Identifying Pyroptosis-Hub Genes and Inflammation Cell Type-Related Genes in Ischemic Stroke DOI Creative Commons

Wei Ge,

Liangbin Cao,

Can Liu

et al.

Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 3, 2025

Stroke is the second-leading global cause of death. The damage attributed to immune storm triggered by ischemia–reperfusion injury (IRI) post-stroke substantial. However, data on transcriptomic dynamics pyroptosis in IRI are limited. This study aimed analyze expression key genes stroke and their correlation with infiltration. Pyroptosis-related were identified from obtained middle cerebral artery occlusion (MCAO) datasets. Differential functional analyses pyroptosis-related performed, differences enrichment between high-risk low-risk groups determined. An MCAO diagnostic model was constructed validated using selected differential expression. High- for cell analysis hub genes. A regulatory network miRNA also constructed, protein domains predicted. an rat model. Twenty-five showed expression, including four genes, namely WISP2, MELK, SDF2L1, AURKB. Characteristic verified real-time quantitative PCR analyses. high- significant SDF2L1. In infiltration analysis, 12 cells samples. Further demonstrated positive correlations gene SDF2L1 cell-activated dendritic group natural killer group. elevated closely associated inflammatory types can predict ischemic risk levels help facilitate treatment.

Language: Английский

Predictive circulating biomarkers of the response to anti‐PD‐1 immunotherapy in advanced HER2 negative breast cancer DOI Creative Commons
Yuhan Wei, Hewei Ge,

Yalong Qi

et al.

Clinical and Translational Medicine, Journal Year: 2025, Volume and Issue: 15(3)

Published: Feb. 25, 2025

Immunotherapy shows promise for treating advanced breast cancer, but only a few patients could respond. Predictive biomarkers from peripheral blood are urgently needed. We designed comprehensive 42-marker mass cytometry panel to profile the samples 57 diagnosed with HER2-negative cancer receiving anti-PD-1 combination therapy. Patients were categorized as responders and non-responders according 6-month progression-free survival (PFS), followed by phenotypic functional comparations identify candidate predictive biomarkers. Longitudinal analysis of paired further revealed dynamic changes in these specific subpopulations. Non-responders exhibited significantly higher frequencies CD39+ Tregs (adjusted p = .031) T-cell milieu at baseline, which positive correlation PD-1+ T cells NR group. assessment indicated significant decrease an increase following treatment, suggesting their potential role immunotherapy resistance. In myeloid compartment, showed CCR2+ monocyte-derived dendritic cell than .037). These positively correlated other negatively naïve non-responders. Based on two efficacy-related biomarkers, we developed prognostic prediction model confirmed its superiority distinguishing patient PFS (p < .001). Peripheral response, serving guide therapeutic choices immunotherapy. associated poor response cancer. Higher correlate better outcomes. A based effectively distinguishes survival. offer non-invasive approach choices.

Language: Английский

Citations

1
Engineering innate immune cells for cancer immunotherapy DOI
Mubin Tarannum,

Xizhong Ding,

Marta Barisa

et al.

Nature Biotechnology, Journal Year: 2025, Volume and Issue: 43(4), P. 516 - 533

Published: April 1, 2025

Language: Английский

Citations

1
Cleavage of Homonuclear Chalcogen‐Chalcogen Bonds in a Hybrid Platform in Response to X‐Ray Radiation Potentiates Tumor Radiochemotherapy DOI Open Access

Yuanyuan You,

Yanzhou Chang,

Shuya Pan

et al.

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 64(1)

Published: Aug. 23, 2024

Chalcogens are used as sensitive redox-responsive reagents in tumor therapy. However, chalcogen bonds triggered by external ionizing radiation, rather than internal environmental stimuli, enable site-directed and real-time drug degradation target lesions. This approach helps to bypass chemoresistance global systemic toxicity, presenting a significant advancement over traditional chemoradiotherapy. In this study, we fabricated hybrid monodisperse organosilica nanoprodrug based on homonuclear single (disulfide (S-S, approximately 240 kJ/mol), diselenium (Se-Se, 172 tellurium (Te-Te, 126 kJ/mol)), including ditelluride-bond-bridged MONs (DTeMSNs), diselenide-bond-bridged (DSeMSNs) disulfide-bond-bridged (DSMSNs). The results demonstrated that differences electronegativities atomic radii influenced their oxidation sensitivities reactivities. Tellurium, with the lowest electronegativity, showed highest sensitivity, followed selenium sulfur. DTeMSNs exhibited highly responsive cleavage upon exposure X-rays, resulting TeO

Language: Английский

Citations

7
Exploring the role of the immune microenvironment in hepatocellular carcinoma: Implications for immunotherapy and drug resistance DOI Creative Commons
Yumin Fu, Xinyu Guo, Linmao Sun

et al.

eLife, Journal Year: 2024, Volume and Issue: 13

Published: Aug. 15, 2024

Hepatocellular carcinoma (HCC), the most common type of liver tumor, is a leading cause cancer-related deaths, and incidence cancer still increasing worldwide. Curative hepatectomy or transplantation only indicated for small population patients with early-stage HCC. However, HCC are not candidates radical resection due to disease progression, choice conventional tyrosine kinase inhibitor drug sorafenib as first-line treatment. In past few years, immunotherapy, mainly immune checkpoint inhibitors (ICIs), has revolutionized clinical strategy Combination therapy ICIs proven more effective than sorafenib, trials have been conducted apply these therapies patients. Despite significant progress in molecular mechanisms behind it remain unclear, resistance often challenging overcome. Several studies pointed out that complex intercellular communication network microenvironment regulates tumor escape response. This underscores urgent need analyze review describes immunosuppressive cell populations HCC, well related trials, aiming provide insights next generation precision immunotherapy.

