Physical Exercise and Selective Autophagy: Benefit and Risk on Cardiovascular Health DOI Creative Commons
Ne N. Wu, Haili Tian, Peijie Chen

et al.

Cells, Journal Year: 2019, Volume and Issue: 8(11), P. 1436 - 1436

Published: Nov. 14, 2019

Physical exercise promotes cardiorespiratory fitness, and is considered the mainstream of non-pharmacological therapies along with lifestyle modification for various chronic diseases, in particular cardiovascular diseases. may positively affect risk factors including body weight, blood pressure, insulin sensitivity, lipid glucose metabolism, heart function, endothelial fat composition. With ever-rising prevalence obesity other types metabolic as well sedentary lifestyle, regular moderate intensity has been indicated to benefit health reduce overall disease mortality. Exercise offers a wide cadre favorable responses system such improved dynamics system, reduced coronary diseases cardiomyopathies, enhanced cardiac reserve capacity, autonomic regulation. Ample clinical experimental evidence an emerging role autophagy, conservative catabolism process degrade recycle cellular organelles nutrients, training-offered benefits. Regular physical unique form physiological stress capable triggering adaptation while autophagy selective seems be permissive adaptation. Here this mini-review, we will summarize mitochondrial namely mitophagy versus on function.

Language: Английский

Role of Renin-Angiotensin-Aldosterone System Activation in Promoting Cardiovascular Fibrosis and Stiffness DOI Open Access
Guanghong Jia, Annayya R. Aroor, Michael A. Hill

et al.

Hypertension, Journal Year: 2018, Volume and Issue: 72(3), P. 537 - 548

Published: July 9, 2018

Language: Английский

Citations

150
FTO – A Common Genetic Basis for Obesity and Cancer DOI Creative Commons
Ning Lan, Ying Lu, Yigan Zhang

et al.

Frontiers in Genetics, Journal Year: 2020, Volume and Issue: 11

Published: Nov. 16, 2020

In recent years, the prevalence of obesity and cancer have been rising. Since this poses a serious threat to human health, relationship between two has attracted much attention. This study examined whether fat mass obesity-associated (FTO) genes are linked, taking into account Genome-wide Association Study (GWAS) that revealed multiple single nucleotide polymorphism sites (SNPs) FTO gene, indicating an association in different populations. proteins proved participate adipogenesis tumorigenesis with post-transcriptional regulation downstream molecular expression or through target mammalian protein rapamycin (mTOR). inhibitors also found share anti-obesity anti-cancer effects vivo. review, we comprehensively discuss correlation by measuring gene polymorphism, as well mechanism involved these diseases, emphasizing common genetic basis cancer.

Language: Английский

Citations

130
Obesity Paradox in Aging: From Prevalence to Pathophysiology DOI
Shuyi Wang, Jun Ren

Progress in Cardiovascular Diseases, Journal Year: 2018, Volume and Issue: 61(2), P. 182 - 189

Published: July 1, 2018

Language: Английский

Citations

109
FUNDC1 interacts with FBXL2 to govern mitochondrial integrity and cardiac function through an IP3R3-dependent manner in obesity DOI Creative Commons
Jun Ren, Mingming Sun, Hao Zhou

et al.

Science Advances, Journal Year: 2020, Volume and Issue: 6(38)

Published: Sept. 16, 2020

The mitophagy receptor FUNDC1 interacts with FBXL2 to preserve mitochondrial Ca 2+ homeostasis and cardiac function in obesity.

Language: Английский

Citations

108
Physical Exercise and Selective Autophagy: Benefit and Risk on Cardiovascular Health DOI Creative Commons
Ne N. Wu, Haili Tian, Peijie Chen

et al.

Cells, Journal Year: 2019, Volume and Issue: 8(11), P. 1436 - 1436

Published: Nov. 14, 2019

Physical exercise promotes cardiorespiratory fitness, and is considered the mainstream of non-pharmacological therapies along with lifestyle modification for various chronic diseases, in particular cardiovascular diseases. may positively affect risk factors including body weight, blood pressure, insulin sensitivity, lipid glucose metabolism, heart function, endothelial fat composition. With ever-rising prevalence obesity other types metabolic as well sedentary lifestyle, regular moderate intensity has been indicated to benefit health reduce overall disease mortality. Exercise offers a wide cadre favorable responses system such improved dynamics system, reduced coronary diseases cardiomyopathies, enhanced cardiac reserve capacity, autonomic regulation. Ample clinical experimental evidence an emerging role autophagy, conservative catabolism process degrade recycle cellular organelles nutrients, training-offered benefits. Regular physical unique form physiological stress capable triggering adaptation while autophagy selective seems be permissive adaptation. Here this mini-review, we will summarize mitochondrial namely mitophagy versus on function.

Language: Английский

Citations

104