Stimuli-responsive therapeutic systems for the treatment of diabetic infected wounds

Nanoscale, Journal Year: 2022, Volume and Issue: 14(36), P. 12967 - 12983

Published: Jan. 1, 2022

Diabetic wound infection is a common disease that has significantly reduced people's quality of life. Although tremendous achievements have been made in clinical treatment, the crucial challenge diabetic infected management stems from detrimental environment and emergence bacterial resistance after long-term medication, which result efficacy, an increased dosage severe side effects. To tackle these issues, it great significance to develop innovative treatment strategy for therapy. Currently, exploitation nanobiomaterial-based therapeutic systems wounds booming, with stimuli-responsive performance received extensive attention. These are able accelerate healing due on-demand release agents response stimulating factors. Based on characteristics wounds, many endogenous (e.g., glucose, enzyme, hypoxia, acidity) employed targeted patients. Additionally, exogenous stimulants, including light, magnetism, temperature, also capable achieving drug activation. In this review, presented, then exogenous/endogenous stimuli summarized. Finally, current challenges future outlook discussed.

Language: Английский

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Management of Type 2 Diabetes Mellitus in Elderly Patients with Frailty and/or Sarcopenia

International Journal of Environmental Research and Public Health, Journal Year: 2022, Volume and Issue: 19(14), P. 8677 - 8677

Published: July 16, 2022

The life expectancy of the population is increasing worldwide due to improvements in prevention, diagnosis, and treatment diseases. This favors a higher prevalence type 2 diabetes mellitus (T2DM) elderly. Sarcopenia frailty are also frequently present aging. These three entities share common mechanisms such as insulin resistance, chronic inflammation, mitochondrial dysfunction. coexistence these situations worsens prognosis elderly patients. In this paper, we review main measures for prevention management sarcopenia and/or patients with T2DM.

Language: Английский

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Cinnamon as a Complementary Therapeutic Approach for Dysglycemia and Dyslipidemia Control in Type 2 Diabetes Mellitus and Its Molecular Mechanism of Action: A Review

Nutrients, Journal Year: 2022, Volume and Issue: 14(13), P. 2773 - 2773

Published: July 5, 2022

The scientific evidence that cinnamon may exert beneficial effects on type 2 diabetes mellitus due to the biological activity of its bioactive compounds has been increasing in recent years. This review provides an overview clinical parameters and summarizes molecular mechanisms action glucose lipid metabolism. Search criteria include electronic search using PubMed, Medline, Cochrane Library databases. English literature references from 2000 up 2022 were included. Following title abstract review, full articles met inclusion results available revealed improved glycemic lipidemic indicators. Clinical trials clarified also possesses anti-inflammatory effect, which act beneficially diabetes. Based vitro vivo studies, seems elicit regulation metabolism tissues by insulin-mimetic effect enzyme improvement. Furthermore, decrease cholesterol fatty acid absorption gut. current showed a considerable number studies diabetic subjects. Some limitations comparing published data should be highlighted, including variability doses, extracts species cinnamon, administration forms, antidiabetic therapy.

Language: Английский

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Anthocyanins in Chronic Diseases: The Power of Purple

Nutrients, Journal Year: 2022, Volume and Issue: 14(10), P. 2161 - 2161

Published: May 23, 2022

Anthocyanins are mainly purple-coloured phenolic compounds of plant origin that as secondary metabolites important in survival. Understanding their health benefits humans requires sourcing these unstable sufficient quantities at a reasonable cost, which has led to improved methods extraction. Dark-coloured fruits, cereals and vegetables current sources compounds. The range potential sustainable is much larger includes non-commercialised native plants from around the world agri-waste containing anthocyanins. In last 5 years, there have been significant advances developing therapeutic anthocyanins chronic human diseases. exert beneficial effects through improvements gut microbiota, oxidative stress inflammation, modulation neuropeptides such insulin-like growth factor-1. Their include reduced cognitive decline; protection organs liver, well cardiovascular system, gastrointestinal tract kidneys; bone obesity; regulation glucose lipid metabolism. This review summarises some mechanisms treatment

Language: Английский

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Insulin Clearance in Health and Disease

Annual Review of Physiology, Journal Year: 2022, Volume and Issue: 85(1), P. 363 - 381

Published: Oct. 19, 2022

Insulin action is impaired in type 2 diabetes. The functions of the hormone are an integrated product insulin secretion from pancreatic β-cells and clearance by receptor-mediated endocytosis degradation, mostly liver (hepatocytes) and, to a lower extent, extrahepatic peripheral tissues. Substantial evidence indicates that genetic or acquired abnormalities predispose In recent years, along with discovery molecular foundation clearance, such as through membrane glycoprotein CEACAM1, consensus has begun emerge reduction contributes disease process. this review, we consider suggesting pathogenic role for reduced resistance, obesity, hepatic steatosis,

Language: Английский

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Biological ageing and the risks of all-cause and cause-specific mortality among people with diabetes: a prospective cohort study

Journal of Epidemiology & Community Health, Journal Year: 2022, Volume and Issue: 76(9), P. 771 - 778

Published: June 23, 2022

Background The aetiology of diabetes is complex with limited treatment strategies. Growing animal studies have shown that targeted antiageing can improve the outcomes diabetes. However, population evidence limited. This study aims to evaluate associations biological ageing all-cause and cause-specific mortality among people Methods A total 5278 from National Health Nutrition Examination Survey 1999–2014 were included. Biological was measured different perspectives, including phenotypic age, telomere length klotho concentration. Phenotypic/biological age acceleration residual resulting a linear model when regressing phenotypic/biological on chronological age. Cox proportional hazards models used examine relationships between all-cause, cardiovascular disease (CVD), cancer mortality. Results Over median follow-up for 7.3 years, 1355 diabetics died. There positive association (HR 1.04; HR CVD 1.04, p<0.001) 1.03; 1.03, p<0.001). Telomere inversely associated (tertile (T)3 vs T1: 0.67, p<0.05). concentration had U-shaped relationship (T2 0.62; 0.48; 0.47, Further, stratified analysis by sex found ageing-related markers more significant in aged female subgroup. Conclusions positively diabetes, indicating therapies targeting could be encouraged halt progression