Language: Английский

Citations

5
The current role of dendritic cells in the progression and treatment of colorectal cancer DOI Creative Commons

Yuanci Zhang,

Songtao Ji,

Ge Miao

et al.

Cancer Biology and Medicine, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 15

Published: Aug. 22, 2024

Colorectal cancer (CRC) is the third most common and second leading cause of cancer-related deaths worldwide. Dendritic cells (DCs) constitute a heterogeneous group antigen-presenting that are important for initiating regulating both innate adaptive immune responses. As crucial component system, DCs have pivotal role in pathogenesis clinical treatment CRC. cross-present tumor-related antigens to activate T trigger an antitumor response. However, function impaired tolerance promoted due presence tumor microenvironment. This review systematically elucidates specific characteristics functions different DC subsets, as well play response within CRC Moreover, how contribute progression potential therapies enhance immunity on basis existing data also discussed, which will provide new perspectives approaches immunotherapy patients with

Language: Английский

Citations

5
Tertiary lymphoid structure formation induced by LIGHT-engineered and photosensitive nanoparticles-decorated bacteria enhances immune response against colorectal cancer DOI

Lijun Hu,

Li Tan, Shaohui Deng

et al.

Biomaterials, Journal Year: 2024, Volume and Issue: 314, P. 122846 - 122846

Published: Sept. 18, 2024

Language: Английский

Citations

5
Turning cold into hot: emerging strategies to fire up the tumor microenvironment DOI
Kejing Ma, Lin Wang, Wenhui Li

et al.

Trends in cancer, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Language: Английский

Citations

5
From antigen uptake to immune modulation: the multifaceted potential of peptide nanofibers as vaccine nanocarriers DOI Creative Commons
Hatem A. F. M. Hassan, Mohamed Haider, Sherif Ashraf Fahmy

et al.

Materials Advances, Journal Year: 2024, Volume and Issue: 5(10), P. 4112 - 4130

Published: Jan. 1, 2024

Peptide nanofibers have exhibited a remarkable ability to enhance immune response induction. Herein, we explore the peptide nanofibers' transformative potential, providing comprehensive examination of their application in vaccine development.

Language: Английский

Citations

4
Cleavage of Homonuclear Chalcogen‐Chalcogen Bonds in a Hybrid Platform in Response to X‐Ray Radiation Potentiates Tumor Radiochemotherapy DOI Open Access

Yuanyuan You,

Yanzhou Chang,

Shuya Pan

et al.

Angewandte Chemie, Journal Year: 2024, Volume and Issue: 137(1)

Published: Aug. 23, 2024

Abstract Chalcogens are used as sensitive redox‐responsive reagents in tumor therapy. However, chalcogen bonds triggered by external ionizing radiation, rather than internal environmental stimuli, enable site‐directed and real‐time drug degradation target lesions. This approach helps to bypass chemoresistance global systemic toxicity, presenting a significant advancement over traditional chemoradiotherapy. In this study, we fabricated hybrid monodisperse organosilica nanoprodrug based on homonuclear single (disulfide (S−S, approximately 240 kJ/mol), diselenium (Se−Se, 172 tellurium (Te−Te, 126 kJ/mol)), including ditelluride‐bond‐bridged MONs (DTeMSNs), diselenide‐bond‐bridged (DSeMSNs) disulfide‐bond‐bridged (DSMSNs). The results demonstrated that differences electronegativities atomic radii influenced their oxidation sensitivities reactivities. Tellurium, with the lowest electronegativity, showed highest sensitivity, followed selenium sulfur. DTeMSNs exhibited highly responsive cleavage upon exposure X‐rays, resulting TeO 3 2− . Furthermore, chalcogen‐hybridized was loaded manganese ions (Mn 2+ ) enhance release of Mn during radiotherapy, thereby activating stimulator interferon genes (STING) pathway enhancing immune response inhibit growth. investigation deepens our understanding chalcogens characteristics radiotherapy enriches design principles for nanomedicine prodrugs.

Language: Английский

Citations

4
Oncolytic virus and tumor-associated macrophage interactions in cancer immunotherapy DOI Creative Commons

Marc Lecoultre,

Paul R. Walker, Aya El Helali

et al.

Clinical and Experimental Medicine, Journal Year: 2024, Volume and Issue: 24(1)

Published: Aug. 28, 2024

Abstract Oncolytic viruses (OV) are a promising strategy in cancer immunotherapy. Their capacity to promote anti-tumoral immunity locally raises hope that cancers unresponsive current immunotherapy approaches could be tackled more efficiently. In this context, tumor-associated macrophages (TAM) must considered because of their pivotal role immunity. Even though TAM tend inhibit responses, ability secrete pro-inflammatory cytokines and phagocytose cells can harnessed therapeutic OVs have the potential functions favor But parallel, induce OV clearance tumor, thereby limiting efficacy highlighting interaction between is double edge sword. Moreover, engineered were recently developed modulate specific such as phagocytic activity. The circulating monocytes deliver into tumor after intravenous administration also emerging. review, we will present TAM, functions, delivery tumor.

Language: Английский

Citations

4