Fungal Biology Reviews, Journal Year: 2024, Volume and Issue: 49, P. 100367 - 100367
Published: May 6, 2024
Over three decades ago, the plant-derived anticancer agent taxol (brand name: paclitaxel) was reported from a fungal endophyte colonizing producing plant. The hope that this finding could ever result in sustainable production process has thus far been disappointed. Modern evidence on evolution of secondary metabolites plants vs. fungi suggests hypothesis (that produce such complex plant metabolites) is invalid. Still, numerous inconclusive original studies -and particular, review papers by non-experts field-are continuously being published claim opposite. current commentary tries to deal with topic, taking findings –OMICS and state-of-the art mycology into account. This can hopefully help stop scientific papermills further spreading fake news were capable taxol.
Language: Английский
Citations
4Comparing total chemical synthesis and total biosynthesis routes to fungal specialized metabolites
Natural Product Reports, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
Here we compare chemical and biological total syntheses to the same metabolites.
Language: Английский
Citations
4Developing filamentous fungal chassis for natural product production
Bioresource Technology, Journal Year: 2024, Volume and Issue: unknown, P. 131703 - 131703
Published: Oct. 1, 2024
Language: Английский
Citations
3Fungi: Pioneers of chemical creativity – Techniques and strategies to uncover fungal chemistry
IMA Fungus, Journal Year: 2025, Volume and Issue: 16
Published: March 7, 2025
Natural product discovery from fungi for drug development and description of novel chemistry has been a tremendous success. This success is expected to accelerate even further, owing the advent sophisticated technical advances that recently led an unparalleled biodiversity in fungal kingdom. review aims give overview on i) important secondary metabolite-derived drugs or leads, ii) discuss analytical strategic framework how natural lead identification transformed earlier days present, iii) knowledge biology facilitates new compounds, iv) point out endeavors understanding metabolite order systematically explore genomes by utilizing synthetic biology. An outlook given, underlining necessity collaborative cooperative scenario harness full potential metabolome.
Language: Английский
Citations
0The Significance of Fungal Specialized Metabolites in One Health Perspectives
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 3120 - 3120
Published: March 28, 2025
Among the emerging threats in global health, fungal pathogens stand out as some of most important, causing over 1.6 million deaths annually and destroying a third all food crops each year, exacerbating insecurity economic losses. Climate change further amplifies threat by enabling pathogenic fungi to survive at mammalian temperatures, increasing risks zoonotic transmission antifungal resistance. In this context, interdisciplinary research, particularly One Health approach, is crucial for understanding evolution resistance improving diagnostic therapeutic tools. Drawing lessons from agriculture, where integrated pest management strategies successfully mitigate threats, could offer new ways tackle infections humans. Advanced metabolomics diagnostics, including metabolites biomarkers, hold promise early detection personalized treatment. Collaborative efforts between medicine, veterinary science, plant pathology are essential develop drugs improve clinical diseases, fostering more resilient health system.
Language: Английский
Citations
0New frontiers in the biosynthesis of psychoactive specialized metabolites
Current Opinion in Plant Biology, Journal Year: 2024, Volume and Issue: 82, P. 102626 - 102626
Published: Sept. 16, 2024
The recent relaxation of psychedelic drug regulations has prompted extensive clinical investigation into their potential use to treat diverse mental health conditions including anxiety, depression, post-traumatic stress, and substance-abuse disorders. Most trials have relied on a small number known molecules found in nature, such as psilocybin, or long-known synthetic analogs natural metabolites, lysergic acid diethylamide (LSD). Elucidation biosynthetic pathways leading several compounds established an opportunity biology complement chemistry for the preparation novel derivatives with potentially superior pharmacological properties compared drugs. Herein we review metabolic biochemistry from plants, fungi animals that yield medicinally important hallucinogenic specialized metabolites ibogaine, mescaline, acid, N,N-dimethyltryptamine (DMT). We also summarize reconstitution these microorganisms comment integration native non-native enzymes prepare derivatives.
Language: Английский
Citations
1A review of the pharmaceutical applications of endophytic fungal secondary metabolites
Natural Product Research, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 17
Published: Nov. 8, 2024
A major challenge to human health is the emergence of drug-resistant pathogenic strains organisms. Studies have found ecologically friendly, cost-effective, and innocuous alternative sources bioactive compounds capable managing menace. This review x-rays endophytic fungal community pharmaceutical applications their secondary metabolites. Endophytic fungi house biologically active compounds, which makes them a good alternative. Also, intrinsic ability produce such an avalanche could be attributed mutualistic interaction with plant's host. Secondary metabolites harvested from been identified categorised: steroids, xanthones, terpenoids, isocoumarins, phenols, tetralones, benzopyranones, enniatrines. also highlights optimisation strategy, co-culture method, chemical epigenetic remodelling, molecular method as approaches adopted boost production compounds. The numerous were equally presented, include properties, well use in industries.
Language: Английский
Citations
0Genomes and Genomics of the Genus Trichoderma
Published: Jan. 1, 2024
Language: Английский
Citations
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