Language: Английский

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Data mining approaches for type 2 diabetes mellitus prediction using anthropometric measurements

Journal of Clinical Laboratory Analysis, Journal Year: 2022, Volume and Issue: 37(1)

Published: Dec. 12, 2022

The aim of this study was to evaluate the anthropometric measurements most associated with type 2 diabetes mellitus (T2DM) using machine learning approaches.A prospective designed for a total population 9354 (43% men and 57% women) aged 35-65. Anthropometric include weight, height, demispan, Hip Circumference (HC), Mid-arm (MAC), Waist (WC), Body Roundness Index (BRI), Adiposity (BAI), A Shape (ABSI), Mass (BMI), Waist-to-height Ratio (WHtR), Waist-to-hip (WHR) were completed all participants. association assessed logistic regression (LR) decision tree (DT) analysis. Receiver operating characteristic (ROC) curve performed DT's accuracy, sensitivity, specificity R software.Traditionally, 1461 women 875 T2DM (T2DM group). According LR, in males, WC BIA (p-value < 0.001) females, demispan had highest correlation development risk. DT indicated that has crucial effect on risk, followed by HC, BAI.Our results showed both women, important factor predict T2DM.

Language: Английский

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Human Digital Twin for Personalized Elderly Type 2 Diabetes Management

Journal of Clinical Medicine, Journal Year: 2023, Volume and Issue: 12(6), P. 2094 - 2094

Published: March 7, 2023

Managing Elderly type 2 diabetes (E-T2D) is challenging due to geriatric conditions (e.g., co-morbidity, multiple drug intake, etc.), and personalization becomes paramount for precision medicine. This paper presents a human digital twin (HDT) framework manage E-T2D that exploits various patient-specific data builds suite of models exploiting the prediction management personalize treatment in patients. These include mathematical deep-learning ones capture different patient aspects. Consequently, HDT virtualizes from viewpoints using an mimics has interfaces update virtual simultaneously measurements. Using these obtains deeper insights about patient. Further, adaptive model fusing this information learning-based predictive control (LB-MPC) algorithm are proposed. The captured as parameters constraints while solving LB-MPC insulin infusion management. deployed on illustrated with 15 patients clinical trials simulations. Our results show helps improve time-in-range 3-75% 86-97% reduces by 14-29%.

Language: Английский

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Lifestyle Intervention Strategy to Treat Diabetes in Older Adults: A Randomized Controlled Trial

Diabetes Care, Journal Year: 2022, Volume and Issue: 45(9), P. 1943 - 1952

Published: July 26, 2022

Lifestyle intervention is recommended as first-line treatment of diabetes at all ages; however, little known about the efficacy lifestyle in older adults with diabetes. We aimed to determine whether would improve glycemic control and age-relevant outcomes comorbidities.A total 100 were randomly assigned 1-year intensive (ILI) (diet exercise a facility transitioned into community-fitness centers homes) or healthy (HL) group. The primary outcome was change HbA1c. Secondary included glucoregulation, body composition, physical function, quality life. Changes between groups analyzed mixed-model repeated-measures ANCOVA following intention-to-treat principle.HbA1c improved more ILI than HL group (mean ± SE -0.8 0.1 vs. 0.1%), associated insulin sensitivity (1.2 0.2 -0.4 0.2) disposition (26.0 8.9 -13.0 8.4 109 min-1) indices (between-group P < 0.001 0.04). Body weight visceral fat decreased (-8.4 0.6 -0.3 kg, 0.001, -261 29 -30 27 cm3, respectively). Physical Performance Test score increased (2.9 -0.1 0.4, 0.001) did VO2peak (2.2 0.3 -1.2 mL/kg/min, 0.001). Strength, gait, 36-Item Short Form Survey (SF-36) Component Summary also (all Total dose by 19.8 4.4 units/day. Adverse events episodes mild hypoglycemia group.A strategy highly successful improving metabolic functional health

Language: Английский

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Higher risk of sarcopenia in older adults with type 2 diabetes: NHANES 1999-2018

Obesity Facts, Journal Year: 2023, Volume and Issue: 16(3), P. 237 - 248

Published: Jan. 1, 2023

Introduction: Recent studies suggested that sarcopenia may be a significant comorbidity of diabetes mellitus (DM). Nonetheless, with nationally representative data are scarce, and the changing trend prevalence over time is largely unknown. Therefore, we aimed to estimate compare in diabetic nondiabetic US older population, explore potential predictors as well prevalent past decades. Methods: Data were retrieved from National Health Nutrition Examination Survey (NHANES). Sarcopenia DM defined according corresponding diagnosis criteria. Weighted was calculated compared between participants. The differences among age ethnicity groups explored. Results: A total 6,381 adults (&gt;50 years) involved. overall 17.8% for elders, higher (27.9% vs. 15.7%) those ones than without. Stepwise regression revealed significantly associated (adjusted odds ratio = 1.37, 95% CI: 1.08–1.22; p &lt; 0.05) after controlling confounders including gender, age, ethnicity, educational level, BMI, muscle strengthening activity. slight fluctuation but increasing observed while no obvious their counterparts recent Conclusion: Diabetic face risk when counterparts. Gender, obesity important influencing factors development.

Language: Английский

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