial fibrillation (AF) is the most common supraventricular arrhythmia affecting up to 1% of general population. Its prevalence dramatically increases with age and could reach ∼10% in elderly. The management AF a complex issue that object extensive ongoing basic clinical research, it depends on its genetic epigenetic causes, varies considerably geographically also according ethnicity. Mechanistically, over last decade, Genome Wide Association Studies have uncovered 100 loci associated AF, shown European ancestry elevated risk AF. These AF-associated revolve around different types disturbances, including inflammation, electrical abnormalities, structural remodeling. Moreover, discovery regulatory mechanisms, involving non-coding RNAs, DNA methylation histone modification, has allowed unravelling what modifications reshape processes leading arrhythmias. Our review provides current state field regarding identification functional characterization AF-related networks, ethnic differences. We discuss clear emerging connections between regulation pathophysiological mechanisms
Language: Английский
Citations
21
Drugs, Journal Year: 2023, Volume and Issue: 83(13), P. 1147 - 1160
Published: Aug. 4, 2023
Cardiac arrhythmias remain a common cause of death and disability. Antiarrhythmic drugs (AADs) antiarrhythmic agents cornerstone current cardiac arrhythmia management, despite moderate efficacy the potential for significant adverse proarrhythmic effects. Due to conceptual, regulatory financial considerations, number novel targets in development pipeline has decreased substantially during last few decades. However, several promising candidates there are exciting developments repurposing reformulating already existing indications related arrhythmias. This review discusses key conceptual considerations new agents, summarizes compounds formulations currently clinical rhythm control atrial fibrillation, highlights drug repurposing. Finally, future directions AAD discussed. Together with an ever-increasing understanding molecular mechanisms underlying arrhythmias, these components support cautiously optimistic outlook towards improved pharmacological treatment opportunities patients suffering from
Language: Английский
Citations
34
Journal of Clinical Investigation, Journal Year: 2023, Volume and Issue: 133(19)
Published: Aug. 15, 2023
Chronic kidney disease (CKD) is associated with a higher risk of atrial fibrillation (AF). The mechanistic link between CKD and AF remains elusive. Interleukin (IL)-1β, main effector 'NLR-family pyrin domain-containing 3' (NLRP3) inflammasome activation, key modulator conditions inflammation, such as CKD. Circulating IL-1β levels were elevated in CKD-patients vs sinus rhythm. Moreover, NLRP3-activity was enhanced atria CKD-patients. To elucidate the role NLRP3/IL-1β signaling pathogenesis CKD-induced AF, wildtype (WT) Nlrp3-/- mice subjected to two-stage subtotal nephrectomy protocol induce 4-weeks post-surgery, serum tissue increased WT-CKD (vs WT-sham) mice. susceptibility pacing-induced longer AF-duration electrical remodeling, enlarged atria, fibrosis. Genetic inhibition NLRP3 or neutralizing anti-IL-1β antibodies effectively reduced IL-1β-levels, normalized left dimensions, fibrosis AF-incidence. These data suggest that creates substrate for development by activating which structural remodeling. Neutralizing may be beneficial prevention AF.
Language: Английский
Citations
30
Journal of the American College of Cardiology, Journal Year: 2024, Volume and Issue: 83(20), P. 2015 - 2027
Published: May 1, 2024
Language: Английский
Citations
15
Journal of Thoracic Disease, Journal Year: 2024, Volume and Issue: 16(2), P. 1503 - 1520
Published: Feb. 1, 2024
Abstract: Postoperative atrial fibrillation (POAF) after cardiac surgery is associated with elevated morbidity and mortality. Although current prediction models have limited efficacy, several perioperative interventions can reduce patients' risk of POAF. These begin preoperative medications, including beta-blockers amiodarone. Moreover, patients should be screened for preexisting (AF) so that concomitant surgical ablation left appendage occlusion performed in appropriate candidates. Intraoperative such as posterior pericardiectomy mediastinal fluid accumulation, which a trigger Furthermore, many preventive strategies POAF are implemented the immediate postoperative period. Initiating beta-blockers, amiodarone, or both reasonable most patients. Overdrive pacing, colchicine, steroids been used by some, although evidence base less robust. For POAF, rate-control rhythm-control comparable outcomes. Decision-making regarding anticoagulation recognize stroke appears to lower than general nonvalvular AF. The oral reduces clear Given tends shorter-lived greater bleeding risks period, decisions individualized. Finally, wearable technology machine learning algorithms better predicting managing appear coming soon. technologies comprehensive clinical program could meaningfully incidence this common complication.
Language: Английский
Citations
13
Cardiovascular Pathology, Journal Year: 2024, Volume and Issue: 73, P. 107683 - 107683
Published: Aug. 6, 2024
Language: Английский
Citations
13
AJP Cell Physiology, Journal Year: 2024, Volume and Issue: 326(2), P. C551 - C566
Published: Jan. 9, 2024
β-Hydroxybutyrate (βOHB) is the major ketone in body, and it recognized as a metabolic energy source an important signaling molecule. While oxidation essential brain during prolonged fasting/starvation, other organs such skeletal muscle heart also use ketones substrates. Additionally, βOHB-mediated molecular events occur cells, via metabolism and/or signaling, may contribute to optimal health cardiac function. Of importance, when of for ATP production molecules becomes disturbed presence underlying obesity, type 2 diabetes, cardiovascular diseases, these changes cardiometabolic disease. As result disturbances disease, multiple approaches have been used elevate circulating with goal optimizing either or ketone-mediated signaling. These produced significant improvements disease wide range benefits that include improved metabolism, weight loss, better glycemic control, vascular function, well reduced inflammation oxidative stress. Herein, we present evidence indicates therapy could be approach help treat diseases by targeting muscles.
Language: Английский
Citations
9
IJC Heart & Vasculature, Journal Year: 2024, Volume and Issue: 51, P. 101372 - 101372
Published: Feb. 23, 2024
Inflammation is related to cardiovascular disease. Among the many inflammatory markers, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte (PLR), and systemic immune-inflammatory index (SII) were considered as novel predictors for atherosclerosis outcomes. We aimed investigate impact of these markers on prognosis patients with atrial fibrillation (AF).
Language: Английский
Citations
9